Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 19, 2008, Pages 6846-6851

  Park, Jong Heum ^a   Mangal, Dipti ^a   Tacka, Kirk A ^a   Quinn, Amy M ^a   Harvey, Ronald G ^b   Blair, Ian A ^a   Penning, Trevor M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

8 oxo dGuo; DNA strand breaks; Reactive oxygen species; Tobacco carcinogens

Indexed keywords

4,5 DIHYDRO 4,5 DIHYDROXYBENZO[A]PYRENE; 7,8 DIHYDRO 7,8 DIHYDROXYBENZO[A]PYRENE; 7,8 DIHYDROXY 9ALPHA,10BETA EPOXY 7,8,9,10 TETRAHYDROBENZO[A]PYRENE; 8 HYDROXYGUANINE; 8 OXOGUANINE HYDROXYLASE; ALDO KETO REDUCTASE; BENZO[A]PYRENE 7,8 DIONE; BENZO[A]PYRENE DERIVATIVE; DICHLOROFLUORESCEIN; GLUTATHIONE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXIDOREDUCTASE; POLYCYCLIC AROMATIC HYDROCARBON; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; 8 OXO 7 HYDRODEOXYGUANOSINE; 8-OXO-7-HYDRODEOXYGUANOSINE; ALCOHOL DEHYDROGENASE; BENZO(A)PYRENE 7,8 DIHYDRODIOL; BENZO(A)PYRENE 7,8 DIONE; BENZO(A)PYRENE 7,8-DIHYDRODIOL; BENZO(A)PYRENE-7,8-DIONE; CARBONYL REDUCTASE (NADPH); CATECHOL METHYLTRANSFERASE; DEOXYGUANOSINE; DIACETYLDICHLOROFLUORESCEIN; DNA GLYCOSYLTRANSFERASE; DRUG DERIVATIVE; ENZYME INHIBITOR; FLUORESCEIN DERIVATIVE; ISOENZYME; OXOGUANINE GLYCOSYLASE 1, HUMAN;

ARTICLE; CANCER CELL CULTURE; COMET ASSAY; DNA STRAND BREAKAGE; ELECTROSPRAY MASS SPECTROMETRY; FLUORESCENCE; GENOTOXICITY; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG CARCINOGENESIS; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; REACTION ANALYSIS; BIOTRANSFORMATION; DOUBLE STRANDED DNA BREAK; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; LUNG; METABOLISM; PATHOLOGY; REPRODUCIBILITY; TUMOR CELL LINE;

NICOTIANA TABACUM;

ALCOHOL OXIDOREDUCTASES; BENZOPYRENES; BIOTRANSFORMATION; CATECHOL O-METHYLTRANSFERASE; CELL LINE, TUMOR; COMET ASSAY; DEOXYGUANOSINE; DIHYDROXYDIHYDROBENZOPYRENES; DNA BREAKS, DOUBLE-STRANDED; DNA GLYCOSYLASES; ENZYME INHIBITORS; FLUORESCEINS; FLUORESCENCE; HUMANS; ISOENZYMES; LUNG; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 44349169635     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802776105     Document Type: Article

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