Role of retinal glial cells in neurotransmitter uptake and metabolism

Neurochemistry International

Volumn 54, Issue 3-4, 2009, Pages 143-160

  Bringmann, Andreas ^a   Pannicke, Thomas ^b   Biedermann, Bernd ^b   Francke, Mike ^b   Iandiev, Ianors ^a,b   Grosche, Jens ^b,c   Wiedemann, Peter ^a   Albrecht, Jan ^d   Reichenbach, Andreas ^b  

^a Eye Hospital   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^d MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

Adenosine; ATP; GABA; Glutamate; Glycine; M ller cells; Recycling; Retina; Retinal pathology

Indexed keywords

4 AMINOBUTYRIC ACID; ADENOSINE TRIPHOSPHATE; AMMONIA; BASIC FIBROBLAST GROWTH FACTOR; CYSTINE; DEXTRO SERINE; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; GLYCINE; N ACETYLASPARTYLGLUTAMIC ACID;

4 AMINOBUTYRIC ACID METABOLISM; 4 AMINOBUTYRIC ACID UPTAKE; CELL FUNCTION; DOWN REGULATION; ENERGY METABOLISM; ENZYME REGULATION; GLIA CELL; HUMAN; MUELLER CELL; NITROSATIVE STRESS; OXIDATIVE STRESS; PRIORITY JOURNAL; RETINA CELL; RETINA DEVELOPMENT; REVIEW;

ANIMALS; ENERGY METABOLISM; EXCITATORY AMINO ACID TRANSPORTER 1; GLUTAMIC ACID; HUMANS; NEUROGLIA; NEURONS; NEUROTRANSMITTER AGENTS; RECEPTORS, PURINERGIC; RETINA; SYNAPTIC TRANSMISSION;

EID: 60949086948     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2008.10.014     Document Type: Review

References (314)

1. Albrecht J., Gadamski R., Kuhrt H., Walski M., and Reichenbach A. Retinal gliopathy accompanying thioacetamide-induced liver insufficiency: light and electron microscopic observations. Acta Neuropathol. 96 (1998) 57-66
2. Allert N., Köller H., and Siebler M. Ammonia-induced depolarization of cultured rat cortical astrocytes. Brain Res. 782 (1998) 261-270
3. Amato A., Barbour B., Szatkowski M., and Attwell D. Counter-transport of potassium by the glutamate uptake carrier in glial cells isolated from the tiger salamander retina. J. Physiol. 479 (1994) 371-380
4. Ambati J., Chalam K.V., Chawla D.K., D'Angio C.T., Guillet E.G., Rose S.J., Vanderlinde R.E., and Ambati B.K. Elevated γ-aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. Arch. Ophthalmol. 115 (1997) 1161-1166
5. Andrade da Costa B.L.S., de Mello F.G., and Hokoc J.N. Transporter-mediated GABA release induced by excitatory amino acid agonist is associated with GAD-67, but not GAD-65 immunoreactive cells of the primate retina. Brain Res. 863 (2000) 132-142
6. Arriza J.L., Eliasof S., Kavanaugh M.P., and Amara S.G. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 4155-4160
7. Asano T., Shigeno T., Johshita H., Usui M., and Hanamura T. A novel concept on the pathogenetic mechanism underlying ischaemic brain oedema: relevance of free radicals and eicosanoids. Acta Neurochir. Suppl. (Wien) 41 (1987) 85-96
8. Balboa M.A., and Balsinde J. Oxidative stress and arachidonic acid mobilization. Biochim. Biophys. Acta 1761 (2006) 385-391
9. Bannai S., and Tateishi N. Role of membrane transport in metabolism and function of glutathione in mammals. J. Membr. Biol. 89 (1986) 1-8
10. Barbour B., Brew H., and Attwell D. Electrogenic glutamate uptake in glial cells is activated by intracellular potassium. Nature 335 (1988) 433-435
11. Barbour B., Szatkowski M., Ingledew N., and Attwell D. Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells. Nature 342 (1989) 918-920
12. Barbour B., Brew H., and Attwell D. Electrogenic uptake of glutamate and aspartate into glial cells isolated from the salamander (Ambystoma) retina. J. Physiol. 436 (1991) 169-193
13. Barbour B., Magnus C., Szatkowski M., Gray P.T., and Attwell D. Changes in NAD(P)H fluorescence and membrane current produced by glutamate uptake into salamander Müller cells. J. Physiol. 466 (1993) 573-597
14. Barnett N.L., and Osborne N.N. Redistribution of GABA immunoreactivity following central retinal artery occlusion. Brain Res. 677 (1995) 337-340
15. Barnett N.L., and Pow D.V. Antisense knockdown of GLAST, a glial glutamate transporter, compromises retinal function. Invest. Ophthalmol. Vis. Sci. 41 (2000) 585-591
16. Barnett N.L., and Grozdanic S.D. Glutamate transporter localization does not correspond to the temporary functional recovery and late degeneration after acute ocular ischemia in rats. Exp. Eye Res. 79 (2004) 513-524
17. Barnett N.L., Pow D.V., and Robinson S.R. Inhibition of Müller cell glutamine synthetase rapidly impairs the retinal response to light. Glia 30 (2000) 64-73
18. Barnett N.L., Pow D.V., and Bull N.D. Differential perturbation of neuronal and glial glutamate transport systems in retinal ischaemia. Neurochem. Int. 39 (2001) 291-299
19. Beard M.E., Davies T., Holloway M., and Holtzman E. Peroxisomes in pigment epithelium and Müller cells of amphibian retina possess D-amino acid oxidase as well as catalase. Exp. Eye Res. 47 (1988) 795-806
20. Beart P.M., and O'Shea R.D. Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement. Br. J. Pharmacol. 150 (2007) 5-17
21. Ben-Dror I., Havazelet N., and Vardimon L. Developmental control of glucocorticoid receptor transcriptional activity in embryonic retina. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 1117-1121
22. Beretta S., Wood J.P., Derham B., Sala G., Tremolizzo L., Ferrarese C., and Osborne N.N. Partial mitochondrial complex I inhibition induces oxidative damage and perturbs glutamate transport in primary retinal cultures. Relevance to Leber Hereditary Optic Neuropathy (LHON). Neurobiol. Dis. 24 (2006) 308-317
23. Berger U.V., and Hediger M.A. Distribution of peptide transporter PEPT2 mRNA in the rat nervous system. Anat. Embryol. (Berl.) 199 (1999) 439-449
24. Berger U.V., Luthi-Carter R., Passani L.A., Elkabes S., Black I., Konradi C., and Coyle J.T. Glutamate carboxypeptidase II is expressed by astrocytes in the adult rat nervous system. J. Comp. Neurol. 415 (1999) 52-64
25. Berko-Flint Y., Levkowitz G., and Vardimon L. Involvement of c-Jun in the control of glucocorticoid receptor transcriptional activity during development of chicken retinal tissue. EMBO J. 13 (1994) 646-654
26. Biedermann B., Bringmann A., and Reichenbach A. High-affinity GABA uptake in retinal glial (Müller) cells of the guinea pig: electrophysiological characterization, immunohistochemical localization, and modeling of efficiency. Glia 39 (2002) 217-228
27. A receptors in Müller glial cells of the human retina. Glia 46 (2004) 302-310
28. Billups B., and Attwell D. Modulation of non-vesicular glutamate release by pH. Nature 379 (1996) 171-174
29. Birkle D.L., and Bazan N.G. Light exposure stimulates arachidonic acid metabolism in intact rat retina and isolated rod outer segments. Neurochem. Res. 14 (1989) 185-190
30. Boulland J.L., Osen K.K., Levy L.M., Danbolt N.C., Edwards R.H., Storm-Mathisen J., and Chaudhry F.A. Cell-specific expression of the glutamine transporter SN1 suggests differences in dependence on the glutamine cycle. Eur. J. Neurosci. 15 (2002) 1615-1631
31. Bouvier M., Miller B.A., Szatkowski M., and Attwell D. Electrogenic uptake of sulphur-containing analogues of glutamate and aspartate by Müller cells from the salamander retina. J. Physiol. 444 (1991) 441-457
32. Boycott B.B., and Wässle H. Morphological classification of bipolar cells of the primate retina. Eur. J. Neurosci. 3 (1991) 1069-1088
