Cellular signaling and factors involved in Müller cell gliosis: Neuroprotective and detrimental effects

Progress in Retinal and Eye Research

Volumn 28, Issue 6, 2009, Pages 423-451

  Bringmann, Andreas ^a   Iandiev, Ianors ^a   Pannicke, Thomas ^a   Wurm, Antje ^a   Hollborn, Margrit ^a   Wiedemann, Peter ^a   Osborne, Neville N ^b   Reichenbach, Andreas ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Gliosis; Immunomodulation; M ller cell; Neural progenitor; Neuroprotection; Proliferation

Indexed keywords

ANTIOXIDANT; NEUROTROPHIC FACTOR;

CELL PROLIFERATION; GLIOSIS; IMMUNOMODULATION; INTERMEDIATE FILAMENT; MUELLER CELL; NERVE DEGENERATION; NEURAL STEM CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RETINA DISEASE; RETINA INJURY; REVIEW; SIGNAL TRANSDUCTION; TISSUE REGENERATION;

ANIMALS; GLIOSIS; HUMANS; NEUROGLIA; NEUROPROTECTIVE AGENTS; RETINAL DISEASES; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 70350423565     PISSN: 13509462     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2009.07.001     Document Type: Review

References (544)

1. Abu-El-Asrar A.M., Desmet S., Meersschaert A., Dralands L., Missotten L., and Geboes K. Expression of the inducible isoform of nitric oxide synthase in the retinas of human subjects with diabetes mellitus. Am. J. Ophthalmol. 132 (2001) 551-556
2. Ahmad I., Tang L., and Pham H. Identification of neural progenitors in the adult mammalian eye. Biochem. Biophys. Res. Commun. 270 (2000) 517-521
3. Ahmed J., Braun R.D., Dunn jr R., and Linsenmeier R.A. Oxygen distribution in the macaque retina. Invest. Ophthalmol. Vis. Sci. 34 (1993) 516-521
4. Aiello L.P., Northrup J.M., Keyt B.A., Takagi H., and Iwamoto M.A. Hypoxic regulation of vascular endothelial growth factor in retinal cells. Arch. Ophthalmol. 113 (1995) 1538-1544
5. Akiyama H., Nakazawa T., Shimura M., Tomita H., and Tamai M. Presence of mitogen-activated protein kinase in retinal Müller cells and its neuroprotective effect ischemia-reperfusion injury. Neuroreport 13 (2002) 2103-2107
6. Albrecht J., Gadamski R., Kuhrt H., Walski M., and Reichenbach A. Retinal gliopathy accompanying thioacetamide-induced liver insufficiency: light and electron microscopic observations. Acta Neuropathol. 96 (1998) 57-66
7. Amin R.H., Frank R.N., Kennedy A., Eliott D., Puklin J.E., and Abrams G.W. Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 38 (1997) 36-47
8. Anderson D.R., and Davis E.B. Sensitivities of ocular tissues to acute pressure-induced ischemia. Arch. Ophthalmol. 93 (1975) 267-274
9. Anderson D.H., Guerin C.J., Erickson P.A., Stern W.H., and Fisher S.K. Morphological recovery in the reattached retina. Invest. Ophthalmol. Vis. Sci. 27 (1986) 168-183
10. 2 receptor subtypes in rat retinal cultures and the neuroprotective effect of the EP2 agonist butaprost. Neurochem. Int. 55 (2009) 199-207
11. Andrews A., Balciunaite E., Leong F.L., Tallquist M., Soriano P., Refojo M., and Kazlauskas A. Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 40 (1999) 2683-2689
12. Angel P., and Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1072 (1991) 129-157
13. Angénieux B., Schorderet D.F., and Arsenijevic Y. Epidermal growth factor is a neuronal differentiation factor for retinal stem cells in vitro. Stem Cells 24 (2006) 696-706
14. Antoniades H.N., and Scher C.D. Radioimmunoassay of a human growth factor for BALB/c-3T3 cells: derivation from platelets. Proc. Natl. Acad. Sci. U.S.A. 74 (1977) 1973-1977
15. Arai-Gaun S., Katai N., Kikuchi T., Kurokawa T., Ohta K., and Yoshimura N. Heme oxygenase-1 induced in Müller cells plays a protective role in retinal ischemia-reperfusion injury in rats. Invest. Ophthalmol. Vis. Sci. 45 (2004) 4226-4232
16. Arora P.D., and McCulloch C.A. Dependence of collagen remodeling on α-smooth muscle actin expression by fibroblasts. J. Cell. Physiol. 159 (1994) 161-175
17. Arsenijevic Y., Tavernev N., Kostic C., Tekava M., Riva F., Zografos L., Schorderet D., and Munier F. Non-neural regions of the adult human eye: a potential source of neurons?. Invest. Ophthalmol. Vis. Sci. 44 (2003) 799-807
18. Avwenagha O., Bird M.M., Lieberman A.R., Yan Q., and Campbell G. Patterns of expression of brain-derived neurotrophic factor and tyrosine kinase B mRNAs and distribution and ultrastructural localization of their proteins in the visual pathway of the adult rat. Neuroscience 140 (2006) 913-928
19. Balse E., Tessier L.H., Fuchs C., Forster V., Sahel J.A., and Picaud S. Purification of mammalian cone photoreceptors by lectin panning and the enhancement of their survival in glia-conditioned medium. Invest. Ophthalmol. Vis. Sci. 46 (2005) 367-374
20. Banati R.B., Gehrmann J., Shubert P., and Kreutzberg G.W. Cytotoxicity of microglia. Glia 7 (1993) 111-118
21. Behzadian M.A., Wang X.L., Jiang B., and Caldwell R.B. Angiostatic role of astrocytes - suppression of vascular endothelial cell growth by TGF-ß and other inhibitory factor(s). Glia 15 (1995) 480-490
22. Bek T. Immunohistochemical characterization of retinal glial cell changes in areas of vascular occlusion secondary to diabetic retinopathy. Acta Ophthalmol. Scand. 75 (1997) 388-392
23. Bek T. Capillary closure secondary to retinal vein occlusion. A morphological, histopathological, and immunohistochemical study. Acta Ophthalmol. Scand. 76 (1998) 643-648
24. Beltran W.A., Rohrer H., and Aguirre G.D. Immunolocalization of ciliary neurotrophic factor receptor α (CNTFRα) in mammalian photoreceptor cells. Mol. Vis. 11 (2005) 232-244
25. Bernardos R.L., Barthel L.K., Meyers J.R., and Raymond P.A. Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells. J. Neurosci. 27 (2007) 7028-7040
26. Bignami A., and Dahl D. The radial glia of Müller in the rat retina and their response to injury: an immunofluorescence study with antibodies to the glial fibrillary acidic (GFA) protein. Exp. Eye Res. 28 (1979) 63-69
27. Bill A., and Sperber G.O. Control of retinal and choroidal blood flow. Eye 4 (1990) 319-325
28. Birkenmeier G., Grosche J., and Reichenbach A. Immunocytochemical demonstration of α2-M-R/LRP on Müller (glial) cells isolated from rabbit and human retina. Neuroreport 8 (1996) 149-151
29. Biswas S., Bhattacherjee P., and Paterson C.A. Prostaglandin E2 receptor subtypes, EP1, EP2, EP3 and EP4 in human and mouse ocular tissues - a comparative immunohistochemical study. Prostaglandins Leukot. Essent. Fatty Acids 71 (2004) 277-288
30. Blackshaw S., Harpavat S., Trimarchi J., Cai L., Huang H., Kuo W.P., Weber G., Lee K., Fraioli R.E., Cho S.H., Yung R., Asch E., Ohno-Machado L., Wong W.H., and Cepko C.L. Genomic analysis of mouse retinal development. PLoS Biol. 2 (2004) E247
31. Blanco R.E., López-Roca A., Soto J., and Blagburn J.M. Basic fibroblast growth factor applied to the optic nerve after injury increases long-term cell survival in the frog retina. J. Comp. Neurol. 423 (2000) 646-658
32. Bovolenta P., Wandosell F., and Nieto-Sampedro M. CNS glial scar tissue: a source of molecules which inhibit central neurite outgrowth. Prog. Brain Res. 94 (1992) 367-379
33. Brew H., and Attwell D. Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells. Nature 327 (1987) 707-709
34. Breyer R.M., Bagdassarian C.K., Myers S.A., and Breyer M.D. Prostanoid receptors: subtypes and signaling. Annu. Rev. Pharmacol. Toxicol. 41 (2001) 661-690
35. Bringmann A., and Reichenbach A. Role of Müller cells in retinal degenerations. Front. Biosci. 6 (2001) E77-E92
36. Bringmann A., Biedermann B., and Reichenbach A. Expression of potassium channels during postnatal differentiation of rabbit Müller glial cells. Eur. J. Neurosci. 11 (1999) 2883-2896
37. Bringmann A., Francke M., Pannicke T., Biedermann B., Faude F., Enzmann V., Wiedemann P., Reichelt W., and Reichenbach A. Human Müller glial cells: altered potassium channel activity in proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 40 (1999) 3316-3323
38. + channels in ontogeny and gliosis: a hypothesis based upon studies on Müller cells. Glia 29 (2000) 35-44
39. Bringmann A., Biedermann B., Schnurbusch U., Enzmann V., Faude F., and Reichenbach A. Age- and disease-related changes of calcium channel-mediated currents in human Müller glial cells. Invest. Ophthalmol. Vis. Sci. 41 (2000) 2791-2796
40. 7 receptor currents in Müller glial cells during proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 42 (2001) 860-867
41. Bringmann A., Pannicke T., Uhlmann S., Kohen L., Wiedemann P., and Reichenbach A. Membrane conductance of Müller glial cells in proliferative diabetic retinopathy. Can. J. Ophthalmol. 37 (2002) 221-227
42. Bringmann A., Pannicke T., Francke M., Milenkovic I., Weick M., Uckermann O., Uhlmann S., Wiedemann P., and Reichenbach A. Proliferation of retinal glial (Müller) cells: role of P2 receptors and potassium channels. Biomed. Res. 14 (2003) 38-46
43. Bringmann A., Reichenbach A., and Wiedemann P. Pathomechanisms of cystoid macular edema. Ophthalmic Res. 36 (2004) 241-249
44. Bringmann A., Pannicke T., Grosche J., Francke M., Wiedemann P., Skatchkov S.N., Osborne N.N., and Reichenbach A. Müller cells in the healthy and diseased retina. Prog. Retin. Eye Res. 25 (2006) 397-424
45. Bringmann A., Pannicke T., Biedermann B., Francke M., Iandiev I., Grosche J., Wiedemann P., Albrecht J., and Reichenbach A. Role of retinal glial cells in neurotransmitter uptake and metabolism. Neurochem. Int. 54 (2009) 143-160
46. Büchi E.R. Cell death in rat retina after pressure-induced ischaemia-reperfusion insult: electron microscopic study. II. Outer nuclear layer. Jpn. J. Ophthalmol. 36 (1992) 62-68
47. Bull N.D., Limb G.A., and Martin K. Human Müller stem cell (MIO-M1) transplantation in a rat model of glaucoma: survival, differentiation and integration. Invest. Ophthalmol. Vis. Sci. 49 (2008) 3449-3456
48. Burke J.M., and Smith J.M. Retinal proliferation in reponse to vitreous hemoglobin or iron. Invest. Ophthalmol. Vis. Sci. 20 (1981) 582-592
49. Burke J.M. Cell-cell contact promotes DNA synthesis in retinal glia but not in fibroblasts. Exp. Cell Res. 146 (1983) 204-206
50. Burke J.M. Growth in retinal glial cells in vitro is affected differentially by two types of cell contact-mediated interactions. Exp. Cell Res. 180 (1989) 13-19
51. Busch S.A., and Silver J. The role of extracellular matrix in CNS regeneration. Curr. Opin. Neurobiol. 17 (2007) 120-127
52. Campochiaro P.A., and Glaser B.M. Platelet-derived growth factor is chemotactic for human retinal pigment epithelial cells. Arch. Ophthalmol. 103 (1985) 576-579
53. Canning D.R., Höke A., Malemud C.J., and Silver J. A potent inhibitor of neurite outgrowth that predominates in the extracellular matrix of reactive astrocytes. Int. J. Dev. Neurosci. 14 (1996) 153-175
54. Cao W., Wen R., Li F., Lavail M.M., and Steinberg R.H. Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina. Exp. Eye Res. 65 (1997) 241-248
55. Cao W., Wen R., Li F., Cheng T., and Steinberg R.H. Induction of basic fibroblast growth factor mRNA by basic fibroblast growth factor in Müller cells. Invest. Ophthalmol. Vis. Sci. 38 (1997) 1358-1366
56. Cao W., Li F., Steinberg R.H., and LaVail M.M. Induction of c-fos and c-jun mRNA expression by basic fibroblast growth factor in cultured rat Müller cells. Invest. Ophthalmol. Vis. Sci. 39 (1998) 565-573
57. Cappelli-Bigazzi M., Ambrosio G., Musci G., Battaglia C., Bonaccorsi di Patti M.C., Golino P., Ragni M., Chiariello M., and Calabrese L. Ceruloplasmin impairs endothelium-dependent relaxation of rabbit aorta. Am. J. Physiol. 273 (1997) H2843-H2849
58. Casaccia-Bonnefil P., Gu C., and Chao M.V. Neurotrophins in cell survival/death decisions. Adv. Exp. Med. Biol. 468 (1999) 275-282
59. Caspi R.R., and Roberge F.G. Glial cells as suppressor cells: characterization of the inhibitory function. J. Autoimmun. 2 (1989) 709-722
60. Castelnovo L., Dosquet C., Gaudric A., Sahel J., and Hicks D. Human platelet suspension stimulates porcine retinal glial proliferation and migration in vitro. Invest. Ophthalmol. Vis. Sci. 41 (2000) 601-609
61. Chaitin M.H., and Brun-Zinkernagel A.M. Immunolocalization of CD44 in the dystrophic rat retina. Exp. Eye Res. 67 (1998) 283-292
62. Chaitin M.H., Wortham H.S., and Brun-Zinkernagel A.M. Immunocytochemical localization of CD44 in the mouse retina. Exp. Eye Res. 58 (1994) 359-366
63. Chaitin M.H., Ankrum M.T., and Wortham H.S. Distribution of CD44 in the retina during development and the rds degeneration. Dev. Brain Res. 94 (1996) 92-98
64. Chakrabarti S., Sima A.A., Lee J., Brachet P., and Dicou E. Nerve growth factor (NGF), proNGF and NGF receptor-like immunoreactivity in BB rat retina. Brain Res. 523 (1990) 11-15
65. Chan C.C., Roberge F.G., Ni M., Zhang W., and Nussenblatt R.B. Injury of Müller cells increases the incidence of experimental autoimmune uveoretinitis. Clin. Immunol. Immunopathol 59 (1991) 201-207
66. Charkrabarti S., Ghahary A., Murphy L.J., and Sima A.A. Insulin-like growth factor-I expression is not increased in the retina of diabetic BB/W-rats. Diabetes Res. Clin. Pract. 14 (1991) 91-97
67. Chang L., and Goldman R.D. Intermediate filaments mediate cytoskeletal crosstalk. Nat. Rev. Mol. Cell. Biol. 5 (2004) 601-613
68. Chang M.L., Wu C.H., Chien H.F., Jiang-Shieh Y.F., Shieh J.Y., and Wen C.Y. Microglia/macrophages responses to kainate-induced injury in the rat retina. Neurosci. Res. 54 (2006) 202-212
