-
1
-
-
0026646604
-
Amyloid beta-peptide is produced by cultured cells during normal metabolism
-
Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, et al. Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 1992; 359(6393): 322-5.
-
(1992)
Nature
, vol.359
, Issue.6393
, pp. 322-325
-
-
Haass, C.1
Schlossmacher, M.G.2
Hung, A.Y.3
Vigo-Pelfrey, C.4
Mellon, A.5
Ostaszewski, B.L.6
-
2
-
-
0026646605
-
Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids
-
Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, Davis D, et al. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature 1992; 359(6393): 325-7.
-
(1992)
Nature
, vol.359
, Issue.6393
, pp. 325-327
-
-
Seubert, P.1
Vigo-Pelfrey, C.2
Esch, F.3
Lee, M.4
Dovey, H.5
Davis, D.6
-
3
-
-
0026760261
-
Production of the Alzheimer amyloid beta protein by normal proteolytic processing
-
Shoji M, Golde TE, Ghiso J, Cheung TT, Estus S, Shaffer LM, et al. Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science 1992; 258(5079): 126-9.
-
(1992)
Science
, vol.258
, Issue.5079
, pp. 126-129
-
-
Shoji, M.1
Golde, T.E.2
Ghiso, J.3
Cheung, T.T.4
Estus, S.5
Shaffer, L.M.6
-
4
-
-
0035066332
-
Alzheimers Disease: Genes, Proteins, and Therapy
-
Selkoe D. Alzheimers Disease: Genes, Proteins, and Therapy. Physiol Rev 2001; 81: 741-766.
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.1
-
5
-
-
0026646280
-
Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat
-
Stephenson DT, Rash K, Clemens JA. Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat. Brain Res 1992; 593(1): 128-35.
-
(1992)
Brain Res
, vol.593
, Issue.1
, pp. 128-135
-
-
Stephenson, D.T.1
Rash, K.2
Clemens, J.A.3
-
6
-
-
0032811459
-
Toxic neuronal apoptosis and modifications of tau and APP gene and protein expressions
-
Hugon J, Esclaire F, Lesort M, Kisby G, Spencer P. Toxic neuronal apoptosis and modifications of tau and APP gene and protein expressions. Drug Metab Rev 1999; 31(3): 635-47.
-
(1999)
Drug Metab Rev
, vol.31
, Issue.3
, pp. 635-647
-
-
Hugon, J.1
Esclaire, F.2
Lesort, M.3
Kisby, G.4
Spencer, P.5
-
7
-
-
0034638240
-
Expression of amyloid precursor protein in human astrocytes in vitro: Isoform-specific increases following heat shock
-
Shepherd CE, Bowes S, Parkinson D, Cambray-Deakin M, Pearson RC. Expression of amyloid precursor protein in human astrocytes in vitro: isoform-specific increases following heat shock. Neuroscience 2000; 99(2): 317-25.
-
(2000)
Neuroscience
, vol.99
, Issue.2
, pp. 317-325
-
-
Shepherd, C.E.1
Bowes, S.2
Parkinson, D.3
Cambray-Deakin, M.4
Pearson, R.C.5
-
8
-
-
0028233494
-
Hydrogen peroxide mediates amyloid beta protein toxicity
-
Behl C, Davis JB, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 1994; 77(6): 817-27.
-
(1994)
Cell
, vol.77
, Issue.6
, pp. 817-827
-
-
Behl, C.1
Davis, J.B.2
Lesley, R.3
Schubert, D.4
-
9
-
-
0036403838
-
Oxidative stress increases expression and activity of BACE in NT2 neurons
-
Tamagno E, Bardini P, Obbili A, Vitali A, Borghi R, Zaccheo D, et al. Oxidative stress increases expression and activity of BACE in NT2 neurons. Neurobiol Dis 2002; 10(3): 279-88.
-
(2002)
Neurobiol Dis
, vol.10
, Issue.3
, pp. 279-288
-
-
Tamagno, E.1
Bardini, P.2
Obbili, A.3
Vitali, A.4
Borghi, R.5
Zaccheo, D.6
-
10
-
-
0036272650
-
Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities
-
Casley CS, Canevari L, Land JM, Clark JB, Sharpe MA. Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J Neurochem 2002; 80(1): 91-100.
