Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase: A role in high glucose-induced apoptosis in retinal Müller cells

Investigative Ophthalmology and Visual Science

Volumn 45, Issue 5, 2004, Pages 1553-1561

  Kusner, Linda L ^a   Sarthy, Vijay P ^c   Mohr, Susanne ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; GLUCOSE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LIPOCORTIN 5; SELEGILINE; CASP3 PROTEIN, HUMAN; CASP3 PROTEIN, RAT; CASPASE; MONOAMINE OXIDASE INHIBITOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ISOLATION; CELL NUCLEUS; CELL TRANSFORMATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; DIABETES MELLITUS; DIABETIC RETINOPATHY; ENZYME ACTIVITY; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERGLYCEMIA; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MUELLER CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; TISSUE CULTURE; ACTIVE TRANSPORT; ANIMAL; CELL CULTURE; CONFOCAL MICROSCOPY; CYTOLOGY; CYTOPLASM; DRUG EFFECT; ENZYMOLOGY; GLIA; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; RETINA;

ACTIVE TRANSPORT, CELL NUCLEUS; ADULT; ANIMALS; ANNEXIN A5; APOPTOSIS; CASPASE 3; CASPASES; CELL NUCLEUS; CELLS, CULTURED; CYTOPLASM; GLUCOSE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; HYPERGLYCEMIA; MALE; MICROSCOPY, CONFOCAL; MONOAMINE OXIDASE INHIBITORS; NEUROGLIA; RATS; RETINA; SELEGILINE;

