Fate of DNA from retinal cells dying during development: Uptake by microglia and macroglia (Muller cells)

Developmental Brain Research

Volumn 97, Issue 1, 1996, Pages 1-8

  Egensperger, R ^a,b   Maslim, J ^c   Bisti, S ^d   Hollander H ^a   Stone, J ^c  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF SYDNEY   (Australia)

^d CNR   (Italy)

Author keywords

Apoptosis; DNA fragmentation; Microglia; Muller cells; Programmed cell death; Retina; TUNEL

Indexed keywords

DNA FRAGMENT;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CAT; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DEVELOPMENT; HISTOCHEMISTRY; MICROGLIA; MUELLER CELL; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; RETINA;

ANIMALS; APOPTOSIS; ASTROCYTES; BIOLOGICAL TRANSPORT; BIOTIN; CATS; DEOXYRIBONUCLEASES; DEOXYURACIL NUCLEOTIDES; DNA; DNA FRAGMENTATION; MICROGLIA; NEURONS; PHAGOCYTOSIS; RABBITS; RATS; RATS, INBRED STRAINS; RETINA; RIBONUCLEASES; STAINING AND LABELING;

ANIMALIA; FELIS CATUS; ORYCTOLAGUS CUNICULUS;

EID: 0030598417     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(96)00119-8     Document Type: Article

References (32)

