Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine

Science

Volumn 298, Issue 5602, 2002, Pages 2390-2392

  Starai, V J ^a   Celic, I ^b   Cole, R N ^b   Boeke, J D ^b   Escalante Semerena, J C ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; CELLS; GENES; MASS SPECTROMETRY; METABOLISM; POLYPEPTIDES; PROTEINS; SYNTHESIS (CHEMICAL);

IMMUNOBLOTTING;

COENZYMES;

ACETIC ACID; ACETYL COENZYME A; ACETYL COENZYME A SYNTHETASE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; COENZYME A; LONG CHAIN FATTY ACID COENZYME A LIGASE; LUCIFERASE; LYSINE; PEPTIDE SYNTHASE; PROTEIN; SILENT INFORMATION REGULATOR PROTEIN 2; SYNTHETASE; THIOESTER; UNCLASSIFIED DRUG;

ENZYME; PROTEIN;

ACETYLATION; ARTICLE; CELL AGING; CHROMOSOME; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; EUKARYOTE; GENE SILENCING; IMMUNOBLOTTING; MASS SPECTROMETRY; METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROKARYOTE; PROTEIN FUNCTION; PROTEIN PROCESSING; REGULATORY MECHANISM; SALMONELLA ENTERICA; SYNTHESIS;

ACETATE-COA LIGASE; ACETYLATION; ACYL COENZYME A; ADENOSINE MONOPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; COENZYME A; CONSERVED SEQUENCE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, BACTERIAL; IMMUNOBLOTTING; LYSINE; MASS SPECTROMETRY; NAD; PEPTIDE MAPPING; SALMONELLA ENTERICA; SIRTUINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EUKARYOTA; NEGIBACTERIA; PROKARYOTA; SALMONELLA ENTERICA;

EID: 0347457075     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1077650     Document Type: Article

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18. Supported by National Institutes of Health grants GM62203 (J.C.E.-S.) and GM62385 (J.D.B.) V.J.S. was supported by Jerome Stefaniak and Pfizer Predoctoral Fellowships. Mass spectrometry data were obtained with the assistance of C. Bradford at the AB Mass Spectrometry Facility at Johns Hopkins University School of Medicine, which is funded by National Center for Research Resources shared instrumentation grant 1S10-RR14702, the Johns Hopkins Fund for Medical Discovery, and the Institute for Cell Engineering.