Paradoxical role of BDNF: BDINF+/- retinas are protected against light damage-mediated stress

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 6, 2007, Pages 2877-2886

  Wilson, R Brooks ^a   Kunchithapautham, Kannan ^a   Rohrer, Bärbel ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUTATHIONE PEROXIDASE; GROWTH FACTOR; MESSENGER RNA; NEUROTROPHIN; NERVE GROWTH FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTRORETINOGRAPHY; ENZYME ACTIVITY; EYE PROTECTION; LIGHT DAMAGE; MOUSE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PHOTORECEPTOR; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETINA INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; FEMALE; GENETICS; LIGHT; MALE; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; RADIATION EXPOSURE; RADIATION INJURY; RETINA; RETINA DEGENERATION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL SURVIVAL; CILIARY NEUROTROPHIC FACTOR; ELECTRORETINOGRAPHY; FEMALE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLUTATHIONE PEROXIDASE; IN SITU NICK-END LABELING; LIGHT; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE GROWTH FACTORS; OXIDATIVE STRESS; RADIATION INJURIES, EXPERIMENTAL; RETINA; RETINAL DEGENERATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 34347250490     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-1079     Document Type: Article

References (52)

1. Stone J, Maslim J, Valter-Kocsi K, et al. Mechanisms of photoreceptor death and survival in mammalian retina. Prog Retin Eye Res. 1999;18:689-735.
2. LaVail MM. Outer segment disc shedding and phagocytosis in the outer retina. Trans Ophthalmol Soc UK. 1983;103(pt 4):397-404.
3. + transport. J Neurosci. 1992;12:840-853.
4. Demontis GC, Longoni B, Gargini C, Cervetto L. The energetic cost of photoreception in retinal rods of mammals. Arch Ital Biol. 1997;135:95-109.
5. Bill A, Sperber G, Ujiie K. Physiology of the choroidal vascular bed. Int Ophthalmol. 1983;6:101-107.
6. Yu DY, Cringle SJ. Retinal degeneration and local oxygen metabolism. Exp Eye Res. 2005;80:745-751.
7. Penn JS, Naash MI, Anderson RE. Effect of light history on retinal antioxidants and light damage susceptibility in the rat. Exp Eye Res. 1987;44:779-788.
8. Liu C, Peng M, Laties AM, Wen R. Preconditioning with bright light evokes a protective response against light damage in the rat retina. J Neurosci. 1998;18:1337-1344.
9. Wenzel A, Grimm C, Samardzija M, Reme CE. Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog Retin Eye Res. 2005;24:275-306.
10. Ranchon I, Gorrand JM, Cluzel J, Droy-Lefaix MT, Doly M. Functional protection of photoreceptors from light-induced damage by dimethylthiourea and Ginkgo biloba extract. Invest Ophthalmol Vis Sci. 1999;40:1191-1199.
11. Ranchon I, Chen S, Alvarez K, Anderson RE. Systemic administration of phenyl-N-tert-butylnitrone protects the retina from light damage. Invest Ophthalmol Vis Sci. 2001;42:1375-1379.
12. Goureau O, Jeanny JC, Becquet F, Hartmann MP, Courtois Y. Protection against light-induced retinal degeneration by an inhibitor of NO synthase. Neuroreport. 1993;5:233-236.
13. Wenzel A, Reme CE, Williams TP, Hafezi F, Grimm C. The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration. J Neurosci. 2001;21:53-58.
14. Machida S, Chaudhry P, Shinohara T, et al. Lens epithelium-derived growth factor promotes photoreceptor survival in light damaged and RCS rats. Invest Ophthalmol Vis Sci. 2001;42:1087-1095.
15. LaVail MM, Yasumura D, Matthes MT, et al. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci. 1998;39:592-602.
16. Cao W, Li F, Steinberg RH, LaVail MM. Development of normal and injury-induced gene expression of aFGF, bFGF, CNTF, BDNF, GFAP and IGF-I in the rat retina. Exp Eye Res. 2001;72:591-604.
17. Harada T, Harada C, Kohsaka S, et al. Microglia-Müller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration. J Neurosci. 2002;22:9228-9236.
18. Liebl DJ, Tessarollo L, Palko ME, Parada LF. Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice. J Neurosci. 1997;17:9113-9121.
19. Wenzel A, Grimm C, Samardzija M, Reme CE. The genetic modifier Rpe65Leu(450): effect on light damage susceptibility in c-Fos-deficient mice. Invest Ophthalmol Vis Sci. 2003;44:2798-2802.
20. Gresh J, Goletz PW, Crouch RK, Rohrer B. Structure-function analysis of rods and cones in juvenile, adult, and aged C57bl/6 and Balb/c mice. Vis Neurosci. 2003;20:211-220.
21. Richards A, Emondi AA, Rohrer B. Long-term ERG analysis in the partially light damaged mouse retina reveals regressive and compensatory changes. Vis Neurosci. 2006;23:91-97.
22. Bayer AU, Cook P, Brodie SE, Maag KP, Mittag T. Evaluation of different recording parameters to establish a standard for flash electroretinography in rodents. Vis Res. 2001;41:2173-2185.