69. Chang M.L., Wu C.H., Jiang-Shieh Y.F., Shieh J.Y., and Wen C.Y. Reactive changes of retinal astrocytes and Müller glial cells in kainate-induced neuroexcitotoxicity. J. Anat. 210 (2007) 54-65
70. Charteris D.G., Sethi C.S., Lewis G.P., and Fisher S.K. Proliferative vitreoretinopathy - developments in adjunctive treatment and retinal pathology. Eye 16 (2002) 369-374
71. Chen H., and Weber A.J. Expression of glial fibrillary acidic protein and glutamine synthetase by Müller cells after optic nerve damage and intravitreal application of brain-derived neurotrophic factor. Glia 38 (2002) 115-125
72. Chen S.T., Garey L.J., and Jen L.S. Bcl-2 proto-oncogene protein immunoreactivity in normally developing and axotomised rat retinas. Neurosci. Lett. 172 (1994) 11-14
73. Chen J., Flannery J.G., LaVail M.M., Steinberg R.H., Xu J., and Simon M.I. Bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations. Proc. Natl. Acad. Sci. U.S.A 93 (1996) 7042-7047
74. Chen L., Dentchev T., Wong R., Hahn P., Wen R., Bennett J., and Dunaief J.L. Increased expression of ceruloplasmin in the retina following photic injury. Mol. Vis. 9 (2003) 151-158
75. Chen S.T., Hsu J.R., Hsu P.C., and Chuang J.I. The retina as a novel in vivo model for studying the role of molecules of the Bcl-2 family in relation to MPTP neurotoxicity. Neurochem. Res. 28 (2003) 805-814
76. 2 induces vascular endothelial growth factor and basic fibroblast growth factor mRNA expression in cultured rat Müller cells. Invest. Ophthalmol. Vis. Sci. 39 (1998) 581-591
77. Cheng L., Sapieha P., Kittlerová P., Hauswirth W.W., and Di Polo A. TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo. J. Neurosci. 22 (2002) 3977-3986
78. Chong D.Y., Boehlke C.S., Zheng Q.D., Zhang L., Han Y., and Zacks D.N. Interleukin-6 as a photoreceptor neuroprotectant in an experimental model of retinal detachment. Invest. Ophthalmol. Vis. Sci. 49 (2008) 3193-3200
79. Christmas N.J., Skolik S.A., Howard M.A., Saito Y., Barnstable C.J., and Liggett P.E. Treatment of retinal breaks with autologous serum in an experimental model. Ophthalmology 102 (1995) 263-271
80. Chu Y., Humphrey M.F., Alder V.V., and Constable I.J. Immunocytochemical localization of basic fibroblast growth factor and glial fibrillary acidic protein after laser photocoagulation in the Royal College of Surgeons rat. Aust. N.Z.J. Ophthalmol. 26 (1998) 87-96
81. Chu Y., Alder V.A., Humphrey M.F., and Constable I.J. Localization of IgG in the normal and dystrophic rat retina after laser lesions. Aust. N.Z.J. Ophthalmol. 27 (1999) 117-125
82. Cinaroglu A., Ozmen Y., Ozdemir A., Ozcan F., Ergorul C., Cayirlioglu P., Hicks D., and Bugra K. Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina. J. Neurosci. Res. 79 (2005) 329-339
83. Claudio L., Martiney J.A., and Brosnan C.F. Ultrastructural studies of the blood-retina barrier after exposure to interleukin-1ß or tumor necrosis factor-α. Lab. Invest. 70 (1994) 850-861
84. Close J.L., Liu J., Gumuscu B., and Reh T.A. Epidermal growth factor receptor expression regulates proliferation in the postnatal rat retina. Glia 54 (2006) 94-104
85. Condon G.P., Brownstein S., Wang N.S., Kearns J.A., and Ewing C.C. Congenital hereditary (juvenile X-linked) retinoschisis. Histopathologic and ultrastructural findings in three eyes. Arch. Ophthalmol. 104 (1986) 576-583
86. Cotinet A., Goureau O., Hicks D., Thillaye-Goldenberg B., and de Kozak Y. Tumor necrosis factor and nitric oxide production by retinal Müller glial cells from rats exhibiting inherited retinal dystrophy. Glia 20 (1997) 59-69
87. Cotinet A., Goureau O., Thillaye-Goldenberg B., Naud M.C., and de Kozak Y. Differential tumor necrosis factor and nitric oxide production in retinal Müller glial cells from C3H/HeN and C3H/HeJ mice. Ocul. Immunol. Inflamm. 5 (1997) 111-116
88. Cox O.T., Simpson D.A., Stitt A.W., and Gardiner T.A. Sources of PDGF expression in murine retina and the effect of short-term diabetes. Mol. Vis. 9 (2003) 665-672
89. Crafoord S., Dafgård Kopp E., Seregard S., and Algvere P.V. Cellular migration into neural retina following implantation of melanin granules in the subretinal space. Graefes Arch. Clin. Exp. Ophthalmol. 238 (2000) 682-689
90. Crawford S.E., Stellmach V., Murphy-Ullrich J.E., Ribeiro S.M., Lawler J., Hynes R.O., Boivin G.P., and Bouck N. Thrombospondin-1 is a major activator of TGF-ß1 in vivo. Cell 93 (1998) 1159-1170
91. Cuthbertson R.A., Lang R.A., and Coghlan J.P. Macrophage products IL-1α, TNFα and bFGF may mediate multiple cytopathic effects in the developing eyes of GM-CSF transgenic mice. Exp. Eye Res. 51 (1990) 335-344
92. Dabin I., and Barnstable C.J. Rat retinal Müller cells express Thy-1 following neuronal cell death. Glia 14 (1995) 23-32
93. Dale N. Dynamic ATP signalling and neural development. J. Physiol. 586 (2008) 2429-2436
94. Das A., Pansky B., Budd G.C., and Kollarits C.R. Immunocytochemistry of mouse and human retina with antisera to insulin and S-100 protein. Curr. Eye Res. 3 (1984) 1397-1403
95. Das A., Pansky B., and Budd G.C. Demonstration of insulin-specific mRNA in cultured rat retinal glial cells. Invest. Ophthalmol. Vis. Sci. 28 (1987) 1800-1810
96. Das A.V., Mallya K.B., Zhao X., Ahmad F., Bhattacharya S., Thoreson W.B., Hegde G.V., and Ahmad I. Neural stem cell properties of Müller glia in the mammalian retina: regulation by Notch and Wnt signaling. Dev. Biol. 299 (2006) 283-302
97. Deeg C.A., Raith A.J., Amann B., Crabb J.W., Thurau S.R., Hauck S.M., Ueffing M., Wildner G., and Stangassinger M. CRALBP is a highly prevalent autoantigen for human autoimmune uveitis. Clin. Dev. Immunol. 2007 (2007) 39245
98. De Jong P.T.V.M., Zrenner E., van Mweel G.J., Keunen J.E.E., and van Norren D. Mizuo phenomenon in X-linked retinoschisis. Pathogenesis of the Mizuo phenomenon. Arch. Ophthalmol. 109 (1991) 1104-1108
99. De Juan E., Dickson J.S., and Hjelmeland L. Serum is chemotactic for retinal-derived glial cells. Arch. Ophthalmol. 106 (1988) 986-990
100. De Kozak Y., Naud M.C., Bellot J., Faure J.P., and Hicks D. Differential tumor necrosis factor expression by resident retinal cells from experimental uveitis-susceptible and -resistant rat strains. J. Neuroimmunol. 55 (1994) 1-9
101. De Kozak Y., Cotinet A., Goureau O., Hicks D., and Thillaye-Goldenberg B. Tumor necrosis factor and nitric oxide production by resident retinal glial cells from rats presenting hereditary retinal degeneration. Ocul. Immunol. Inflamm. 5 (1997) 85-94
102. Delyfer M.N., Simonutti M., Neveux N., Léveillard T., and Sahel J.A. Does GDNF exert its neuroprotective effects on photoreceptors in the rd1 retina through the glial glutamate transporter GLAST?. Mol. Vis. 11 (2005) 677-687
103. Delyfer M.N., Forster V., Neveux N., Picaud S., Léveillard T., and Sahel J.A. Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina. Mol. Vis. 11 (2005) 688-696
104. Dicou E., Nerriere V., Naud M.C., and Dekozak Y. NGF involvement in ocular inflammation: secretion by rat resident retinal cells. Neuroreport 6 (1994) 26-28
105. Diem R., Meyer R., Weishaupt J.H., and Bahr M. Reduction of potassium currents and phosphatidylinositol 3-kinase-dependent AKT phosphorylation by tumor necrosis factor-α rescues axotomized retinal ganglion cells from retrograde cell death in vivo. J. Neurosci. 21 (2001) 2058-2066
106. Ding J., Hu B., Tang L.S., and Yip H.K. Study of the role of the low-affinity neurotrophin receptor p75 in naturally occurring cell death during development of the rat retina. Dev. Neurosci. 23 (2001) 390-398
107. Di Polo A., Aigner L.J., Dunn R.J., Bray G.M., and Aguayo A.J. Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells. Proc. Natl. Acad. Sci. U.S.A 95 (1998) 3978-3983
108. Di Polo A., Cheng L., Bray G.M., and Aguayo A.J. Co-localization of TrkB and brain-derived neurotrophic factor proteins in green/red-sensitive cone outer segments. Invest. Ophthalmol. Vis. Sci. 41 (2000) 4014-4021
109. Drescher K.M., and Whittum-Hudson J.A. Herpes simplex virus type 1 alters transcript levels of tumor necrosis factor-α and interleukin-6 in retinal glial cells. Invest. Ophthalmol. Vis. Sci. 37 (1996) 2302-2312
110. Drescher K.M., and Whittum-Hudson J.A. Modulation of immune-associated surface markers and cytokine production by murine retinal glial cells. J. Neuroimmunol 64 (1996) 71-81
111. Drescher K.M., and Whittum-Hudson J.A. Evidence for induction of interferon-α and interferon-ß in retinal glial cells of Müller. Virology 234 (1997) 309-316
112. Du S., Rubin A., Klepper S., Barrett C., Kim Y.C., Rhim H.W., Lee E.B., Park C.W., Markelonis G.J., and Oh T.H. Calcium influx and activation of calpain I mediate acute reactive gliosis in injured spinal cord. Exp. Neurol. 157 (1999) 96-105
113. Dubois-Dauphin M., Poitry-Yamate C., de Bilbao F., Julliard A.K., Jourdan F., and Donati G. Early postnatal Müller cell death leads to retinal but not optic nerve degeneration in NSE-Hu-Bcl-2 transgenic mice. Neuroscience 95 (2000) 9-21
114. Dyer M.A., and Cepko C.L. Control of Müller glial cell proliferation and activation following retinal injury. Nat. Neurosci. 3 (2000) 873-880
115. Eckes B., Colucci-Guyon E., Smola H., Nodder S., Babinet C., Krieg T., and Martin P. Impaired wound healing in embryonic and adult mice lacking vimentin. J. Cell Sci. 113 (2000) 2455-2462
116. Eder C. Regulation of microglial behavior by ion channel activity. J. Neurosci. Res. 81 (2005) 314-321
117. Egensperger R., Maslim J., Bisti S., Holländer H., and Stone J. Fate of DNA from retinal cells dying during development: uptake by microglia and macroglia (Müller cells). Dev. Brain Res. 97 (1996) 1-8
118. Ehrenberg M., Thresher R.J., and Machemer R. Vitreous hemorrhage nontoxic to retina as a stimulator of glial and fibrous proliferation. Am. J. Ophthalmol. 97 (1984) 611-626
119. Eichler W., Kuhrt H., Hoffmann S., Wiedemann P., and Reichenbach A. VEGF release by retinal glia depends on both oxygen and glucose supply. Neuroreport 11 (2000) 3533-3537
120. Eichler W., Yafai Y., Kuhrt H., Gräter R., Hoffmann S., Wiedemann P., and Reichenbach A. Hypoxia: modulation of endothelial cell proliferation by soluble factors released by retinal cells. Neuroreport 12 (2001) 4103-4108
121. Eichler W., Yafai Y., Wiedemann P., and Reichenbach A. Angiogenesis-related factors derived from retinal glial (Müller) cells in hypoxia. Neuroreport 15 (2004) 1633-1637
122. Eichler W., Yafai Y., Keller T., Wiedemann P., and Reichenbach A. PEDF derived from glial Müller cells: a possible regulator of retinal angiogenesis. Exp. Cell Res. 299 (2004) 68-78
123. Elner S.G., Strieter R.M., Kunkel S.L., and Elner V.M. Intercellular adhesion molecule-1 gene expression and production by human Müller cells. Invest. Ophthalmol. Vis. Res. 33 (1992) S797
124. Engelhardt M., Bogdahn U., and Aigner L. Adult retinal pigment epithelium cells express neural progenitor properties and the neuronal precursor protein doublecortin. Brain Res. 1040 (2005) 98-111
125. Erickson P.A., Fisher S.K., Anderson D.H., Stern W.H., and Borgula G.A. Retinal detachment in the cat: the outer nuclear and outer plexiform layers. Invest. Ophthalmol. Vis. Sci. 24 (1983) 927-942
126. Faktorovich E.G., Steinberg R.H., Yasumura D., Matthes M.T., and LaVail M.M. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature 347 (1990) 83-86
127. Fan W., Lin N., Sheedlo H.J., and Turner J.E. Müller and RPE cell response to photoreceptor cell degeneration in aging Fischer rats. Exp. Eye Res. 63 (1996) 9-18
128. Faude F., Francke M., Makarov F., Schuck J., Gärtner U., Reichelt W., Wiedemann P., Wolburg H., and Reichenbach A. Experimental retinal detachment causes widespread and multilayered degeneration in rabbit retina. J. Neurocytol 30 (2001) 379-390
129. Fausett B.V., and Goldman D. A role for α1 tubulin-expressing Müller glia in regeneration of the injured zebrafish retina. J. Neurosci. 26 (2006) 6303-6313
130. Fausett B.V., Gumerson J.D., and Goldman D. The proneural basic helix-loop-helix gene ascl1a is required for retina regeneration. J. Neurosci. 28 (2008) 1109-1117
131. Fawcett J.W., and Asher R.A. The glial scar and central nervous system repair. Brain Res. Bull. 49 (1999) 377-391
132. Felmy F., Pannicke T., Richt J.A., Reichenbach A., and Guenther E. Electrophysiological properties of rat retinal Müller (glial) cells in postnatally developing and in pathologically altered retinae. Glia 34 (2001) 190-199
133. Fimbel S.M., Montgomery J.E., Burket C.T., and Hyde D.R. Regeneration of inner retinal neurons after intravitreal injection of ouabain in zebrafish. J. Neurosci. 27 (2007) 1712-1724
134. Fischer A.J., and Reh T.A. Müller glia are a potential source of neural regeneration in the postnatal chicken retina. Nat. Neurosci. 4 (2001) 247-252
135. Fischer A.J., and Reh T.A. Exogenous growth factors stimulate the regeneration of ganglion cells in the retina. Dev. Biol. 251 (2002) 367-379
136. Fischer A.J., and Reh T.A. Potential of Müller glia to become neurogenic retinal progenitor cells. Glia 43 (2003) 70-76
137. Fischer A.J., and Omar G. Transitin, a nestin-related intermediate filament, is expressed by neural progenitors and can be induced in Müller glia in the chicken retina. J. Comp. Neurol. 484 (2005) 1-14
