Retinal gene expression and müller cell responses after branch retinal vein occlusion in the rat

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 5, 2009, Pages 2359-2367

  Rehak, Matus ^a   Hollborn, Margrit ^a,b   Iandiev, Ianors ^a,c   Pannicke, Thomas ^a   Karl, Anett ^a   Wurm, Antje ^a   Kohen, Leon ^a,d   Reichenbach, Andreas ^a   Wiedemann, Peter ^a   Bringmann, Andreas ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^c Translational Center for Regenerative Medicine   (Germany)

^d HELIOS Klinikum Aue   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 1; AQUAPORIN 4; MESSENGER RNA; PIGMENT EPITHELIUM DERIVED FACTOR; POTASSIUM CHANNEL; POTASSIUM CHANNEL KIR1.4; PROTHROMBIN; THROMBOPLASTIN; UNCLASSIFIED DRUG; VASCULOTROPIN A; AQP1 PROTEIN, RAT; AQP4 PROTEIN, RAT; EYE PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; NERVE GROWTH FACTOR; PIGMENT EPITHELIUM-DERIVED FACTOR; POTASSIUM INWARDLY RECTIFYING CHANNEL, SUBFAMILY J, MEMBER 10; POTASSIUM INWARDLY-RECTIFYING CHANNEL, SUBFAMILY J, MEMBER 10; SERINE PROTEINASE INHIBITOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A, RAT; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRANCH RETINAL VEIN OCCLUSION; CELL SWELLING; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HYPOOSMOTIC STRESS; LASER COAGULATION; MUELLER CELL; NERVE CELL DEGENERATION; NONHUMAN; PIGMENT EPITHELIUM; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RETINA EDEMA; RETINA NEUROEPITHELIAL LAYER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; ANIMAL; CELL MEMBRANE POTENTIAL; DISEASE MODEL; ELECTROPHYSIOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; LONG EVANS RAT; METABOLISM; PHYSIOLOGY; RETINA; RETINA DEGENERATION; RETINA MACULA EDEMA; RETINA NERVE CELL; RETINA VEIN OCCLUSION;

ANIMALS; AQUAPORIN 1; AQUAPORIN 4; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGY; EYE PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; MACULAR EDEMA; MEMBRANE POTENTIALS; NERVE GROWTH FACTORS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTHROMBIN; RATS; RATS, LONG-EVANS; RETINA; RETINAL DEGENERATION; RETINAL NEURONS; RETINAL VEIN OCCLUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERPINS; THROMBOPLASTIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VIMENTIN;

EID: 65549105567     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2332     Document Type: Article

References (33)