33. Braun N., Brendel P., and Zimmermann H. Distribution of 5′-nucleotidase in the developing mouse retina. Brain Res. Dev. Brain Res. 88 (1995) 79-86
34. Brecha N.C., and Weigmann C. Expression of GAT-1, a high-affinity γ-aminobutyric acid plasma membrane transporter in the rat retina. J. Comp. Neurol. 345 (1994) 602-611
35. Brew H., and Attwell D. Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells. Nature 327 (1987) 707-709
36. Bringmann A., Kuhrt H., Germer A., Biedermann B., and Reichenbach A. Müller (glial) cell development in vivo and in retinal explant cultures: morphology and electrophysiology, and the effects of elevated ammonia. J. Hirnforsch. 39 (1998) 193-206
37. Bringmann A., Francke M., Pannicke T., Biedermann B., Faude F., Enzmann V., Wiedemann P., Reichelt W., and Reichenbach A. Human Müller glial cells: altered potassium channel activity in proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 40 (1999) 3316-3323
38. Bringmann A., Pannicke T., Biedermann B., Uhlmann S., Kohen L., Wiedemann P., and Reichenbach A. Activation of P2Y receptors stimulates potassium and cation currents in acutely isolated human Müller (glial) cells. Glia 37 (2002) 139-152
39. Bringmann A., Kohen L., Wolf S., Wiedemann P., and Reichenbach A. Age-related decrease of potassium currents in human retinal glial (Müller) cells. Can. J. Ophthalmol. 38 (2003) 464-468
40. Bringmann A., Reichenbach A., and Wiedemann P. Pathomechanisms of cystoid macular edema. Ophthal. Res. 36 (2004) 241-249
41. Bringmann A., Pannicke T., Grosche J., Francke M., Wiedemann P., Skatchkov S.N., Osborne N.N., and Reichenbach A. Müller cells in the healthy and diseased retina. Prog. Retin. Eye Res. 25 (2006) 397-424
42. Brooks D.E., Garcia G.A., Dreyer E.B., Zurakowski D., and Franco-Bourland R.E. Vitreous body glutamate concentrations in dogs with glaucoma. Am. J. Vet. Res. 58 (1997) 864-867
43. Bull N.D., and Barnett N.L. Antagonists of protein kinase C inhibit rat retinal glutamate transport activity in situ. J. Neurochem. 81 (2002) 472-480
44. Calaza K.C., de Mello F.G., and Gardino P.F. GABA release induced by aspartate-mediated activation of NMDA receptors is modulated by dopamine in a selective subpopulation of amacrine cells. J. Neurocytol. 301 (2001) 81-93
45. Calaza K.C., Gardino P.F., and de Mello F.G. Transporter mediated GABA release in the retina: role of excitatory amino acids and dopamine. Neurochem. Int. 49 (2006) 769-777
46. Cao W., Wen R., Li F., Lavail M.M., and Steinberg R.H. Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina. Exp. Eye Res. 65 (1997) 241-248
47. Castillo J., Davalos A., and Noya M. Progression of ischaemic stroke and excitotoxic amino acids. Lancet 348 (1997) 79-83
48. Chen H., and Weber A.J. Expression of glial fibrillary acidic protein and glutamine synthetase by Müller cells after optic nerve damage and intravitreal application of brain-derived neurotrophic factor. Glia 38 (2002) 115-125
49. Chen C.T., Alyahya K., Gionfriddo J.R., Dubielzig R.R., and Madl J.E. Loss of glutamine synthetase immunoreactivity from the retina in canine primary glaucoma. Vet. Ophthalmol. 11 (2008) 150-157
50. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1 (1988) 623-634
51. Choi Y.K., and Kim K.W. Blood-neural barrier: its diversity and coordinated cell-to-cell communication. BMB Rep. 41 (2008) 345-352
52. +. J. Physiol. 495 (1996) 305-318
53. Copenhagen D.R., Ashmore J.F., and Schnapf J.K. Kinetics of synaptic transmission from photoreceptors to horizontal and bipolar cells in turtle retina. Vision Res. 23 (1983) 363-369
54. Coyle J.T. The nagging question of the function of N-acetylaspartylglutamate. Neurobiol. Dis. 4 (1997) 231-238
55. Cubells J.F., Walkley S.U., and Makman M.H. The effects of gabaculine in vivo on the distribution of GABA-like immunoreactivity in the rat retina. Brain Res. 458 (1988) 82-90
56. Davanger S., Ottersen O.P., and Storm-Mathisen J. Glutamate, GABA, and glycine in the human retina: an immunocytochemical investigation. J. Comp. Neurol. 311 (1991) 483-494
57. Davidge S.T., Baker P.N., Laughlin M.K., and Roberts J.M. Nitric oxide produced by endothelial cells increases production of eicosanoids through activation of prostaglandin H synthase. Circ. Res. 77 (1995) 274-283
58. Delyfer M.N., Forster V., Neveux N., Picaud S., Léveillard T., and Sahel J.A. Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina. Mol. Vis. 11 (2005) 688-696
59. Derouiche A., and Rauen T. Coincidence of L-glutamate/L-aspartate transporter (GLAST) and glutamine synthetase (GS) immunoreactions in retinal glia: evidence for coupling of GLAST and GS in transmitter clearance. J. Neurosci. Res. 42 (1995) 131-143
60. De Sampaio Schitine C., Kubrusly R.C., de Melo Reis R.A., Yamasaki E.N., de Mello M.C., and de Mello F.G. GABA uptake by purified avian Müller glia cells in culture. Neurotox. Res. 12 (2007) 145-153
61. Diaz C.M., Macnab L.T., Williams S.M., Sullivan R.K., and Pow D.V. EAAT1 and D-serine expression are early features of human retinal development. Exp. Eye Res. 84 (2007) 876-885
62. Dkhissi O., Chanut E., Wasowicz M., Savoldelli M., Nguyen-Legros J., Minvielle F., and Versaux-Botteri C. Retinal TUNEL-positive cells and high glutamate levels in vitreous humor of mutant quail with a glaucoma-like disorder. Invest. Ophthalmol. Vis. Sci. 40 (1999) 990-994
63. Du J.L., Xu L.Y., and Yang X.L. Glycine receptors and transporters on bullfrog retinal Müller cells. Neuroreport 13 (2002) 1653-1656
64. Dun Y., Mysona B., Itagaki S., Martin-Studdard A., Ganapathy V., and Smith S.B. Functional and molecular analysis of D-serine transport in retinal Müller cells. Exp. Eye Res. 84 (2007) 191-199
65. Dun Y., Duplantier J., Roon P., Martin P.M., Ganapathy V., and Smith S.B. Serine racemase expression and D-serine content are developmentally regulated in neuronal ganglion cells of the retina. J. Neurochem. 104 (2008) 970-978
66. Ekström P., and Anzelius M. GABA and GABA-transporter (GAT-1) immunoreactivities in the retina of the salmon (Salmo salar L.). Brain Res. 812 (1998) 179-185
67. Eliasof S., and Jahr C.E. Retinal glial cell glutamate transporter is coupled to an anionic conductance. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 4153-4158
68. Eliasof S., Arriza J.L., Leighton B.H., Kavanaugh M.P., and Amara S.G. Excitatory amino acid transporters of the salamander retina: identification, localization, and function. J. Neurosci. 18 (1998) 698-712
69. Failer B.U., Aschrafi A., Schmalzing G., and Zimmermann H. Determination of native oligomeric state and substrate specificity of rat NTPDase1 and NTPDase2 after heterologous expression in Xenopus oocytes. Eur. J. Biochem. 270 (2003) 1802-1809
70. Faktorovich E.G., Steinberg R.H., Yasumura D., Matthes M.T., and LaVail M.M. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature 347 (1990) 83-86
71. Faktorovich E.G., Steinberg R.H., Yasumura D., Matthes M.T., and LaVail M.M. Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat. J. Neurosci. 12 (1992) 3554-3567
72. Fletcher E.L., and Kalloniatis M. Neurochemical architecture of the normal and degenerating rat retina. J. Comp. Neurol. 376 (1996) 343-360
73. Fletcher E.L., and Kalloniatis M. Localization of amino acid neurotransmitters during postnatal development of the rat retina. J. Comp. Neurol. 380 (1997) 449-471
