메뉴 건너뛰기




Volumn 6, Issue 4, 2005, Pages 429-434

Forward in reverse: How reverse genetics complements chemical genetics

Author keywords

Chemical biology; Chemical genetics; Mechanism of action; Molecular libraries initiative; Reverse genetics; RNAi; Small molecule; Target identification

Indexed keywords

FARNESYL TRANS TRANSFERASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR;

EID: 21444458446     PISSN: 14622416     EISSN: None     Source Type: Journal    
DOI: 10.1517/14622416.6.4.429     Document Type: Article
Times cited : (7)

References (57)
  • 2
    • 0346731237 scopus 로고    scopus 로고
    • The discovery of ezetimibe: A view from outside the receptor
    • Clader JW: The discovery of ezetimibe: a view from outside the receptor. J. Med. Chem. 47, 1-9 (2004).
    • (2004) J. Med. Chem. , vol.47 , pp. 1-9
    • Clader, J.W.1
  • 3
    • 0142121432 scopus 로고    scopus 로고
    • Trends in development and approval times for new therapeutics in the United States
    • Reichert JM: Trends in development and approval times for new therapeutics in the United States. Nature Rev. Drug Discov. 2, 695-702 (2003).
    • (2003) Nature Rev. Drug Discov. , vol.2 , pp. 695-702
    • Reichert, J.M.1
  • 4
    • 0037454388 scopus 로고    scopus 로고
    • DNA 50 years on: Has it helped drug discovery?
    • Higgs G: DNA 50 years on: has it helped drug discovery? Lancet 361, 1394 (2003).
    • (2003) Lancet , vol.361 , pp. 1394
    • Higgs, G.1
  • 5
    • 0037432765 scopus 로고    scopus 로고
    • From knowing to controlling: A path from genomics to drugs using small molecule probes
    • Strausberg RL, Schreiber SL: From knowing to controlling: a path from genomics to drugs using small molecule probes. Science 300, 294-295 (2003).
    • (2003) Science , vol.300 , pp. 294-295
    • Strausberg, R.L.1    Schreiber, S.L.2
  • 6
    • 8844264615 scopus 로고    scopus 로고
    • A flexible data analysis tool for chemical genetic screens
    • Kelley BP, Lunn MR, Root DE et al.: A flexible data analysis tool for chemical genetic screens. Chem. Biol. 11, 1495-1503 (2004).
    • (2004) Chem. Biol. , vol.11 , pp. 1495-1503
    • Kelley, B.P.1    Lunn, M.R.2    Root, D.E.3
  • 7
    • 0141521869 scopus 로고    scopus 로고
    • Biological mechanism profiling using an annotated compound library
    • Root DE, Flaherty SP, Kelley BP, Stockwell BR: Biological mechanism profiling using an annotated compound library. Chem. Biol. 10, 881-892 (2003).
    • (2003) Chem. Biol. , vol.10 , pp. 881-892
    • Root, D.E.1    Flaherty, S.P.2    Kelley, B.P.3    Stockwell, B.R.4
  • 8
    • 7044227922 scopus 로고    scopus 로고
    • Quantification of the proliferation index of human dermal fibroblast-cultures with the ArrayScan high-content screening reader
    • Gasparri F, Marani M, Sola F, Galvani A: Quantification of the proliferation index of human dermal fibroblast-cultures with the ArrayScan high-content screening reader. J. Biomol. Screen 9, 232-243 (2004).
    • (2004) J. Biomol. Screen , vol.9 , pp. 232-243
    • Gasparri, F.1    Marani, M.2    Sola, F.3    Galvani, A.4
  • 9
    • 1442335997 scopus 로고    scopus 로고
    • Gene expression-based high-throughput screening (GE-HTS) and application to leukemia differentiation
    • Stegmaier K, Ross KN, Colavito SA et al.: Gene expression-based high-throughput screening (GE-HTS) and application to leukemia differentiation. Nature Genet. 36, 257-263 (2004).
