Neurturin enhances the survival of axotomized retinal ganglion cells in vivo: Combined effects with glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor

Neuroscience

Volumn 110, Issue 3, 2002, Pages 555-567

  Koeberle, Paulo D ^a   Ball, Alexander K ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Axotomy; BDNF; GDNF; GFR 1; Neurturin; Retina

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN RECEPTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR ALPHA 1 RECEPTOR; NEURTURIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL DENSITY; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; FEMALE; IMMUNOREACTIVITY; IN VIVO STUDY; MOTONEURON; MUELLER CELL; NERVE FIBER TRANSECTION; NEUROPROTECTION; NONHUMAN; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RECEPTOR AFFINITY; RETINA GANGLION CELL;

ANIMALS; AXONS; AXOTOMY; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DROSOPHILA PROTEINS; DRUG COMBINATIONS; DRUG INTERACTIONS; FEMALE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; IMMUNOHISTOCHEMISTRY; NERVE DEGENERATION; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEUROFILAMENT PROTEINS; NEURTURIN; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RETINAL GANGLION CELLS;

EID: 0037139305     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00557-7     Document Type: Article

References (80)

1. Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons
2. Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants
3. Developmental expression of the RET protooncogene
4. GDNF upregulates GLAST-1 expression in retinal glial cells following optic nerve transection
5. Neuroprotective utility and neurotrophic action of neurturin in postnatal motor neurons: Comparison with GDNF and persephin
6. Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase
7. Induction of basic fibroblast growth factor mRNA by basic fibroblast growth factor in Muller cells
8. Rod outer segment maintenance is enhanced in the presence of bFGF, CNTF and GDNF
9. Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse
10. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse
11. Repeated injections of a ciliary neurotrophic factor analogue leading to long-term photoreceptor survival in hereditary retinal degeneration
12. GDNF improves survival and reduces apoptosis in human embryonic dopaminergic neurons in vitro
13. GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged parkinsonian mice
14. Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Muller cells temporarily rescues injured retinal ganglion cells
15. Activation of phosphatidylinositol 3-kinase, but not extracellular-regulated kinases, is necessary to mediate brain-derived neurotrophic factor-induced motoneuron survival
16. A proposed role for excitotoxicity in glaucoma
17. Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y
18. Spatial and temporal growth factor influences on developing midbrain dopaminergic neurons
19. Prevention of dopaminergic neuron death by adeno-associated virus vector-mediated GDNF gene transfer in rat mesencephalic cells in vitro
20. Differential signaling of glial cell line-derived neurothrophic factor and brain-derived neurotrophic factor in cultured ventral mesencephalic neurons
21. Adenoviral gene transfer of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to long-term survival of axotomized motor neurons
22. Neurotrophins promote motor neuron survival and are present in embryonic limb bud
23. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
24. TGFbeta trophic factors differentially modulate motor axon outgrowth and protection from excitotoxicity
25. Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons
26. Different forms of the neurotrophin receptor trkB mRNA predominate in rat retina and optic nerve
27. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF
28. GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family
29. Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells
30. Expression patterns of neurturin and its receptor components in developing and degenerative mouse retina
31. Expression of CNTF in Muller cells of the rat retina after pressure-induced ischemia
32. CNTF and GDNF, but not NT-4, support corticospinal motor neuron growth via direct mechanisms
33. A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor
34. In vivo neurotrophic effects of GDNF on axotomized retinal ganglion cells
35. Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells In vivo
36. Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3′-kinase/protein kinase B signaling
37. Effects of GDNF on retinal ganglion cell survival following axotomy
38. Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo
39. Neurturin, a relative of glial-cell-line-derived neurotrophic factor
40. The survival response of mesencephalic dopaminergic neurons to the neurotrophins BDNF and NT-4 requires priming with serum: Comparison with members of the TGF-beta superfamily and characterization of the serum-free culture system
41. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light
42. Protection of mouse photoreceptors by survival factors in retinal degenerations
43. Lens injury stimulates axon regeneration in the mature rat optic nerve
44. Intrinsic survival mechanisms for retinal ganglion cells
45. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
46. Glial cell line-derived neurotrophic factor prevents death, but not reductions in tyrosine hydroxylase, of injured nigrostriatal neurons in adult rats
47. Brain-derived neurotrophic factor-transduced fibroblasts: Production of BDNF and effects of grafting to the adult rat brain
48. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats
49. Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells
50. Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo
51. Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture
52. Nitric oxide: A potential mediator of retinal ganglion cell damage in glaucoma
53. Retinal ganglion cell death in glaucoma: The how, the why, and the maybe
54. Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system
55. Growth factors in combination, but not individually, rescue rd mouse photoreceptors in organ culture
56. Expression of the c-ret proto-oncogene during mouse embryogenesis
57. Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study
58. Neuronal death in glaucoma
59. Neurturin enhances the survival of intrastriatal fetal dopaminergic transplants
60. Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle
61. Glial cell line-derived neurotrophic factor increases survival, growth and function of intrastriatal fetal nigral dopaminergic grafts
62. Adenovirus-mediated glial cell line-derived neurotrophic factor gene delivery reduces motor neuron injury after transient spinal cord ischemia in rabbits
63. Effects of combined BDNF and GDNF treatment on cultured dopaminergic midbrain neurons
64. Fibroblast growth factors promote the survival of adult rat retinal ganglion cells after transection of the optic nerve
65. GDNF enhances dopaminergic cell survival and fibre outgrowth in embryonic nigral grafts
66. Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons
67. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
68. Functional receptor for GDNF encoded by the c-ret proto-oncogene
69. Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy
70. Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor
71. Fluorogold is not suitable for models of optic nerve injury that require long-term labeling of retinal ganglion cells
72. Rescue of lesioned adult rat spinal motoneurons by adenoviral gene transfer of glial cell line-derived neurotrophic factor
73. Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs
74. Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease
75. Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase
76. Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death
77. Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of axotomized retinal ganglion cells in adult rats: Comparison to and combination with brain-derived neurotrophic factor (BDNF)
78. Early BDNF, NT-3, and NT-4 signaling events
79. Effects of basic fibroblast growth factor in retinal ischemia
80. Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro