메뉴 건너뛰기




Volumn 19, Issue 4, 1997, Pages 201-214

Sustained nontumorigenic phenotype correlates with a largely stable chromosome content during long-term culture of the human keratinocyte line HaCat

Author keywords

[No Author keywords available]

Indexed keywords

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL TRANSFORMATION; CHROMOSOME ABERRATION; HUMAN; HUMAN CELL; KARYOTYPE; KERATINOCYTE; PHENOTYPE; PRIORITY JOURNAL;

EID: 0030758588     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199708)19:4<201::AID-GCC1>3.0.CO;2-0     Document Type: Article
Times cited : (120)

References (61)
  • 1
    • 0023302614 scopus 로고
    • Isolation and characterization of a spontaneously arising long-lived line of human keratinocytes (NM1)
    • Baden HP, Kubilus J, Kvedar JC, Steinberg ML, Wolman SR (1987) Isolation and characterization of a spontaneously arising long-lived line of human keratinocytes (NM1). In Vitro Cell Dev Biol 23:205-213.
    • (1987) In Vitro Cell Dev Biol , vol.23 , pp. 205-213
    • Baden, H.P.1    Kubilus, J.2    Kvedar, J.C.3    Steinberg, M.L.4    Wolman, S.R.5
  • 2
    • 0026546158 scopus 로고
    • Tumorigenic transformation and neoplastic progression of human uroepithelial cells after exposure in vitro to 4-aminobiphenyl or its metabolites
    • Bookland EA, Swaminathan S, Oyasu R, Gilchrist KW, Lindstrom M, Reznikoff CA (1992) Tumorigenic transformation and neoplastic progression of human uroepithelial cells after exposure in vitro to 4-aminobiphenyl or its metabolites. Cancer Res 52:1606-1614.
    • (1992) Cancer Res , vol.52 , pp. 1606-1614
    • Bookland, E.A.1    Swaminathan, S.2    Oyasu, R.3    Gilchrist, K.W.4    Lindstrom, M.5    Reznikoff, C.A.6
  • 4
    • 0022373473 scopus 로고
    • Environmental modulation of the expression of differentiation and malignancy in six human squamous cell carcinoma cell lines
    • Boukamp P, Rupniak TR, Fusenig NE (1985) Environmental modulation of the expression of differentiation and malignancy in six human squamous cell carcinoma cell lines. Cancer Res 45:5582-5592.
    • (1985) Cancer Res , vol.45 , pp. 5582-5592
    • Boukamp, P.1    Rupniak, T.R.2    Fusenig, N.E.3
  • 6
    • 0025083224 scopus 로고
    • Mesenchyme-mediated and endogenous regulation of growth and differentiation of human skin keratinocytes derived from different body sites
    • Boukamp P, Breitkreutz D, Stark HJ, Fusenig NE (1990a) Mesenchyme-mediated and endogenous regulation of growth and differentiation of human skin keratinocytes derived from different body sites. Differentiation 44:150-161.
    • (1990) Differentiation , vol.44 , pp. 150-161
    • Boukamp, P.1    Breitkreutz, D.2    Stark, H.J.3    Fusenig, N.E.4
  • 7
    • 0025275853 scopus 로고
    • c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy
    • Boukamp P, Stanbridge EJ, Foo DY, Cerutti PA, Fusenig NE (1990b). c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy. Cancer Res 50:2840-2847.
    • (1990) Cancer Res , vol.50 , pp. 2840-2847
    • Boukamp, P.1    Stanbridge, E.J.2    Foo, D.Y.3    Cerutti, P.A.4    Fusenig, N.E.5
  • 8
    • 0003130940 scopus 로고
    • In vitro transformation and tumor progression: A multistep model for skin carcinogensis
    • Leigh IM, Lane EB, Watt FM (eds). Cambridge, MA: Cambridge University Press
    • Boukamp P, Breitkreutz D, Hülsen A, Tomakidi P, Fusenig NE (1994) In vitro transformation and tumor progression: A multistep model for skin carcinogensis. In Leigh IM, Lane EB, Watt FM (eds): The Keratinocyte Handbook. Cambridge, MA: Cambridge University Press, pp 485-499.
    • (1994) The Keratinocyte Handbook , pp. 485-499
    • Boukamp, P.1    Breitkreutz, D.2    Hülsen, A.3    Tomakidi, P.4    Fusenig, N.E.5
  • 11
    • 0025942711 scopus 로고
    • Epidermal morphogenesis and keratin expression in c-Ha-ras-transfected tumorigenic clones of the human HaCaT cell lines
    • Breitkreutz D, Boukamp P, Ryle CM, Stark HJ, Roop DR, Fusenig NE (1991) Epidermal morphogenesis and keratin expression in c-Ha-ras-transfected tumorigenic clones of the human HaCaT cell lines. Cancer Res 51:4402-4409.
    • (1991) Cancer Res , vol.51 , pp. 4402-4409
    • Breitkreutz, D.1    Boukamp, P.2    Ryle, C.M.3    Stark, H.J.4    Roop, D.R.5    Fusenig, N.E.6
  • 13
    • 0023620257 scopus 로고
    • Malignant progression of an SV 40-transformed human epidermal keratinocyte cell line
    • Brown KW, Gallimore PH (1987) Malignant progression of an SV 40-transformed human epidermal keratinocyte cell line. Br J Cancer 56:545-554.
    • (1987) Br J Cancer , vol.56 , pp. 545-554
    • Brown, K.W.1    Gallimore, P.H.2
  • 14
    • 0027465586 scopus 로고
    • Genetic analysis of in vitro progression of human papillomavirus-transfected human cervical cells
    • Chen T-M, Pecoraro G, Defendi V (1993) Genetic analysis of in vitro progression of human papillomavirus-transfected human cervical cells. Cancer Res 53:1167-1171.
    • (1993) Cancer Res , vol.53 , pp. 1167-1171
    • Chen, T.-M.1    Pecoraro, G.2    Defendi, V.3
  • 15
    • 0028004226 scopus 로고
    • Comparative genomic hybridization, allelic imbalance, and fluorescence in situ hybridization on chromosome 8 in prostate cancer
    • Cher ML, MacGrogan D, Bookstein R, Brown JA, Jenkins RB, Jensen RH (1994) Comparative genomic hybridization, allelic imbalance, and fluorescence in situ hybridization on chromosome 8 in prostate cancer. Genes Chromosom Cancer 11:153-162.
    • (1994) Genes Chromosom Cancer , vol.11 , pp. 153-162
    • Cher, M.L.1    MacGrogan, D.2    Bookstein, R.3    Brown, J.A.4    Jenkins, R.B.5    Jensen, R.H.6
  • 18
    • 0024784328 scopus 로고
    • Glucocorticoid enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene
    • Dürst M, Gallahan D, Jay G, Rhim JS (1989) Glucocorticoid enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene. Virology 173:767-771.
    • (1989) Virology , vol.173 , pp. 767-771
    • Dürst, M.1    Gallahan, D.2    Jay, G.3    Rhim, J.S.4
  • 19
  • 20
    • 0029111826 scopus 로고
    • Genetic instability of chromosome 3 in HPV-immortalized and tumorigenic human keratinocytes
    • Dyer Montgomery K, Tedford KL, McDougall K (1995) Genetic instability of chromosome 3 in HPV-immortalized and tumorigenic human keratinocytes. Genes Chromosom Cancer 14:97-105.
    • (1995) Genes Chromosom Cancer , vol.14 , pp. 97-105
    • Dyer Montgomery, K.1    Tedford, K.L.2    McDougall, K.3
  • 21
    • 0025312728 scopus 로고
    • A genetic model for colorectal carcinogenesis
    • Fearon ER, Vogelstein BA (1990) A genetic model for colorectal carcinogenesis. Cell 61:759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.A.2
  • 23
    • 0016721494 scopus 로고
    • Mouse epidermal cell cultures: II. Isolation, characterization, and cultivation of epidermal cells from perinatal mouse skin
    • Fusenig NE, Worst PKM (1975) Mouse epidermal cell cultures: II. Isolation, characterization, and cultivation of epidermal cells from perinatal mouse skin. Exp Cell Res 93:445-457.
    • (1975) Exp Cell Res , vol.93 , pp. 445-457
    • Fusenig, N.E.1    Worst, P.K.M.2
  • 24
    • 0020551327 scopus 로고
    • Growth and differentiation characteristics of transformed keratinocytes from mouse and human skin in vitro and in vivo
    • Fusenig NE, Breitkreutz D, Dzarlieva RT, Boukamp P, Bohnert A, Tilgen W (1983) Growth and differentiation characteristics of transformed keratinocytes from mouse and human skin in vitro and in vivo. J Invest Dermatol 81:168-175.
    • (1983) J Invest Dermatol , vol.81 , pp. 168-175
    • Fusenig, N.E.1    Breitkreutz, D.2    Dzarlieva, R.T.3    Boukamp, P.4    Bohnert, A.5    Tilgen, W.6
  • 25
    • 0021777472 scopus 로고
    • Phenotypic and cytogenetic characteristics of different stages during spontaneous transformation of mouse keratinocytes in vitro
    • Fusenig NE, Dzarlieva-Petrusevska RT, Breitkreutz D (1985) Phenotypic and cytogenetic characteristics of different stages during spontaneous transformation of mouse keratinocytes in vitro. Carcinogenesis 9:293-326.
    • (1985) Carcinogenesis , vol.9 , pp. 293-326
    • Fusenig, N.E.1    Dzarlieva-Petrusevska, R.T.2    Breitkreutz, D.3
  • 26
    • 0003165623 scopus 로고
    • Transformation of human skin epithelial cells in vitro: Concepts and stages of transformation
    • Chadwig KH, Seymour C, Bernhard B (eds). Bristol and New York: Adam Hilger IOP Publishing Ltd.
    • Fusenig NE, Boukamp P, Breitkreutz D, Hülsen A, Karjetta S, Stanbridge E (1989) Transformation of human skin epithelial cells in vitro: Concepts and stages of transformation. In Chadwig KH, Seymour C, Bernhard B (eds): Cell Transformation and Radiation-induced Cancer. Bristol and New York: Adam Hilger IOP Publishing Ltd., pp 45-56.
    • (1989) Cell Transformation and Radiation-induced Cancer , pp. 45-56
    • Fusenig, N.E.1    Boukamp, P.2    Breitkreutz, D.3    Hülsen, A.4    Karjetta, S.5    Stanbridge, E.6
  • 27
    • 0002181243 scopus 로고
    • Altered regulation of growth and differentiation at different stages of transformation of human skin keratinocytes
    • Rhim JS, Dritschilo A (eds). Totowa, NJ: Humana Press
    • Fusenig NE, Boukamp P, Breitkreutz D, Hülsen A (1991) Altered regulation of growth and differentiation at different stages of transformation of human skin keratinocytes. In Rhim JS, Dritschilo A (eds): Neoplastic Transformation in Human Cell Culture. Totowa, NJ: Humana Press, pp 235-250.
    • (1991) Neoplastic Transformation in Human Cell Culture , pp. 235-250
    • Fusenig, N.E.1    Boukamp, P.2    Breitkreutz, D.3    Hülsen, A.4
  • 28
    • 0002531631 scopus 로고
    • Epithelial-mesenchymal interactions regulate keratinocyte growth and differentiation in vitro
    • Leigh IM, Lane EB, Watt, FM (eds). Cambridge, MA: Cambridge University Press
    • Fusenig NE (1994) Epithelial-mesenchymal interactions regulate keratinocyte growth and differentiation in vitro. In Leigh IM, Lane EB, Watt, FM (eds): The Keratinocyte Handbook. Cambridge, MA: Cambridge University Press, pp 71-94.
    • (1994) The Keratinocyte Handbook , pp. 71-94
    • Fusenig, N.E.1
  • 29
    • 0028897627 scopus 로고
    • Reduction of translation initiation factor 4E decreases the malignancy of ras-transformed cloned rat embryo fibroblasts
    • Graff JR, Boghaert ER, De Benedetti A, Tudor DL, Zimmer CC, Chan SK, Zimmer SG (1995) Reduction of translation initiation factor 4E decreases the malignancy of ras-transformed cloned rat embryo fibroblasts. Int J Cancer 60:255-263.
    • (1995) Int J Cancer , vol.60 , pp. 255-263
    • Graff, J.R.1    Boghaert, E.R.2    De Benedetti, A.3    Tudor, D.L.4    Zimmer, C.C.5    Chan, S.K.6    Zimmer, S.G.7
  • 30
    • 0024329752 scopus 로고
    • Spontaneous Ha-ras gene activation in cultured primary murine keratinocytes: Consequences of Ha-ras gene activation in malignant conversion and malignant progression
    • Greenhalgh DE, Welty DJ, Strickland JF, Yuspa SH (1989) Spontaneous Ha-ras gene activation in cultured primary murine keratinocytes: consequences of Ha-ras gene activation in malignant conversion and malignant progression. Mol Carcinogen 2:199-207.
    • (1989) Mol Carcinogen , vol.2 , pp. 199-207
    • Greenhalgh, D.E.1    Welty, D.J.2    Strickland, J.F.3    Yuspa, S.H.4
  • 35
    • 0026741962 scopus 로고
    • A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells
    • Klein-Szanto AJ, Iizasa T, Momiki S, Garcia-Palazzo I, Metcalf R, Welsh J, Harris CC (1992) A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells. Proc Natl Acad Sci USA 89:6693-6697.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6693-6697
    • Klein-Szanto, A.J.1    Iizasa, T.2    Momiki, S.3    Garcia-Palazzo, I.4    Metcalf, R.5    Welsh, J.6    Harris, C.C.7
  • 37
    • 0027109075 scopus 로고
    • P53, guardian of the genome
    • Lane DP (1992) P53, guardian of the genome. Nature 358:15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 39
    • 0028027866 scopus 로고
    • Identification of frequent novel genetic alterations in small cell lung carcinoma
    • Levin NA, Brzoka P, Gupta N, Minna JD, Gray JW, Christman MF (1994) Identification of frequent novel genetic alterations in small cell lung carcinoma. Cancer Res 54:5086-5091.
    • (1994) Cancer Res , vol.54 , pp. 5086-5091
    • Levin, N.A.1    Brzoka, P.2    Gupta, N.3    Minna, J.D.4    Gray, J.W.5    Christman, M.F.6
  • 40
    • 0028278457 scopus 로고
    • Detection of DNA amplification in 17 primary breast carcinomas with homogeneously staining regions by a modified comparative genomic hybridization technique
    • Muleris M, Almeida A, Gerbault-Seureau M, Malfoy B, Dutrillaux B (1994) Detection of DNA amplification in 17 primary breast carcinomas with homogeneously staining regions by a modified comparative genomic hybridization technique. Genes Chromosom Cancer 10:160-170.
    • (1994) Genes Chromosom Cancer , vol.10 , pp. 160-170
    • Muleris, M.1    Almeida, A.2    Gerbault-Seureau, M.3    Malfoy, B.4    Dutrillaux, B.5
  • 41
    • 0342548846 scopus 로고
    • Possible mechanism of tumorigenic conversion of HPV 18 immortalized human cervical epithelial cell lines
    • Seattle, WA
    • Pecoraro G, Lee M, Defendi V (1991) Possible mechanism of tumorigenic conversion of HPV 18 immortalized human cervical epithelial cell lines. In: International Papillomavirus Workshop. Seattle, WA, p 14.
    • (1991) International Papillomavirus Workshop , pp. 14
    • Pecoraro, G.1    Lee, M.2    Defendi, V.3
  • 44
    • 0016729431 scopus 로고
    • Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells
    • Rheinwald JG, Green H (1975) Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells. Cell 6:331-344.
    • (1975) Cell , vol.6 , pp. 331-344
    • Rheinwald, J.G.1    Green, H.2
  • 46
    • 0027399720 scopus 로고
    • Elevation of cell cycle control proteins during spontaneous immortalization of human keratinocytes
    • Rice RH, Steinmann KE, deGraffenried LA, Qin Q, Taylor N, Schlegel N (1993) Elevation of cell cycle control proteins during spontaneous immortalization of human keratinocytes. Mol Biol Cell 4:185-194.
    • (1993) Mol Biol Cell , vol.4 , pp. 185-194
    • Rice, R.H.1    Steinmann, K.E.2    DeGraffenried, L.A.3    Qin, Q.4    Taylor, N.5    Schlegel, N.6
  • 47
    • 0028351198 scopus 로고
    • Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization
    • Ried T, Petersen I, Holtgreve-Grez H, Speicher MR, Schrock E, du Manoir S, Cremer T (1944) Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization. Cancer Res 54:1801-1806.
