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Volumn 12, Issue 7, 2002, Pages 535-541

Deposition of Alzheimer's β-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans

Author keywords

amyloid; Ageing; Alzheimer's disease; Apolipoprotein E; MDR1; Neurodegeneration; P glycoprotein; Proteopathy; Vascular endothelium

Indexed keywords

ABC TRANSPORTER; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1;

EID: 0036797713     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200210000-00005     Document Type: Article
Times cited : (322)

References (33)
  • 1
    • 0034458454 scopus 로고    scopus 로고
    • The cerebral proteopathies: Neurodegenerative disorders of protein conformation and assembly
    • Walker LC, LeVine HL. The cerebral proteopathies: neurodegenerative disorders of protein conformation and assembly. Mol Neurobiol 2000; 21:83-95.
    • (2000) Mol Neurobiol , vol.21 , pp. 83-95
    • Walker, L.C.1    LeVine, H.L.2
  • 2
    • 0033600274 scopus 로고    scopus 로고
    • Translating cell biology into therapeutic advances in Alzheimer's disease
    • Selkoe DJ. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 1999; 399:A23-A31.
    • (1999) Nature , vol.399
    • Selkoe, D.J.1
  • 3
    • 0034521392 scopus 로고    scopus 로고
    • Clearance of Alzheimer's amyloid-β 1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
    • Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, et al. Clearance of Alzheimer's amyloid-β 1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest 2000; 106:1489-1499.
    • (2000) J Clin Invest , vol.106 , pp. 1489-1499
    • Shibata, M.1    Yamada, S.2    Kumar, S.R.3    Calero, M.4    Bading, J.5    Frangione, B.6
  • 5
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • Juliano RL, Ling V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 1976; 455:152-162.
    • (1976) Biochim Biophys Acta , vol.455 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 6
    • 0033724658 scopus 로고    scopus 로고
    • The effect of rifampin treatment on intestinal expression of human MRP transporters
    • Fromm MF, Kaufmann HM, Fritz P, Burk O, Kroemer HK, Warzok RW, et al. The effect of rifampin treatment on intestinal expression of human MRP transporters. Am J Pathol 2000; 157:1575-1580.
    • (2000) Am J Pathol , vol.157 , pp. 1575-1580
    • Fromm, M.F.1    Kaufmann, H.M.2    Fritz, P.3    Burk, O.4    Kroemer, H.K.5    Warzok, R.W.6
  • 7
    • 0033980182 scopus 로고    scopus 로고
    • P-glycoprotein: A defense mechanism limiting oral bioavailability and CNS accumulation of drugs
    • Fromm MF. P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs. Int J Clin Pharmacol Ther 2000; 38:69-74.
    • (2000) Int J Clin Pharmacol Ther , vol.38 , pp. 69-74
    • Fromm, M.F.1
  • 8
    • 0031158805 scopus 로고    scopus 로고
    • The physiological function of drug transporting P-glycoproteins
    • Schinkel AH. The physiological function of drug transporting P-glycoproteins. Semin Cancer Biol 1997; 8:161-170.
    • (1997) Semin Cancer Biol , vol.8 , pp. 161-170
    • Schinkel, A.H.1
  • 9
    • 0035054725 scopus 로고    scopus 로고
    • The gut as a barrier to drug absorption. Combined role of cytochrome P4503A and P-glycoprotein
    • Zhang Y, Benet LZ. The gut as a barrier to drug absorption. Combined role of cytochrome P4503A and P-glycoprotein. Clin Pharmacokinet 2001; 40:159-168.
    • (2001) Clin Pharmacokinet , vol.40 , pp. 159-168
    • Zhang, Y.1    Benet, L.Z.2
  • 11
    • 0033865280 scopus 로고    scopus 로고
    • Oral bioavailability of digoxin is enhanced by talinolol: Evidence for involvement of intestinal P-glycoprotein
    • Westphal K, Weinbrenner A, Gießmann T, Stuhr M, Franke G, Zschiesche M, et al. Oral bioavailability of digoxin is enhanced by talinolol: evidence for involvement of intestinal P-glycoprotein. Clin Pharmacol Ther 2000; 68:6-12.