1. [1] Arends, M.J., Morris, R.G. and Wyllie, A.H., Apoptosis. The role of the endonuclease, Am. J. Pathol., 136 (1990) 593-608.
2. [2] Arends, M.J. and Wyllie, A.H., Apoptosis: mechanisms and roles in pathology, Int. Rev. Exp. Pathol., 32 (1991) 223-254.
3. [3] Ashwell, K., Development of microglia in the albino rabbit retina, J. Comp. Neurol., 287 (1989) 286-301.
4. [4] Ashwell, K., Holländer, H., Streit, W. and Stone, J., The appearance and distribution of microglia in the developing retina of the rat, Vis. Neurosci., 2 (1989) 437-448.
5. [5] Chang, G.-Q., Hao, Y. and Wong, F., Apoptosis: final common pathway of photoreceptor death in rd, rds and rhodopsin mutant mice, Neuron, 11 (1993) 595-605.
6. [6] Dreher, B., Potts, R.A. and Bennett, M.R., Evidence that the early postnatal reduction in the number of rat retinal ganglion cells is due to a wave of ganglion cell death, Neurosci. Lett., 36 (1983) 255-260.
7. [7] Dunlop, S.A. and Beazley, L.D., Cell death in the developing retinal ganglion cell layer of the wallaby Setonix brachyurus, J. Comp. Neurol., 264 (1987) 14-23.
8. [8] Ferrer, I., Bernet, E., Soriano, E., del Rio, T. and Fonseca, M., Naturally occurring cell death in the cerebral cortex of the rat and removal of dead cells by transitory phagocytes, Neuroscience, 39 (1990) 451-458.
9. [9] Ferrer, I., Tortosa, A., Condom, E., Blanco, R., Bacaya, A. and Planas, A., Increased expression of bcl-2 immunoreactivity in the developing cerebral cortex of the rat, Neurosci. Lett., 179 (1994) 13-16.
10. [10] Gavrieli, Y., Sherman, Y. and Ben-Sasson, S.A., Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation, J. Cell Biol., 119 (1992) 493-501.
11. [11] Hamburger, V. and Oppenheim, R.W., Naturally occurring neuronal death in vertebrates, Neurosci. Comm., 1 (1982) 39-55.
12. [12] Harman, A.M., Snell, L.L. and Beazley, L.D., Cell death in the inner and outer nuclear layers of the developing retina in the wallaby Setonix brachyurus (quokka), J. Comp. Neurol., 289 (1989) 1-10.
13. [13] Holländer, H., Makarov, F., Dreher, Z., van Driel, D., Chan-Ling, T. and Stone, J., Functions of the macroglia of the retina: the sharing and division of labour between astrocytes and Müller cells, J. Comp. Neurol., 313 (1991) 587-603.
14. [14] Hume, D.A., Perry, V.H. and Gordon, S., Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers, J. Cell Biol., 97 (1983) 253-257.
15. [15] Kreutzberg, G.W., Microglia, the first line of defence in brain pathologies, Arzneim.-Forsch., 45 (1995) 357-60.
16. [16] Lolley, R.N., Rong, H. and Craft, C.M., Linkage of photoreceptor degeneration by apoptosis with inherited defect in phototransduction, Invest. Ophthal. Vis. Sci., 35 (1994) 358-362.
17. [17] Maslim, J., Egensperger, R., Holländer, H., Humphrey, M. and Stone, J., Receptor degeneration is a normal part of retinal development. In Andersen et al., Degenerative Diseases of the Retina, Plenum Press, New York, 1995, pp. 187-193.
18. [18] Ng, A.Y.K. and Stone, J., The optic nerve of the cat: appearance and loss of axons during normal development, Dev. Brain Res., 5 (1982) 263-271.
19. [19] Penfold, P. and Provis, J., Cell death in the development of the human retina: phagocytosis of pyknotic and apoptotic bodies by retinal cells, Graefe's Arch. Clin. Exp. Ophthalmol., 224 (1986) 549-553.
20. [20] Portera-Cailliau, C., Sung, C.-H., Nathans, J. and Adler R, Apoptotic cell death in mouse models of retinitis pigmentosa, Proc. Natl. Acad. Sci. USA, 91 (1993) 974-978.
21. [21] Provis, J.M. and Penfold, P.L., Cell death and the elimination of retinal axons during development, Prog. Neurobiol., 31 (1988) 331-347.
22. [22] Rakic, P. and Riley, K.P., Overproduction and elimination of retinal axons in the fetal rhesus monkey, Science, 219 (1983) 1441-1444.
23. [23] Ramon y Cajal, S., La Rétine des vertébrés, Cellule, 9 (1892).
24. [24] Robinson, S.R., Cell death in the inner and outer nuclear layers of the developing cat retina, J. Comp. Neurol., 267 (1988) 506-515.
25. [25] Roque, R.S., Imperial, C.J. and Caldwell, R.B., Microglial cells invade the outer retina as photoreceptors degenerate in Royal College of Surgeons rats, Invest. Ophthalmol. Vis. Sci., 37 (1996) 196-203.
26. [26] Schnitzer, J., Enzyme-histochemical demonstration of microglial cells in the adult and postnatal rabbit retina, J. Comp. Neurol., 282 (1989) 249-263.
27. [27] Stone, J., Makarov, F. and Holländer, H., The glial investment of the somas and axons of retinal ganglion cells, Vis. Neurosci., 12 (1995) 273-279.
28. [28] Stone, J. and Rapaport, D.H., The role of cell death in shaping the ganglion cell population of the adult cat retina. In: Festschrift for P.O. Bishop, Cambridge University Press, Cambbridge, 1986.
29. [29] Thanos, S., The relationship of microglial cells to dying neurons during natural neuronal cell death and axotomy-induced degeneration of the rat retina, Eur. J. Neurosci., 3 (1991) 1188-1207.
30. [30] Thanos, S., Sick photoreceptors attract activated microglia from the ganglion cell layer: a model to study the inflammatory cascades in rats with inherited retinal dystrophy, Brain Res., 588 (1992) 21-28.
31. [31] Thomas, W.E., Brain macrophages: evaluation of microglia and their functions, Brain Res. Rev., 17 (1992) 61-74.
32. [32] Tso, M.O.M., Zhang, C., Abler, A.S., Chang, C.J., Wong, F., Chang, G.Q. and Lam, T.T., Apoptosis leads to photoreceptor degeneration in inherited retinal dystrophy of res rats, Invest. Ophthal. Vis. Sci., 35 (1994) 2693-2699.