138. Fischer A.J., McGuire C.R., Dierks B.D., and Reh T.A. Insulin and fibroblast growth factor 2 activate a neurogenic program in Müller glia of the chicken retina. J. Neurosci. 22 (2002) 9387-9398
139. Fischer A.J., Schmidt M., Omar G., and Reh T.A. BMP4 and CNTF are neuroprotective and suppress damage-induced proliferation of Müller glia in the retina. Mol. Cell. Neurosci. 27 (2004) 531-542
140. Fischer A.J., Wang S.Z., and Reh T.A. NeuroD induces the expression of visinin and calretinin by proliferating cells derived from toxin-damaged chicken retina. Dev. Dyn. 229 (2004) 555-563
141. Fisher S.K., and Lewis G.P. Müller cell and neuronal remodeling in retinal detachment and reattachment and their potential consequences for visual recovery: a review and reconsideration of recent data. Vis. Res. 43 (2003) 887-897
142. Fisher S.K., Erickson P.A., Lewis G.P., and Anderson D.H. Intraretinal proliferation induced by retinal detachment. Invest. Ophthalmol. Vis. Sci. 32 (1991) 1739-1748
143. Fontaine V., Kinkl N., Sahel J., Dreyfus H., and Hicks D. Survival of purified rat photoreceptors in vitro is stimulated directly by fibroblast growth factor-2. J. Neurosci. 18 (1998) 9662-9672
144. Frade J.M., and Barde Y.A. Microglia-derived nerve growth factor causes cell death in the developing retina. Neuron 20 (1998) 35-41
145. Francke M., Pannicke T., Biedermann B., Faude F., and Reichelt W. Sodium current amplitude increases dramatically in human retinal glial cells during diseases of the eye. Eur. J. Neurosci. 8 (1996) 2662-2670
146. Francke M., Pannicke T., Biedermann B., Faude F., Wiedemann P., Reichenbach A., and Reichelt W. Loss of inwardly rectifying potassium currents by human retinal glial cells in diseases of the eye. Glia 20 (1997) 210-218
147. Francke M., Faude F., Pannicke T., Bringmann A., Eckstein P., Reichelt W., Wiedemann P., and Reichenbach A. Electrophysiology of rabbit Müller (glial) cells in experimental retinal detachment and PVR. Invest. Ophthalmol. Vis. Sci. 42 (2001) 1072-1079
148. Francke M., Makarov F., Kacza J., Wendt S., Gärtner U., Faude F., Wiedemann P., and Reichenbach A. Retinal pigment epithelium melanin granules are phagocytozed by Müller glial cells in experimental retinal detachment. J. Neurocytol. 30 (2001) 131-136
149. Francke M., Weick M., Pannicke T., Uckermann O., Grosche J., Goczalik I., Milenkovic I., Uhlmann S., Faude F., Wiedemann P., Reichenbach A., and Bringmann A. Up-regulation of extracellular ATP-induced Müller cell responses in a dispase model of proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 43 (2002) 870-881
150. Francke M., Faude F., Pannicke T., Uckermann O., Weick M., Wolburg H., Wiedemann P., Reichenbach A., Uhlmann S., and Bringmann A. Glial-cell mediated spread of retinal degeneration during detachment: a hypothesis based upon studies in rabbits. Vis. Res. 45 (2005) 2256-2267
151. Frasson M., Picaud S., Leveillard T., Simonutti M., Mohand-Said S., Dreyfus H., Hicks D., and Sabel J. Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse. Invest. Ophthalmol. Vis. Sci. 40 (1999) 2724-2734
152. Fu Q.L., Wu W., Wang H., Li X., Lee V.W., and So K.F. Up-regulated endogenous erythropoietin/erythropoietin receptor system and exogenous erythropoietin rescue retinal ganglion cells after chronic ocular hypertension. Cell. Mol. Neurobiol. 28 (2008) 317-329
153. Fuhrmann V., Kinkl N., Leveillard T., Sahel J., and Hicks D. Fibroblast growth factor receptor 4 (FGFR4) is expressed in adult rat and human retinal photoreceptors and neurons. J. Mol. Neurosci. 13 (1999) 187-197
154. Funata M., Wendel R.T., de la Cruz Z., and Green W.R. Clinicopathologic study of bilateral macular holes treated with pars planar vitrectomy and gas tamponade. Retina 12 (1992) 289-298
155. Gao H., and Hollyfield J.G. Basic fibroblast growth factor (bFGF) immunolocalization in the rodent outer retina demonstrated with an anti-rodent bFGF antibody. Brain Res. 585 (1992) 355-360
156. Gao H., and Hollyfield J.G. Basic fibroblast growth factor in retinal development: differential levels of bFGF expression and content in normal and retinal degeneration (rd) mutant mice. Dev. Biol. 169 (1995) 168-184
157. Gao H., and Hollyfield J.G. Elevated expression of basic fibroblast growth factor during photoreceptor degeneration caused by light damage and genetic defects. Invest. Ophthalmol. Vis. Sci. 36 (1995) S203
158. Gao H., and Hollyfield J.G. Basic fibroblast growth factor: increased gene expression in inherited and light induced photoreceptor degeneration. Exp. Eye Res. 62 (1996) 181-189
159. Garcia M., and Vecino E. Role of Müller glia in neuroprotection and regeneration in the retina. Histol. Histopathol 18 (2003) 1205-1218
160. García M., Forster V., Hicks D., and Vecino E. In vivo expression of neurotrophins and neurotrophin receptors is conserved in adult porcine retina in vitro. Invest. Ophthalmol. Vis. Sci. 44 (2003) 4532-4541
161. Garner C.D., Lee E.W., and Louis-Ferdinand R.T. Müller cell involvement in methanol-induced retinal toxicity. Toxicol. Appl. Pharmacol. 130 (1995) 101-107
162. Gass J.D. Müller cell cone, an overlooked part of the anatomy of the fovea centralis. Hypotheses concerning its role in the pathogenesis of macular hole and foveomacular retinoschisis. Arch. Ophthalmol. 117 (1999) 821-823
163. Gass J.D., Donald M., Agarwal A., Lavina A.M., and Tawansy K.A. Focal inner retinal hemorrhages in patients with drusen: an early sign of occult choroidal neovascularization and chorioretinal anastomosis. Retina 23 (2003) 741-751
164. Gauthier R., Joly S., Pernet V., Lachapelle P., and Di Polo A. Brain-derived neurotrophic factor gene delivery to Müller glia preserves structure and function of light-damaged photoreceptors. Invest. Ophthalmol. Vis. Sci. 46 (2005) 3383-3392
165. Geller S.F., Lewis G.P., Anderson D.H., and Fisher S.K. Use of the MIB-1 antibody for detecting proliferating cells in the retina. Invest. Ophthalmol. Vis. Sci. 36 (1995) 737-744
166. Geller S.F., Lewis G.P., and Fisher S.K. FGFR1, signaling, and AP-1 expression after retinal detachment: reactive Müller and RPE cells. Invest. Ophthalmol. Vis. Sci. 42 (2001) 1363-1369
167. Gerhardinger C., Costa M.B., Coulombe M.C., Toth I., Hoehn T., and Grosu P. Expression of acute-phase response proteins in retinal Müller cells in diabetes. Invest. Ophthalmol. Vis. Sci. 46 (2005) 349-357
168. Ghiardi G.J., Gidday J.M., and Roth S. The purine nucleoside adenosine in retinal ischemia-reperfusion injury. Vis. Res. 39 (1999) 2519-2535
169. Giardino I., Fard A.K., Hatchell D.L., and Brownlee M. Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis. Diabetes 47 (1998) 1114-1120
170. Goczalik I., Raap M., Weick M., Milenkovic I., Heidmann J., Enzmann V., Wiedemann P., Reichenbach A., and Francke M. The activation of IL-8 receptors in cultured guinea pig Müller glial cells is modified by signals from retinal pigment epithelium. J. Neuroimmunol. 161 (2005) 49-60
171. Goczalik I., Ulbricht E., Hollborn M., Raap M., Uhlmann S., Weick M., Pannicke T., Wiedemann P., Bringmann A., Reichenbach A., and Francke M. Expression of CXCL8, CXCR1, and CXCR2 in neurons and glial cells of the human and rabbit retina. Invest. Ophthalmol. Vis. Sci. 49 (2008) 4578-4589
172. Gohdo T., Ueda H., Ohno S., Iijima H., and Tsukahara S. Heat shock protein 70 expression increased in rabbit Müller cells in the ischemia-reperfusion model. Ophthalmic Res. 33 (2001) 298-302
173. Goldstein I.M., Ostwald P., and Roth S. Nitric oxide: a review of its role in retinal function and disease. Vision Res. 36 (1996) 2979-2994
174. Gorovits R., Avidan N., Avisar N., Shaked I., and Vardimon L. Glutamine synthetase protects against neuronal degeneration in injured retinal tissue. Proc. Natl. Acad. Sci. U.S.A 94 (1997) 7024-7029
175. Goureau O., Hicks D., Courtois Y., and de Kozak Y. Induction and regulation of nitric oxide synthetase in retinal Müller glial cells. J. Neurochem. 63 (1994) 310-317
176. Goureau O., Regnier-Ricard F., and Courtois Y. Requirement for nitric oxide in retinal neuronal cell death induced by activated Müller glial cells. J. Neurochem. 72 (1999) 2506-2515
177. Grosche J., Härtig W., and Reichenbach A. Expression of glial fibrillary acidic protein (GFAP), glutamine synthetase (GS), and Bcl-2 protooncogene protein by Müller (glial) cells in retinal light damage of rats. Neurosci. Lett. 185 (1995) 119-122
178. Guerin C.J., Wolfshagen R.W., Eifrig D.E., and Anderson D.H. Immunocytochemical identification of Müller's glia as a component of human epiretinal membranes. Invest. Ophthalmol. Vis. Sci. 31 (1990) 1483-1491
179. Guidry C. The role of Müller cells in fibrocontractive retinal disorders. Prog. Retin. Eye Res. 24 (2005) 75-86
180. Guillonneau X., Régnier-Ricard F., Laplace O., Jonet L., Bryckaert M., Courtois Y., and Mascarelli F. Fibroblast growth factor (FGF) soluble receptor 1 acts as a natural inhibitor of FGF2 neurotrophic activity during retinal degeneration. Mol. Biol. Cell. 9 (1998) 2785-2802
181. Gwon J.S., Kim I.B., Lee M.Y., Oh S.J., and Chun M.H. Expression of clusterin in Müller cells of the rat retina after pressure-induced ischemia. Glia 47 (2004) 35-45
182. Hammes H.P., Federoff H.J., and Brownlee M. Nerve growth factor prevents both neuroretinal programmed cell death and capillary pathology in experimental diabetes. Mol. Med. 1 (1995) 527-534
183. Hansson H.A., Holmgren A., Norstedt G., and Rozell B. Changes in the distribution of insulin-like growth factor I, thioredoxin, thioredoxin reductase and ribonucleotide reductase during the development of the retina. Exp. Eye Res. 48 (1989) 411-420
184. Harada T., and Harada C. Function of glial cell network as a modulator of neural cell death during retinal degeneration. Nippon Ganka Gakkai Zasshi 108 (2004) 674-681
185. Harada T., Harada C., Nakayama N., Okuyama S., Yoshida K., Kohsaka S., Matsuda H., and Wada K. Modification of glial-neuronal cell interactions prevents photoreceptor apoptosis during light-induced retinal degeneration. Neuron 26 (2000) 533-541
186. Harada T., Harada C., Kohsaka S., Wada E., Yoshida K., Ohno S., Mamada H., Tanaka K., Parada L.F., and Wada K. Microglia-Müller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration. J. Neurosci. 22 (2002) 9228-9236
187. Harada T., Harada C., Mitamura Y., Akazawa C., Ohtsuka K., Ohno S., Takeuchi S., and Wada K. Neurotrophic factor receptors in epiretinal membranes after human diabetic retinopathy. Diabetes Care 25 (2002) 1060-1065
188. Harada C., Harada T., Quah H.M.A., Maekawa F., Yoshida K., Ohno S., Wada K., Parada L.F., and Tanaka K. Potential role of glial cell line-derived neurotrophic factor receptors in Müller glial cells during light-induced retinal degeneration. Neuroscience 122 (2003) 229-235
189. Härtig W., Grosche J., Distler C., Grimm D., Elhifnawi E., and Reichenbach A. Alterations of Müller (glial) cells in dystrophic retinae of RCS rats. J. Neurocytol. 24 (1995) 507-517
190. Hartnett M.E., Weiter J.J., Staurenghi G., and Elsner A.E. Deep retinal vascular anomalous complexes in advanced age-related macular degeneration. Ophthalmology 103 (1996) 2042-2053
191. Harvey A.K., Roberge F., and Hjelmeland L.M. Chemotaxis of rat retinal glia to growth factors found in repairing wounds. Invest. Ophthalmol. Vis. Sci. 28 (1987) 1092-1099
192. Hauck S.M., Kinkl N., Deeg C.A., Swiatek-de Lange M., Schöffmann S., and Ueffing M. GDNF family ligands trigger indirect neuroprotective signaling in retinal glial cells. Mol. Cell. Biol. 26 (2006) 2746-2757
193. Hauck S.M., Schoeffmann S., Amann B., Stangassinger M., Gerhards H., Ueffing M., and Deeg C.A. Retinal Müller glial cells trigger the hallmark inflammatory process in autoimmune uveitis. J. Proteome Res. 6 (2007) 2121-2131
194. Hauck S.M., Gloeckner C.J., Harley M.E., Schoeffmann S., Boldt K., Ekstrom P.A., and Ueffing M. Identification of paracrine neuroprotective candidate proteins by a functional assay-driven proteomics approach. Mol. Cell. Proteomics 7 (2008) 1349-1361
195. Hayashi H., Campenot R.B., Vance D.E., and Vance J.E. Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1. J. Neurosci. 27 (2007) 1933-1941
196. Hayes S., Nelson B.R., Buckingham B., and Reh T.A. Notch signaling regulates regeneration in the avian retina. Dev. Biol. 312 (2007) 300-311
197. Haynes T., and Del Rio-Tsonis K. Retina repair, stem cells and beyond. Curr. Neurovasc. Res. 1 (2004) 231-239
198. Heidinger V., Dreyfus H., Sahel J., Christen Y., and Hicks D. Excitotoxic damage of retinal glial cells depends upon normal neuron-glial interactions. Glia 23 (1998) 146-155
199. Helfand B.T., Chou Y.H., Shumaker D.K., and Goldman R.D. Intermediate filament proteins participate in signal transduction. Trends Cell Biol. 15 (2005) 568-570
200. Hicks D., and Courtois Y. Fibroblast growth factor stimulates photoreceptor differentiation in vitro. J. Neurosci. 12 (1992) 2022-2033
201. Hisatomi T., Sakamoto T., Yamanaka I., Sassa Y., Kubota T., Ueno H., Ohnishi Y., and Ishibashi T. Photocoagulation-induced retinal gliosis is inhibited by systemically expressed soluble TGF-ß receptor type II via adenovirus mediated gene transfer. Lab. Invest. 82 (2002) 863-870
202. Hisatomi T., Sakamoto T., Sonoda K.H., Tsutsumi C., Qiao H., Enaida H., Yamanaka I., Kubota T., Ishibashi T., Kura S., Susin S.A., and Kroemer G. Clearance of apoptotic photoreceptors: elimination of apoptotic debris into the subretinal space and macrophage-mediated phagocytosis via phosphatidylserine receptor and integrin αvß3. Am. J. Pathol. 162 (2003) 1869-1879