    • (1944) Cancer Res , vol.54 , pp. 1801-1806
    • Ried, T.1    Petersen, I.2    Holtgreve-Grez, H.3    Speicher, M.R.4    Schrock, E.5    Du Manoir, S.6    Cremer, T.7
  • 48
    • 0027430146 scopus 로고
    • Cellular epigenetics: Effects of passage history on competence of cells for "spontaneous" transformation
    • Rubin H (1993) Cellular epigenetics: Effects of passage history on competence of cells for "spontaneous" transformation. Proc Natl Acad Sci USA 90:10715-10719.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10715-10719
    • Rubin, H.1
  • 49
    • 0024402762 scopus 로고
    • Density-dependent modulation of synthesis of keratins 1 and 10 in the human keratinocyte line HaCaT and in ras-transfected tumorigenic clones
    • Ryle CM, Breitkreutz D, Stark H-J, Leigh IM, Steinert PM, Roop D, Fusenig NE (1989) Density-dependent modulation of synthesis of keratins 1 and 10 in the human keratinocyte line HaCaT and in ras-transfected tumorigenic clones. Differentiation 40:42-54.
    • (1989) Differentiation , vol.40 , pp. 42-54
    • Ryle, C.M.1    Breitkreutz, D.2    Stark, H.-J.3    Leigh, I.M.4    Steinert, P.M.5    Roop, D.6    Fusenig, N.E.7
  • 52
    • 0027496456 scopus 로고
    • The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen
    • Shay JW, Van Der Haegen BA, Ying Y, Wright WE (1993) The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen. Exp Cell Res 209:45-52.
    • (1993) Exp Cell Res , vol.209 , pp. 45-52
    • Shay, J.W.1    Van Der Haegen, B.A.2    Ying, Y.3    Wright, W.E.4
  • 53
    • 0024810844 scopus 로고
    • Cytogenetic analysis of eight human papillomavirus immortalized human keratinocyte cell lines
    • Smith PP, Bryant EM, Kaur P, McDougall JK (1989) Cytogenetic analysis of eight human papillomavirus immortalized human keratinocyte cell lines. Int J Cancer 44:1124-1131.
    • (1989) Int J Cancer , vol.44 , pp. 1124-1131
    • Smith, P.P.1    Bryant, E.M.2    Kaur, P.3    McDougall, J.K.4
  • 54
    • 0027219202 scopus 로고
    • Mutual induction of growth factor gene expression by epidermal-dermal cell interaction
    • Smola H, Thiekötter G, Fusenig NE (1993) Mutual induction of growth factor gene expression by epidermal-dermal cell interaction. J Cell Biol 122:417-429.
    • (1993) J Cell Biol , vol.122 , pp. 417-429
    • Smola, H.1    Thiekötter, G.2    Fusenig, N.E.3
  • 56
    • 0028129399 scopus 로고
    • Specific loss of chromosomes 1,2,6,10,13,17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization
    • Speicher MR, Schoell B, du Manoir S, Schrock E Ried T, Cremer T, Storkel S, Kovacs G (1994b) Specific loss of chromosomes 1,2,6,10,13,17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization. Am J Pathol 145:356-364.
    • (1994) Am J Pathol , vol.145 , pp. 356-364
    • Speicher, M.R.1    Schoell, B.2    Du Manoir, S.3    Schrock, E.4    Ried, T.5    Cremer, T.6    Storkel, S.7    Kovacs, G.8
  • 57
    • 0028861631 scopus 로고
    • Mechanisms involved in the immortalization of mammalian cells by ionizing radiation and chemical carcinogens
    • Trott DA, Cuthbert AP, Overell RW, Russo I, Newbold RF (1995) Mechanisms involved in the immortalization of mammalian cells by ionizing radiation and chemical carcinogens. Carcinogenesis 16:193-204.
    • (1995) Carcinogenesis , vol.16 , pp. 193-204
    • Trott, D.A.1    Cuthbert, A.P.2    Overell, R.W.3    Russo, I.4    Newbold, R.F.5
  • 59
    • 0026604284 scopus 로고
    • Malignant transformation of human fibroblast cell strain MSU-1.1 by (+-)-7 beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene
    • Yang D, Louden C, Reinhold DS, Kohler SK, Maher VM, McCormick JJ (1992) Malignant transformation of human fibroblast cell strain MSU-1.1 by (+-)-7 beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. Proc Natl Acad Sci USA 89:2237-2241.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2237-2241
    • Yang, D.1    Louden, C.2    Reinhold, D.S.3    Kohler, S.K.4    Maher, V.M.5    McCormick, J.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.