    • (2004) Nature Genet. , vol.36 , pp. 257-263
    • Stegmaier, K.1    Ross, K.N.2    Colavito, S.A.3
  • 10
    • 21444455866 scopus 로고    scopus 로고
    • HITS: A high-throughput integrated transcriptional screen for identifying potential therapeutic agents
    • Soppet DR, Castaneda J, Majolagbe A et al.: HITS: a high-throughput integrated transcriptional screen for identifying potential therapeutic agents. Proc. Am. Assoc. Cancer Res. 44, 907 (2003).
    • (2003) Proc. Am. Assoc. Cancer Res. , vol.44 , pp. 907
    • Soppet, D.R.1    Castaneda, J.2    Majolagbe, A.3
  • 11
    • 17044431370 scopus 로고    scopus 로고
    • High-content screening with siRNA optimizes a cell biological approach to drug discovery: Defining the role of P53 activation in the cellular response to anticancer drugs
    • Giuliano KA, Chen YT, Taylor DL: High-content screening with siRNA optimizes a cell biological approach to drug discovery: defining the role of P53 activation in the cellular response to anticancer drugs. J. Biomol. Screen 9, 557-568 (2004).
    • (2004) J. Biomol. Screen , vol.9 , pp. 557-568
    • Giuliano, K.A.1    Chen, Y.T.2    Taylor, D.L.3
  • 12
    • 8444223104 scopus 로고    scopus 로고
    • Multidimensional drug profiling by automated microscopy
    • Perlman ZE, Slack MD, Feng Y et al.: Multidimensional drug profiling by automated microscopy. Science 306, 1194-1198 (2004).
    • (2004) Science , vol.306 , pp. 1194-1198
    • Perlman, Z.E.1    Slack, M.D.2    Feng, Y.3
  • 13
    • 0041913991 scopus 로고    scopus 로고
    • Cell-active dual specificity phosphatase inhibitors identified by high-content screening
    • Vogt A, Cooley KA, Brisson M et al.: Cell-active dual specificity phosphatase inhibitors identified by high-content screening. Chem. Biol. 10, 733-742 (2003).
    • (2003) Chem. Biol. , vol.10 , pp. 733-742
    • Vogt, A.1    Cooley, K.A.2    Brisson, M.3
  • 14
    • 4243191447 scopus 로고    scopus 로고
    • Ligand dependency of 5-hydroxytryptamine 2C receptor internalization
    • Schlag BD, Lou Z, Fennell M, Dunlop J: Ligand dependency of 5-hydroxytryptamine 2C receptor internalization. J. Pharmacol. Exp. Ther. 310, 865-870 (2004).
    • (2004) J. Pharmacol. Exp. Ther. , vol.310 , pp. 865-870
    • Schlag, B.D.1    Lou, Z.2    Fennell, M.3    Dunlop, J.4
  • 15
    • 2642553258 scopus 로고    scopus 로고
    • Target identification in chemical genetics: The (often) missing link
    • Burdine-L, Kodadek T: Target identification in chemical genetics: the (often) missing link. Chem. Biol. 11, 593-597 (2004).
    • (2004) Chem. Biol. , vol.11 , pp. 593-597
    • Burdine, L.1    Kodadek, T.2
  • 16
    • 9344247454 scopus 로고    scopus 로고
    • Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips
    • Huang J, Zhu H, Haggarty SJ et al.: Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proc. Natl. Acad. Sci. USA 101, 16594-16599 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 16594-16599
    • Huang, J.1    Zhu, H.2    Haggarty, S.J.3
  • 17
    • 0041706175 scopus 로고    scopus 로고
    • Data integration - Connecting the dots
    • Searls DB: Data integration - connecting the dots. Nature Biotechnol. 21, 844-845 (2003).
    • (2003) Nature Biotechnol. , vol.21 , pp. 844-845
    • Searls, D.B.1
  • 18
    • 12144262660 scopus 로고    scopus 로고
    • Data integration: Challenges for drug discovery
    • Searls DB: Data integration: challenges for drug discovery. Nature Rev. Drug Discov. 4, 45-58 (2005).