203. Hiscott P.S., Grierson I., Trombetta C.J., Rahi A.H., Marshall J., and McLeod D. Retinal and epiretinal glia-an immunohistochemical study. Br. J. Ophthalmol. 68 (1984) 698-707
204. Hitchcock P.F., and Raymond P.A. Retinal regeneration. Trends Neurosci. 15 (1992) 103-108
205. Hollborn M., Krauß C., Iandiev I., Yafai Y., Tenckhoff S., Bigl M., Schnurrbusch U.E.K., Limb G.A., Reichenbach A., Kohen L., Wolf S., Wiedemann P., and Bringmann A. Glial cell expression of hepatocyte growth factor in vitreoretinal proliferative disease. Lab. Invest. 84 (2004) 963-972
206. Hollborn M., Jahn K., Limb G.A., Kohen L., Wiedemann P., and Bringmann A. Characterization of the basic fibroblast growth factor-evoked proliferation of the human Müller cell line, MIO-M1. Graefes Arch. Clin. Exp. Ophthalmol. 242 (2004) 414-422
207. Hollborn M., Birkenmeier G., Saalbach A., Iandiev I., Reichenbach A., Wiedemann P., and Kohen L. Expression of LRP1 in retinal pigment epithelial cells and its regulation by growth factors. Invest. Ophthalmol. Vis. Sci. 45 (2004) 2033-2038
208. Hollborn M., Tenckhoff S., Jahn K., Iandiev I., Biedermann B., Schnurrbusch U.E.K., Limb G.A., Reichenbach A., Wolf S., Wiedemann P., Kohen L., and Bringmann A. Changes in retinal gene expression in proliferative vitreoretinopathy: glial cell expression of HB-EGF. Mol. Vis. 11 (2005) 397-413
209. Hollborn M., Francke M., Iandiev I., Bühner E., Foja C., Kohen L., Reichenbach A., Wiedemann P., Bringmann A., and Uhlmann S. Early activation of inflammation- and immune response-related genes after experimental detachment of the porcine retina. Invest. Ophthalmol. Vis. Sci. 49 (2008) 1262-1273
210. Honjo M., Tanihara H., Kido N., Inatani M., Okazaki K., and Honda Y. Expression of ciliary neurotrophic factor activated by retinal Müller cells in eyes with NMDA- and kainic acid-induced neuronal death. Invest. Ophthalmol. Vis. Sci. 41 (2000) 552-560
211. Housley G.D., Bringmann A., and Reichenbach A. Purinergic signaling in special senses. Trends Neurosci. 32 (2009) 128-141
212. Hu B., Yip H.K., and So K.F. Localization of p75 neurotrophin receptor in the retina of the adult SD rat: an immunocytochemical study at light and electron microscopic levels. Glia 24 (1998) 187-197
213. Hui Y.N., Goodnight R., Zhang X.J., Sorgente N., and Ryan S.J. Glial epiretinal membranes and contraction. Immunohistochemical and morphological studies. Arch. Ophthalmol. 106 (1988) 1280-1285
214. Iandiev I., Uckermann O., Pannicke T., Wurm A., Pietsch U.-C., Reichenbach A., Wiedemann P., Bringmann A., and Uhlmann S. Glial cell reactivity in a porcine model of retinal detachment. Invest. Ophthalmol. Vis. Sci. 47 (2006) 2161-2171
215. Iandiev I., Biedermann B., Bringmann A., Reichel M.B., Reichenbach A., and Pannicke T. Atypical gliosis in Müller cells of the slowly degenerating rds mutant mouse retina. Exp. Eye Res. 82 (2006) 449-457
216. Iandiev I., Pannicke T., Hollborn M., Wiedemann P., Reichenbach A., Grimm C., Remé C.E., and Bringmann A. Localization of glial aquaporin-4 and Kir4.1 in the light-injured murine retina. Neurosci. Lett. 434 (2008) 317-321
217. Igarashi Y., Chiba H., Utsumi H., Miyajima H., Ishizaki T., Gotoh T., Kuwahara K., Tobioka H., Satoh M., Mori M., and Sawada N. Expression of receptors for glial cell line-derived neurotrophic factor (GDNF) and neurturin in the inner blood-retinal barrier of rats. Cell. Struct. Funct. 25 (2000) 237-241
218. Ikeda T., and Puro D.G. Nerve growth factor: a mitogenic signal for retinal Müller glial cells. Brain Res. 649 (1994) 260-264
219. Ikeda T., and Puro D.G. Regulation of retinal glial cell proliferation by antiproliferative molecules. Exp. Eye Res. 60 (1995) 435-443
220. Ikeda T., Waldbillig R.J., and Puro D.G. Truncation of IGF-I yields two mitogens for retinal Müller glial cells. Brain Res. 686 (1995) 87-92
221. Ikeda T., Homma Y., Nisida K., Hirase K., Sotozono C., Kinoshita S., and Puro D.G. Expression of transforming growth factor-ß s and their receptors by human retinal glial cells. Curr. Eye Res. 17 (1998) 546-550
222. Ikuno Y., and Kazlauskas A. An in vivo gene therapy approach for experimental proliferative vitreoretinopathy using the truncated platelet-derived growth factor α receptor. Invest. Ophthalmol. Vis. Sci. 43 (2002) 2406-2411
223. Ikuno Y., Leong F.-L., and Kazlauskas A. Attenuation of experimental proliferative vitreoretinopathy by inhibiting the platelet-derived growth factor receptor. Invest. Ophthalmol. Vis. Sci. 41 (2000) 3107-3116
224. Inatani M., and Tanihara H. Proteoglycans in retina. Prog. Retin. Eye Res. 21 (2002) 429-447
225. Inatani M., Tanihara H., Oohira A., Honjo M., Kido N., and Honda Y. Upregulated expression of neurocan, a nervous tissue specific proteoglycan, in transient retinal ischemia. Invest. Ophthalmol. Vis. Sci. 41 (2000) 2748-2754
226. 3H-tymidine. Ophthalmologica 170 (1975) 462-474
227. Inomata Y., Hirata A., Yonemura N., Koga T., Kido N., and Tanihara H. Neuroprotective effects of interleukin-6 on NMDA-induced rat retinal damage. Biochem. Biophys. Res. Commun. 302 (2003) 226-232
228. Isenmann S., Klöcker N., Gravel C., and Bähr M. Protection of axotomized retinal ganglion cells by adenovirally delivered BDNF in vivo. Eur. J. Neurosci. 10 (1998) 2751-2756
229. Jensen A.M., and Wallace V.A. Expression of sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina. Development 124 (1997) 363-371
230. Johns P.R., and Fernald R.D. Genesis of rods in teleost fish retina. Nature 293 (1981) 141-142
231. Joly S., Pernet V., Chemtob S., Di Polo A., and Lachapelle P. Neuroprotection in the juvenile rat model of light-induced retinopathy: evidence suggesting a role for FGF-2 and CNTF. Invest. Ophthalmol. Vis. Sci. 48 (2007) 2311-2320
232. Joly S., Lange C., Thiersch M., Samardzija M., and Grimm C. Leukemia inhibitory factor extends the lifespan of injured photoreceptors in vivo. J. Neurosci. 28 (2008) 13765-13774
233. Jones S.E., Jomary C., Grist J., Thomas M.R., and Neal M.J. Expression of αB-crystallin in a mouse model of inherited retinal degeneration. Neuroreport 9 (1998) 4161-4165
234. Jones B.W., Watt C.B., Frederick J.M., Baehr W., Chen C.K., Levine E.M., Milam A.H., Lavail M.M., and Marc R.E. Retinal remodeling triggered by photoreceptor degenerations. J. Comp. Neurol. 464 (2003) 1-16
235. Ju W.K., Lee M.Y., Hofmann H.D., Kirsch M., and Chun M.H. Expression of CNTF in Müller cells of the rat retina after pressure-induced ischemia. Neuroreport 10 (1999) 419-422
236. Julian D., Ennis K., and Korenbrot J.I. Birth and fate of proliferative cells in the inner nuclear layer of the mature fish retina. J. Comp. Neurol. 394 (1998) 271-282
237. Kacza J., Vahlenkamp T.W., Enbergs H., Richt J.A., Germer A., Kuhrt H., Reichenbach A., Müller H., Herden C., Stahl T., and Seeger J. Neuron-glia interactions in the rat retina infected with Borna disease virus. Arch. Virol. 145 (2000) 127-147
238. Kalisch F., Wurm A., Iandiev I., Uckermann O., Dilsiz N., Reichenbach A., Wiedemann P., and Bringmann A. Atrial natriuretic peptide inhibits osmotical glial cell swelling in the ischemic rat retina: dependence on glutamatergic-purinergic signaling. Exp. Eye Res. 83 (2006) 962-971
239. Kaneko R., Hagiwara N., Leader K., and Sueoka N. Glial-specific cAMP response of the glial fibrillary acidic protein gene cell lines. Proc. Natl. Acad. Sci. U.S.A 91 (1994) 4529-4533
240. Kip1 after retinal detachment. Graefes Arch. Clin. Exp. Ophthalmol. 244 (2006) 352-358
241. Kashii S., Mandai M., Kikuchi M., Honda Y., Tamura Y., Kaneda K., and Akaike A. Dual actions of nitric oxide in N-methyl- D-aspartate receptor-mediated neurotoxicity in cultured retinal neurons. Brain Res. 711 (1996) 93-101
242. Kashiwagi K., Iizuka Y., Araie M., Suzuki Y., and Tsukahara S. Effects of retinal glial cells on isolated rat retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 42 (2001) 2686-2694
243. Kashiwagi K., Iizuka Y., Tanaka Y., Araie M., Suzuki Y., and Tsukahara S. Molecular and cellular reactions of retinal ganglion cells and retinal glial cells under centrifugal force loading. Invest. Ophthalmol. Vis. Sci. 45 (2004) 3778-3786
244. Kassen S.C., Thummel R., Burket C.T., Campochiaro L.A., Harding M.J., and Hyde D.R. The Tg(ccnb1:EGFP) transgenic zebrafish line labels proliferating cells during retinal development and regeneration. Mol. Vis. 14 (2008) 951-963
245. Kaur C., Sivakumar V., Yong Z., Lu J., Foulds W.S., and Ling E.A. Blood-retinal barrier disruption and ultrastructural changes in the hypoxic retina in adult rats: the beneficial effect of melatonin administration. J. Pathol. 212 (2007) 429-439
246. Kawasaki I., Wakakura M., and Ishikawa S. Possible roles of AMPA/KA receptor in cultured Müller cells. Jpn. J. Ophthalmol. 40 (1996) 158-166
247. Kawasaki A., Otori Y., and Barnstable C.J. Müller cell protection of rat retinal ganglion cells from glutamate and nitric oxide neurotoxicity. Invest. Ophthalmol. Vis. Sci. 41 (2000) 3444-3450
248. Kellner U., Kraus H., Heimann H., Helbig H., Bornfeld N., and Foerster M.H. Electrophysiological evaluation of visual loss in Müller cell sheen dystrophy. Br. J. Ophthalmol. 82 (1998) 650-654
249. Kim M.K., Chan C.C., Belfort jr R., Farah M., Burnier M.P., Nussenblatt R.B., Kuwabara T., and Palestine A.G. Histopathologic and immunohistopathologic features of subretinal fibrosis and uveitis syndrome. Am. J. Ophthalmol. 104 (1987) 15-23
250. Kim I.B., Kim K.Y., Joo C.K., Lee M.Y., Oh S.J., Chung J.W., and Chun M.H. Reaction of Müller cells after increased intraocular pressure in the rat retina. Exp. Brain Res. 121 (1998) 419-424
251. Kim D., Kim M.J., Lee J.H., Im J.O., Won Y.J., Yoon S.Y., and Hong H.N. Concomitant distribution shift of glial GABA transporter and S100 calcium-binding proteins in the rat retina after kainate-induced excitotoxic injury. Neurosci. Lett. 353 (2003) 17-20
252. Kimura H., Spee C., Sakamoto T., Hinton D.R., Ogura Y., Tabata Y., Ikada Y., and Ryan S.J. Cellular responses in subretinal neovascularization induced by bFGF-impregnated microspheres. Invest. Ophthalmol. Vis. Sci. 40 (1999) 524-528
253. Kinkl N., Sahel J., and Hicks D. Alternate FGF2-ERK1/2 signaling pathways in retinal photoreceptor and glial cells in vitro. J. Biol. Chem. 276 (2001) 43871-43878
254. Kinkl N., Hageman G.S., Sahel J.A., and Hicks D. Fibroblast growth factor receptor (FGFR) and candidate signaling molecule distribution within rat and human retina. Mol. Vis. 8 (2002) 149-160
255. Kinouchi R., Takeda M., Yang L., Wilhelmsson U., Lundkvist A., Pekny M., and Chen D.F. Robust neural integration from retinal transplants in mice deficient in GFAP and vimentin. Nat. Neurosci. 6 (2003) 8636-8688
256. Kirsch L.S., Brownstein S., and de Wolff-Rouendaal D. A histopathological, ultrastructural and immunohistochemical study of congenital hereditary retinoschisis. Can. J. Ophthalmol. 31 (1996) 301-310
257. Kitano S., Morgan J., and Caprioli J. Hypoxic and excitotoxic damage to cultured rat retinal ganglion cells. Exp. Eye Res. 63 (1996) 105-112
258. Kobayashi M., Kuroiwa T., Shimokawa R., Okeda R., and Tokoro T. Nitric oxide synthase expression in ischemic rat retinas. Jpn. J. Ophthalmol. 44 (2000) 235-244
259. Kodal H., Weick M., Moll V., Biedermann B., Reichenbach A., and Bringmann A. Involvement of calcium-activated potassium channels in the regulation of DNA synthesis in cultured Müller glial cells. Invest. Ophthalmol. Vis. Sci. 41 (2000) 4262-4267
260. Koeberle P.D., and Ball A.K. Nitric oxide synthase inhibition delays axonal degeneration and promotes the survival of axotomized retinal ganglion cells. Exp. Neurol. 158 (1999) 366-381
261. Koeberle P.D., and Ball A.K. Neurturin enhances the survival of axotomized retinal ganglion cells in vivo: combined effects with glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor. Neuroscience 110 (2002) 555-567
262. Koeberle P.D., and Bähr M. The upregulation of GLAST-1 is an indirect antiapoptotic mechanism of GDNF and neurturin in the adult CNS. Cell Death Differ. 15 (2008) 471-483
263. Kohno H., Sakai T., and Kitahara K. Induction of nestin, Ki-67, and cyclin D1 expression in Müller cells after laser injury in adult rat retina. Graefes Arch. Clin. Exp. Ophthalmol. 244 (2006) 90-95
264. Krady J.K., Basu A., Allen C.M., Xu Y., LaNoue K.F., Gardner T.W., and Levison S.W. Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes 54 (2005) 1559-1565
265. Krishnamoorthy R., Agarwal N., and Chaitin M.H. Upregulation of CD44 expression in the retina during the rds degeneration. Mol. Brain Res. 77 (2000) 125-130
266. Kruchkova Y., Ben-Dror I., Herschkovitz A., David M., Yayon A., and Vardimon L. Basic fibroblast growth factor: a potential inhibitor of glutamine synthetase expression in injured neural tissue. J. Neurochem. 77 (2001) 1641-1649
267. Krum J.M., and Khaibullina A. Inhibition of endogenous VEGF impedes revascularization and astroglial proliferation: roles for VEGF in brain repair. Exp. Neurol. 181 (2003) 241-257
268. Kubota A., Nishida K., Nakashima K., and Tano Y. Conversion of mammalian Müller glial cells into a neuronal lineage by in vitro aggregate-culture. Biochem. Biophys. Res. Commun. 351 (2006) 514-520