    • (2000) Clin Pharmacol Ther , vol.68 , pp. 6-12
    • Westphal, K.1    Weinbrenner, A.2    Gießmann, T.3    Stuhr, M.4    Franke, G.5    Zschiesche, M.6
  • 12
    • 0033753435 scopus 로고    scopus 로고
    • Induction of p-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: A new type of drug/drug interaction
    • Westphal K, Weinbrenner A, Zschiesche M, Franke G, Knoke M, Oertel R, et al. Induction of p-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: a new type of drug/drug interaction. Clin Pharmacol Ther 2000; 68:345-355.
    • (2000) Clin Pharmacol Ther , vol.68 , pp. 345-355
    • Westphal, K.1    Weinbrenner, A.2    Zschiesche, M.3    Franke, G.4    Knoke, M.5    Oertel, R.6
  • 13
    • 0000006828 scopus 로고    scopus 로고
    • Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)
    • Johne A, Brockmoeller J, Bauer S, Maurer A, Langheinrich M, Roots I. Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum). Clin Pharmacol Ther 1999; 66:338-345.
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 338-345
    • Johne, A.1    Brockmoeller, J.2    Bauer, S.3    Maurer, A.4    Langheinrich, M.5    Roots, I.6
  • 14
    • 0033514320 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine
    • Fromm MF, Kim RB, Stein CM, Wilkinson GR, Roden DM. Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine. Circulation 1999; 99:552-557.
    • (1999) Circulation , vol.99 , pp. 552-557
    • Fromm, M.F.1    Kim, R.B.2    Stein, C.M.3    Wilkinson, G.R.4    Roden, D.M.5
  • 15
    • 0032823160 scopus 로고    scopus 로고
    • Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil
    • Gramatté T, Oertel R. Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil. Clin Pharmacol Ther 1999; 66:239-245.
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 239-245
    • Gramatté, T.1    Oertel, R.2
  • 16
    • 0035104031 scopus 로고    scopus 로고
    • Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects
    • Cascorbi I, Gerloff T, Johne A, Meisel C, Hoffmeyer S, Schwab M, et al. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. Clin Pharmacol Ther 2001; 69:169-174.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 169-174
    • Cascorbi, I.1    Gerloff, T.2    Johne, A.3    Meisel, C.4    Hoffmeyer, S.5    Schwab, M.6
  • 17
    • 0034724324 scopus 로고    scopus 로고
    • Functional polymorphisms of the human multidrug resistance gene: Multiple sequence variations and correlation with P-glycoprotein expression and activity in vivo
    • Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmöller Johne A, Cascorbi I, et al. Functional polymorphisms of the human multidrug resistance gene: multiple sequence variations and correlation with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 2000; 97:3473-3478.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3473-3478
    • Hoffmeyer, S.1    Burk, O.2    Von Richter, O.3    Arnold, H.P.4    Brockmöller Johne, A.5    Cascorbi, I.6
  • 18
    • 0034811880 scopus 로고    scopus 로고
    • Isolation of endothelial cells from brain, lung, and kidney: Expression of the multidrug resistance P- glycoprotein isoforms
    • Demeule M, Labelle M, Regina A, Berthelet F, Beliveau R. Isolation of endothelial cells from brain, lung, and kidney: expression of the multidrug resistance P- glycoprotein isoforms. Biochem Biophys Res Commun 2001; 281:827-834.
    • (2001) Biochem Biophys Res Commun , vol.281 , pp. 827-834
    • Demeule, M.1    Labelle, M.2    Regina, A.3    Berthelet, F.4    Beliveau, R.5
  • 19
    • 0033961896 scopus 로고    scopus 로고
    • Brain microvascular P-glycoprotein and a revised model of multidrug resistance in brain
    • Golden PL, Pardridge WM. Brain microvascular P-glycoprotein and a revised model of multidrug resistance in brain. Cell Mol Neurobiol 2000; 20:165-181.
    • (2000) Cell Mol Neurobiol , vol.20 , pp. 165-181