    • (2005) Nature Rev. Drug Discov. , vol.4 , pp. 45-58
    • Searls, D.B.1
  • 19
    • 0037173615 scopus 로고    scopus 로고
    • Functional profiling of the Saccharomyces cerevisiae genome
    • Giaever G, Chu AM, Ni L et al.: Functional profiling of the Saccharomyces cerevisiae genome. Nature 418, 387-391 (2002).
    • (2002) Nature , vol.418 , pp. 387-391
    • Giaever, G.1    Chu, A.M.2    Ni, L.3
  • 20
    • 10744225364 scopus 로고    scopus 로고
    • Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes
    • Lum PY, Armour CD, Stepaniants SB et al.: Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell 116, 121-137 (2004).
    • (2004) Cell , vol.116 , pp. 121-137
    • Lum, P.Y.1    Armour, C.D.2    Stepaniants, S.B.3
  • 21
    • 9144268287 scopus 로고    scopus 로고
    • Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast
    • Giaever G, Flaherty P, Kumm J et al.: Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proc. Natl Acad. Sci. USA 101, 793-798 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 793-798
    • Giaever, G.1    Flaherty, P.2    Kumm, J.3
  • 22
    • 10744230485 scopus 로고    scopus 로고
    • Global mapping of the yeast genetic interaction network
    • Tong AH, Lesage G, Bader GD et al.: Global mapping of the yeast genetic interaction network. Science 303, 808-813 (2004).
    • (2004) Science , vol.303 , pp. 808-813
    • Tong, A.H.1    Lesage, G.2    Bader, G.D.3
  • 23
    • 0037277456 scopus 로고    scopus 로고
    • Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae
    • Enyenihi AH, Saunders WS: Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163, 47-54 (2003).
    • (2003) Genetics , vol.163 , pp. 47-54
    • Enyenihi, A.H.1    Saunders, W.S.2
  • 24
    • 0034616930 scopus 로고    scopus 로고
    • Functional discovery via a compendium of expression profiles
    • Hughes TR, Marton MJ, Jones AR et al.: Functional discovery via a compendium of expression profiles. Cell 102, 109-126 (2000).
    • (2000) Cell , vol.102 , pp. 109-126
    • Hughes, T.R.1    Marton, M.J.2    Jones, A.R.3
  • 25
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK et al.: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998).
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3
  • 26
    • 0035128859 scopus 로고    scopus 로고
    • Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi
    • Maeda I, Kohara Y, Yamamoto M, Sugimoto A: Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Curr. Biol. 11, 171-176 (2001).
    • (2001) Curr. Biol. , vol.11 , pp. 171-176
    • Maeda, I.1    Kohara, Y.2    Yamamoto, M.3    Sugimoto, A.4
  • 27
    • 0035229245 scopus 로고    scopus 로고
    • Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans
    • Kamath RS, Martinez-Campos M, Zipperlen P, Fraser AG, Ahringer J: Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol. 2, 1-10 (2001).
    • (2001) Genome Biol. , vol.2 , pp. 1-10
    • Kamath, R.S.1    Martinez-Campos, M.2    Zipperlen, P.3    Fraser, A.G.4    Ahringer, J.5
  • 28
    • 0034676457 scopus 로고    scopus 로고
    • Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
    • Fraser AG, Kamath RS, Zipperlen P et al.: Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408, 325-330 (2000).
    • (2000) Nature , vol.408 , pp. 325-330
    • Fraser, A.G.1    Kamath, R.S.2    Zipperlen, P.3
  • 29
    • 0037448528 scopus 로고    scopus 로고
    • Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
    • Ashrafi K, Chang FY, Watts JL et al.: Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421, 268-272 (2003).