269. Kubrusly R.C., da Cunha M.C., Reis R.A., Soares H., Ventura A.L., Kurtenbach E., de Mello M.C., and de Mello F.G. Expression of functional receptors and transmitter enzymes in cultured Müller cells. Brain Res. 1038 (2005) 141-149
270. Kubrusly R.C., Panizzutti R., Gardino P.F., Stutz B., Reis R.A., Ventura A.L., de Mello M.C., and de Mello F.G. Expression of functional dopaminergic phenotype in purified cultured Müller cells from vertebrate retina. Neurochem. Int. 53 (2008) 63-70
271. Kuhrt H., Härtig W., Grimm D., Faude F., Kasper M., and Reichenbach A. Changes in CD44 and ApoE immunoreactivities due to retinal pathology of man and rat. J. Hirnforsch 38 (1997) 223-229
272. Kuhrt H., Wurm A., Karl A., Iandiev I., Wiedemann P., Reichenbach A., Bringmann A., and Pannicke T. Müller cell gliosis in retinal organ culture mimics ischemic alterations in vivo. Int. J. Dev. Neurosci. 26 (2008) 745-751
273. Kurihara T., Ozawa Y., Shinoda K., Nagai N., Inoue M., Oike Y., Tsubota K., Ishida S., and Okano H. Neuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation. Invest. Ophthalmol. Vis. Sci. 47 (2006) 5545-5552
274. Kusner L.L., Sarthy V.P., and Mohr S. Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase: a role in high glucose-induced apoptosis in retinal Müller cells. Invest. Ophthalmol. Vis. Sci. 45 (2004) 1553-1561
275. Laqua H., and Machemer R. Glial cell proliferation in retinal detachment (massive periretinal proliferation). Am. J. Ophthalmol. 80 (1975) 602-618
276. Larsen A.K., and Osborne N.N. Involvement of adenosine in retinal ischemia. Studies on the rat. Invest. Ophthalmol. Vis. Sci. 37 (1996) 2603-2611
277. Lawrence J.M., Singhal S., Bhatia B., Keegan D.J., Reh T.A., Luthert P.J., Khaw P.T., and Limb G.A. MOI-M1 cells and similar Müller glial cell lines derived from adult human retina exhibit neural stem cell characteristics. Stem Cells 25 (2007) 2033-2043
278. Layton C.J., Becker S., and Osborne N.N. The effect of insulin and glucose levels on retinal glial cell activation and pigment epithelium-derived fibroblast growth factor-2. Mol. Vis. 12 (2006) 43-54
279. Lee W.H., Javedan S., and Bondy C.A. Coordinate expression of insulin-like growth factor system components by neurons and neuroglia during retinal and cerebellar development. J. Neurosci. 12 (1992) 4737-4744
280. Lesnik Oberstein S.Y., Lewis G.P., Chapin E.A., and Fisher S.K. Ganglion cell neurites in human idiopathic epiretinal membranes. Br. J. Ophthalmol. 92 (2008) 981-985
281. Lewis G.P., and Fisher S.K. Müller cell outgrowth after retinal detachment: association with cone photoreceptors. Invest. Ophthalmol. Vis. Sci. 41 (2000) 1542-1545
282. Lewis G.P., and Fisher S.K. Up-regulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expression. Int. Rev. Cytol. 230 (2003) 263-290
283. Lewis G.P., Erickson P.A., Guerin C.J., Anderson D.H., and Fisher S.K. Changes in the expression of specific Müller cell proteins during long-term retinal detachment. Exp. Eye Res. 49 (1989) 93-111
284. Lewis G.P., Erickson P.A., Guerin C.J., Anderson D.H., and Fisher S.K. Basic fibroblast growth factor: a potential regulator of proliferation and intermediate filament expression in the retina. J. Neurosci. 12 (1992) 3968-3978
285. Lewis G.P., Guerin C.J., Anderson D.H., Matsumoto B., and Fisher S.K. Rapid changes in the expression of glial cell proteins caused by experimental retinal detachment. Am. J. Ophthalmol. 118 (1994) 368-376
286. Lewis G.P., Linberg K.A., Geller S.F., Guérin C.J., and Fisher S.K. Effects of the neurotrophin brain-derived neurotrophic factor in an experimental model of retinal detachment. Invest. Ophthalmol. Vis. Sci. 40 (1999) 1530-1544
287. Lewis G.P., Talaga K.C., Linberg K.A., Avery R.L., and Fisher S.K. The efficacy of delayed oxygen therapy in the treatment of experimental retinal detachment. Am. J. Ophthalmol. 137 (2004) 1085-1095
288. Liberto C.M., Albrecht P.J., Herx L.M., Yong V.W., and Levison S.W. Pro-regenerative properties of cytokine-activated astrocytes. J. Neurochem. 89 (2004) 1092-1100
289. Lieth E., Barber A., Xu B., Dice C., Ratz M.J., Tanase D., and Strother J.M. Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Diabetes 47 (1998) 815-820
290. Limb G.A., Salt T.E., Munro P.M., Moss S.E., and Khaw P.T. In vitro characterization of a spontaneously immortalized human Müller cell line (MIO-M1). Invest. Ophthalmol. Vis. Sci. 43 (2002) 864-869
291. Limb G.A., Lawrence J.M., Reh T.A., and Khaw P.T. Localization of Müller glia with neural stem cell characteristics in the adult human retina. Abstr. Ann. ARVO Meet. 3231 (2005)
292. Linberg K.A., Sakai T., Lewis G.P., and Fisher S.K. Experimental retinal detachment in the cone-dominant ground squirrel retina: morphology and basic immunocytochemistry. Vis. Neurosci. 19 (2002) 603-619
293. Linsenmeier R.A. Effects of light and darkness on oxygen distribution and consumption in the cat retina. J. Gen. Physiol. 88 (1986) 521-542
294. Liu C., Peng M., Laties A.M., and Wen R. Preconditioning with bright light evokes a protective response against light damage in the rat retina. J. Neurosci. 18 (1998) 1337-1344
295. Lopez T., Lopez-Colome A.M., and Ortega A. Changes in GluR4 expression induced by metabotropic receptor activation in radial glia cultures. Mol. Brain Res. 58 (1998) 40-46
296. Lucas D.R., and Newhouse J.P. The toxic effect of sodium l-glutamate on the inner layers of the retina. Arch. Ophthalmol. 58 (1957) 193-201
297. Lundkvist A., Reichenbach A., Betsholtz C., Carmeliet P., Wolburg H., and Pekny M. Under stress, the absence of intermediate filaments from Müller cells in the retina has structural and functional consequences. J. Cell Sci. 117 (2004) 3481-3488
298. Mack A.F., Germer A., Janke C., and Reichenbach A. Müller (glial) cells in the teleost retina: consequences of continuous growth. Glia 22 (1998) 306-313
299. Madreperla S.A., Geiger G.L., Funata M., de la Cruz Z., and Green W.R. Clinicopathologic correlation of a macular hole treated by cortical vitreous peeling and gas tamponade. Ophthalmology 101 (1994) 682-686
300. Magalhães M.M., and Coimbra A. The rabbit retina Müller cell. A fine structural and cytochemical study. J. Ultrastruct. Res. 39 (1972) 310-326
301. Maldonado C.A., Castagna L.F., Rabinovich G.A., and Landa C.A. Immunocytochemical study of the distribution of a 16-kDa galectin in the chicken retina. Invest. Ophthalmol. Vis. Sci. 40 (1999) 2971-2977
302. Mano T., and Puro D.G. Phagocytosis by human retinal glial cells in culture. Invest. Ophthalmol. Vis. Sci. 31 (1990) 1047-1055
303. Mano T., Tokuda N., and Puro D.G. Interferon-γ induces the expression of major histocompatibility antigens by human retinal glial cells. Exp. Eye Res. 53 (1991) 603-607
304. Marc R.E., Murry R.F., Fisher S.K., Linberg K.A., and Lewis G.P. Amino acid signatures in the detached cat retina. Invest. Ophthalmol. Vis. Sci. 39 (1998) 1694-1702
305. Marc R.E., Jones B.W., Watt C.B., and Strettoi E. Neural remodeling in retinal degeneration. Prog. Retin. Eye Res. 22 (2003) 607-655
306. Marín-Teva J.L., Cuadros M.A., Calvente R., Almendros A., and Navascués J. Naturally occurring cell death and migration of microglial precursors in the quail retina during normal development. J. Comp. Neurol. 412 (1999) 255-275
307. Martinasevic M.K., Green M.D., Baron J., and Tephly T.R. Folate and 10-formyltetrahydrofolate dehydrogenase in human and rat retina: relation to methanol toxicity. Toxicol. Appl. Pharmacol. 141 (1996) 373-381
308. Mascarelli F., Raulais D., and Courtois Y. Fibroblast growth factor phosphorylation and receptors in rod outer segments. EMBO J. 8 (1989) 2265-2273
309. Mascarelli F., Tassin J., and Courtois Y. Effect of FGFs on adult bovine Müller cells: proliferation, binding and internalization. Growth Factors 4 (1991) 81-95
310. Matsuda A., Tagawa Y., Yoshida K., Matsuda H., and Nishihira J. Expression of macrophage migration inhibitory factor in rat retina and its immunohistochemical localization. J. Neuroimmunol. 77 (1997) 85-90
311. Matsushima M., Yamada H., Yamamoto C., Miyashiro M., Ogata N., and Uyama M. Expression of basic fibroblast growth factor and fibroblast growth factor receptor 1 in the experimental retinal vein occlusion model. Nippon Ganka Gakkai Zasshi 101 (1997) 564-570
312. Maw M.A., Kennedy B., Knight A., Bridges R., Roth K.E., Mani E.J., Mukkadan J.K., Nancarrow D., Crabb J.W., and Denton M.J. Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa. Nat. Genet. 17 (1997) 198-200
313. Mayer E.J., Hughes E.H., Carter D.A., and Dick A.D. Nestin positive cells in adult human retina and in epiretinal membranes. Br. J. Ophthalmol. 87 (2003) 1154-1158
314. Mayer E.J., Carter D.A., Ren Y., Hughes E.H., Rice C.M., Halfpenny C.A., Scolding N.J., and Dick A.D. Neural progenitor cells from postmortem adult human retina. Br. J. Ophthalmol. 89 (2005) 102-106
315. McGillem G.S., and Dacheux R.F. Rabbit retinal Müller cells undergo antigenic changes in response to experimentally induced proliferative vitreoretinopathy. Exp. Eye Res. 68 (1999) 617-627
316. Mendonca Torres P.M., and de Araujo E.G. Interleukin-6 increases the survival of retinal ganglion cells in vitro. J. Neuroimmunol. 117 (2001) 43-50
317. Meuillet E., Cremel G., Dreyfus H., and Hicks D. Differential modulation of basic fibroblast and epidermal growth factor receptor activation by ganglioside GM3 in cultured retinal Müller glia. Glia 17 (1996) 206-216
318. Milenkovic I., Weick M., Wiedemann P., Reichenbach A., and Bringmann A. P2Y receptor-mediated stimulation of Müller glial cell DNA synthesis: dependence on EGF and PDGF receptor transactivation. Invest. Ophthalmol. Vis. Sci. 44 (2003) 1211-1220
319. Milenkovic I., Weick M., Wiedemann P., Reichenbach A., and Bringmann A. Neuropeptide Y-evoked proliferation of retinal glial (Müller) cells. Graefes Arch. Clin. Exp. Ophthalmol. 242 (2004) 944-950
320. Milenkovic I., Birkenmeier G., Wiedemann P., Reichenbach A., and Bringmann A. Effect of α2-macroglobulin on retinal glial cell proliferation. Graefes Arch. Clin. Exp. Ophthalmol. 243 (2005) 811-816
321. Miyahara T., Kikuchi T., Akimoto M., Kurokawa T., Shibuki H., and Yoshimura N. Gene microarray analysis of experimental glaucomatous retina from cynomologous monkey. Invest. Ophthalmol. Vis. Sci. 44 (2003) 4347-4356
322. Miyake K., and Ibaraki N. Prostaglandins and cystoid macular edema. Surv. Ophthalmol. 47 (2002) S203-S218
323. Mizutani M., Gerhardinger C., and Lorenzi M. Müller cell changes in human diabetic retinopathy. Diabetes 47 (1998) 445-449
324. Moll V., Weick M., Milenkovic I., Kodal H., Reichenbach A., and Bringmann A. P2Y receptor-mediated stimulation of Müller glial DNA synthesis. Invest. Ophthalmol. Vis. Sci. 43 (2002) 766-773
325. Molthagen M., Schachner M., and Bartsch U. Apoptotic cell death of photoreceptor cells in mice deficient for the adhesion molecule on glia (AMOG, the ß2- subunit of the Na, K-ATPase). J. Neurocytol. 25 (1996) 243-255
326. Monnier P.P., Sierra A., Schwab J.M., Henke-Fahle S., and Mueller B.K. The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar. Mol. Cell. Neurosci. 22 (2003) 319-330
327. Moon L.D., Asher R.A., and Fawcett J.W. Limited growth of severed CNS axons after treatment of adult rat brain with hyaluronidase. J. Neurosci. Res. 71 (2003) 23-37
328. Morimoto A., Matsuda S., Uryu K., Fujita H., Okumura N., and Sakanaka M. Light- and electron-microscopic localization of basic fibroblast growth factor in adult rat retina. Okajimas Folia Anat. Jpn. 70 (1993) 7-12
329. Morimoto T., Miyoshi T., Matsuda S., Tano Y., Fujikado T., and Fukuda Y. Transcorneal electrical stimulation rescues axotomized retinal ganglion cells by activating endogenous retinal IGF-1 system. Invest. Ophthalmol. Vis. Sci. 46 (2005) 2147-2155
330. Morris A.C., Scholz T.L., Brockerhoff S.E., and Fadool J.M. Genetic dissection reveals two separate pathways for rod and cone regeneration in the teleost retina. Dev. Neurobiol. 68 (2008) 605-619
331. Moscona A.A., and Degenstein L. Lentoids in aggregates of embryonic neural retina cells. Cell Diff. 10 (1981) 39-46
332. Moscona A.A., Brown M., Degenstein L., Fox L., and Soh B.M. Transformation of retinal glia cells into lens phenotype: expression of MP26, a lens plasma membrane antigen. Proc. Natl. Acad. Sci. U.S.A 80 (1983) 7239-7243
333. -/- mice. J. Neurosci. 24 (2004) 229-237
334. Moshiri A., McGuire C.R., and Reh T.A. Sonic hedgehog regulates proliferation of the retinal ciliary marginal zone in posthatch chicks. Dev. Dyn. 233 (2005) 66-75
335. Mudhar H.S., Pollock R.A., Wang C., Stiles C.D., and Richardson W.D. PDGF and its receptors in the developing rodent retina and optic nerve. Development 118 (1993) 539-552
336. Mukhopadhyay P., Bian L., Yin H., Bhattacherjee P., and Paterson C.A. Localization of EP1 and FP receptors in human ocular tissues by in situ hybridization. Invest. Ophthalmol. Vis. Sci. 42 (2001) 424-428
337. Nag T.C., and Wadhwa S. Neurotrophin receptors (Trk A, Trk B, and Trk C) in the developing and adult human retina. Dev. Brain Res. 117 (1999) 179-189
338. + siphoning and water transport in rat retinal Müller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains. Glia 26 (1999) 47-54
339. 2 receptors. J. Appl. Physiol. 89 (2000) 777-784