-
(2002)
J Neurochem
, vol.80
, Issue.1
, pp. 91-100
-
-
Casley, C.S.1
Canevari, L.2
Land, J.M.3
Clark, J.B.4
Sharpe, M.A.5
-
11
-
-
0037437192
-
Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells
-
Anandatheerthavarada HK, Biswas G, Robin MA, Avadhani NG. Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. J Cell Biol 2003; 161(1): 41-54.
-
(2003)
J Cell Biol
, vol.161
, Issue.1
, pp. 41-54
-
-
Anandatheerthavarada, H.K.1
Biswas, G.2
Robin, M.A.3
Avadhani, N.G.4
-
12
-
-
11144353586
-
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease
-
Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, Wang N, et al. ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science 2004; 304(5669): 448-52.
-
(2004)
Science
, vol.304
, Issue.5669
, pp. 448-452
-
-
Lustbader, J.W.1
Cirilli, M.2
Lin, C.3
Xu, H.W.4
Takuma, K.5
Wang, N.6
-
13
-
-
9144235443
-
Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta
-
Atwood CS, Perry G, Zeng H, Kato Y, Jones WD, Ling KQ, et al. Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta. Biochemistry 2004; 43(2): 560-8.
-
(2004)
Biochemistry
, vol.43
, Issue.2
, pp. 560-568
-
-
Atwood, C.S.1
Perry, G.2
Zeng, H.3
Kato, Y.4
Jones, W.D.5
Ling, K.Q.6
-
14
-
-
0036127328
-
Redox Properties of Met35 in Neurotoxic β-Amyloid Peptide
-
A Molecular Modeling Study
-
Pogocki D and Schoneich C. Redox Properties of Met35 in Neurotoxic β-Amyloid Peptide. A Molecular Modeling Study. Chem. Res. Toxicol. 2002; 15, 408-418.
-
(2002)
Chem. Res. Toxicol.
, vol.15
, pp. 408-418
-
-
Pogocki, D.1
Schoneich, C.2
-
15
-
-
0033601338
-
Cu(II) potentiation of Alzheimer Abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction
-
Huang X, Cuajungco MP, Atwood CS, Hartshorn MA, Tyndall JD, Hanson GR, et al. Cu(II) potentiation of Alzheimer Abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem 1999; 274(52): 37111-6.
-
(1999)
J Biol Chem
, vol.274
, Issue.52
, pp. 37111-37116
-
-
Huang, X.1
Cuajungco, M.P.2
Atwood, C.S.3
Hartshorn, M.A.4
Tyndall, J.D.5
Hanson, G.R.6
-
16
-
-
0034801348
-
Different mechanisms of oxidative stress and neurotoxicity for Alzheimer's A beta (1-42) and A beta (25-35)
-
Varadarajan S, Kanski J, Aksenova M, Lauderback C, Butterfield DA. Different mechanisms of oxidative stress and neurotoxicity for Alzheimer's A beta (1-42) and A beta (25-35). J Am Chem Soc 2001; 123(24): 5625-31.
-
(2001)
J Am Chem Soc
, vol.123
, Issue.24
, pp. 5625-5631
-
-
Varadarajan, S.1
Kanski, J.2
Aksenova, M.3
Lauderback, C.4
Butterfield, D.A.5
-
17
-
-
0035827681
-
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
-
Curtain CC, Ali F, Volitakis I, Cherny RA, Norton RS, Beyreuther K, Barrow CJ, et al. Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits. J Biol Chem 2001; 276(23): 20466-73.
-
(2001)
J Biol Chem
, vol.276
, Issue.23
, pp. 20466-20473
-
-
Curtain, C.C.1
Ali, F.2
Volitakis, I.3
Cherny, R.A.4
Norton, R.S.5
Beyreuther, K.6
Barrow, C.J.7
-
18
-
-
36348945906
-
Redox processes of methionine relevant to beta-amyloid oxidation and aging
-
Schoneich C. Redox processes of methionine relevant to beta-amyloid oxidation and aging. Science 1992; 257: 1220-1224.