74. Francke M., Faude F., Pannicke T., Bringmann A., Eckstein P., Reichelt W., Wiedemann P., and Reichenbach A. Electrophysiology of rabbit Müller (glial) cells in experimental retinal detachment and PVR. Invest. Ophthalmol. Vis. Sci. 42 (2001) 1072-1079
75. Francke M., Weick M., Pannicke T., Uckermann O., Grosche J., Goczalik I., Milenkovic I., Uhlmann S., Faude F., Wiedemann P., Reichenbach A., and Bringmann A. Up-regulation of extracellular ATP-induced Müller cell responses in a dispase model of proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 43 (2002) 870-881
76. Fyk-Kolodziej B., Qin P., Dzhagaryan A., and Pourcho R.G. Differential cellular and subcellular distribution of glutamate transporters in the cat retina. Vis. Neurosci. 21 (2004) 551-565
77. Gadea A., Lopez E., and Lopez-Colome A.M. Characterization of glycine transport in cultured Müller glial cells from the retina. Glia 26 (1999) 273-279
78. 2+ and calmodulin-dependent enzymes in the regulation of glycine transport in Müller glia. J. Neurochem. 80 (2002) 634-645
79. Gadea A., Lopez E., and Lopez-Colome A.M. Glutamate-induced inhibition of d-aspartate uptake in Müller glia from the retina. Neurochem. Res. 29 (2004) 295-304
80. Gao H., and Hollyfield J.G. Basic fibroblast growth factor in retinal development: differential levels of bFGF expression and content in normal and retinal degeneration (rd) mutant mice. Dev. Biol. 169 (1995) 168-184
81. Gao H., and Hollyfield J.G. Elevated expression of basic fibroblast growth factor during photoreceptor degeneration caused by light damage and genetic defects. Invest. Ophthalmol. Vis. Sci. 36 (1995) S203
82. Gao H., and Hollyfield J.G. Basic fibroblast growth factor: increased gene expression in inherited and light induced photoreceptor degeneration. Exp. Eye Res. 62 (1996) 181-189
83. Gass J.D. Stereoscopic Atlas of Macular Diseases: Diagnosis and Treatment (1997), Mosby, St. Louis, MO 1061 p
84. Gebhard R. Cytochemical demonstration of aspartate aminotransferase activity in the rat retina. Brain Res. 539 (1991) 337-341
85. Gebhard R. Histochemical demonstration of glutamate dehydrogenase and phosphate-activated glutaminase activities in semithin sections of the rat retina. Histochemistry 97 (1992) 101-103
86. Geller S.F., Lewis G.P., and Fisher S.K. FGFR1, signaling, and AP-1 expression after retinal detachment: reactive Müller and RPE cells. Invest. Ophthalmol. Vis. Sci. 42 (2001) 1363-1369
87. Gerhardinger C., Costa M.B., Coulombe M.C., Toth I., Hoehn T., and Grosu P. Expression of acute-phase response proteins in retinal Müller cells in diabetes. Invest. Ophthalmol. Vis. Sci. 46 (2005) 349-357
88. Germer A., Jahnke C., Mack A., Enzmann V., and Reichenbach A. Modification of glutamine synthetase expression by mammalian Müller (glial) cells in retinal organ cultures. Neuroreport 8 (1997) 3067-3072
89. Germer A., Biedermann B., Wolburg H., Schuck J., Grosche J., Kuhrt H., Reichelt W., Schousboe A., Paasche G., Mack A.F., and Reichenbach A. Distribution of mitochondria within Müller cells: I, correlation with retinal vascularization in different mammalian species. J. Neurocytol. 27 (1998) 329-345
90. Gonzalez M.I., Lopez-Colome A.M., and Ortega A. Sodium-dependent glutamate transport in Müller glial cells: regulation by phorbol esters. Brain Res. 831 (1999) 140-145
91. Gorovits R., Yakir A., Fox L.E., and Vardimon L. Hormonal and non-hormonal regulation of glutamine synthetase in the developing neural retina. Mol. Brain Res. 43 (1996) 321-329
92. Gorovits R., Avidan N., Avisar N., Shaked I., and Vardimon L. Glutamine synthetase protects against neuronal degeneration in injured retinal tissue. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 7024-7029
93. Grewer C., and Rauen T. Electrogenic glutamate transporters in the CNS: molecular mechanism, pre-steady-state kinetics, and their impact on synaptic signaling. J. Membr. Biol. 203 (2005) 1-20
94. Grosche J., Härtig W., and Reichenbach A. Expression of glial fibrillary acidic protein (GFAP), glutamine synthetase (GS), and Bcl-2 protooncogene protein by Müller (glial) cells in retinal light damage of rats. Neurosci. Lett. 185 (1995) 119-122
95. Hanna M., and Calkins D.J. Expression of genes encoding glutamate receptors and transporters in rod and cone bipolar cells of the primate retina determined by single-cell polymerase chain reaction. Mol. Vis. 13 (2007) 2194-2208
96. Harada T., Harada C., Watanabe M., Inoue Y., Sakagawa T., Nakayama N., Sasaki S., Okuyama S., Watase K., Wada K., and Tanaka K. Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 4663-4666
97. Harada C., Harada T., Slusher B.S., Yoshida K., Matsuda H., and Wada K. N-acetylated-α-linked-acidic dipeptidase inhibitor has a neuroprotective effect on mouse retinal ganglion cells after pressure-induced ischemia. Neurosci. Lett. 292 (2000) 134-136
98. Harada T., Harada C., Nakamura K., Quah H.M., Okumura A., Namekata K., Saeki T., Aihara M., Yoshida H., Mitani A., and Tanaka K. The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. J. Clin. Invest. 117 (2007) 1763-1770
99. Härtig W., Grosche J., Distler C., Grimm D., Elhifnawi E., and Reichenbach A. Alterations of Müller (glial) cells in dystrophic retinae of RCS rats. J. Neurocytol. 24 (1995) 507-517
100. Hasegawa J., Obara T., Tanaka K., and Tachibana M. High-density presynaptic transporters are required for glutamate removal from the first visual synapse. Neuron 50 (2006) 63-74
101. Hauck S.M., Schoeffmann S., Amann B., Stangassinger M., Gerhards H., Ueffing M., and Deeg C.A. Retinal Müller glial cells trigger the hallmark inflammatory process in autoimmune uveitis. J. Proteome Res. 6 (2007) 2121-2131
102. Haverkamp S., Haeseleer F., and Hendrickson A. A comparison of immunocytochemical markers to identify bipolar cell types in human and monkey retina. Vis. Neurosci. 20 (2003) 589-600
103. Hertz L., Peng L., Westergaard N., Yudkoff M., and Schousboe A. Neuronal-astrocyte interactions in metabolism of transmitter amino acids of the glutamate family. In: Schousboe A., Diemer N.H., and Kofod H. (Eds). Drug Research Related to Neuroactive Amino Acids (1992), Munksgaard, Copenhagen 30-48
104. Higgs M.H., and Lukasiewicz P.D. Glutamate uptake limits synaptic excitation of retinal ganglion cells. J. Neurosci. 19 (2002) 3691-3700
105. Holcombe D.J., Lengefeld N., Gole G.A., and Barnett N.L. The effects of acute intraocular pressure elevation on rat retinal glutamate transport. Acta Ophthalmol. Scand. 86 (2008) 408-414
106. Holländer H., Makarov F., Dreher Z., van Driel D., Chan-Ling T.L., and Stone J. Structure of the macroglia of the retina: sharing and division of labour between astrocytes and Müller cells. J. Comp. Neurol. 313 (1991) 587-603
107. Honda S., Yamamoto M., and Saito N. Immunocytochemical localization of three subtypes of GABA transporter in rat retina. Mol. Brain Res. 33 (1995) 319-325
108. Hu M., Bruun A., and Ehinger B. Expression of GABA transporter subtypes (GAT1, GAT3) in the adult rabbit retina. Acta Ophthalmol. Scand. 77 (1999) 255-260
109. Hussain S.T., and Baydoun E.A. Cytochemical localization of 5′-nucleotidase in the frog (Rana pipiens) retina. A histochemical and cytochemical study. J. Histochem. Cytochem. 33 (1985) 1067-1072
