First pharmacophore-based identification of androgen receptor down-regulating agents: Discovery of potent anti-prostate cancer agents

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 10, 2007, Pages 3413-3421

  Purushottamachar, Puranik ^a   Khandelwal, Aakanksha ^a   Chopra, Pankaj ^a   Maheshwari, Neha ^a   Gediya, Lalji K ^a   Vasaitis, Tadas S ^a   Bruno, Robert D ^a   Clement, Omoshile O ^b   Njar, Vincent C O ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b BIO RAD LABORATORIES   (United States)

Author keywords

Androgen receptor down regulating agents; Anti prostate cancer agents; Catalyst hypothesis; Pharmacophore

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; ANDROGEN RECEPTOR; ANTIANDROGEN; ANTINEOPLASTIC AGENT; BTB 01434; CURCUMIN; EPICATECHIN; FLUFENAMIC ACID; HORMONE RECEPTOR BLOCKING AGENT; KM 06622; NCI 0001009; NCI 0002091; NCI 0002815; NCI 0004355; QUERCETIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CATALYST; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; MITOSIS INHIBITION; MODEL; MOLECULE; PHARMACOPHORE; PROSTATE CANCER; QUALITATIVE ANALYSIS; RECEPTOR DOWN REGULATION;

ANDROGEN ANTAGONISTS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CATALYSIS; CELL LINE, TUMOR; COMPUTATIONAL BIOLOGY; DATABASES, FACTUAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMANS; MALE; MODELS, MOLECULAR; NEOPLASM PROTEINS; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLIUM SALTS; THIAZOLES;

EID: 34047135626     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.03.019     Document Type: Article

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