-
(1992)
Science
, vol.257
, pp. 1220-1224
-
-
Schoneich, C.1
-
19
-
-
0037980148
-
Alzheimer's beta-amyloid peptide as a source of neurotoxic free radicals: The role of structural effects
-
Pogocki D. Alzheimer's beta-amyloid peptide as a source of neurotoxic free radicals: the role of structural effects. Acta Neurobiol Exp (Wars) 2003; 63(2): 131-45.
-
(2003)
Acta Neurobiol Exp (Wars)
, vol.63
, Issue.2
, pp. 131-145
-
-
Pogocki, D.1
-
20
-
-
70449136625
-
Prolongation of the normal life span by radiation protection chemicals
-
Harman D. Prolongation of the normal life span by radiation protection chemicals. J Gerontol 1957; 12(3): 257-63.
-
(1957)
J Gerontol
, vol.12
, Issue.3
, pp. 257-263
-
-
Harman, D.1
-
21
-
-
0026795635
-
Protein oxidation and aging
-
Stadtman ER. Protein oxidation and aging. Science 1992; 257: 1220-24.
-
(1992)
Science
, vol.257
, pp. 1220-1224
-
-
Stadtman, E.R.1
-
22
-
-
0035872001
-
Age-related changes in oxidative damage to lipids and DNA in rat skin
-
Tahara, S, Matsuo M, Kaneko T. Age-related changes in oxidative damage to lipids and DNA in rat skin. Mech Ageing Dev 2001; 122(4): 415-26.
-
(2001)
Mech Ageing Dev
, vol.122
, Issue.4
, pp. 415-426
-
-
Tahara, S.1
Matsuo, M.2
Kaneko, T.3
-
23
-
-
0034524859
-
Human studies related to protein oxidation: Protein carbonyl content as a marker of damage
-
Chevion M, Berenshtein E, Stadtman ER. Human studies related to protein oxidation: protein carbonyl content as a marker of damage. Free Radic Res 2000; 33 Suppl: S99-108.
-
(2000)
Free Radic Res
, vol.33
, Issue.SUPPL.
-
-
Chevion, M.1
Berenshtein, E.2
Stadtman, E.R.3
-
24
-
-
3042830849
-
Perineuronal nets potentially protect against oxidative stress
-
Morawski M, Bruckner MK, Riederer P, Bruckner G, Arendt T. Perineuronal nets potentially protect against oxidative stress. Exp Neurol 2004; 188(2): 309-15.
-
(2004)
Exp Neurol
, vol.188
, Issue.2
, pp. 309-315
-
-
Morawski, M.1
Bruckner, M.K.2
Riederer, P.3
Bruckner, G.4
Arendt, T.5
-
25
-
-
0036934286
-
Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer's disease
-
Dei R, Takeda A, Niwa H, Li M, Nakagomi Y, Watanabe M, et al. Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer's disease. Acta Neuropathol (Berl) 2002; 104(2): 113-22.
-
(2002)
Acta Neuropathol (Berl)
, vol.104
, Issue.2
, pp. 113-122
-
-
Dei, R.1
Takeda, A.2
Niwa, H.3
Li, M.4
Nakagomi, Y.5
Watanabe, M.6
-
26
-
-
0030881686
-
Oxidative damage during aging targets mitochondrial aconitase
-
Yan LJ, Levine RL, Sohal RS. Oxidative damage during aging targets mitochondrial aconitase. Proc Natl Acad Sci USA 1997; 94(21):11168-72.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, Issue.21
, pp. 11168-11172
-
-
Yan, L.J.1
Levine, R.L.2
Sohal, R.S.3
-
27
-
-
0032531735
-
Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation
-
Hensley K, Maidt ML, Yu Z, Sang H, Markesbery WR, Floyd RA. Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation. J Neurosci 1998; 18(20): 8126-32.