340. Nakamichi N., Chidlow G., and Osborne N.N. Effects of intraocular injection of a low concentration of zinc on the rat retina. Neuropharmacology 45 (2003) 637-648
341. Nakamura N., Hasegawa G., Obayashi H., Yamazaki M., Ogata M., Nakano K., Yoshikawa T., Watanabe A., Kinoshita S., Fujinami A., Ohta M., Imamura Y., and Ikeda T. Increased concentration of pentosidine, an advanced glycation end product, and interleukin-6 in the vitreous of patients with proliferative diabetic retinopathy. Diabetes Res. Clin. Pract. 61 (2003) 93-101
342. NTR on the regulation of photoreceptor apoptosis in the rd mouse. Mol. Vis. 11 (2005) 1229-1235
343. Nakamura R.E., Hunter D.D., Yi H., Brunken W.J., and Hackam A.S. Identification of two novel activities of the Wnt signaling regulator Dickkopf 3 and characterization of its expression in the mouse retina. BMC Cell Biol. 8 (2007) 52
344. Nakazawa T., Matsubara A., Noda K., Hisatomi T., She H., Skondra D., Miyahara S., Sobrin L., Thomas K.L., Chen D.F., Grosskreutz C.L., Hafezi-Moghadam A., and Miller J.W. Characterization of cytokine responses to retinal detachment in rats. Mol. Vis. 12 (2006) 867-878
345. Nakazawa T., Hisatomi T., Nakazawa C., Noda K., Maruyama K., She H., Matsubara A., Miyahara S., Nakao S., Yin Y., Benowitz L., Hafezi-Moghadam A., and Miller J.W. Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis. Proc. Natl. Acad. Sci. U.S.A 104 (2007) 2425-2430
346. Nakazawa T., Takeda M., Lewis G.P., Cho K.S., Jiao J., Wilhelmsson U., Fisher S.K., Pekny M., Chen D.F., and Miller J.W. Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin. Invest. Ophthalmol. Vis. Sci. 48 (2007) 2760-2768
347. Nakazawa T., Shimura M., Ryu M., Nishida K., Pagès G., Pouysségur J., and Endo S. ERK1 plays a critical protective role against N-methyl- D-aspartate-induced retinal injury. J. Neurosci. Res. 86 (2008) 136-144
348. Näpänkangas U., Lindqvist N., Lindholm D., and Hallböök F. Rat retinal ganglion cells upregulate the pro-apoptotic BH3-only protein Bim after optic nerve transection. Mol. Brain Res. 120 (2003) 30-37
349. Narumiya S., Sugimoto Y., and Ushikubi F. Prostanoid receptors: structures, properties, and functions. Physiol. Rev. 79 (1999) 1193-1226
350. Neophytou C., Vernallis A.B., Smith A., and Raff M.C. Müller-cell-derived leukaemia inhibitory factor arrests rod photoreceptor differentiation at a postmitotic pre-rod stage of development. Development 124 (1997) 2345-2354
351. Neufeld A.H., Kawai S., Das S., Vora S., Gachie E., Connor J.R., and Manning P.T. Loss of retinal ganglion cells following retinal ischemia: the role of inducible nitric oxide synthase. Exp. Eye Res. 75 (2002) 521-528
352. Nishida A., Takahashi M., Tanihara H., Nakano I., Takahashi J.B., Mizoguchi A., Ide C., and Honda Y. Incorporation and differentiation of hippocampus-derived neural stem cells transplanted in injured adult rat retina. Invest. Ophthalmol. Vis. Sci. 41 (2000) 4268-4274
353. Nishizono H., Murata Y., Tanaka M., Soji T., and Herbert D.C. Evidence that Müller cells can phagocytize egg-lecithin-coated silicone particles. Tissue Cell 25 (1993) 305-310
354. Noji S., Matsuo T., Koyama E., Yamaai T., Nohno T., Matsuo N., and Taniguchi S. Expression pattern of acidic and basic fibroblast growth factor genes in adult rat eyes. Biochem. Biophys. Res. Commun. 168 (1990) 343-349
355. Nork T.M., Ghobrial M.W., Peyman G.A., and Tso M.O. Massive retinal gliosis. A reactive proliferation of Müller cells. Arch. Ophthalmol. 104 (1986) 1383-1389
356. Nunes P.H.C., Calaza K.C., Albuquerque L.M., Fragel-Madeira L., Sholl-Franco A., and Ventura A.L. Signal transduction pathways associated with ATP-induced proliferation of cell progenitors in the intact embryonic retina. Int. J. Dev. Neurosci. 25 (2007) 499-508
357. O'Driscoll C., O'Connor J., O'Brien C.J., and Cotter T.G. Basic fibroblast growth factor-induced protection from light damage in the mouse retina in vivo. J. Neurochem. 105 (2008) 524-536
358. Oku H., Ikeda T., Honma Y., Sotozono C., Nishida K., Nakamura Y., Kida T., and Kinoshita S. Gene expression of neurotrophins and their high-affinity Trk receptors in cultured human Müller cells. Ophthalmic Res. 34 (2002) 38-42
359. Ooto S. Potential for neural regeneration in the adult mammalian retina. Nippon Ganka Gakkai Zasshi 110 (2006) 864-871
360. Ooto S., Akagi T., Kageyama R., Akita J., Mandai M., Honda Y., and Takahashi M. Potential for neural regeneration after neurotoxic injury in the adult mammalian retina. Proc. Natl. Acad. Sci. U.S.A 101 (2004) 13654-13659
361. Osakada F., Ooto S., Akagi T., Mandai M., Akaike A., and Takahashi M. Wnt signaling promotes regeneration in the retina of adult mammals. J. Neurosci. 27 (2007) 4210-4219
362. 2 receptors under conditions of aging and stress and the protective effect of the EP2 agonist butaprost on retinal ischemia. Invest. Ophthalmol. Vis. Sci. 50 (2009) 3238-3248
363. Oster S.F., Deiner M., Birgbauer E., and Sretavan D.W. Ganglion cell axon pathfinding in the retina and optic nerve. Semin. Cell. Dev. Biol. 15 (2004) 125-136
364. Otteson D.C., and Hitchcock P.F. Stem cells in the teleost retina: persistent neurogenesis and injury-induced regeneration. Vis. Res. 43 (2003) 927-936
365. Paasche G., Huster D., and Reichenbach A. The glutathione content of retinal Müller (glial) cells: the effects of aging and of application of free-radical scavengers. Ophthalmic Res. 30 (1998) 351-360
366. +-dependent glutamate transport into acutely isolated Müller glial cells from guinea pig retina. Pflügers Arch. 429 (1994) 140-142
367. Pannicke T., Weick M., Uckermann O., Wheeler-Schilling T., Fries J.E., Reichel M.B., Mohr C., Stahl T., Fluess M., Kacza J., Seeger J., Richt J.A., and Reichenbach A. Electrophysiological alterations and upregulation of ATP receptors in retinal glial Müller cells from rats infected with the Borna disease virus. Glia 35 (2001) 213-223
368. Pannicke T., Iandiev I., Uckermann O., Biedermann B., Kutzera F., Wiedemann P., Wolburg H., Reichenbach A., and Bringmann A. A potassium channel-linked mechanism of glial cell swelling in the postischemic retina. Mol. Cell. Neurosci. 26 (2004) 493-502
369. Pannicke T., Uckermann O., Iandiev I., Biedermann B., Wiedemann P., Perlman I., Reichenbach A., and Bringmann A. Altered membrane physiology in Müller glial cells after transient ischemia of the rat retina. Glia 50 (2005) 1-11
370. Pannicke T., Uckermann O., Iandiev I., Wiedemann P., Reichenbach A., and Bringmann A. Ocular inflammation alters swelling and membrane characteristics of rat Müller glial cells. J. Neuroimmunol 161 (2005) 145-154
371. Pannicke T., Iandiev I., Wurm A., Uckermann O., vom Hagen F., Reichenbach A., Wiedemann P., Hammes H.-P., and Bringmann A. Diabetes alters osmotic swelling characteristics and membrane conductance of glial cells in rat retina. Diabetes 55 (2006) 633-639
372. Paramio J.M., and Jorcano J.L. Beyond structure: do intermediate filaments modulate cell signalling?. BioEssays 24 (2002) 836-844
373. Pardue M.T., Stubbs Jr. E.B., Perlman J.I., Narfström K., Chow A.Y., and Peachey N.S. Immunohistochemical studies of the retina following long-term implantation with subretinal microphotodiode arrays. Exp. Eye Res. 73 (2001) 333-343
374. Peek R., Verbraak F., Coevoet H.M.N., and Kijlstra A. Müller cell-specific autoantibodies in a patient with progressive loss of vision. Invest. Ophthalmol. Vis. Sci. 39 (1998) 1976-1979
375. 2-Adrenergic agonists selectively activate extracellular signal-regulated kinases in Müller cells in vivo. Invest. Ophthalmol. Vis. Sci. 39 (1998) 1721-1726
376. Pekny M., Johansson C.B., Eliasson C., Stakeberg J., Wallén A., Perlmann T., Lendahl U., Betsholtz C., Berthold C.H., and Frisén J. Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin. J. Cell. Biol. 145 (1999) 503-514
377. Penn J.S., Naash M.I., and Anderson R.E. Effect of light history on retinal antioxidants and light damage susceptibility in the rat. Exp. Eye Res. 44 (1987) 779-788
378. Perlson E., Medzihradszky K.F., Darula Z., Munno D.W., Syed N.I., Burlingame A.L., and Fainzilber M. Differential proteomics reveals multiple components in retrogradely transported axoplasm after nerve injury. Mol. Cell. Proteomics 3 (2004) 510-520
379. Pernet V., Bourgeois P., and Di Polo A. A role for polyamines in retinal ganglion cell excitotoxic death. J. Neurochem. 103 (2007) 1481-1490
380. Peterson W.M., Wang Q., Tzekova R., and Wiegand S.J. Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia. J. Neurosci. 20 (2000) 4081-4090
381. Pfeffer B.A., Flanders K.C., Guerin C.J., Danielpour D., and Anderson D.M. Transforming growth factor-ß2 is the predominant isoform in the neural retina, retinal pigment epithelium-choroid and vitreous of the monkey eye. Exp. Eye Res. 59 (1994) 323-333
382. C receptors in adult porcine cones: evidence from a photoreceptor-glia co-culture model. J. Physiol. 513 (1998) 33-42
383. Plouët J., Mascarelli F., Loret M.D., Faure J.P., and Courtois Y. Regulation of eye derived growth factor binding to membranes by light, ATP or GTP in photoreceptor outer segments. EMBO J. 7 (1988) 373-376
384. Polit L., Rotstein N., and Carri N. Effects of docosahexaenoic acid on retinal development: cellular and molecular aspects. Lipids 36 (2001) 927-935
385. Ponta H., Sherman L., and Herrlich P.A. CD44: from adhesion molecules to signalling regulators. Nat. Rev. Mol. Cell. Biol. 4 (2003) 33-45
386. Prada C., Puga J., Perez-Mendez L., Lopez R., and Ramirez G. Spatial and temporal patterns of neurogenesis in the chick retina. Eur. J. Neurosci. 3 (1991) 559-569
387. Privat A. Astrocytes as support for axonal regeneration in the central nervous system of mammals. Glia 43 (2003) 91-93
388. Profyris C., Cheema S.S., Zang D., Azari M.F., Boyle K., and Petratos S. Degenerative and regenerative mechanisms governing spinal cord injury. Neurobiol. Dis. 15 (2004) 415-436
389. Puro D.G. A calcium-activated, calcium-permeable ion channel in human retinal glial cells: modulation by basic fibroblast growth factor. Brain Res. 548 (1991) 329-333
390. Puro D.G. Growth factors and Müller cells. Prog. Retin. Eye Res. 15 (1995) 89-101
391. Puro D.G., and Mano T. Modulation of calcium channels in human retinal glial cells by basic fibroblast growth factor: a possible role in retinal pathobiology. J. Neurosci. 11 (1991) 1873-1880
392. Puro D.G., and Stuenkel E.L. Thrombin-induced inhibition of potassium currents in human retinal glial (Müller) cells. J. Physiol. 485 (1995) 337-348
393. Puro D.G., Roberge F., and Chan C.-C. Retinal glial cell proliferation and ion channels: a possible link. Invest. Ophthalmol. Vis. Sci. 30 (1989) 521-529
394. Puro D.G., Mano T., Chan C.C., Fukuda M., and Shimada H. Thrombin stimulates the proliferation of human retinal glial cells. Graefes Arch. Clin. Exp. Ophthalmol. 228 (1990) 169-173
395. Ramírez J.M., Ramírez A.I., Salazar J.J., de Hoz R., and Triviño A. Changes of astrocytes in retinal ageing and age-related macular degeneration. Exp. Eye Res. 73 (2001) 601-615
396. Rattner A., and Nathans J. The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia. J. Neurosci. 25 (2005) 4540-4549
397. Raymond P.A. Retinal regeneration in teleost fish. Ciba Found. Symp. 160 (1991) 171-186
398. Raymond P.A., and Hitchcock P.F. Retinal regeneration: common principles but a diversity of mechanisms. Adv. Neurol. 72 (1997) 171-184
399. Raymond P.A., Reifler M.J., and Rivlin P.K. Regeneration of goldfish retina: rod precursors are a likely source of regenerated cells. J. Neurobiol. 19 (1988) 431-463
400. Raymond P.A., Barthel L.K., and Rounsifer M.E. Immunolocalization of basic fibroblast growth factor and its receptor in adult goldfish retina. Exp. Neurol. 115 (1992) 73-78
401. Reh T.A., and Levine E.M. Multipotential stem cells and progenitors in the vertebrate retina. J. Neurobiol. 36 (1998) 206-220
402. Reh T.A., and Fischer A.J. Stem cells in the vertebrate retina. Brain Behav. Evol. 58 (2001) 296-305
403. Reh T.A., and Fischer A.J. Retinal stem cells. Methods Enzymol. 419 (2006) 52-73
404. Rehak M., Hollborn M., Iandiev I., Pannicke T., Karl A., Wurm A., Kohen L., Reichenbach A., Wiedemann P., and Bringmann A. Retinal gene expression and Müller cell responses after branch retinal vein occlusion in the rat. Invest. Ophthalmol. Vis. Sci. 50 (2009) 2359-2367
405. Reichelt W., Dettmer D., Brückner G., Brust P., Eberhardt W., and Reichenbach A. Potassium as a signal for both proliferation and differentiation of rabbit retinal (Müller) glia growing in cell culture. Cell Signal. 1 (1989) 187-194
406. Reichelt W., Pannicke T., Biedermann B., Francke M., and Faude F. Comparison between functional characteristics of healthy and pathological human retinal Müller glial cells. Surv. Ophthalmol. 42 (1997) S105-S117
407. Reichenbach A., Hagen E., Schippel K., and Eberhardt W. Quantitative electron microscopy of rabbit Müller (glial) cells in dependence on retinal topography. Z. Mikrosk. Anat. Forsch 102 (1988) 721-755
408. Reichenbach A., Kasper M., El-Hifnawi E., Eckstein A.K., and Fuchs U. Hepatic retinopathy: morphological features of retinal glial (Müller) cells accompanying hepatic failure. Acta Neuropathol. 90 (1995) 273-281
409. Reichenbach A., Stolzenburg J.U., Wolburg H., Härtig W., El-Hifnawi E., and Martin H. Effects of enhanced extracellular ammonia concentration on cultured mammalian retinal glial (Müller) cells. Glia 13 (1995) 195-208