110. Huster D., Hjelle O.P., Haug F.M., Nagelhus E.A., Reichelt W., and Ottersen O.P. Subcellular compartmentation of glutathione and glutathione precursors. A high resolution immunogold analysis of the outer retina of guinea pig. Anat. Embryol. (Berl.) 198 (1998) 277-287
111. Iandiev I., Uckermann O., Pannicke T., Wurm A., Pietsch U.-C., Reichenbach A., Wiedemann P., Bringmann A., and Uhlmann S. Glial cell reactivity in a porcine model of retinal detachment. Invest. Ophthalmol. Vis. Sci. 47 (2006) 2161-2171
112. Iandiev I., Wurm A., Pannicke T., Wiedemann P., Reichenbach A., Robson S.C., Zimmermann H., and Bringmann A. Ecto-nucleotidases in Müller glial cells of the rodent retina: involvement in inhibition of osmotic cell swelling. Purinergic Sign. 3 (2007) 423-433
113. Imasawa M., Kashiwagi K., Iizuka Y., Tanaka M., and Tsukahara S. Different expression role among glutamate transporters in rat retinal glial cells under various culture conditions. Mol. Brain Res. 142 (2005) 1-8
114. Ishikawa A., Ishiguro S., and Tamai M. Accumulation of gamma-aminobutyric acid in diabetic rat retinal Müller cells evidenced by electron microscopic immunocytochemistry. Curr. Eye Res. 15 (1996) 958-964
115. Ishikawa A., Ishiguro S., and Tamai M. Changes in GABA metabolism in streptozotocin-induced diabetic rat retinas. Curr. Eye Res. 15 (1996) 63-71
116. Izumi Y., Kirby-Sharkey C.O., Benz A.M., Mennerick S., Labruyere J., Price M.T., Olney J.W., and Zorumski C.F. Swelling of Müller cells induced by AP3 and glutamate transport substrates in rat retina. Glia 17 (1996) 285-293
117. Izumi Y., Kirby C.O., Benz A.M., Olney J.W., and Zorumski C.F. Müller cell swelling, glutamate uptake, and excitotoxic neurodegeneration in the isolated rat retina. Glia 25 (1999) 379-389
118. Izumi Y., Shimamoto K., Benz A.M., Hammerman S.B., Olney J.W., and Zorumski C.F. Glutamate transporters and retinal excitotoxicity. Glia 39 (2002) 58-68
119. Jablonski M.M., Tombran-Tink J., Mrazek D.A., and Iannaccone A. Pigment epithelium-derived factor supports normal Müller cell development and glutamine synthetase expression after removal of the retinal pigment epithelium. Glia 35 (2001) 14-25
120. Janaky R., Ogita K., Pasqualotto B.A., Bains J.S., Oja S.S., Yoneda Y., and Shaw C.A. Glutathione and signal transduction in the mammalian CNS. J. Neurochem. 73 (1999) 889-902
121. Jiang Z., Li B., Jursky F., and Shen W. Differential distribution of glycine transporters in Müller cells and neurons in amphibian retinas. Vis. Neurosci. 24 (2007) 157-168
122. Johnson J., Chen T.K., Rickman D.W., Evans C., and Brecha N.C. Multiple γ-aminobutyric acid plasma membrane transporters (GAT-1, GAT-2, GAT-3) in the rat retina. J. Comp. Neurol. 375 (1996) 212-224
123. Kalisch F., Wurm A., Iandiev I., Uckermann O., Dilsiz N., Reichenbach A., Wiedemann P., and Bringmann A. Atrial natriuretic peptide inhibits osmotical glial cell swelling in the ischemic rat retina: dependence on glutamatergic-purinergic signaling. Exp. Eye Res. 83 (2006) 962-971
124. Kalloniatis M., and Napper G.A. Retinal neurochemical changes following application of glutamate as a metabolic substrate. Clin. Exp. Optom. 85 (2002) 27-36
125. Kalloniatis M., Tomisich G., and Marc R.E. Neurochemical signatures revealed by glutamine labeling in the chicken retina. Vis. Neurosci. 11 (1994) 793-804
126. Kalloniatis M., Marc R.E., and Murry R.F. Amino acid signatures in the primate retina. J. Neurosci. 16 (1996) 6807-6829
127. Kanai Y., and Hediger M.A. The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects. Pflügers Arch. 447 (2004) 469-479
128. Kang T.C., Park S.K., Jo S.M., Lee J.Y., Won M.H., Park J., and Choi S.Y. Comparative studies on the distribution of glutamate transporters in the retinae of the Mongolian gerbil and the rat. Anat. Histol. Embryol. 29 (2000) 381-383
129. Kannan R., Bao Y., Wang Y., Sarthy V.P., and Kaplowitz N. Protection from oxidant injury by sodium-dependent GSH uptake in retinal Müller cells. Exp. Eye Res. 68 (1999) 609-616
130. Kapetanios A.D., Poitry S., Poitry-Yamate C.L., and Tsacopoulos M. Exposure to lactate induces rapid mitochondrial metabolic changes in solitary rods. Invest. Ophthalmol. Vis. Sci. 39 (1998) S1057
131. Kashii S., Mandai M., Kikuchi M., Honda Y., Tamura Y., Kaneda K., and Akaike A. Dual actions of nitric oxide in N-methyl-D-aspartate receptor-mediated neurotoxicity in cultured retinal neurons. Brain Res. 711 (1996) 93-101
132. Kato S., Ishita S., Sugawara K., and Mawatari K. Cystine/glutamate antiporter expression in retinal Müller glial cells: implications for DL-α-aminoadipate toxicity. Neuroscience 57 (1993) 473-482
133. Kim D., Kim M.J., Lee J.H., Im J.O., Won Y.J., Yoon S.Y., and Hong H.N. Concomitant distribution shift of glial GABA transporter and S100 calcium-binding proteins in the rat retina after kainate-induced excitotoxic injury. Neurosci. Lett. 353 (2003) 17-20
134. Kobayashi N., Ishiguro S., Tomita H., Nishikawa S., and Tamai M. Changes of GABA metabolic enzymes in acute retinal ischemia. Exp. Eye Res. 69 (1999) 91-96
135. Kowluru R.A., and Kennedy A. Therapeutic potential of anti-oxidants and diabetic retinopathy. Expert. Opin. Investig. Drugs 10 (2001) 1665-1676
136. Kreutzberg G.W., and Hussain S.T. Cytochemical heterogeneity of the glial plasma membrane: 5′-nucleotidase in retinal Müller cells. J. Neurocytol. 11 (1982) 53-64
137. Kruchkova Y., Ben-Dror I., Herschkovitz A., David M., Yayon A., and Vardimon L. Basic fibroblast growth factor: a potential inhibitor of glutamine synthetase expression in injured neural tissue. J. Neurochem. 77 (2001) 1641-1649
138. Kubrusly R.C., da Cunha M.C., Reis R.A., Soares H., Ventura A.L., Kurtenbach E., de Mello M.C., and de Mello F.G. Expression of functional receptors and transmitter enzymes in cultured Müller cells. Brain Res. 1038 (2005) 141-149
139. Kugler P., and Beyer A. Expression of glutamate transporters in human and rat retina and rat optic nerve. Histochem. Cell. Biol. 120 (2003) 199-212
140. Kusaka S., Kapousta-Bruneau N.V., and Puro D.G. Plasma-induced changes in the physiology of mammalian retinal glial cells: role of glutamate. Glia 25 (1999) 205-215
141. 3H)D-aspartate uptake sites in monkey retina. Cell Tissue Res. 243 (1986) 59-63
142. 2 isoforms by cell swelling and ischaemia/hypoxia. Acta Physiol. (Oxf.) 187 (2006) 75-85
143. LaNoue K.F., Berkich D.A., Conway M., Barber A.J., Hu L.Y., Taylor C., and Hutson S. Role of specific aminotransferases in de novo glutamate synthesis and redox shuttling in the retina. J. Neurosci. Res. 66 (2001) 914-922
144. Lee S.C., Zhong Y.M., and Yang X.L. Expression of glycine receptor and transporter on bullfrog retinal Müller cells. Neurosci. Lett. 387 (2005) 75-79
145. Lees G.J. Inhibition of sodium-potassium-ATPase: a potentially ubiquitous mechanism contributing to central nervous system neuropathology. Brain Res. Rev. 16 (1991) 283-380
146. Lehre K.P., Davanger S., and Danbolt N.C. Localization of the glutamate transporter protein GLAST in rat retina. Brain Res. 744 (1997) 129-137
147. Lewis G.P., Erickson P.A., Guerin C.J., Anderson D.H., and Fisher S.K. Changes in the expression of specific Müller cell proteins during long-term retinal detachment. Exp. Eye Res. 49 (1989) 93-111
148. Li Q., and Puro D.G. Diabetes-induced dysfunction of the glutamate transporter in retinal Muller cells. Invest. Ophthalmol. Vis. Sci. 43 (2002) 3109-3116