EID: 2442693140     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Newman E, Reichenbach A. The Müller cell: a functional element of the retina. Trends Neurosci. 1996;19:307-312.
2. Winkler B, Arnold M, Brassell M, Puro D. Energy metabolism in human retinal Müller cells. Invest Ophthalmol Vis Sci. 2000;41:3183-3190.
3. Mizutani M, Gerhardinger C, Lorenzi M. Müller cell changes in human diabetic retinopathy. Diabetes. 1998;47:445-449.
4. Lorenzi M, Gerhardinger C. Early cellular and molecular changes induced by diabetes in the retina. Diabetologia, 2001;44:791-804.
5. Li Q, Puro D. Diabetes-Induced Dysfunction of the glutamate transporter in retinal Müller cells. Invest Ophthalmol Vis Sci. 2002;43:3109-3116.
6. Asnaghi V, Gerhardinger C, Hoehn T, Adeboje A, Lorenzi M. A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat. Diabetes. 2003;52:506-511.
7. Mohr S, Xi X, Tang J, Kern T. Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients. Diabetes. 2002;51:1172-1179.
8. Sirover M. Role of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in normal cell function and in cell pathology. J Cell Biochem. 1997;66:133-140.
9. Mohr S, Hallak H, de Boitte A, Lapetina E, Brune B. Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem. 1999;274:9427-9430.
10. Sirover M. New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase. Biochim Biophys Acta. 1999;1432:159-184.
11. Tatton N. Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease. Exp Neurol. 2000;166:29-43.
12. Senatorov V, Charles V, Reddy P, Tagle D, Chuang D. Overexpression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase in a transgenic mouse model of Huntington's disease. Mol Cell Neurosci. 2003;22:285-297.
13. Mazzola J, Sirover M. Subcellular localization of human glyceraldehyde-3-phosphate dehydrogenase is independent of its glycolytic function. Biochim Biophys Acta. 2003;1622:50-56.
14. Ishitani R, Sunaga K, Hirano A, Saunders P, Katsube N, Chuang D. Evidence that glyceraldehyde-3-phosphate dehydrogenase is involved in age-induced apoptosis in mature cerebellar neurones in culture. J Neurochem. 1996;66:928-935.
15. Sawa A, Khan A, Hester L, Snyder S. Glyceraldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and nonneuronal cell death. Proc Natl Acad Sci USA. 1997;94:11669-11674.
16. Ishitani R, Tanaka M, Sunaga K, Katsube N, Chuang D. Nuclear localization of overexpressed glyceraldehyde-3-phosphate dehydrogenase in culture cerebellar neurons undergoing apoptosis. Mol Pharmacol. 1998;53:701-707.
17. Dastoor Z, Dreyer J. Potential role of nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase in apoptosis and oxidative stress. J Cell Sci. 2001;114:1643-1653.
18. Carlile GW, Chalmers-Redman R, Tatton N, Pong A, Borden K, Tatton W. Reduced apoptosis after nerve growth factor and serum withdrawal: conversion of tetrameric glyceraldehyde-3-phosphate dehydrogenase to a dimer. Mol Pharmacol. 2000;57:2-12.
19. Group TPS. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med. 1993;328:176-183.
20. Kragten E, Lalande I, Zimmermann K, et al. Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl. J Biol Chem. 1998;273:5821-5828.
21. Sarthy V, Brodijian S, Dutt K, Kennedy B, French R, Crabb J. Establishment and characterization of a retinal Müller cell line. Invest Ophthalmol Vis Sci. 1998;39:212-216.
22. Puro DG, Mano T. Modulation of calcium channels in human retinal glial cells by basic fibroblast growth factor: a possible role in retinal pathobiology. J Neurosci. 1991;11:1873-1880.
23. Laemmli U. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
24. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA. 1979;76:4350-4354.
25. Mohr S, McCormick T, Lapetina E. Macrophages resistant to endogenously generated nitric oxide mediated apoptosis are hypersensitive to exogenously added nitric oxide donors: dichotomous apoptosis response independent of caspase-3 and reversal by the MEK inhibitor PD098059. Proc Natl Acad Sci USA. 1998;95:5045-5050.
26. Saunders P, Chen R, Chuang D. Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase isoforms during neuronal apoptosis. J Neurochem. 1999;72:925-932.
27. Riepe RE, Norenberg MD. Müller cell localization of glutamine synthetase in rat retina. Nature. 1977;268:654-655.
28. Mizutani M, Kern T, Lorenzi M. Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J Clin Invest. 1996;97:2883-2890.
29. Barber A, Lieth E, Khin S, Antonetti D, Buchanan A, Gardner T. Neural apoptosis in the retina during experimental and human diabetes: early onset and effect of insulin. J Clin Invest. 1998;102:783-791.
30. Sunaga K, Takahashi H, Chuang D, Ishitani R. Glyceraldehyde-3-phosphate dehydrogenase is over-expressed during apoptotic death of neuronal cultures and is recognized by a monoclonal antibody against amyloid plaques from Alzheimer's brain. Neurosci Lett. 1995;200:133-136.
31. Shashidharan P, Chalmers-Redman R, Carlile G, et al. Nuclear translocation of GAPDH-GFP fusion protein during apoptosis. Neuroreport. 1999;10:1149-1153.
32. Ishitani R, Tajima H, Takata H, et al. Proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase: a possible site of action of antiapoptotic drugs. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27:291-301.
33. Berry M, Boulton A. Glyceraldehyde-3-phosphate dehydrogenase and apoptosis. J Neurosci Res. 2000;60:150-154.
34. Mazzola JL, Sirover MA. Subcellular alteration of glyceraldehyde-3- phosphate dehydrogenase in Alzheimer's disease fibroblasts. J Neurosci Res. 2003;71:279-285.
35. Saunders P, Chalecka-Franaszek E, Chuang D. Subcellular distribution of glyceraldehyde-3-phosphate dehydrogenase in cerebellar granule cells undergoing cytosine arabinoside-induced apoptosis. J Neurochem. 1997;69:1820-1828.
36. Tatton W, Chalmers-Redman R, Elstner M, et al. Glyceraldehyde-3-phosphate dehydrogenase in neurodegeneration and apoptosis signaling. J Neural Transm Suppl. 2000;77-100.
37. Schmitz HD. Reversible nuclear translocation of glyceraldehyde-3phosphate dehydrogenase upon serum depletion. EurJ Cell Biol. 2001;80:419-427.
38. Du XL, Takeshi M, Edelstein D, et al. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Invest. 2003;112:1049-1057.
39. Tatton W, Chalmers-Redman R, Ju W, et al. Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells. J Pharmacol Exp Ther. 2002;301:753-764.