410. Represa A., Niquet J., Pollard H., and Ben-Ari Y. Cell death, gliosis, and synaptic remodeling in the hippocampus of epileptic rats. J. Neurobiol. 26 (1995) 413-425
411. Ribelayga C., and Mangel S.C. A circadian clock and light/dark adaptation differentially regulate adenosine in mammalian retina. J. Neurosci. 25 (2005) 215-222
412. Richardson P.R., Boulton M.E., Duvall-Young J., and McLeod D. Immunocytochemical study of retinal diode laser photocoagulation in the rat. Br. J. Ophthalmol. 80 (1996) 1092-1098
413. Rivera J.C., Aranda J., Riesgo J., Nava G., Thebault S., López-Barrera F., Ramírez M., Martínez de la Escalera G., and Clapp C. Expression and cellular localization of prolactin and the prolactin receptor in mammalian retina. Exp. Eye Res. 86 (2008) 314-321
414. Roberge F.G., Caspi R.R., and Nussenblatt R.B. Glial retinal Müller cells produce IL-1 activity and have a dual effect on autoimmune T helper lymphocytes. J. Immunol. 140 (1988) 2193-2196
415. Roberge F.G., Caspi R.R., Chan C.C., and Nussenblatt R.B. Inhibition of T lymphocyte proliferation by retinal glial Müller cells: reversal of inhibition by glucocorticoids. J. Autoimmun. 4 (1991) 307-314
416. Roesch K., Jadhav A.P., Trimarchi J.M., Stadler M.B., Roska B., Sun B.B., and Cepko C.L. The transcriptome of retinal Müller glial cells. J. Comp. Neurol. 509 (2008) 225-238
417. Rohrer B., Korenbrot J.I., LaVail M.M., Reichardt L.F., and Xu B. Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina. J. Neurosci. 19 (1999) 8919-8930
418. Roque R.S., Caldwell R.B., and Behzadian M.A. Cultured Müller cells have high levels of epidermal growth factor receptors. Invest. Ophthalmol. Vis. Sci. 33 (1992) 2587-2595
419. Roque R.S., Rosales A.A., Jingjing L., Agarwal N., and Al-Ubaidi M.R. Retina-derived microglial cells induce photoreceptor cell death in vitro. Brain Res. 836 (1999) 110-119
420. Rosenkranz S., DeMali K.A., Gelderloos J.A., Bazenet C., and Kazlauskas A. Identification of the receptor-associated signaling enzymes that are required for platelet-derived growth factor-AA-dependent chemotaxis and DNA synthesis. J. Biol. Chem. 274 (1999) 28335-28343
421. Rosenthal A.R., and Appleton B. Histochemical localization of intraocular copper foreign bodies. Am. J. Ophthalmol. 97 (1975) 613-619
422. Roth S. Role of nitric oxide in retinal cell death. Clin. Neurosci. 4 (1997) 216-223
423. + channel block-induced mammalian neuroblastoma cell swelling: a possible mechanism to influence proliferation. J. Physiol. 510 (1998) 93-102
424. Rowan S., and Cepko C.L. Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter. Dev. Biol. 271 (2004) 388-402
425. Saadoun S., Papadopoulos M.C., Watanabe H., Yan D., Manley G.T., and Verkman A.S. Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J. Cell. Sci. 118 (2005) 5691-5698
426. Sagar S.M., Edwards R.M., and Sharp F.R. Epidermal growth factor and transforming growth factor α induce c-fos gene expression in retinal Müller cells in vivo. J. Neurosci. Res. 29 (1991) 549-559
427. Sakaguchi D.S., Janick L.M., and Reh T.A. Basic fibroblast growth factor (FGF-2) induced transdifferentiation of retinal pigment epithelium: generation of retinal neurons and glia. Dev. Dyn. 209 (1997) 387-398
428. Sakamoto T., Ueno H., Goto Y., Oshima Y., Ishibashi T., and Inomata H. A vitrectomy improves the transfection efficiency of adenoviral vector-mediated gene transfer to Müller cells. Gene Ther. 5 (1998) 1088-1097
429. Sanchez R.N., Chan C.K., Garg S., Kwong J.M., Wong M.J., Sadun A.A., and Lam T.T. Interleukin-6 in retinal ischemia reperfusion injury in rats. Invest. Ophthalmol. Vis. Sci. 44 (2003) 4006-4011
430. Sarid J. Identification of a cis-acting positive regulatory element of the glial fibrillary acidic protein gene. J. Neurosci. Res. 28 (1991) 217-228
431. Sarup V., Patil K., and Sharma S.C. Ciliary neurotrophic factor and its receptors are differentially expressed in the optic nerve transected adult rat retina. Brain Res. 1013 (2004) 152-158
432. Scherer J., and Schnitzer J. Growth factor effects on the proliferation of different retinal glial cells in vitro. Dev. Brain Res. 80 (1994) 209-221
433. Schlötzer-Schrehardt U., Zenkel M., and Nüsing R.M. Expression and localization of FP and EP prostanoid receptor subtypes in human ocular tissues. Invest. Ophthalmol. Vis. Sci. 43 (2002) 1475-1487
434. Schuetz E., Rose K., and Thanos S. Regeneration of ganglion cell axons into a peripheral nerve graft alters retinal expression of glial markers and decreases vulnerability to re-axotomy. Restor. Neurol. Neurosci. 21 (2003) 11-18
435. Schütte M., and Werner P. Redistribution of glutathione in the ischemic rat retina. Neurosci. Lett. 246 (1998) 53-56
436. Seigel G.M., Mutchler A.L., and Imperato E.L. Expression of glial markers in a retinal precursor cell line. Mol. Vis. 2 (1996) 2
437. Seiler M., and Turner J.E. The activities of host and graft glial cells following retinal transplantation into the lesioned adult rat eye: developmental expression of glial markers. Brain Res. 471 (1988) 111-122
438. Seki M., Tanaka T., Sakai Y., Fukuchi T., Abe H., Nawa H., and Takei N. Müller cells as a source of brain-derived neurotrophic factor in the retina: noradrenaline upregulates brain-derived neurotrophic factor levels in cultured rat Müller cells. Neurochem. Res. 30 (2005) 1163-1170
439. Sellés-Navarro I., Ellezam B., Fajardo R., Latour M., and McKerracher L. Retinal ganglion cell and nonneuronal cell responses to a microcrush lesion of adult rat optic nerve. Exp. Neurol. 167 (2001) 282-289
440. Sennlaub F., Valamanesh F., Vazquez-Tello A., El-Asrar A.M., Checchin D., Brault S., Gobeil F., Beauchamp M.H., Mwaikambo B., Courtois Y., Geboes K., Varma D.R., Lachapelle P., Ong H., Behar-Cohen F., and Chemtob S. Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy. Circulation 108 (2003) 198-204
441. Sethi C.S., Lewis G.P., Fisher S.K., Leitner W.P., Mann D.L., Luthert P.J., and Charteris D.G. Glial remodeling and neural plasticity in human retinal detachment with proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 46 (2005) 329-342
442. Sharma R.K. Bcl-2 expression during the development and degeneration of RCS rat retinae. Dev. Brain Res. 132 (2001) 81-86
443. Shay J., and Ames A. Retina subjected to components of ischemia in vitro. Selective vulnerability and minimum lethal exposure of neurons and glia to oxygen and/or glucose deprivation and to loss of exchange with incubating medium. Arch. Neurol. 33 (1976) 715-721
444. Silver J. Inhibitory molecules in development and regeneration. J. Neurol. 242 (1994) S22-S24
445. Silver I.A., Deas J., and Erecinska M. Ion homeostasis in brain cells: differences in intracellular ion responses to energy limitation between cultured neurons and glial cells. Neuroscience 78 (1997) 589-601
446. Silverman M.S., and Hughes S.E. Photoreceptor rescue in the RCS rat without pigment epithelium transplantation. Curr. Eye Res. 9 (1990) 183-191
447. Singhal S., Lawrence J.M., Bhatia B., Ellis J.S., Kwan A.S., Macneil A., Luthert P.J., Fawcett J.W., Perez M.T., Khaw P.T., and Limb G.A. Chondroitin sulfate proteoglycans and microglia prevent migration and integration of grafted Müller stem cells into degenerating retina. Stem Cells 26 (2008) 1074-1082
448. Small R.K., Patel P., and Watkins B.A. Response of Müller cells to growth factors alters with time in culture. Glia 4 (1991) 469-483
449. Sofroniew M.V. Reactive astrocytes in neural repair and protection. Neuroscientist 11 (2005) 400-407
450. Sramek S.J., Wallow I.H., Stevens T.S., and Nork T.M. Immunostaining of preretinal membranes for actin, fibronectin, and glial fibrillary acidic protein. Ophthalmology 96 (1989) 835-841
451. Stolzenburg J.U., Haas J., Härtig W., Paulke B.R., Wolburg H., Reichelt W., Chao T.I., Wolff J.R., and Reichenbach A. Phagocytosis of latex beads by rabbit retinal Müller (glial) cells in vitro. J. Hirnforsch 33 (1992) 557-564
452. Stone J., Maslim J., Valter-Kocsi K., Mervin K., Bowers F., Chu Y., Barnett N., Provis J., Lewis G., Fisher S.K., Bisti S., Gargini C., Cervetto L., Merin S., and Peer J. Mechanisms of photoreceptor death and survival in mammalian retina. Prog. Retin. Eye Res. 18 (1999) 689-735
453. Sugimoto Y., and Narumiya S. Prostaglandin E receptors. J. Biol. Chem. 282 (2007) 11613-11617
454. Sugioka M., Zhou W.L., Hofmann H.D., and Yamashita M. Involvement of P2 purinoceptors in the regulation of DNA synthesis in the neural retina of chick embryo. Int. J. Dev. Neurosci. 17 (1999) 135-144
455. Sugiyama T., Katsumura K., Nakamura K., Kobayashi M., Muramatsu M., Maruichi M., Oku H., Takai S., Miyazaki M., and Ikeda T. Effects of chymase on the macular region in monkeys and porcine Müller cells: probable involvement of chymase in the onset of idiopathic macular holes. Ophthalmic Res. 38 (2006) 201-208
456. Sullivan R., Penfold P., and Pow D.V. Neuronal migration and glial remodeling in degenerating retinas of aged rats and in nonneovascular AMD. Invest. Ophthalmol. Vis. Sci. 44 (2003) 856-865
457. Sun G., Asami M., Ohta H., Kosaka J., and Kosaka M. Retinal stem/progenitor properties of iris pigment epithelial cells. Dev. Biol. 289 (2006) 243-252
458. Szél A., and Röhlich P. Two cone types of rat retina detected by anti-visual pigment antibodies. Exp. Eye Res. 55 (1992) 47-52
459. Takeda M., Takamiya A., Yoshida A., and Kiyama H. Extracellular signal-regulated kinase activation predominantly in Müller cells of retina with endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 43 (2002) 907-911
460. Takeda M., Takamiya A., Jiao J.W., Cho K.S., Trevino S.G., Matsuda T., and Chen D.F. α-Aminoadipate induces progenitor cell properties of Müller glia in adult mice. Invest. Ophthalmol. Vis. Sci. 49 (2008) 1142-1150
461. Taylor S., Srinivasan B., Wordinger R.J., and Roque R.S. Glutamate stimulates neurotrophin expression in cultured Müller cells. Mol. Brain Res. 111 (2003) 189-197
462. Tenckhoff S., Hollborn M., Kohen L., Wolf S., Wiedemann P., and Bringmann A. Diversity of aquaporin mRNA expressed by rat and human retinas. Neuroreport 16 (2005) 53-56
463. Tezel G., and Wax M.B. Increased production of tumor necrosis factor-α by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells. J. Neurosci. 20 (2000) 8693-8700
464. Tezel G., Chauhan B.C., LeBlanc R.P., and Wax M.B. Immunohistochemical assessment of the glial mitogen-activated protein kinase activation in glaucoma. Invest. Ophthalmol. Vis. Sci. 44 (2003) 3025-3033
465. Tezel G., Yang X., Luo C., Peng Y., Sun S.L., and Sun D. Mechanisms of immune system activation in glaucoma: oxidative stress-stimulated antigen presentation by the retina and optic nerve head glia. Invest. Ophthalmol. Vis. Sci. 48 (2007) 705-714
466. Thanos S. Genesis, neurotrophin responsiveness, and apoptosis of a pronounced direct connection between the two eyes of the chick embryo: a natural error or a meaningful developmental event?. J. Neurosci. 19 (1999) 3900-3917
467. Thanos S., Mey J., and Wild M. Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro. J. Neurosci. 13 (1993) 455-466
468. Thanos S., Richter W., and Thiel H.J. The protective role of microglia-inhibiting factor in the retina suffering of hereditary photoreceptor degeneration. In: Pleyer U., Schmidt K., and Thiel H.J. (Eds). Cell and Tissue Protection in Ophthalmology (1995), Hippokrates Verl., Stuttgart 195-203
469. Thummel R., Burket C.T., and Hyde D.R. Two different transgenes to study gene silencing and re-expression during zebrafish caudal fin and retinal regeneration. ScientificWorld Journal 6 Suppl. 1 (2006) 65-81
470. Thummel R., Kassen S.C., Montgomery J.E., Enright J.M., and Hyde D.R. Inhibition of Müller glial cell division blocks regeneration of the light-damaged zebrafish retina. Dev. Neurobiol. 68 (2008) 392-408
471. Tolentino M.J., McLeod D.S., Taomoto M., Otsuji T., Adamis A.P., and Lutty G.A. Pathologic features of vascular endothelial growth factor-induced retinopathy in the nonhuman primate. Am. J. Ophthalmol. 133 (2002) 373-385
472. Tomita M., Adachi Y., Yamada H., Takahashi K., Kiuchi K., Oyaizu H., Ikebukuro K., Kaneda H., Matsumura M., and Ikehara S. Bone marrow-derived stem cells can differentiate into retinal cells in injured rat retina. Stem Cells 20 (2002) 279-283
473. Traub P. Are intermediate filament proteins involved in gene expression?. Ann. N.Y. Acad. Sci. 455 (1985) 68-78
474. Tripathi R.C., Borisuth N.S., and Tripathi B.J. Mapping of Fc γ receptors in the human and porcine eye. Exp. Eye Res. 53 (1991) 647-656
475. Trivino A., Ramirez A.I., Salazar J.J., de Hoz R., Rojas B., Padilla E., Tejerina T., and Ramirez J.M. A cholesterol-enriched diet induces ultrastructural changes in retinal and macroglial rabbit cells. Exp. Eye Res. 83 (2006) 357-366
476. Tropepe V., Coles B.L., Chiasson B.J., Horsford D.J., Elia A.J., McInnes R.R., and van der Kooy D. Retinal stem cells in the adult mammalian eye. Science 287 (2000) 2032-2036
477. Tucker B., Klassen H., Yang L., Chen D.F., and Young M.J. Elevated MMP expression in the MRL mouse retina creates a permissive environment for retinal regeneration. Invest. Ophthalmol. Vis. Sci. 49 (2008) 1686-1695