-
(1998)
J Neurosci
, vol.18
, Issue.20
, pp. 8126-8132
-
-
Hensley, K.1
Maidt, M.L.2
Yu, Z.3
Sang, H.4
Markesbery, W.R.5
Floyd, R.A.6
-
28
-
-
0032891777
-
Oxidized amino acids in the urine of aging rats: Potential markers for assessing oxidative stress in vivo
-
Leeuwenburgh C, Hansen PA, Holloszy JO, Heinecke JW. Oxidized amino acids in the urine of aging rats: potential markers for assessing oxidative stress in vivo. Am J Physiol 1999; 276(1 Pt 2): R128-35.
-
(1999)
Am J Physiol
, vol.276
, Issue.1 PART 2
-
-
Leeuwenburgh, C.1
Hansen, P.A.2
Holloszy, J.O.3
Heinecke, J.W.4
-
29
-
-
0028037679
-
Quantitative analysis of lipofuscin and neurofibrillary tangles in the hippocampal neurons of Alzheimer disease brains
-
Stojanovic A, Roher AE, Ball MJ. Quantitative analysis of lipofuscin and neurofibrillary tangles in the hippocampal neurons of Alzheimer disease brains. Dementia 1994; 5(5): 229-33.
-
(1994)
Dementia
, vol.5
, Issue.5
, pp. 229-233
-
-
Stojanovic, A.1
Roher, A.E.2
Ball, M.J.3
-
30
-
-
0041764354
-
Glutathione reverses early effects of glycation on myosin function
-
Ramamurthy B, Jones AD, Larsson L. Glutathione reverses early effects of glycation on myosin function. Am J Physiol Cell Physiol 2003; 285(2): C419-24.
-
(2003)
Am J Physiol Cell Physiol
, vol.285
, Issue.2
-
-
Ramamurthy, B.1
Jones, A.D.2
Larsson, L.3
-
31
-
-
12144278195
-
Age- and Stage-dependent Accumulation of Advanced Glycation End Products in Intracellular Deposits in Normal and Alzheimer's Disease Brains
-
Luth HJ, Ogunlade V, Kuhla B, Kientsch-Engel R, Stahl P, Webster J, et al. Age- and Stage-dependent Accumulation of Advanced Glycation End Products in Intracellular Deposits in Normal and Alzheimer's Disease Brains. Cereb Cortex 2005; 15(2): 211-20.
-
(2005)
Cereb Cortex
, vol.15
, Issue.2
, pp. 211-220
-
-
Luth, H.J.1
Ogunlade, V.2
Kuhla, B.3
Kientsch-Engel, R.4
Stahl, P.5
Webster, J.6
-
32
-
-
2342420034
-
Lipid peroxidation and oxidative imbalance: Early functional events in Alzheimer's disease
-
Pratico D, Sung S. Lipid peroxidation and oxidative imbalance: early functional events in Alzheimer's disease. J Alzheimers Dis 2004; 6(2): 171-5.
-
(2004)
J Alzheimers Dis
, vol.6
, Issue.2
, pp. 171-175
-
-
Pratico, D.1
Sung, S.2
-
33
-
-
15344342522
-
Micronutrients prevent cancer and delay aging
-
Ames BN. Micronutrients prevent cancer and delay aging. Toxicol Lett 1998; 102-103: 5-18.
-
(1998)
Toxicol Lett
, vol.102-103
, pp. 5-18
-
-
Ames, B.N.1
-
34
-
-
0036799799
-
Antioxidants as treatment for neurodegenerative disorders
-
Moosmann B, Behl C. Antioxidants as treatment for neurodegenerative disorders. Expert Opin Investig Drugs 2002; 11(10): 1407-35.
-
(2002)
Expert Opin Investig Drugs
, vol.11
, Issue.10
, pp. 1407-1435
-
-
Moosmann, B.1
Behl, C.2
-
35
-
-
0036254698
-
Oxidative nerve cell death in Alzheimer's disease and stroke: Antioxidants as neuroprotective compounds
-
Behl C, Moosmann B. Oxidative nerve cell death in Alzheimer's disease and stroke: antioxidants as neuroprotective compounds. Biol Chem 2002; 383(34): 521-36.
