Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: Key regulators of innate immunity

Pharmacology and Therapeutics

Volumn 124, Issue 2, 2009, Pages 219-234

  Barral, Paola M ^a,d   Sarkar, Devanand ^a,b   Su, Zao zhong ^a   Barber, Glen N ^c   DeSalle, Rob ^e   Racaniello, Vincent R ^d   Fisher, Paul B ^a,b,d  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c UNIVERSITY OF MIAMI   (United States)

^d Sackler Institute for Comparative Genomics ^*  (United States)

^e DIVISION OF INVERTEBRATE ZOOLOGY   (United States)

Author keywords

Antiviral innate immunity; Apoptosis; Cell signaling; Domain grafting; MDA 5; RIG I; Viral pathogenesis

Indexed keywords

CELL PROTEIN; CYTOKINE; INTERFERON; LIPOPROTEIN; MELANOMA DIFFERENTIATION ASSOCIATED PROTEIN 5; NUCLEIC ACID; PATTERN RECOGNITION RECEPTOR; RETINOIC ACID INDUCIBLE PROTEIN I; RNA HELICASE; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS RNA;

ADAPTIVE IMMUNITY; ANTIGEN RECOGNITION; ANTIVIRAL ACTIVITY; APOPTOSIS; BACTERIAL CELL WALL; CYTOKINE PRODUCTION; DEVELOPMENT; DIABETES MELLITUS; DIFFERENTIATION; IMMUNOREGULATION; INFECTION; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSCRIPTION REGULATION; VIRUS INFECTION;

ANIMALS; CYTOKINES; CYTOPLASM; DEAD-BOX RNA HELICASES; GENE EXPRESSION REGULATION, VIRAL; HUMANS; IMMUNITY, INNATE; RECEPTORS, RETINOIC ACID; RNA, VIRAL; SIGNAL TRANSDUCTION; VIRUS DISEASES;

EID: 70349139611     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2009.06.012     Document Type: Review

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