478. Uchihori Y., and Puro D.G. Mitogenic and chemotactic effects of platelet-derived growth factor on human retinal glial cells. Invest. Ophthalmol. Vis. Sci. 32 (1991) 2689-2695
479. Uchihori Y., and Puro D.G. Glutamate as a neuron-to-glial signal for mitogenesis: role of glial N-methyl- D-aspartate receptors. Brain Res. 613 (1993) 212-220
480. Uckermann O., Uhlmann S., Weick M., Pannicke T., Francke M., Reichenbach A., Wiedemann P., and Bringmann A. Upregulation of purinergic P2Y receptor-mediated calcium responses in glial cells during experimental detachment of the rabbit retina. Neurosci. Lett. 338 (2003) 131-134
481. Uckermann O., Uhlmann S., Pannicke T., Francke M., Gamsalijew R., Makarov F., Ulbricht E., Wiedemann P., Reichenbach A., Osborne N.N., and Bringmann A. Ischemia-reperfusion causes exudative detachment of the rabbit retina. Invest. Ophthalmol. Vis. Sci. 46 (2005) 2592-2600
482. Uckermann O., Wolf A., Kutzera F., Kalisch F., Beck-Sickinger A., Wiedemann P., Reichenbach A., and Bringmann A. Glutamate release by neurons evokes a purinergic inhibitory mechanism of osmotic glial cell swelling in the rat retina: activation by neuropeptide. Y. J. Neurosci. Res. 83 (2006) 538-550
483. Uehara F., Ohba N., and Ozawa M. Isolation and characterization of galectins in the mammalian retina. Invest. Ophthalmol. Vis. Sci. 42 (2001) 2164-2172
484. Ueki Y., Wang J., Chollangi S., and Ash J.D. STAT3 activation in photoreceptors by leukemia inhibitory factor is associated with protection from light damage. J. Neurochem. 105 (2008) 784-796
485. Uhlmann S., Bringmann A., Uckermann O., Pannicke T., Weick M., Ulbricht E., Goczalik I., Reichenbach A., Wiedemann P., and Francke M. Early glial cell reactivity in experimental retinal detachment: effect of suramin. Invest. Ophthalmol. Vis. Sci. 44 (2003) 4114-4122
486. Ulyanova T., Szél A., Kutty R.K., Wiggert B., Caffé A.R., Chader G.J., and van Veen T. Oxidative stress induces heme oxygenase-1 immunoreactivity in Müller cells of mouse retina in organ culture. Invest. Ophthalmol. Vis. Sci. 42 (2001) 1370-1374
487. Umino Y., and Saito T. Spatial and temporal patterns of distribution of the gap junctional protein connexin 43 during retinal regeneration of adult newt. J. Comp. Neurol. 454 (2002) 255-262
488. Valter K., Bisti S., and Stone J. Location of CNTFRα on outer segments: evidence of the site of action of CNTF in rat retina. Brain Res. 985 (2003) 169-175
489. Valter K., Bisti S., Gargini C., Di Loreto S., Maccarone R., Cervetto L., and Stone J. Time course of neurotrophic factor upregulation and retinal protection against light-induced damage after optic nerve section. Invest. Ophthalmol. Vis. Sci. 46 (2005) 1748-1754
490. Van Adel B.A., Arnold J.M., Phipps J., Doering L.C., and Ball A.K. Ciliary neurotrophic factor protects retinal ganglion cells from axotomy-induced apoptosis via modulation of retinal glia in vivo. J. Neurobiol. 63 (2005) 215-234
491. Van Horn D.L., Aaberg T.M., Machemer R., and Fenzl R. Glial cell proliferation in human retinal detachment with massive periretinal proliferation. Am. J. Ophthalmol. 84 (1977) 383-393
492. Van Rossum A.G., Aartsen W.M., Meuleman J., Klooster J., Malysheva A., Versteeg I., Arsanto J.P., Le Bivic A., and Wijnholds J. Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Müller glia cells. Hum. Mol. Genet. 15 (2006) 2659-2672
493. Van de Pavert S.A., Sanz A.S., Aartsen W.M., Vos R.M., Versteeg I., Beck S.C., Klooster J., Seeliger M.W., and Wijnholds J. Crb1 is a determinant of retinal apical Müller glia cell features. Glia 55 (2007) 1486-1497
494. Vecino E., Caminos E., Ugarte M., Martin-Zanca D., and Osborne N.N. Immunohistochemical distribution of neurotrophins and their receptors in the rat retina and the effects of ischemia and reperfusion. Gen. Pharmacol. 30 (1998) 305-314
495. Verardo M., Lewis G.P., Takeda M., Linberg K.A., Byun J., Luna G., Wilhelmsson U., Pekny M., Chen D.F., and Fisher S.K. Abnormal reactivity of Müller cells after retinal detachment in mice deficient in GFAP and vimentin. Invest. Ophthalmol. Vis. Sci. 49 (2008) 3659-3665
496. Vihtelic T.S., and Hyde D.R. Light-induced rod and cone cell death and regeneration in the adult albino zebrafish (Danio rerio) retina. J. Neurobiol. 44 (2000) 289-307
497. Vihtelic T.S., Soverly J.E., Kassen S.C., and Hyde D.R. Retinal regional differences in photoreceptor cell death and regeneration in light-lesioned albino zebrafish. Exp. Eye Res. 82 (2006) 558-575
498. - currents inhibit endothelia cell proliferation. Pflügers Archiv. 431 (1995) 132-134
499. Vogt S.D., Barnum S.R., Curcio C.A., and Read R.W. Distribution of complement anaphylatoxin receptors and membrane-bound regulators in normal human retina. Exp. Eye Res. 83 (2006) 834-840
500. Wahlin K.J., Campochiaro P.A., Zack D.J., and Adler R. Neurotrophic factors cause activation of intracellular signaling pathways in Müller cells and other cells of the inner retina, but not photoreceptors. Invest. Ophthalmol. Vis. Sci. 41 (2000) 927-936
501. Wahlin K.J., Adler R., Zack D.J., and Campochiaro P.A. Neurotrophic signaling in normal and degenerating rodent retinas. Exp. Eye Res. 73 (2001) 693-701
502. Wakakura M., and Foulds W.S. Comparative ultrastructural study of rabbit Müller cells in vitro and in situ. Eye 2 (1988) 664-669
503. Walcott J.C., and Provis J.M. Müller cells express the neuronal progenitor cell marker nestin in both differentiated and undifferentiated human foetal retina. Clin. Exp. Ophthalmol. 31 (2003) 246-249
504. Walsh N., Valter K., and Stone J. Cellular and subcellular patterns of expression of bFGF and CNTF in the normal and light stressed adult rat retina. Exp. Eye Res. 72 (2001) 495-501
505. Walsh D.T., Montero R.M., Bresciani L.G., Jen A.Y., Leclercq P.D., Saunders D., EL-Amir A.N., Gbadamoshi L., Gentleman S.M., and Jen L.S. Amyloid-ß peptide is toxic to neurons in vivo via indirect mechanisms. Neurobiol. Dis. 10 (2002) 20-27
506. Wan J., Zheng H., Xiao H.L., She Z.J., and Zhou G.M. Sonic hedgehog promotes stem-cell potential of Müller glia in the mammalian retina. Biochem. Biophys. Res. Commun. 363 (2007) 347-354
507. Wan J., Zheng H., Chen Z.L., Xiao H.L., Shen Z.J., and Zhou G.M. Preferential regeneration of photoreceptor from Müller glia after retinal degeneration in adult rat. Vis. Res. 48 (2008) 223-234
508. Wang Y., Smith S.B., Ogilvie J.M., McCool D.J., and Sarthy V. Ciliary neurotrophic factor induces glial fibrillary acidic protein in retinal Müller cells through the JAK/STAT signal transduction pathway. Curr. Eye Res. 24 (2002) 305-312
509. Wen R., Song Y., Cheng T., Matthes M.T., Yasumura D., LaVail M.M., and Steinberg R.H. Injury-induced upregulation of bFGF and CNTF mRNAs in the rat retina. J. Neurosci. 15 (1995) 7377-7385
510. Wen R., Cheng T., Li Y., Cao W., and Steinberg R.H. α2-Adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage. J. Neurosci. 16 (1996) 5986-5992
511. Weuste M., Wurm A., Iandiev I., Wiedemann P., Reichenbach A., and Bringmann A. HB-EGF: increase in the ischemic rat retina and inhibition of osmotic glial cell swelling. Biochem. Biophys. Res. Commun. 347 (2006) 310-318
512. Wexler E.M., Berkovich O., and Nawy S. Role of the low-affinity NGF receptor (p75) in survival of retinal bipolar cells. Vis. Neurosci. 15 (1998) 211-218
513. Wilhelmsson U., Li L., Pekna M., Berthold C.H., Blom S., Eliasson C., Renner O., Bushong E., Ellisman M., Morgan T.E., and Pekny M. Absence of glial fibrillary acidic protein and vimentin prevents hypertrophy of astrocytic processes and improves post-traumatic regeneration. J. Neurosci. 24 (2004) 5016-5021
514. Wilson J.X. Antioxidant defense of the brain: a role for astrocytes. Can. J. Physiol. Pharmacol. 75 (1997) 1149-1163
515. +/- retinas are protected against light damage-mediated stress. Invest. Ophthalmol. Vis. Sci. 48 (2007) 2877-2886
516. Woodford B.J., Tso M.O., and Lam K.W. Reduced and oxidized ascorbates in guinea pig retina under normal and light-exposed conditions. Invest. Ophthalmol. Vis. Sci. 24 (1983) 862-867
517. Wu D.M., Schneiderman T., Burgett J., Gokhale P., Barthel L., and Raymond P.A. Cones regenerate from retinal stem cells sequestered in the inner nuclear layer of adult goldfish retina. Invest. Ophthalmol. Vis. Sci. 42 (2001) 2115-2124
518. Wu W.C., Lai C.C., Chen S.L., Xiao X., Chen T.L., Tsai R.J.F., Kuo S.W., and Tsao Y.P. Gene therapy for detached retina by adeno-associated virus vector expressing glial cell line-derived neurotrophic factor. Invest. Ophthalmol. Vis. Sci. 43 (2002) 3480-3488
519. Wu K.H., Madigan M.C., Billson F.A., and Penfold P.L. Differential expression of GFAP in early v late AMD: a quantitative analysis. Br. J. Ophthalmol. 87 (2003) 1159-1166
520. Wu L.J., Vadakkan K.I., and Zhuo M. ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia 55 (2007) 810-821
521. Wurm A., Pannicke T., Iandiev I., Bühner E., Pietsch U.C., Reichenbach A., Wiedemann P., Uhlmann S., and Bringmann A. Changes in membrane conductance play a pathogenic role in osmotic glial cell swelling in detached retinas. Am. J. Pathol. 169 (2006) 1990-1998
522. Wurm A., Pannicke T., Wiedemann P., Reichenbach A., and Bringmann A. Glial cell-derived glutamate mediates autocrine cell volume regulation in the retina: activation by VEGF. J. Neurochem. 104 (2008) 386-399
523. Xi X., Gao L., Hatala D.A., Smith D.G., Codispoti M.C., Gong B., Kern T.S., and Zhang J.Z. Chronically elevated glucose-induced apoptosis is mediated by inactivation of Akt in cultured Müller cells. Biochem. Biophys. Res. Commun. 326 (2005) 548-553
524. Xue L.P., Lu J., Cao Q., Kaur C., and Ling E.A. Nestin expression in Müller glial cells in postnatal rat retina and its upregulation following optic nerve transection. Neuroscience 143 (2006) 117-127
525. Xue L.P., Lu J., Cao Q., Hu S., Ding P., and Ling E.A. Müller glial cells express nestin coupled with glial fibrillary acidic protein in experimentally induced glaucoma in the rat retina. Neuroscience 139 (2006) 723-732
526. Yafai Y., Iandiev I., Wiedemann P., Reichenbach A., and Eichler W. Retinal endothelial angiogenic activity: effects of hypoxia and glial (Müller) cells. Microcirculation 11 (2004) 577-586
527. Yamada H., Yamada E., Hackett S.F., Ozaki H., Okamoto N., and Campochiaro P.A. Hyperoxia causes decreased expression of vascular endothelial growth factor and endothelial cell apoptosis in adult retina. J. Cell. Physiol. 179 (1999) 149-156
528. Yannuzzi L.A., Negrão S., Iida T., Carvalho C., Rodriguez-Coleman H., Slakter J., Freund K.B., Sorenson J., Orlock D., and Borodoker N. Retinal angiomatous proliferation in age-related macular degeneration. Retina 21 (2001) 416-434
529. Yasuhara T., Shingo T., and Date I. The potential role of vascular endothelial growth factor in the central nervous system. Rev. Neurosci. 15 (2004) 293-307
530. Yi H., Nakamura R.E., Mohamed O., Dufort D., and Hackam A.S. Characterization of Wnt signaling during photoreceptor degeneration. Invest. Ophthalmol. Vis. Sci. 48 (2007) 5733-5741
531. Yoshida K., Muraki Y., Ohki K., Harada T., Ohashi T., Matsuda H., and Imaki J. c-Fos gene expression in rat retinal cells after focal retinal injury. Invest. Ophthalmol. Vis. Sci. 36 (1995) 251-254
532. Yoshida S., Sotozono C., Ikeda T., and Kinoshita S. Interleukin-6 (IL-6) production by cytokine-stimulated human Müller cells. Curr. Eye Res. 22 (2001) 341-347
533. Yoshida S., Yoshida A., and Ishibashi T. Induction of IL-8, MCP-1, and bFGF by TNF-α in retinal glial cells: implications for retinal neovascularization during post-ischemic inflammation. Graefes Arch. Clin. Exp. Ophthalmol. 242 (2004) 409-413
534. Kip1, cyclin D1, and proliferating cell nuclear antigen after retinal detachment. Graefes Arch. Clin. Exp. Ophthalmol. 242 (2004) 437-441
535. Yu D.Y., and Cringle S.J. Retinal degeneration and local oxygen metabolism. Exp. Eye Res. 80 (2005) 745-751
536. Yuan L., and Neufeld A.H. Tumor necrosis factor-α: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head. Glia 32 (2000) 42-50
537. Yurco P., and Cameron D.A. Cellular correlates of proneural and Notch-delta gene expression in the regenerating zebrafish retina. Vis. Neurosci. 24 (2007) 437-443
538. Zack D.J. Neurotrophic rescue of photoreceptors: are Müller cells the mediators of survival?. Neuron 26 (2000) 285-286
539. Zeiss C.J., and Dubielzig R.R. Lentoid bodies in the avian retina. J. Comp. Pathol. 135 (2006) 243-248
540. Zhang J., Wu G.S., Ishimoto S., Pararajasegaram G., and Rao N.A. Expression of major histocompatibility complex molecules in rodent retina. Immunohistochemical study. Invest. Ophthalmol. Vis. Sci. 38 (1997) 1848-1857
541. Zhang Y., Rauch U., and Perez M.T. Accumulation of neurocan, a brain chondroitin sulfate proteoglycan, in association with the retinal vasculature in RCS rats. Invest. Ophthalmol. Vis. Sci. 44 (2003) 1252-1261
542. Zhang S.X., Wang J.J., Gao G., Parke K., and Ma J.X. Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy. J. Mol. Endocrinol. 37 (2006) 1-12
543. Zhang Y., Klassen H.J., Tucker B.A., Perez M.T., and Young M.J. CNS progenitor cells promote a permissive environment for neurite outgrowth via a matrix metalloproteinase-2-dependent mechanism. J. Neurosci. 27 (2007) 4499-4506
544. 2 receptor subtypes in porcine ocular tissues. II. Nonuveal tissues. J. Ocul. Pharmacol. Ther. 11 (1995) 437-445