149. Lieth E., Barber A., Xu B., Dice C., Ratz M.J., Tanase D., and Strother J.M. Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Diabetes 47 (1998) 815-820
150. Lieth E., LaNoue K.F., Antonetti D.A., and Ratz M. Diabetes reduces glutamate oxidation and glutamine synthesis in the retina. Exp. Eye Res. 70 (2000) 723-730
151. Linser P.J., and Moscona A.A. Induction of glutamine synthetase in embryonic neural retina: localization in Müller fibers and dependence on cell interactions. Proc. Natl. Acad. Sci. U.S.A. 76 (1979) 6476-6480
152. Lo T.C., Klunder L., and Fletcher E.L. Increased Müller cell density during diabetes is ameliorated by aminoguanidine and ramipril. Clin. Exp. Optom. 84 (2001) 276-281
153. Lopez-Colome A.M., Ortega A., and Romo-de-Vivar M. Excitatory amino acid-induced phosphoinositide hydrolysis in Müller glia. Glia 9 (1993) 127-135
154. Lutty G.A., and McLeod D.S. A new technique for visualization of the human retinal vasculature. Arch. Ophthalmol. 110 (1992) 267-276
155. Lutty G.A., Merges C., and McLeod D.S. 5′ nucleotidase and adenosine during retinal vasculogenesis and oxygen-induced retinopathy. Invest. Ophthalmol. Vis. Sci. 41 (2000) 218-229
156. Macnab L.T., and Pow D.V. Central nervous system expression of the exon 9 skipping form of the glutamate transporter GLAST. Neuroreport 18 (2007) 741-745
157. Macnab L.T., Williams S.M., and Pow D.V. Expression of the exon 3 skipping form of GLAST, GLAST1a, in brain and retina. Neuroreport 17 (2006) 1867-1870
158. Maguire G., Simko H., Weinreb R.N., and Ayoub G. Transport-mediated release of endogenous glutamate in the vertebrate retina. Pflügers Arch. 436 (1998) 481-484
159. Marc R.E. Structural organization of GABAergic circuitry in ectotherm retinas. Prog. Brain Res. 90 (1992) 61-92
160. Marc R.E., and Cameron D. A molecular phenotype atlas of the zebrafish retina. J. Neurocytol. 30 (2001) 593-654
161. Marc R.E., Liu W.L., Kalloniatis M., Raiguel S.F., and van Haesendonck E. Patterns of glutamate immunoreactivity in the goldfish retina. J. Neurosci. 10 (1990) 4006-4034
162. Marc R.E., Murry R.F., and Basinger S.F. Pattern recognition of amino acid signatures in retinal neurons. J. Neurosci. 15 (1995) 5106-5129
163. Marc R.E., Murry R.F., Fisher S.K., Linberg K.A., Lewis G.P., and Kalloniatis M. Amino acid signatures in the normal cat retina. Invest. Ophthalmol. Vis. Sci. 39 (1998) 1685-1693
164. Marc R.E., Murry R.F., Fisher S.K., Linberg K.A., and Lewis G.P. Amino acid signatures in the detached cat retina. Invest. Ophthalmol. Vis. Sci. 39 (1998) 1694-1702
165. Marcaggi P., and Coles J.A. Ammonium in nervous tissue: transport across cell membranes, fluxes from neurons to glial cells, and role in signalling. Prog. Neurobiol. 65 (2001) 209-210
166. +: separate routes of uptake into glial cells of bee retina. Eur. J. Neurosci. 19 (2004) 966-976
167. Marcaggi P., Hirji N., and Attwell D. Release of L-aspartate by reversal of glutamate transporters. Neuropharmacology 49 (2005) 843-849
168. 3H γ-aminobutyric acid in the isolated retinas of pigeons and chickens. Invest. Ophthalmol. 13 (1974) 602-607
169. Martin K.R., Levkovitch-Verbin H., Valenta D., Baumrind L., Pease M.E., and Quigley H.A. Retinal glutamate transporter changes in experimental glaucoma and after optic nerve transection in the rat. Invest. Ophthalmol. Vis. Sci. 43 (2002) 2236-2243
170. Massey S.C., and Miller R.F. Excitatory amino acid receptors of rod- and cone-driven horizontal cells in the rabbit retina. J. Neurophysiol. 57 (1987) 645-659
171. Massey S.C., and Miller R.F. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J. Neurophysiol. 63 (1990) 16-30
172. Matsui K., Hosoi N., and Tachibana M. Active role of glutamate uptake in the synaptic transmission from retinal nonspiking neurons. J. Neurosci. 19 (1999) 6755-6766
173. Matsushima M., Yamada H., Yamamoto C., Miyashiro M., Ogata N., and Uyama M. Expression of basic fibroblast growth factor and fibroblast growth factor receptor 1 in the experimental retinal vein occlusion model. Nippon Ganka Gakkai Zasshi 101 (1997) 564-570
174. McLeod D.S., Hasegawa T., Prow T., Merges C., and Lutty G. The initial fetal human retinal vasculature develops by vasculogenesis. Dev. Dyn. 235 (2006) 3336-3347
175. Meister A. Glutamine synthetase of mammals. In: Boyer P.D. (Ed). The Enzymes. ed. 3 vol. 10 (1974), Academic, New York 699-754
176. Metea M.R., and Newman E.A. Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling. J. Neurosci. 26 (2006) 2862-2870
177. Miller R.F. D-Serine as a glial modulator of nerve cells. Glia 47 (2004) 275-283
178. Miyashiro M., Ogata N., Takahashi K.I., Matsushima M., Yamamoto C., Yamada H., and Uyama M. Expression of basic fibroblast growth factor and its receptor mRNA in retinal tissue following ischemic injury in the rat. Clin. Exp. Ophthalmol. 236 (1988) 295-300
179. Mizutani M., Gerhardinger C., and Lorenzi M. Müller cell changes in human diabetic retinopathy. Diabetes 47 (1998) 445-449
180. 3H]GABA preferentially from horizontal cells. Brain Res. 398 (1986) 276-287
181. Moreno M.C., Sande P., Marcos H.A., de Zavalía N., Keller Sarmiento M.I., and Rosenstein R.E. Effect of glaucoma on the retinal glutamate/glutamine cycle activity. FASEB J. 19 (2005) 1161-1162
182. Mort D., Marcaggi P., Grant J., and Attwell D. Effect of acute exposure to ammonia on glutamate transport in glial cells isolated from the salamander retina. J. Neurophysiol. 86 (2001) 836-844
183. +-ATPase via actin depolymerization. Mol. Cell. Biol. 28 (2008) 3273-3280
184. Napper G.A., Pianta M.J., and Kalloniatis M. Reduced glutamate uptake by retinal glial cells under ischemic/hypoxic conditions. Vis. Neurosci. 16 (1999) 149-158
185. Napper G.A., Pianta M.J., and Kalloniatis M. Localization of amino acid neurotransmitters following in vitro ischemia and anoxia in the rat retina. Vis. Neurosci. 18 (2001) 413-427
186. Naskar R., Vorwerk C.K., and Dreyer E.B. Concurrent downregulation of a glutamate transporter and receptor in glaucoma. Invest. Ophthalmol. Vis. Sci. 41 (2000) 1940-1944
187. Neal M.J., and Bowery N.G. Differential effects of veratridine and potassium depolarization on neuronal and glial GABA release. Brain Res. 167 (1979) 337-343
188. Neal M.J., and Cunningham J.R. Modulation by endogenous ATP of the light-evoked release of ACh from retinal cholinergic neurones. Br. J. Pharmacol. 113 (1994) 1085-1087
189. Neal M.J., Cunningham J.R., Shah M.A., and Yazulla S. Immunocytochemical evidence that vigabatrin in rats causes GABA accumulation in glial cells of the retina. Neurosci. Lett. 98 (1989) 29-32
190. Neal M.J., Cunningham J.R., and Dent Z. Modulation of extracellular GABA levels in the retina by activation of glial P2X-purinoceptors. Br. J. Pharmacol. 124 (1998) 317-322
191. Newman E.A. Propagation of intercellular calcium waves in retinal astrocytes and Müller cells. J. Neurosci. 21 (2001) 2215-2223
192. Newman E.A. Glial cell inhibition of neurons by release of ATP. J. Neurosci. 23 (2003) 1659-1666
193. Newman E.A. Glial modulation of synaptic transmission in the retina. Glia 47 (2004) 268-274
194. Newman E.A. Calcium increases in retinal glial cells evoked by light-induced neuronal activity. J. Neurosci. 25 (2005) 5502-5510
195. Newman E.A., and Reichenbach A. The Müller cell: a functional element of the retina. Trends Neurosci. 19 (1996) 307-317
196. Nishiyama T., Nishukawa S., Tomita H., and Tamai M. Müller cells in the preconditioned retinal ischemic injury rat. Tohoku J. Exp. Med. 191 (2000) 221-232
197. O'Brien K.B., Miller R.F., and Bowser M.T. D-serine uptake by isolated retinas is consistent with ASCT-mediated transport. Neurosci. Lett. 385 (2005) 58-63
198. Ola M.S., Barber A., Hosoya K.I., and LaNoue K. Hydrocortisone regulates the expression of glutamine synthetase (GS) and aspartate/glutamate carrier (AGC) in cultured rat retinal Müller cells (TR-MUL). Abstr. Ann. ARVO Meet. (2005) 165
199. Oliet S.H., and Mothet J.P. Molecular determinants of D-serine-mediated gliotransmission: from release to function. Glia 54 (2006) 726-737
200. Osborne N.N., McCord R.J., and Wood J. The effect of kainate on protein kinase C, GABA, and the uptake of serotonin in the rabbit retina in vivo. Neurochem. Res. 20 (1995) 635-641
201. Otori Y., Shimada S., Tanaka K., Ishimoto I., Tano Y., and Tohyama M. Marked increase in glutamate-aspartate transporter (GLAST/GluT-1) mRNA following transient retinal ischemia. Mol. Brain Res. 27 (1994) 310-314
202. Owe S.G., Marcaggi P., and Attwell D. The ionic stoichiometry of the GLAST glutamate transporter in salamander retinal glia. J. Physiol. 577 (2006) 591-599
203. Paasche G., Huster D., and Reichenbach A. The glutathione content of retinal Müller (glial) cells: the effects of aging and of application of free-radical scavengers. Ophthal. Res. 30 (1998) 351-360
204. Palmer M.J., Taschenberger H., Hull C., Tremere L., and von Gersdorff H. Synaptic activation of presynaptic glutamate transporter currents in nerve terminals. J. Neurosci. 23 (2003) 4831-4841
205. +-dependent glutamate transport into acutely isolated Müller glial cells from guinea pig retina. Pflügers Arch. 429 (1994) 140-142
206. 7 receptors in Müller glial cells from the human retina. J. Neurosci. 20 (2000) 5965-5972
207. Pannicke T., Iandiev I., Uckermann O., Biedermann B., Kutzera F., Wiedemann P., Wolburg H., Reichenbach A., and Bringmann A. A potassium channel-linked mechanism of glial cell swelling in the postischemic retina. Mol. Cell. Neurosci. 26 (2004) 493-502
208. Pannicke T., Uckermann O., Iandiev I., Biedermann B., Wiedemann P., Perlman I., Reichenbach A., and Bringmann A. Altered membrane physiology in Müller glial cells after transient ischemia of the rat retina. Glia 50 (2005) 1-11
209. Pannicke T., Uckermann O., Iandiev I., Wiedemann P., Reichenbach A., and Bringmann A. Ocular inflammation alters swelling and membrane characteristics of rat Müller glial cells. J. Neuroimmunol. 161 (2005) 145-154
210. Pannicke T., Iandiev I., Wurm A., Uckermann O., vom Hagen F., Reichenbach A., Wiedemann P., Hammes H.-P., and Bringmann A. Diabetes alters osmotic swelling characteristics and membrane conductance of glial cells in rat retina. Diabetes 55 (2006) 633-639
211. Perez M.T.R., Ehinger B.E., Lindström K., and Fredholm B.B. Release of endogenous and radioactive purines from the rabbit retina. Brain Res. 398 (1986) 106-112
212. Perez M.T.R., Arner K., and Ehinger B. Stimulation evoked release of purines from rabbit retina. Neurochem. Int. 13 (1988) 307-318
213. Perlman J.I., McCole S.M., Pulluru P., Chang C.J., Lam T.T., and Tso M.O. Disturbances in the distribution of neurotransmitters in the rat retina after ischemia. Curr. Eye Res. 15 (1996) 589-596
214. Pignataro L., Sitaramayya A., Finnemann S.C., and Sarthy V.P. Nonsynaptic localization of the excitatory amino acid transporter 4 in photoreceptors. Mol. Cell. Neurosci. 28 (2005) 440-451
215. Poitry S., Poitry-Yamate C., Ueberfeld J., MacLeish P.R., and Tsacopoulos M. Mechanisms of glutamate metabolic signaling in retinal glial (Müller) cells. J. Neurosci. 20 (2000) 1809-1821
216. Poitry-Yamate C.L., Poitry S., and Tsacopoulos M. Lactate released by Müller glial cells is metabolized by photoreceptors from mammalian retina. J. Neurosci. 15 (1995) 5179-5191
217. Pow D.V. Taurine, amino acid transmitters, and related molecules in the retina of the Australian lungfish Neoceratodus forsteri: a light-microscopic immunocytochemical and electron-microscopic study. Cell Tissue Res. 278 (1994) 311-326
218. Pow D.V. Visualising the activity of the cystine-glutamate antiporter in glial cells using antibodies to aminoadipic acid, a selectively transported substrate. Glia 34 (2001) 27-38
219. Pow D.V. Amino acids and their transporters in the retina. Neurochem. Int. 38 (2001) 463-484
220. Pow D.V., and Robinson S.R. Glutamate in some retinal neurons is derived solely from glia. Neuroscience 60 (1994) 355-366
221. Pow D.V., and Crook D.K. Immunocytochemical evidence for the presence of high levels of reduced glutathione in radial glial cells and horizontal cells in the rabbit retina. Neurosci. Lett. 193 (1995) 25-28
222. Pow D.V., and Crook D.K. Direct immunocytochemical evidence for the transfer of glutamine from glial cells to neurons: use of specific antibodies directed against the d-stereoisomers of glutamate and glutamine. Neuroscience 70 (1996) 295-302
223. Pow D.V., and Barnett N.L. Changing patterns of spatial buffering of glutamate in developing rat retinae are mediated by the Müller cell glutamate transporter GLAST. Cell Tissue Res. 297 (1999) 57-66
224. Pow D.V., and Hendrickson A.E. Distribution of the glycine transporter glyt-1 in mammalian and nonmammalian retinae. Vis. Neurosci. 16 (1999) 231-239
225. Pow D.V., and Barnett N.L. Developmental expression of excitatory amino acid transporter 5: a photoreceptor and bipolar cell glutamate transporter in rat retina. Neurosci. Lett. 280 (2000) 21-24
226. Pow D.V., and Barnett N.L. Aminoadipic acid transport, probing the role of the cystine-glutamate antiporter in the retina. Invest. Ophthalmol. Vis. Sci. 41 (2000) S188
227. Pow D.V., Baldridge W., and Crook D.K. Activity-dependent transport of GABA analogues into specific cell types demonstrated at high resolution using a novel immunocytochemical strategy. Neuroscience 73 (1996) 1129-1143
228. Pow D.V., Barnett N.L., and Penfold P. Are neuronal transporters relevant in retinal glutamate homeostasis?. Neurochem. Int. 37 (2000) 191-198
229. Puro D.G., and Stuenkel E.L. Thrombin-induced inhibition of potassium currents in human retinal glial (Müller) cells. J. Physiol. 485 (1995) 337-348
230. 3 purinoceptors in the rat retina. Neuroscience 146 (2007) 403-414
231. Qian H., Malchow R.P., and Ripps H. The effects of lowered extracellular sodium on gamma-aminobutyric acid (GABA)-induced currents of Müller (glial) cells of the skate retina. Cell. Mol. Neurobiol. 13 (1993) 147-158
232. Rauen T. Diversity of glutamate transporter expression and function in the mammalian retina. Amino Acids 19 (2000) 53-62
233. Rauen T., and Kanner B.I. Localization of the glutamate transporter GLT-1 in rat and macaque monkey retinae. Neurosci. Lett. 169 (1994) 137-140
234. Rauen T., and Wiessner M. Fine tuning of glutamate uptake and degradation in glial cells: common transcriptional regulation of GLAST1 and GS. Neurochem. Int. 37 (2000) 179-189
235. Rauen T., Rothstein J.D., and Wässle H. Differential expression of three glutamate transporter subtypes in the rat retina. Cell Tissue Res. 286 (1996) 325-336