23. Rohrer B, Matthes MT, LaVail MM, Reichardt LF. Lack of p75 receptor does not protect photoreceptors from light-induced cell death. Exp Eye Res. 2003;76:125-129.
24. Lohr HR, Kuntchithapautham K, Sharma AK, Rohrer B. Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death. Exp Eye Res. 2006;83:380-389.
25. Rohrer B, Pinto FR, Hulse KE, Lohr HR, Zhang L, Almeida JS. Multidestructive pathways triggered in photoreceptor cell death of the rd mouse as determined through gene expression profiling. J Biol Chem. 2004;279:41903-41910.
26. Mitas M, Mikhitarian K, Walters C, et al. Quantitative real-time RT-PCR detection of breast cancer micrometastasis using a multigene marker panel. Int J Cancer. 2001;93:162-171.
27. Wahlin KJ, Campochiaro PA, Zack DJ, Adler R. Neurotrophic factors cause activation of intracellular signaling pathways in Müller cells and other cells of the inner retina, but not photoreceptors. Invest Ophthalmol Vis Sci. 2000;41:927-936.
28. Rohrer B, Korenbrot JI, LaVail MM, Reichardt LF, Xu B. Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina. J Neurosci. 1999;19:8919-8930.
29. Valter K, Bisti S, Gargini C, et al. Time course of neurotrophic factor upregulation and retinal protection against light-induced damage after optic nerve section. Invest Ophthalmol Vis Sci. 2005;46:1748-1754.
30. Frasson M, Picaud S, Leveillard T, et al. Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse. Invest Ophthalmol Vis Sci. 1999;40:2724-2734.
31. Jeon CJ, Strettoi E, Masland RH. The major cell populations of the mouse retina. J Neurosci. 1998;18:8936-8946.
32. Hao W, Wenzel A, Obin MS, et al. Evidence for two apoptotic pathways in light-induced retinal degeneration. Nat Genet. 2002;32:254-260.
33. Redmond TM, Yu S, Lee E, et al. Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nat Genet. 1998;20:344-351.
34. Danciger M, Lyon J, Worrill D, et al. New retinal light damage QTL in mice with the light-sensitive RPE65 LEU variant. Mamm Genome. 2004;15:277-283.
35. Rohrer B. Gene dosage effect of the TrkB receptor on rod physiology and biochemistry in juvenile mouse retina. Mol Vis. 2001;7:288-296.
36. Rohrer B, Blanco R, Marc RE, et al. Functionally intact glutamate-mediated signaling in bipolar cells of the TRKB knockout mouse retina. Vis Neurosci. 2004;21:703-713.
37. Lawrence JM, Keegan DJ, Muir EM, et al. Transplantation of Schwann cell line clones secreting GDNF or BDNF into the retinas of dystrophic Royal College of Surgeons rats. Invest Ophthalmol Vis Sci. 2004;45:267-274.
38. McGee Sanftner LH, Abel H, Hauswirth WW, Flannery JG. Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa. Mol Ther. 2001;4:622-629.
39. Andrieu-Soler C, Aubert-Pouessel A, Doat M, et al. Intravitreous injection of PLGA microspheres encapsulating GDNF promotes the survival of photoreceptors in the rd1/rd1 mouse. Mol Vis. 2005;11:1002-1011.
40. Wu WC, Lai CC, Chen SL, et al. GDNF gene therapy attenuates retinal ischemic injuries in rats. Mol Vis. 2004;10:93-102.
41. Jomary C, Darrow RM, Wong P, Organisciak DT, Jones SE. Expression of neurturin, glial cell line-derived neurotrophic factor, and their receptor components in light-induced retinal degeneration. Invest Ophthalmol Vis Sci. 2004;45:1240-1246.
42. Lathe R. Mice, gene targeting and behaviour: more than just genetic background. Trends Neurosci. 1996;19:183-186.
43. Gerlai R. Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci. 1996;19:177-181.
44. Crusio WE. Gene-targeting studies: new methods, old problems. Trends Neurosci. 1996;19:186-187, discussion 188-189.
45. Crawley JN. Unusual behavioral phenotypes of inbred mouse strains. Trends Neurosci. 1996;19:181-182, discussion 188-189.
46. Nelson RJ, Young KA. Behavior in mice with targeted disruption of single genes. Neurosci Biobehav Rev. 1998;22:453-462.
47. Lowenstein PR, Castro MG. Genetic engineering within the adult brain: implications for molecular approaches to behavioral neuroscience. Physiol Behav. 2001;73:833-839.
48. Kos CH. Cre/loxP system for generating tissue-specific knockout mouse models. Nutr Rev. 2004;62:243-246.
49. Aigner A. Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs. J Biotechnol. 2006;124:12-25.
50. Conover JC, Yancopoulos GD. Neurotrophin regulation of the developing nervous system: analyses of knockout mice. Rev Neurosci. 1997;8:13-27.
51. Bender R, Heimlich B, Meyer M, Frotscher M. Hippocampal mossy fiber sprouting is not impaired in brain-derived neurotrophic factor-deficient mice. Exp Brain Res. 1998;120:399-402.
52. Gosbell AD, Stefanovic N, Scurr LL, et al. Retinal light damage: structural and functional effects of the antioxidant glutathione peroxidase-1. Invest Ophthalmol Vis Sci. 2006;47:2613-2622.