Generation of aggregated β-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits

Journal of Neuroscience

Volumn 21, Issue 15, 2001, Pages 5703-5714

  Stéphan, Aline ^a   Laroche, Serge ^a   Davis, Sabrina ^a  

^a CNRS   (France)

Author keywords

Alzheimer's disease; A 40; A 43; Dentate gyrus; Senile plaque; Synaptic plasticity; Working memory

Indexed keywords

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ARTICLE; MALE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION; TASK PERFORMANCE;

EID: 0035425615     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-15-05703.2001     Document Type: Article

References (74)

1. Heterosynaptic changes accompany long-term but not short-term potentiation of the perforant path in the anaesthetized rat
2. Inflammation and Alzheimer's disease
3. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-Golgi compartments of hippocampal neurons
4. A new definition of Alzheimer's disease: A hippocampal dementia
5. The effects of NGF and fetal cell transplants on spatial learning after intradentate administration of colchicine
6. Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxy-terminus amyloid precursor protein
7. Neuropathological staging of Alzheimer-related changes
8. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
9. Beta-amyloid(1-40) effects on behaviour and memory
10. Selective loss of hippocampal granule cells following adrenalectomy: Implications for spatial memory
11. β-Amyloid produces a delayed NMDA receptor-dependent reduction in synaptic transmission in rat hippocampus
12. Dysfunctional regulation of αCaMKII and syntaxin 1B transcription after induction of LTP in the aged rat
13. The pathogenesis of senile plaques
14. Bilateral injections of βA(25-35)+IBO into the hippocampus disrupt acquisition of spatial learning in the rat
15. Dissociation of Alzheimer type pathology in a disconnected piece of cortex
16. Cleavage of amyloid beta peptide during constitutive processing of its precursor
17. Cognitive impairment in Alzheimer disease
18. Presymptomatic hippocampal atrophy in Alzheimer's disease. A longitudinal MRI study
19. Effects of injected Alzheimer β-amyloid cores into rat brain
20. Rodent models of Alzheimer's disease: Rat Aβ infusion approaches to amyloid deposits
21. Activation of the hippocampus and dentate gyrus by working memory: A 2-deoxyglucose study of behaving rhesus monkeys
22. Lack of Alzheimer pathology after β-amyloid protein injections in rat brain
23. Differential effects of amyloid peptides β-(1-40) and β-(25-35) injections into the rat nucleus basalis
24. Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
25. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease
26. The COOH terminus of the Alzheimer amyloid Aβ peptide: Differences in length influences the process of amyloid deposition in Alzheimer brain and tell us something about relationships among parenchymal and vessel-associated amyloid deposits
27. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models
28. Transgenic mice expressing Alzheimer amyloid precursor proteins
29. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
30. Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation
31. Perforant pathway changes in the memory impairment in Alzheimer's disease
32. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer's disease
33. Visualisation of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initial deposited species is Aβ42(43)
34. On the use of ibotenic acid to lesion selectively different components of the hippocampal formation
35. On the role of hippocampal connections in the performance of place and cue task: Comparisons with damage to the hippocampus
36. Seeding "one-dimensional crystallisation" of amyloid: A pathogenic mechanism in Alzheimer's disease and Scrapie?
37. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
38. Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice
39. β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
40. Beta-amyloid peptide in vitro toxicity: Lot to lot variability
41. Present imperfect: A critical review of animal models of the mnemonic impairments in Alzheimer's disease
42. Effects of exogenous β-amyloid peptide on retention for spatial learning
43. Reversal of β-amyloid-inducing retention deficit after exposure to training and state cues
44. "Dead reckoning," landmark learning and the sense of direction: A neurophysiological and computational hypothesis
45. Neuroplasticity failure in Alzheimer's disease: Bridging the gap between plaques and tangles
46. Age-related learning deficits in transgenic mice expressing human β-APP751
47. Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein
48. β-Amyloid protein-induced Alzheimer's disease animal model
49. Continuous infusion of β-amyloid protein into the rat cerebral ventral induces learning impairment and neuronal and morphological degeneration
50. Delayed behavioural effects following intrahippocampal injection of aggregated Aβ(1-42)
51. Aggregation-related toxicity of synthetic β-amyloid protein in hippocampal cultures
52. Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state
53. The molecular pathology of Alzheimer's disease
54. Alzheimer's disease: Genotypes, phenotypes and treatments
55. Secretion of β-amyloid precursor protein cleaved at the amino-terminus of the β-amyloid peptide
56. Purification and cloning of amyloid precursor protein β-secretase from human brain
57. Beta-amyloid precursor protein cleavage by a membrane-bound protease
58. An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar Aβ amyloid in the rat brain
59. Amyloid β aggregation: Selective inhibition in mixtures of amyloid with different chain lengths
60. Mechanisms of memory
61. A behavioural analysis of spatial localisation following electrolytic, kainate- or colchicine-induced damage to the hippocampal formation in the rat
62. High tissue content of soluble β1-40 is linked to cerebral amyloid angiopathy
63. Effects of adrenalectomy on spatial memory performance and dentate gyrus morphology
64. Fos imaging reveals differential patterns of activity of hippocampal and parahippocampal subfield activation in rats in response to different spatial memory tests
65. Beta-secretase cleavage of Alzheimer's amyloid precursor protein beta transmembrane aspartic protease BACE
66. Apolipoprotein E4 promotes the early deposition of Aβ42 and then Aβ40 in the elderly
67. The hippocampus as an associator of discontiguous events
68. Fibrillar β-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo
69. Hippocampal, granule cell and CA3-4 lesions impair formation of a place learning-set in the rat and induce reflex epilepsy
70. Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro
71. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
72. Protective effects of idebenone and α-tocopherol on β-amyloid-(1-42)-induced learning and memory deficits in rats: Implication of oxidative stress in β-amyloid-induced neurotoxicity in vivo
73. Neurotrophic and neurotoxic effects of amyloid β-protein: Reversal by tachykinin neuropeptides