The Reactive Oxygen Species- and Michael Acceptor-inducible Human Aldo-Keto Reductase AKR1C1 Reduces the α,β-Unsaturated Aldehyde 4-Hydroxy-2-nonenal to 1,4-Dihydroxy-2-nonene

Journal of Biological Chemistry

Volumn 276, Issue 4, 2001, Pages 2890-2897

  Burczynski, Michael E ^a   Sridhar, Gopishetty R ^c   Palackal, Nisha T ^c   Penning, Trevor M ^b  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; AROMATIC HYDROCARBONS; LIPIDS; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXYGEN; RNA;

PEROXIDATION;

BIOCHEMISTRY;

1,4 DIHYDROXY 2 NONENE; 2 QUINONE; 20ALPHA HYDROXYSTEROID DEHYDROGENASE; 20ALPHA(3ALPHA) HYDROXYSTEROID DEHYDROGENASE; 4 HYDROXYNONENAL; ALDEHYDE DERIVATIVE; ANTIOXIDANT; ETACRYNIC ACID; GLUTATHIONE; HYDROXYSTEROID; ISOENZYME; MESSENGER RNA; NICOTINAMIDE; OXIDOREDUCTASE; PROTEIN AKR1C1; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; 1,4-DIHYDROXY-2-NONENE; 3 ALPHA BETA, 20 BETA HYDROXYSTEROID DEHYDROGENASE; 3 ALPHA-BETA, 20 BETA-HYDROXYSTEROID DEHYDROGENASE; 3ALPHA(OR 20BETA) HYDROXYSTEROID DEHYDROGENASE; 4-HYDROXY-2-NONENAL; ALDEHYDE; ALKENE; DEHYDROASCORBIC ACID; GLUTATHIONE DEHYDROGENASE (ASCORBATE); GLUTATHIONE TRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RECOMBINANT PROTEIN;

ARTICLE; CATALYSIS; CATALYST; CELL STRAIN HEPG2; CYTOSOL; DNA RESPONSIVE ELEMENT; ENZYME INDUCTION; HUMAN; HUMAN CELL; KINETICS; LIPID PEROXIDATION; MICHAEL ADDITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATIVE STRESS; PRIORITY JOURNAL; REACTION ANALYSIS; REDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY;

FELIS CATUS;

20-HYDROXYSTEROID DEHYDROGENASES; ALDEHYDES; ALKENES; DEHYDROASCORBIC ACID; ENZYME INDUCTION; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; NAD; NADP; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXIDOREDUCTASES; RECOMBINANT PROTEINS;

EID: 0035951825     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M006655200     Document Type: Article

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