1. Finkelstein D. Ischemic macular edema: recognition and favorable natural history in branch vein occlusion. Arch Ophthalmol. 1992; 110:1427-1434.
2. Rehak J, Rehak M. Branch retinal vein occlusion: pathogenesis, visual prognosis, and treatment modalities. Curr Eye Res. 2008;33: 111-131.
3. Branch Retinal Vein Occlusion Study Group. Argon laser photocoagulation for macular edema in branch vein occlusion. Am J Ophthalmol. 1984;98:271-282.
4. Pe'er J, Shweiki D, Itin A, Hemo I, Gnessin H, Keshet E. Hypoxiainduced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases. Lab Invest. 1995;72:638-645.
5. Aiello LP, Bursell SE, Clermont A, et al. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform- selective inhibitor. Diabetes. 1997;46:1473-1480.
6. Adamis AP, Shima DT. The role of vascular endothelial growth factor in ocular health and disease. Retina. 2005;25:111-118.
7. Noma H, Funatsu H, Yamasaki M, et al. Pathogenesis of macular edema with branch retinal vein occlusion and intraocular levels of vascular endothelial growth factor and interleukin-6. Am J Ophthalmol. 2005;140:256-261.
8. Wu L, Arevalo JF, Roca JA, et al. Comparison of two doses of intravitreal bevacizumab (Avastin) for treatment of macular edema secondary to branch retinal vein occlusion: results from the Pan-American Collaborative Retina Study Group at 6 months of follow-up. Retina. 2008;28:212-219.
9. Campochiaro PA, Hafiz G, Shah SM, et al. Ranibizumab for macular edema due to retinal vein occlusions: implication of VEGF as a critical stimulator. Mol Ther. 2008;16:791-799.
10. Zhang SX, Wang JJ, Gao G, Parke K, Ma JX. Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy. J Mol Endocrinol. 2006;37:1-12.
11. Yamagishi S, Nakamura K, Matsui T, et al. Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression. J Biol Chem. 2006;281:20213-20220.
12. Derevjanik NL, Vinores SA, Xiao WH, et al. Quantitative assessment of the integrity of the blood-retinal barrier in mice. Invest Ophthalmol Vis Sci. 2002;43:2462-2467.
13. Sakamoto T, Sakamoto H, Sheu SJ, Gabrielian K, Ryan SJ, Hinton DR. Intercellular gap formation induced by thrombin in confluent cultured bovine retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1994;35:720-729.
14. Bian ZM, Elner SG, Elner VM. Thrombin-induced VEGF expression in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2007;48:2738-2746.
15. Walsh PN, Ahmad SS. Proteases in blood clotting. Essays Biochem. 2002;38:95-111.
16. Mori F, Hikichi T, Takahashi J, Nagaoka T, Yoshida A. Dysfunction of active transport of blood-retinal barrier in patients with clinically significant macular edema in type 2 diabetes. Diabetes Care. 2002;25:1248-1249.
17. Bringmann A, Reichenbach A, Wiedemann P. Pathomechanisms of cystoid macular edema. Ophthalmic Res. 2004;36:241-249.
18. Pederson JE. Fluid physiology of the subretinal space. In: Wilkinson CP, ed. Retina. St Louis: Mosby-Year Book; 1994:1955-1968.
19. Bringmann A, Pannicke T, Grosche J, et al. Müller cells in the healthy and diseased retina. Prog Retin Eye Res. 2006;25:397-424.
20. Stamer WD, Bok D, Hu J, Jaffe GJ, McKay BS. Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement. Invest Ophthalmol Vis Sci. 2003;44:2803-2808.
21. Iandiev I, Pannicke T, Reichel MB, Wiedemann P, Reichenbach A, Bringmann A. Expression of aquaporin-1 immunoreactivity by photoreceptor cells in the mouse retina. Neurosci Lett. 2005;388:96-99.
22. Nagelhus EA, Horio Y, Inanobe A, et al. Immunogold evidence suggests that coupling of K siphoning and water transport in rat retinal Müller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains. Glia. 1999;26:47-54.
23. Pannicke T, Iandiev I, Uckermann O, et al. A potassium channel-linked mechanism of glial cell swelling in the postischemic retina. Mol Cell Neurosci. 2004;26:493-502.
24. Pannicke T, Iandiev I, Wurm A, et al. Diabetes alters osmotic swelling characteristics and membrane conductance of glial cells in rat retina. Diabetes. 2006;55:633-639.
25. Uckermann O, Iandiev I, Francke M, et al. Selective staining by vital dyes of Müller glial cells in retinal wholemounts. Glia. 2004; 45:59-66.
26. Kofuji P, Ceelen P, Zahs KR, Surbeck LW, Lester HA, Newman EA. Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina. J Neurosci. 2000;20:5733-5740.
27. Pannicke T, Uckermann O, Iandiev I, et al. Altered membrane physiology in Müller glial cells after transient ischemia of the rat retina. Glia. 2005;50:1-11.
28. Eichler W, Yafai Y, Keller T, Wiedemann P, Reichenbach A. PEDF derived from glial Müller cells: a possible regulator of retinal angiogenesis. Exp Cell Res. 2004;299:68-78.
29. Iandiev I, Uckermann O, Pannicke T, et al. Glial cell reactivity in a porcine model of retinal detachment. Invest Ophthalmol Vis Sci. 2006;47:2161-2171.
30. Puwarawuttipanit W, Bragg AD, Frydenlund DS, et al. Differential effect of -syntrophin knockout on aquaporin-4 and Kir4.1 expression in retinal macroglial cells in mice. Neuroscience. 2006;137: 165-175.
31. Hollborn M, Francke M, Iandiev I, et al. Early activation of inflammation- and immune response-related genes after experimental detachment of the porcine retina. Invest Ophthalmol Vis Sci. 2008;49:1262-1273.
32. Zhang Y, Fortune B, Atchaneeyasakul LO, et al. Natural history and histology in a rat model of laser-induced photothrombotic retinal vein occlusion. Curr Eye Res. 2008;33:365-376.
33. Uckermann O, Kutzera F, Wolf A, et al. The glucocorticoid triamcinolone acetonide inhibits osmotic swelling of retinal glial cells via stimulation of endogenous adenosine signaling. J Pharmacol Exp Ther. 2005;315:1036-1045.