SIR2: The biochemical mehanism of NAD+-dependent protein deacetylation and ADP-ribosyl enzyme intermediates

Current Medicinal Chemistry

Volumn 11, Issue 7, 2004, Pages 807-826

  Sauve, Anthony A ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Acetyl ADP ribose; ADP ribose intermediates; CD38; Gene silencing; Lifespan; Longevity; Protein deacetylation; SIR2

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE DIPHOSPHATE RIBOSE ACETATE; ADENOSINE DIPHOSPHATE RIBOSYL CYCLASE; CD38 ANTIGEN; LYSINE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RIBOSE; SILENT INFORMATION REGULATOR PROTEIN 2; WATER; HISTONE DEACETYLASE; LEUKOCYTE ANTIGEN; NICOTINAMIDE; SILENT INFORMATION REGULATOR PROTEIN; SIR2 PROTEIN, S CEREVISIAE; SIRTUIN;

BIOCHEMISTRY; CALORIC RESTRICTION; COMPLEX FORMATION; CRYSTAL STRUCTURE; DEACETYLATION; ENZYME MECHANISM; ENZYME REGULATION; ENZYME STRUCTURE; GENE SILENCING; GENETIC STABILITY; HUMAN; LIFESPAN; NONHUMAN; OSMOTIC STRESS; PROTEIN HYDROLYSIS; REVIEW; SACCHAROMYCES CEREVISIAE; STRUCTURE ANALYSIS; ACETYLATION; BIOSYNTHESIS; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; HYDROLYSIS; KINETICS; METABOLISM; PHYSIOLOGY; PROTEIN PROCESSING; PROTEIN TERTIARY STRUCTURE;

ACETYLATION; ADENOSINE DIPHOSPHATE RIBOSE; ADP-RIBOSYL CYCLASE; ANTIGENS, CD; ANTIGENS, CD38; CATALYSIS; HISTONE DEACETYLASES; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; NAD; NIACINAMIDE; O-ACETYL-ADP-RIBOSE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS;

EID: 1842430616     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867043455675     Document Type: Review

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