Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

Toxicology and Applied Pharmacology

Volumn 237, Issue 3, 2009, Pages 267-280

  Higgins, Larry G ^a   Kelleher, Michael O ^a   Eggleston, Ian M ^b   Itoh, Ken ^c   Yamamoto, Masayuki ^c,d,e   Hayes, John D ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b University of Bath   (United Kingdom)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Acrolein; Cancer chemoprevention; Chlorambucil; Glutathione; Glutathione S transferases; Menadione

Indexed keywords

ACROLEIN; BUTHIONINE SULFOXIMINE; CARBONYL DERIVATIVE; CHLORAMBUCIL; CUMENE HYDROPEROXIDE; ELECTROPHILE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HALIDE; HYDROPEROXIDE DERIVATIVE; ISOTHIOCYANIC ACID DERIVATIVE; MENADIONE; PEROXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; FIBROBLAST; GLUTATHIONE METABOLISM; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; UPREGULATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; CELLS, CULTURED; FIBROBLASTS; FREE RADICALS; GLUTATHIONE; ISOTHIOCYANATES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; PEROXIDES; THIOCYANATES; XENOBIOTICS;

EID: 67349247003     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.03.005     Document Type: Article

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