-
(2002)
Biol Chem
, vol.383
, Issue.34
, pp. 521-536
-
-
Behl, C.1
Moosmann, B.2
-
36
-
-
0346688728
-
Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: The Cache County Study
-
Zandi PP, Anthony JC, Khachaturian AS, Stone SV, Gustafson D, Tschanz JT, et al. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol 2004; 61(1): 82-8.
-
(2004)
Arch Neurol
, vol.61
, Issue.1
, pp. 82-88
-
-
Zandi, P.P.1
Anthony, J.C.2
Khachaturian, A.S.3
Stone, S.V.4
Gustafson, D.5
Tschanz, J.T.6
-
37
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
-
Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 2001; 30(3): 665-76.
-
(2001)
Neuron
, vol.30
, Issue.3
, pp. 665-676
-
-
Cherny, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
Gray, D.N.4
Jones, W.D.5
McLean, C.A.6
-
38
-
-
10744224267
-
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial
-
Ritchie CW, Bush AI, Mackinnon A, Macfarlane S, Mastwyk M, MacGregor L, et al. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol 2003; 60(12): 1685-91.
-
(2003)
Arch Neurol
, vol.60
, Issue.12
, pp. 1685-1691
-
-
Ritchie, C.W.1
Bush, A.I.2
Mackinnon, A.3
Macfarlane, S.4
Mastwyk, M.5
MacGregor, L.6
-
39
-
-
10744226316
-
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice
-
Bayer TA, Schafer S, Simons A, Kemmling A, Kamer T, Tepest R, et al. Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice. Proc Natl Acad Sci USA 2003; 100(24): 14187-92.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.24
, pp. 14187-14192
-
-
Bayer, T.A.1
Schafer, S.2
Simons, A.3
Kemmling, A.4
Kamer, T.5
Tepest, R.6
-
40
-
-
0001052504
-
Copper catalyzed oxidation of Alzheimer Abeta
-
Atwood CS, Huang X, Khatri A, Scarpa, RC, Kim YS, Moir RD, et al. Copper catalyzed oxidation of Alzheimer Abeta. Cell Mol Biol (Noisy-le-grand) 2000; 46(4): 777-83.
-
(2000)
Cell Mol Biol (Noisy-le-grand)
, vol.46
, Issue.4
, pp. 777-783
-
-
Atwood, C.S.1
Huang, X.2
Khatri, A.3
Scarpa, R.C.4
Kim, Y.S.5
Moir, R.D.6
-
41
-
-
20044366019
-
Oxidative stress, antioxidants and neurodegenerative diseases
-
Casetta I, Govoni V, Granieri E. Oxidative stress, antioxidants and neurodegenerative diseases. Curr Pharm Design 2005; 11(16): 2033-52.
-
(2005)
Curr Pharm Design
, vol.11
, Issue.16
, pp. 2033-2052
-
-
Casetta, I.1
Govoni, V.2
Granieri, E.3
-
42
-
-
20044383235
-
Experimental antioxidant biotherapy for protection of the vascular wall by modified forms of superoxide dismutase and catalase
-
Maksimenko AV. Experimental antioxidant biotherapy for protection of the vascular wall by modified forms of superoxide dismutase and catalase. Curr Pharm Design 2005; 11(16): 2007-16.
-
(2005)
Curr Pharm Design
, vol.11
, Issue.16
, pp. 2007-2016
-
-
Maksimenko, A.V.1
-
43
-
-
2342417699
-
The antioxidants and proantioxidants network: An overview
-
Vertuani S, Angusti A, Manfredini S. The antioxidants and proantioxidants network: an overview. Curr Pharm Design 2004; 10(14): 1677-94.
-
(2004)
Curr Pharm Design
, vol.10
, Issue.14
, pp. 1677-1694
-
-
Vertuani, S.1
Angusti, A.2
Manfredini, S.3
|