236. Rauen T., Taylor W.R., Kuhlbrodt K., and Wiessner M. High-affinity glutamate transporters in the rat retina: a major role of the glial glutamate transporter GLAST-1 in transmitter clearance. Cell Tissue Res. 291 (1998) 19-31
237. Rauen T., Wiessner M., Sullivan R., Lee A., and Pow D.V. A new GLT1 splice variant: cloning and immunolocalization of GLT1c in the mammalian retina and brain. Neurochem. Int. 45 (2004) 1095-1106
238. Reichelt W., Pannicke T., Biedermann B., Francke M., and Faude F. Comparison between functional characteristics of healthy and pathological human retinal Müller glial cells. Surv. Ophthalmol. 42 (1997) S105-S117
239. Reichelt W., Stabel-Burow J., Pannicke T., Weichert H., and Heinemann U. The glutathione level of retinal Müller glial cells is dependent on the high-affinity sodium-dependent uptake of glutamate. Neuroscience 77 (1997) 1213-1224
240. Reichenbach A., Stolzenburg J.-U., Eberhardt W., Chao I.T., Dettmer D., and Hertz L. What do retinal Müller (glial) cells do for their neuronal 'small siblings'?. J. Chem. Neuroanat. 6 (1993) 201-213
241. Reichenbach A., Stolzenburg J.U., Wolburg H., Härtig W., El-Hifnawi E., and Martin H. Effects of enhanced extracellular ammonia concentration on cultured mammalian retinal glial (Müller) cells. Glia 13 (1995) 195-208
242. Reichenbach A., Pálhalmi J., Bringmann A., Biedermann B., Francke M., Pannicke T., Paasche G., Germer A., Kuhrt H., Grosche J., Härtig W., Reichelt W., Juhász G., Skatchkov S.N., and Faude F. Interactions between neurons and glial cells in the retina. Sém. Ophtalmol. d'IPSEN 10 (1999) 39-54
243. Reisfeld S., and Vardimon L. Cell to cell contacts control the transcription activity of the glucocorticoid receptor. Mol. Endocrinol. 8 (1994) 1224-1233
244. Reye P., Penfold P., and Pow D.V. Glyt-1 expression in cultured human Müller cells and intact retinae. Glia 34 (2001) 311-315
245. Reye P., Sullivan R., Fletcher E.L., and Pow D.V. Distribution of two splice variants of the glutamate transporter GLT1 in the retinas of humans, monkeys, rabbits, rats, cats, and chickens. J. Comp. Neurol. 445 (2002) 1-12
246. Reye P., Sullivan R., and Pow D.V. Distribution of two splice variants of the glutamate transporter GLT-1 in the developing rat retina. J. Comp. Neurol. 447 (2002) 323-330
247. Ribeiro C.S., Reis M., Panizzutti R., de Miranda J., and Wolosker H. Glial transport of the neuromodulator D-serine. Brain Res. 929 (2002) 202-209
248. Riepe R.E., and Norenburg M.D. Müller cell localisation of glutamine synthetase in rat retina. Nature 268 (1977) 654-655
249. Ryan R.M., Mitrovic A.D., and Vandenberg R.J. The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway. J. Biol. Chem. 279 (2004) 20742-20751
250. Sakai T., Lewis G.P., Linberg K.A., and Fisher S.K. The ability of hyperoxia to limit the effects of experimental detachment in cone-dominated retina. Invest. Ophthalmol. Vis. Sci. 42 (2001) 3264-3273
251. Sakai T., Yoshitoshi T., Nagai Y., and Kitahara K. Increased glutamate uptake and GLAST expression by cyclic AMP in retinal glial cells. Graefes Arch. Clin. Exp. Ophthalmol. 244 (2006) 359-363
252. Santos P.F., Caramelo O.L., Carvalho A.P., and Duarte C.B. Characterization of ATP release from cultures enriched in cholinergic amacrine-like neurons. J. Neurobiol. 41 (1999) 340-348
253. Sarantis M., and Attwell D. Glutamate uptake in mammalian retinal glia is voltage- and potassium-dependent. Brain Res. 516 (1990) 322-325
254. Sarantis M., and Mobbs P. The spatial relationship between Müller cell processes and the photoreceptor output synapse. Brain Res. 584 (1992) 299-304
255. 3H]γ-aminobutyric acid by isolated glial (Müller) cells from the mouse retina. J. Neurosci. Methods 5 (1982) 77-82
256. +, veratridine, and ethylenediamine. J. Neurosci. 3 (1983) 2494-2503
257. Sarthy P.V., and Lam D.M.K. Biochemical studies of isolated glial (Müller) cells from the turtle retina. J. Cell. Biol. 78 (1978) 675-684
258. Sarthy V.P., Marc R.E., Pignataro L., and Tanaka K. Contribution of a glial glutamate transporter to GABA synthesis in the retina. Neuroreport 15 (2004) 1895-1898
259. Sarthy V.P., Pignataro L., Pannicke T., Weick M., Reichenbach A., Harada T., Tanaka K., and Marc R. Glutamate transport by retinal Müller cells in glutamate/aspartate transporter-knockout mice. Glia 49 (2005) 184-196
260. Schniepp R., Kohler K., Ladewig T., Guenther E., Henke G., Palmada M., Boehmer C., Rothstein J.D., Bröer S., and Lang F. Retinal colocalization and in vitro interaction of the glutamate transporter EAAT3 and the serum- and glucocorticoid-inducible kinase SGK1. Invest. Ophthalmol. Vis. Sci. 45 (2004) 1442-1449
261. Schousboe A. Role of astrocytes in the maintenance and modulation of glutamatergic and GABAergic neurotransmission. Neurochem. Res. 28 (2003) 347-352
262. Schousboe I., Bro B., and Schousboe A. Intramitochondrial localization of the 4-aminobutyrate-2-oxoglutarate transaminase from ox brain. Biochem. J. 162 (1977) 303-307
263. Schultz K., and Stell W.K. Immunocytochemical localization of the high-affinity glutamate transporter, EAAC1, in the retina of representative vertebrate species. Neurosci. Lett. 211 (1996) 191-194
264. Schütte M., and Werner P. Redistribution of glutathione in the ischemic rat retina. Neurosci. Lett. 246 (1998) 53-56
265. Schwartz E.A., and Tachibana M. Electrophysiology of glutamate and sodium co-transport in a glial cell of the salamander retina. J. Physiol. 426 (1990) 43-80
266. Shen F., Chen B., Danias J., Lee K.C., Lee H., Su Y., Podos S.M., and Mittag T.W. Glutamate-induced glutamine synthetase expression in retinal Muller cells after short-term ocular hypertension in the rat. Invest. Ophthalmol. Vis. Sci. 45 (2004) 3107-3112
267. Sherry D.M., and Townes-Anderson E. Rapid glutamatergic alterations in the neural retina induced by retinal detachment. Invest. Ophthalmol. Vis. Sci. 41 (2000) 2779-2790
268. Spiridon M., Kamm D., Billups B., Mobbs P., and Attwell D. Modulation by zinc of the glutamate transporters in glial cells and cones isolated from the tiger salamander retina. J. Physiol. 506 (1998) 363-376
269. Staub F., Winkler A., Peters J., Kempski O., Kachel V., and Baethmann A. Swelling, acidosis, and irreversible damage of glial cells from exposure to arachidonic acid in vitro. J. Cereb. Blood Flow Metab. 14 (1994) 1030-1039
270. Stevens E.R., Esguerra M., Kim P.M., Newman E.A., Snyder S.H., Zahs K.R., and Miller R.F. D-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 6789-6794
271. 2+ responses to ATP via purinoceptors in the early embryonic chick retina. J. Physiol. (Lond.) 493 (1996) 855-863
272. Sugioka M., Zhou W.L., Hofmann H.D., and Yamashita M. Involvement of P2 purinoceptors in the regulation of DNA synthesis in the neural retina of chick embryo. Int. J. Dev. Neurosci. 17 (1999) 135-144
273. Sullivan R.K., Woldemussie E., Macnab L., Ruiz G., and Pow D.V. Evoked expression of the glutamate transporter GLT-1c in retinal ganglion cells in human glaucoma and in a rat model. Invest. Ophthalmol. Vis. Sci. 47 (2006) 3853-3859
274. Szatkowski M., Barbour B., and Attwell D. Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake. Nature 348 (1990) 443-446
