Sir2 protein deacetylases: Evidence for chemical intermediates and functions of a conserved histidine

Biochemistry

Volumn 45, Issue 1, 2006, Pages 272-282

  Smith, Brian C ^a   Denu, John M ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ANALYSIS; CHEMICAL REACTIONS; FATTY ACIDS; GENETIC ENGINEERING; METABOLISM; OXYGEN; SOLVENTS;

CARBONYL OXYGEN; GENE SILENCING; SIR2 PROTEIN DEACETYLASES;

PROTEINS;

ACYLTRANSFERASE; ADENOSINE DIPHOSPHATE RIBOSE; ALANINE; HISTIDINE; HYDROXYL GROUP; SILENT INFORMATION REGULATOR PROTEIN 2; SIR2 PROTEIN DEACETYLASE; UNCLASSIFIED DRUG; WATER;

APOPTOSIS; ARTICLE; CATALYSIS; CELL FUNCTION; DEACETYLATION; ENZYME KINETICS; ENZYME MECHANISM; FATTY ACID METABOLISM; GENE SILENCING; ISOTOPE LABELING; LIFESPAN; METHANOLYSIS; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; WILD TYPE;

ACETYLATION; ADENOSINE DIPHOSPHATE RIBOSE; ALANINE; BINDING SITES; CATALYSIS; HISTIDINE; HYDROGEN-ION CONCENTRATION; KINETICS; MUTATION; NAD; PROTEIN CONFORMATION; SIRTUINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 30144431571     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi052014t     Document Type: Article

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