    • (2003) Nature , vol.421 , pp. 268-272
    • Ashrafi, K.1    Chang, F.Y.2    Watts, J.L.3
  • 30
    • 0043202980 scopus 로고    scopus 로고
    • A genome-wide screen identifies 27 genes involved in transposon silencing in C. elegans
    • Vastenhouw NL, Fischer SE, Robert VJ et al.: A genome-wide screen identifies 27 genes involved in transposon silencing in C. elegans. Curr. Biol. 13, 1311-1316 (2003).
    • (2003) Curr. Biol. , vol.13 , pp. 1311-1316
    • Vastenhouw, N.L.1    Fischer, S.E.2    Robert, V.J.3
  • 31
    • 0037228016 scopus 로고    scopus 로고
    • A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
    • Lee SS, Lee RY, Fraser AG et al.: A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nature Genet. 33, 40-48 (2003).
    • (2003) Nature Genet. , vol.33 , pp. 40-48
    • Lee, S.S.1    Lee, R.Y.2    Fraser, A.G.3
  • 32
    • 0037443054 scopus 로고    scopus 로고
    • Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi
    • Pothof J, van Haaften G, Thijssen K et al.: Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Genes Dev. 17, 443-448 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 443-448
    • Pothof, J.1    van Haaften, G.2    Thijssen, K.3
  • 33
    • 8844239144 scopus 로고    scopus 로고
    • Genome-wide RNAi identifies p53-dependent and -independent regulators of germ cell apoptosis in C. elegans
    • Lettre G, Kritikou EA, Jaeggi M et al.: Genome-wide RNAi identifies p53-dependent and -independent regulators of germ cell apoptosis in C. elegans. Cell Death Differ. 11, 1198-1203 (2004).
    • (2004) Cell Death Differ. , vol.11 , pp. 1198-1203
    • Lettre, G.1    Kritikou, E.A.2    Jaeggi, M.3
  • 34
    • 0037237117 scopus 로고    scopus 로고
    • C. elegans: A model for exploring the genetics of fat storage
    • McKay RM, McKay JP, Avery L, Graff JM: C. elegans: a model for exploring the genetics of fat storage. Dev. Cell 4, 131-142 (2003).
    • (2003) Dev. Cell , vol.4 , pp. 131-142
    • McKay, R.M.1    McKay, J.P.2    Avery, L.3    Graff, J.M.4
  • 35
    • 19344370696 scopus 로고    scopus 로고
    • Functional dissection of an innate immune response by a genome-wide RNAi screen
    • Foley E, O'Farrell PH: Functional dissection of an innate immune response by a genome-wide RNAi screen. PLoS Biol. 2, E203 (2004).
    • (2004) PLoS Biol. , vol.2
    • Foley, E.1    O'Farrell, P.H.2
  • 36
    • 0842309871 scopus 로고    scopus 로고
    • Genome-wide RNAi analysis of growth and viability in Drosophila cells
    • Boutros M, Kiger AA, Armknecht S et al.: Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science 303, 832-835 (2004).
    • (2004) Science , vol.303 , pp. 832-835
    • Boutros, M.1    Kiger, A.A.2    Armknecht, S.3
  • 37
    • 4544374422 scopus 로고    scopus 로고
    • Terminal cytokinesis events uncovered after an RNAi screen
    • Echard A, Hickson GR, Foley E, O'Farrell PH: Terminal cytokinesis events uncovered after an RNAi screen. Curr. Biol. 14, 1685-1693 (2004).
    • (2004) Curr. Biol. , vol.14 , pp. 1685-1693
    • Echard, A.1    Hickson, G.R.2    Foley, E.3    O'Farrell, P.H.4
  • 38
    • 17644415317 scopus 로고    scopus 로고
    • RNAi living-cell microarrays for loss-of-function screens in Drosophila Melanogaster cells
    • Wheeler DB, Bailey SN, Guertin DA et al.: RNAi living-cell microarrays for loss-of-function screens in Drosophila Melanogaster cells. Nature Methods 1, 127-132 (2004).