    • Golden, P.L.1    Pardridge, W.M.2
  • 20
    • 0033664346 scopus 로고    scopus 로고
    • Xenobiotic transport across isolated brain microvessels studied by confocal microscopy
    • Miller DS, Mobmann SN, Gutmann H, Toeroek M, Drewe J, Fricker G. Xenobiotic transport across isolated brain microvessels studied by confocal microscopy. Mol Pharmacol 2000; 58:1357-1367.
    • (2000) Mol Pharmacol , vol.58 , pp. 1357-1367
    • Miller, D.S.1    Mobmann, S.N.2    Gutmann, H.3    Toeroek, M.4    Drewe, J.5    Fricker, G.6
  • 23
    • 0034516988 scopus 로고    scopus 로고
    • Towards a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid β-protein
    • Selkoe DJ. Towards a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid β-protein. Ann NY Acad Sci 2000; 924:17-25.
    • (2000) Ann NY Acad Sci , vol.924 , pp. 17-25
    • Selkoe, D.J.1
  • 24
    • 0032323641 scopus 로고    scopus 로고
    • Evolutionary relationships among ABC transporters
    • Croop JM. Evolutionary relationships among ABC transporters. Methods Enzymol 1998; 292:101-117.
    • (1998) Methods Enzymol , vol.292 , pp. 101-117
    • Croop, J.M.1
  • 25
    • 0342378042 scopus 로고    scopus 로고
    • Interaction of Alzheimer β-amyloid peptide (1-40) with lipid membranes
    • Terzi E, Holzemann G, Seelig J. Interaction of Alzheimer β-amyloid peptide (1-40) with lipid membranes. J Biochem 1997; 36:14845-14852.
    • (1997) J Biochem , vol.36 , pp. 14845-14852
    • Terzi, E.1    Holzemann, G.2    Seelig, J.3
  • 26
    • 0035882515 scopus 로고    scopus 로고
    • Pharmacogenetics of the human drug-transporter gene MDR1: Impact of polymorphisms on pharmacotherapy
    • Brinkmann U, Roots I, Eichelbaum M. Pharmacogenetics of the human drug-transporter gene MDR1: impact of polymorphisms on pharmacotherapy. Drug Discov Today 2001; 6:835-839.
    • (2001) Drug Discov Today , vol.6 , pp. 835-839
    • Brinkmann, U.1    Roots, I.2    Eichelbaum, M.3
  • 27
    • 0034997034 scopus 로고    scopus 로고
    • Expression of P-glycoprotein in human placenta: Relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene
    • Tanabe M, Ieiri I, Nagata N, Inoue K, Ito S, Kanamori Y, et al. Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene J Pharmacol Exp Ther 2001; 297:1137-1143.
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 1137-1143
    • Tanabe, M.1    Ieiri, I.2    Nagata, N.3    Inoue, K.4    Ito, S.5    Kanamori, Y.6
  • 30
    • 0034051677 scopus 로고    scopus 로고
    • Enhanced cerebral uptake of receptor ligands by modulation of p-glycoprotein function in the blood-brain barrier
    • Doze P, van Waarde A, Elsinga PH, Hendrikse NH, Vaalburg W. Enhanced cerebral uptake of receptor ligands by modulation of p-glycoprotein function in the blood-brain barrier. Synapse 2000; 36:66-74.
    • (2000) Synapse , vol.36 , pp. 66-74
    • Doze, P.1    Van Waarde, A.2    Elsinga, P.H.3    Hendrikse, N.H.4    Vaalburg, W.5
  • 31
    • 0001504829 scopus 로고    scopus 로고
    • Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo
    • Fassbender K, Simons M, Bergmann C, Stroick M, Lütjohann D, Keller P, et al. Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo. Proc Natl Acad Sci USA 2001; 98:5856-5861.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5856-5861
    • Fassbender, K.1    Simons, M.2    Bergmann, C.3    Stroick, M.4    Lütjohann, D.5    Keller, P.6
  • 33
    • 0032819120 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats
    • Hooiveld GJEJ, Vos TA, Scheffer GL, van Goor H, Koning H, Bloks V, et al. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats. Gastroenterology 1999; 117:678-687.
    • (1999) Gastroenterology , vol.117 , pp. 678-687
    • Hooiveld, G.J.E.J.1    Vos, T.A.2    Scheffer, G.L.3    Van Goor, H.4    Koning, H.5    Bloks, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.