Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathy

Investigative Ophthalmology and Visual Science

Volumn 38, Issue 1, 1997, Pages 36-47

  Amin, Rajesh H ^a   Frank, Robert N ^a   Kennedy, Alexander ^a   Eliott, Dean ^a   Puklin, James E ^a   Abrams, Gary W ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

basic fibroblast growth factor; diabetic retinopathy; glial cell; optic nerve; retina; vascular endothelial growth factor

Indexed keywords

ANTIBODY; BASIC FIBROBLAST GROWTH FACTOR; BLOOD CLOTTING FACTOR 8; GLIAL FIBRILLARY ACIDIC PROTEIN; VASCULOTROPIN; VIMENTIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; FEMALE; GLIA CELL; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MALE; MICROSCOPY; NEOVASCULARIZATION (PATHOLOGY); OPTIC NERVE; PRIORITY JOURNAL; RETINA;

AGED; AGED, 80 AND OVER; DIABETIC RETINOPATHY; ENDOTHELIAL GROWTH FACTORS; FACTOR VIII; FEMALE; FIBROBLAST GROWTH FACTOR 2; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHOKINES; MACULAR DEGENERATION; MALE; MIDDLE AGED; NEUROGLIA; OPTIC NERVE; RETINA; RETINAL VESSELS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; VIMENTIN;

EID: 0031018867     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. D'Amore PA. Mechanisms of retinal and choroidal neovascularization. Invest Ophthalmol Vis Sci. 1994;35:3974-3979.
2. Aiello LP, Avery RL, Arrigg PG, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. TV Engl J Med. 1994;331:1480-1487.
3. Adamis AP, Miller JW, Bernal M-T, et al. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol. 1994;118:445-450.
4. Pierce EA, Avery RL, Foley ED, Aiello LP, Smith LE. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci USA. 1995;92:905-909.
5. Miller JW, Adamis AP, Shima DT, et al. Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol 1994;145:574-584.
6. Frank RN. Vascular endothelial growth factor - its role in retinal vascular proliferation. N Engl J Med. 1994;331:1519-1520.
7. Pe'er J, Shweiki D, Itin A, Hemo I, Gnessin H, Keshet E. Hypoxia-induced expression of vascular endothelial growth factor (VEGF) by retinal cells is a common factor in neovascularization. Lab Invest. 1995;72:638-645.
8. Dvorak HF, Brown LF, Detmar M, Dvorak M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol. 1995;146:1029-1039.
9. Aiello LP, Pierce EA, Foley ED, et al. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci USA. 1995;92:10457-10461.
10. Malecaze F, Clamens S, Simorre-Pinatel V, et al. Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy. Arch Ophthalmol. 1994;112:1476-1482.
11. Murata T, Nakagawa K, Khalil A, Ishibashi T, Inomata H, Sueishi K. The relation between expression of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas. Lab Invest. 1996;74:819-825.
12. Kuwabara T, Cogan DG. Studies of retinal vascular patterns: Part I: Normal architecture. Arch Ophthalmol. 1960;64:904-911.
13. Laver NM, Robison WG Jr, Pfeffer BA. Novel procedures for isolating intact retinal vascular beds from diabetic humans and animal models. Invest Ophthalmol Vis Sci. 1993;34:2097-2104.
14. Hageman GS, Kirchoff-Rempe MA, Lewis GP, Fisher SK, Anderson DH. Sequestration of basic fibroblast growth factor in the primate retinal interphotoreceptor matrix. Proc Natl Acad Sci USA. 1991;88:6706-6710.
15. Vinores SA, Küchle M, Mahlow J, et al. Blood-ocular barrier breakdown in eyes with ocular melanoma: A potential role for vascular endothelial growth factor/vascular permeability factor. Am J Pathol. 1995;147:1289-1297.
16. Thomas KA. Vascular endothelial growth factor, a potent and selective angiogenic agent. J Biol Chem. 1996;271:603-606.
17. Kim I, Tolentino MJ, Miller JW, Adamis AP. Constitutive VEGF mRNA expression in the tissues of normal adult eyes. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1996;37:S792.
18. Adamis AP, Shima DT, Yeo K-T, et al. Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cells. Biochem Biophys Res Commun. 1993;193:631-638.
19. Stone J, Itin A, Alon T, et al. Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J Neurosci. 1995;15:4738-4747.
20. Smith LEH, Wesolowski E, McLellan A, et al. Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci. 1994;35:101-111.
21. Lewis GP, Matsumoto B, Fisher SK. Changes in the organization and expression of cytoskeletal proteins during etinal degeneration induced by retinal detachment. Invest Ophthalmol Vis Sci. 1995;36:2404-2416.
22. Bignami A, Dahl D. The radial glia of Müller in the rat retina and their response to injury: An immunofluorescence study with antibodies to the glial fibrillary acidic (GFA) protein. Exp Eye Res. 1979;28:63-69.
23. Bunt-Milam AH, Saari JC. Immunocytochemical localization of two retinoid-binding proteins in vertebrate retina. J Cell Biol. 1983;97:703-712.
24. Eisenfeld AJ, Bunt-Milam AH, Sarthy PV. Müller cell expression of glial fibrillary acidic protein after genetic and experimental photoreceptor degeneration in the rat retina. Invest Ophthalmol Vis Sci. 1984;25:1321-1328.
25. Ogden TE. Glia of the retina. In: Ryan SJ, ed. Retina. 2nd ed. St. Louis: CV Mosby; 1994:54-57.
26. Feke GT, Buzney SM, Ogasawara H, et al. Retinal circulatory abnormalities in type 1 diabetes. Invest Ophthalmol Vis Sci. 1994;35:2968-2975.
27. Bursell S-E, Clermont AC, Kinsley BT, Simonson DC, Aiello LM, Wolpert HA. Retinal blood flow changes in patients with insulin-dependent diabetes mellitus and no diabetic retinopathy: A video fluorescein angiographic study. Invest Ophthalmol Vis Sci. 1996;37:886-897.
28. Hanneken A, De Juan E Jr, Lutty GA, Fox GM, Schiffer S, Hjelmeland LM. Altered distribution of basic fibroblast growth factor in diabetic retinopathy. Arch Ophthalmol. 1991;109:1005-1011.
29. Hanneken A, Baird A. Immunolocalization of basic fibroblast growth factor: dependence on antibody type and tissue fixation. Exp Eye Res. 1992;54:1011-1014.
30. Patz A. Studies on retinal neovascularization. Invest Ophthalmol Vis Sci. 1980;19:1133-1138.
31. Henkind P. Ocular neovascularization. Am J Ophthalmol. 1978;85:287-301.
32. Williamson JR, Chang K, Frangos M, et al. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes. 1993;42:801-813.