275. Takatsuna Y., Chiba T., Adachi-Usami E., and Kaneko T. Distribution of phosphate-activated glutaminase-like immunoreactivity in the retina of rodents. Curr. Eye Res. 13 (1994) 629-637
276. Takeo-Goto S., Doi M., Ma N., Goto R., Semba R., and Uji Y. Immunohistochemical localization of amino acids in the diabetic retina of Goto-Kakizaki rats. Ophthal. Res. 34 (2002) 139-145
277. Taylor S., Srinivasan B., Wordinger R.J., and Roque R.S. Glutamate stimulates neurotrophin expression in cultured Müller cells. Mol. Brain Res. 111 (2003) 189-197
278. Thoreson W.B., and Witkovsky P. Glutamate receptors and circuits in the vertebrate retina. Prog. Retin. Eye Res. 18 (1999) 765-810
279. Tieman S.B., and Tieman D.G. N-acetylaspartylglutamate immunoreactivity in human retina. Vision Res. 36 (1996) 941-947
280. -, in the newly developed rat retinal Müller cell line (TR-MUL). Glia 43 (2003) 208-217
281. Tout S., Chan-Ling T., Hollander H., and Stone J. The role of Müller cells in the formation of the blood-retinal barrier. Neuroscience 55 (1993) 291-301
282. Tsacopoulos M., and Magistretti P.J. Metabolic coupling between glia and neurons. J. Neurosci. 16 (1996) 877-885
283. Tsacopoulos M., Poitry-Yamate C.L., and Poitry S. Ammonium and glutamate released by neurons are signals regulating the nutritive function of a glial cell. J. Neurosci. 17 (1997) 2383-2390
284. Tsacopoulos M., Poitry-Yamate C.L., MacLeish P.R., and Poitry S. Trafficking of molecules and metabolic signals in the retina. Prog. Retin. Eye Res. 17 (1998) 429-442
285. Uckermann O., Wolf A., Kutzera F., Kalisch F., Beck-Sickinger A., Wiedemann P., Reichenbach A., and Bringmann A. Glutamate release by neurons evokes a purinergic inhibitory mechanism of osmotic glial cell swelling in the rat retina: activation by neuropeptide Y. J. Neurosci. Res. 83 (2006) 538-550
286. Uhlmann S., Bringmann A., Uckermann O., Pannicke T., Weick M., Ulbricht E., Goczalik I., Reichenbach A., Wiedemann P., and Francke M. Early glial cell reactivity in experimental retinal detachment: effect of suramin. Invest. Ophthalmol. Vis. Sci. 44 (2003) 4114-4122
287. Umapathy N.S., Li W., Mysona B.A., Smith S.B., and Ganapathy V. Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Müller cells. Invest. Ophthalmol. Vis. Sci. 46 (2005) 3980-3987
288. Vandenberg R.J., Mitrovic A.D., and Johnston G.A. Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions. Mol. Pharmacol. 54 (1998) 189-196
289. Vandenbranden C.A., Verweij J., Kamermans M., Müller L.J., Ruijter J.M., Vrensen G.F., and Spekreijse H. Clearance of neurotransmitter from the cone synaptic cleft in goldfish retina. Vision Res. 36 (1996) 3859-3874
290. Vandenbranden C.A., Yazulla S., Studholme K.M., Kamphuis W., and Kamermans M. Immunocytochemical localization of the glutamate transporter GLT-1 in goldfish (Carassius auratus) retina. J. Comp. Neurol. 423 (2000) 440-451
291. Vardimon L., Fox L.E., Degenstein L., and Moscona A.A. Cell contacts are required for induction by cortisol of glutamine synthetase gene transcription in the retina. Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 5981-5985
292. Vardimon L., Fox L.E., Cohen-Kupiec R., Degenstein L., and Moscona A.A. Expression of v-src in embryonic neural retina alters cell adhesion, inhibits histogenesis, and prevents induction of glutamine synthetase. Mol. Cell. Biol. 11 (1991) 5275-5284
293. Varoqui H., Zhu H., Yao D., Ming H., and Erickson J.D. Cloning and functional identification of a neuronal glutamine transporter. J. Biol. Chem. 275 (2000) 4049-4054
294. Voutsinos-Porche B., Bonvento G., Tanaka K., Steiner P., Welker E., Chatton J.Y., Magistretti P.J., and Pellerin L. Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex. Neuron 37 (2003) 275-286
295. Wadiche J.I., Arriza J.L., Amara S.G., and Kavanaugh M.P. Kinetics of a human glutamate transporter. Neuron 14 (1995) 1019-1027
296. Walcott J.C., and Provis J.M. Müller cells express the neuronal progenitor cell marker nesting in both differentiated and undifferentiated human foetal retina. Clin. Exp. Ophthalmol. 31 (2003) 246-249
297. Ward M.M., Jobling A.I., Puthussery T., Foster L.E., and Fletcher E.L. Localization and expression of the glutamate transporter, excitatory amino acid transporter 4, within astrocytes of the rat retina. Cell Tissue Res. 315 (2004) 305-310
298. Ward M.M., Jobling A.I., Kalloniatis M., and Fletcher E.L. Glutamate uptake in retinal glial cells during diabetes. Diabetologia 48 (2005) 351-360
299. Wersinger E., Schwab Y., Sahel J.A., Rendon A., Pow D.V., Picaud S., and Roux M.J. The glutamate transporter EAAT5 works as a presynaptic receptor in mouse rod bipolar cells. J. Physiol. 577 (2006) 221-234
300. Weuste M., Wurm A., Iandiev I., Wiedemann P., Reichenbach A., and Bringmann A. HB-EGF: increase in the ischemic rat retina and inhibition of osmotic glial cell swelling. Biochem. Biophys. Res. Commun. 347 (2006) 310-318
301. White R.D., and Neal M.J. The uptake of L-glutamate by the retina. Brain Res. 111 (1976) 79-93
302. Wiessner M., Fletcher E.L., Fischer F., and Rauen T. Localization and possible function of the glutamate transporter, EAAC1, in the rat retina. Cell Tissue Res. 310 (2002) 31-40
303. Wu B., and Beitz E. Aquaporins with selectivity for unconventional permeants. Cell. Mol. Life Sci. 64 (2007) 2413-2421
304. + channels in retinal glial cells is associated with a decrease of osmotic cell swelling. Glia 54 (2006) 411-423
305. Wurm A., Pannicke T., Iandiev I., Bühner E., Pietsch U.-C., Reichenbach A., Wiedemann P., Uhlmann S., and Bringmann A. Changes in membrane conductance play a pathogenic role in osmotic glial cell swelling in detached retinas. Am. J. Pathol. 169 (2006) 1990-1998
306. Wurm A., Pannicke T., Wiedemann P., Reichenbach A., and Bringmann A. Glial cell-derived glutamate mediates autocrine cell volume regulation in the retina: activation by VEGF. J. Neurochem. 104 (2008) 386-399
307. Xu Y., Ola M.S., Berkich D.A., Gardner T.W., Barber A.J., Palmieri F., Hutson S.M., and LaNoue K.F. Energy sources for glutamate neurotransmission in the retina: absence of the aspartate/glutamate carrier produces reliance on glycolysis in glia. J. Neurochem. 101 (2007) 120-131
308. Yang C.Y., Brecha N.C., and Tsao E. Immunocytochemical localization of gamma-aminobutyric acid plasma membrane transporters in the tiger salamander retina. J. Comp. Neurol. 389 (1997) 117-126
309. Yazulla S. GABAergic mechanisms in the retina. In: Osborne N.N., and Chader G.J. (Eds). Progress in Retinal Research vol. 5 (1986), Pergamon, Oxford 1-52
310. Yazulla S., Studholme K.M., and Pinto L.H. Differences in the retinal GABA system among control, spastic mutant and retinal degeneration mutant mice. Vision Res. 37 (1997) 3471-3482
311. Zhang H.Y., and Young A.P. A single upstream glucocorticoid response element juxtaposed to an ap1/atf/cre-like site renders the chicken glutamine synthetase gene hormonally inducible in transfected retina. J. Biol. Chem. 266 (1991) 24332-24338
312. Zhao J.W., and Yang X.L. Glutamate transporter EAAC1 is expressed on Müller cells of lower vertebrate retinas. J. Neurosci. Res. 66 (2001) 89-95
313. Zhao J.W., Du J.L., Li J.S., and Yang X.L. Expression of GABA transporters on bullfrog retinal Müller cells. Glia 31 (2000) 104-117
314. Zimmermann H. 5′-Nucleotidase: molecular structure and functional aspects. Biochem. J. 285 (1992) 345-365