    • (2004) Nature Methods , vol.1 , pp. 127-132
    • Wheeler, D.B.1    Bailey, S.N.2    Guertin, D.A.3
  • 39
    • 1442311568 scopus 로고    scopus 로고
    • Flying in the face of total disruption
    • Hiesinger PR, Bellen HJ: Flying in the face of total disruption. Nature Genet. 36, 211-212 (2004).
    • (2004) Nature Genet. , vol.36 , pp. 211-212
    • Hiesinger, P.R.1    Bellen, H.J.2
  • 40
    • 7644232462 scopus 로고    scopus 로고
    • Quantitative genetic analyses of complex behaviours in Drosophila
    • Anholt RR, Mackay TF: Quantitative genetic analyses of complex behaviours in Drosophila. Nature Rev. Genet. 5, 838-849 (2004).
    • (2004) Nature Rev. Genet. , vol.5 , pp. 838-849
    • Anholt, R.R.1    Mackay, T.F.2
  • 41
    • 0037086052 scopus 로고    scopus 로고
    • Morpholino, oligos: Making sense of antisense?
    • Heasman J: Morpholino, oligos: making sense of antisense? Dev. Biol 243, 209-214 (2002).
    • (2002) Dev. Biol. , vol.243 , pp. 209-214
    • Heasman, J.1
  • 42
    • 4844220944 scopus 로고    scopus 로고
    • Zebrafish as a genomics research model
    • Chen E, Ekker SC: Zebrafish as a genomics research model. Curr. Pharm. Biotechnol. 5, 409-413 (2004).
    • (2004) Curr. Pharm. Biotechnol. , vol.5 , pp. 409-413
    • Chen, E.1    Ekker, S.C.2
  • 43
    • 21444453504 scopus 로고    scopus 로고
    • Chemical mutagenesis in the mouse: A powerful tool in drug target identification and validation
    • Carroll PM & Fitzgerald K (Eds), John Wiley and Sons, Chichester, UK
    • Russ A, Dear N, Mudde G et al.: Chemical mutagenesis in the mouse: a powerful tool in drug target identification and validation. In: Model Organisms in Drug Discovery. Carroll PM & Fitzgerald K (Eds), John Wiley and Sons, Chichester, UK, 223-250 (2003).
    • (2003) Model Organisms in Drug Discovery , pp. 223-250
    • Russ, A.1    Dear, N.2    Mudde, G.3
  • 44
    • 3242686492 scopus 로고    scopus 로고
    • Saturation screening of the druggable mammalian genome
    • Carroll PM & Fitzgerald K (Ed.), John Wiley and Sons, Chichester, UK
    • Beltrandelrio H, Kern F, Liggott T et al.: Saturation screening of the druggable mammalian genome. In: Model Organisms in Drug Discovery. Carroll PM & Fitzgerald K (Ed.), John Wiley and Sons, Chichester, UK, 251-278 (2003).
    • (2003) Model Organisms in Drug Discovery , pp. 251-278
    • Beltrandelrio, H.1    Kern, F.2    Liggott, T.3
  • 45
    • 4344627055 scopus 로고    scopus 로고
    • Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
    • Douma S, Van Laar T, Zevenhoven J et al.: Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature 430, 1034-1039 (2004).
    • (2004) Nature , vol.430 , pp. 1034-1039
    • Douma, S.1    Van Laar, T.2    Zevenhoven, J.3
  • 46
    • 1542513776 scopus 로고    scopus 로고
    • Identification of p53 regulators by genome-wide functional analysis
    • Huang Q, Raya A, DeJesus P et al.: Identification of p53 regulators by genome-wide functional analysis. Proc. Natl Acad. Sci. USA 101, 3456-3461 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 3456-3461
    • Huang, Q.1    Raya, A.2    DeJesus, P.3
  • 47
    • 0142059834 scopus 로고    scopus 로고
    • Genome-scale functional profiling of the mammalian AP-1 signaling pathway
    • Chanda SK, White S, Orth AP et al.: Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proc. Natl Acad. Sci. USA 100, 12153-12158 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12153-12158
    • Chanda, S.K.1    White, S.2    Orth, A.P.3
  • 48
    • 19944367565 scopus 로고    scopus 로고
    • An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division
    • Kittler R, Putz G, Pelletier L et al.: An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division. Nature 432, 1036-1040 (2004).
    • (2004) Nature , vol.432 , pp. 1036-1040
    • Kittler, R.1    Putz, G.2    Pelletier, L.3
  • 49
    • 12144289681 scopus 로고    scopus 로고
    • A large-scale RNAi screen in human cells identifies new components of the p53 pathway
    • Berns K, Hijmans EM, Mullenders J et al.: A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428, 431-437 (2004).
    • (2004) Nature , vol.428 , pp. 431-437
    • Berns, K.1    Hijmans, E.M.2    Mullenders, J.3
  • 50
    • 0347089019 scopus 로고    scopus 로고
    • An approach to genome-wide screens of expressed small interfering RNAs in mammalian cells
    • Zheng L, Liu J, Batalov S et al.: An approach to genome-wide screens of expressed small interfering RNAs in mammalian cells. Proc Natl. Acad Sci. USA 101, 135-140 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 135-140
    • Zheng, L.1    Liu, J.2    Batalov, S.3
  • 51
    • 21444432399 scopus 로고    scopus 로고
    • Mechanism of action in model organisms: Interfacing chemistry, genetics and genomics
    • Carroll PM & Fitzgerald K (Ed.), John Wiley and Sons, Chichester, UK
    • Carroll PM, Fitzgerald K, Kindt R: Mechanism of action in model organisms: interfacing chemistry, genetics and genomics. In: Model Organisms in Drug Discovery. Carroll PM & Fitzgerald K (Ed.), John Wiley and Sons, Chichester, UK, 153-184 (2003).
    • (2003) Model Organisms in Drug Discovery , pp. 153-184
    • Carroll, P.M.1    Fitzgerald, K.2    Kindt, R.3
  • 52
    • 0037271081 scopus 로고    scopus 로고
    • γ-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila
    • Micchelli CA, Esler WP, Kimberly WT et al.: γ-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. Faseb. J. 17, 79-81 (2003).
    • (2003) Faseb J. , vol.17 , pp. 79-81
    • Micchelli, C.A.1    Esler, W.P.2    Kimberly, W.T.3
  • 53
    • 1542618335 scopus 로고    scopus 로고
    • Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport
    • Smart EJ, De Rose RA, Farber SA: Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport. Proc. Natl. Acad. Sci. USA 101, 3450-3455 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 3450-3455
    • Smart, E.J.1    De Rose, R.A.2    Farber, S.A.3
  • 54
    • 10744221008 scopus 로고    scopus 로고
    • Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption
    • Altmann SW, Davis HR Jr, Zhu LJ et al.: Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science 303, 1201-1204 (2004).
    • (2004) Science , vol.303 , pp. 1201-1204
    • Altmann, S.W.1    Davis Jr., H.R.2    Zhu, L.J.3
  • 55
    • 20244378061 scopus 로고    scopus 로고
    • Chemical genetics identifies rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors
    • Lackner MR, Kindt RM, Carroll PM et al.: Chemical genetics identifies rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors. Cancer Cell 7, 325-326 (2005).
    • (2005) Cancer Cell , vol.7 , pp. 325-326
    • Lackner, M.R.1    Kindt, R.M.2    Carroll, P.M.3
  • 56
    • 12344288635 scopus 로고    scopus 로고
    • Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets
    • Eggert US, Kiger AA, Richter C et al.: Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2, E379 (2004).
    • (2004) PLoS Biol. , vol.2
    • Eggert, U.S.1    Kiger, A.A.2    Richter, C.3
  • 57
    • 0037452981 scopus 로고    scopus 로고
    • Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin
    • Zewail A, Xie MW, Xing Y et al.: Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin. Proc. Natl. Acad. Sci. USA 100, 3345-3350 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 3345-3350
    • Zewail, A.1    Xie, M.W.2    Xing, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.