Fish, Long-Chain Omega-3 Polyunsaturated Fatty Acids and Prevention of Cardiovascular Disease-Eat Fish or Take Fish Oil Supplement?

Progress in Cardiovascular Diseases

Volumn 52, Issue 2, 2009, Pages 95-114

  He, Ka ^a,b  

^a University of North Carolina   (United States)

^b IL   (United States)

Author keywords

Cardiovascular disease; Epidemiology; Fish; Omega 3 fatty acids; Prevention

Indexed keywords

ALPHA TOCOPHEROL; DOCOSAHEXAENOIC ACID; FISH OIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ICOSATETRAENOIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PLACEBO; POLYUNSATURATED FATTY ACID;

ANGINA PECTORIS; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; BLOOD PRESSURE REGULATION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR INFLAMMATION; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; COOKING; CORONARY ARTERY ATHEROSCLEROSIS; DIET SUPPLEMENTATION; DISEASE MARKER; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; EXERCISE; FAT INTAKE; FOOD COMPOSITION; FOOD CONTAMINATION; FOOD PROCESSING; FOOD SAFETY; HEART ARRHYTHMIA; HEART INFARCTION; HEART PROTECTION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; ISCHEMIC HEART DISEASE; LIFESTYLE MODIFICATION; LIPID METABOLISM; MORTALITY; NONHUMAN; NUTRITIONAL VALUE; RISK REDUCTION; THROMBOCYTE AGGREGATION; TREATMENT RESPONSE; VASCULAR ENDOTHELIUM;

ALPHA-LINOLENIC ACID; ANIMALS; ARRHYTHMIAS, CARDIAC; CARDIOVASCULAR DISEASES; CORONARY DISEASE; DIETARY SUPPLEMENTS; FATTY ACIDS, OMEGA-3; FISH OILS; FISHES; HUMANS; RISK ASSESSMENT; SEAFOOD; STROKE;

EID: 69249214134     PISSN: 00330620     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pcad.2009.06.003     Document Type: Article

References (159)

1. Bang H.O., Dyerberg J., and Hjoorne N. The composition of food consumed by Greenland Eskimos. Acta Med Scand 200 (1976) 69-73
2. Kromann N., and Green A. Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974. Acta Med Scand 208 (1980) 401-406
3. Bang H.O., Dyerberg J., and Sinclair H.M. The composition of the Eskimo food in northwestern Greenland. Am J Clin Nutr 33 (1980) 2657-2661
4. Bjerregaard P., and Dyerberg J. Mortality from ischaemic heart disease and cerebrovascular disease in Greenland. Int J Epidemiol 17 (1988) 514-519
5. Bang H.O., and Dyerberg J. Plasma lipids and lipoproteins in Greenlandic west coast Eskimos. Acta Med Scand 192 (1972) 85-94
6. Middaugh J.P. Cardiovascular deaths among Alaskan Natives, 1980-86. Am J Public Health 80 (1990) 282-285
7. Newman W.P., Middaugh J.P., Propst M.T., et al. Atherosclerosis in Alaska Natives and non-natives. Lancet 341 (1993) 1056-1057
8. Hirai A., Hamazaki T., Terano T., et al. Eicosapentaenoic acid and platelet function in Japanese. Lancet 2 (1980) 1132-1133
9. Kagawa Y., Nishizawa M., Suzuki M., et al. Eicosapolyenoic acids of serum lipids of Japanese islanders with low incidence of cardiovascular diseases. J Nutr Sci Vitaminol (Tokyo) 28 (1982) 441-453
10. Yamori Y., Nara Y., Iritani N., et al. Comparison of serum phospholipid fatty acids among fishing and farming Japanese populations and American inlanders. J Nutr Sci Vitaminol (Tokyo) 31 (1985) 417-422
11. Keys A. Seven countries: a multivariate analysis of death and coronary heart disease (1980), Harvard University Press, Cambridge, MA
12. Zhang J., Sasaki S., Amano K., et al. Fish consumption and mortality from all causes, ischemic heart disease, and stroke: an ecological study. Prev Med 28 (1999) 520-529
13. Schmidt E.B., and Dyerberg J. Omega-3 fatty acids. Current status in cardiovascular medicine. Drugs 47 (1994) 405-424
14. National Oceanic and Atmospheric Association (NOAA). Per capita fish consumption. http://www.st.nmfs.noaa.gov/st1/fus/fus05/08_perita2005.pdf Accessed on May 26, 2009
15. Wijendran V., and Hayes K.C. Dietary n-6 and n-3 fatty acid balance and cardiovascular health. Annu Rev Nutr 24 (2004) 597-615
16. Goyens P.L., Spilker M.E., Zock P.L., et al. Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses. J Lipid Res 46 (2005) 1474-1483
17. Kris-Etherton P.M., Harris W.S., and Appel L.J. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106 (2002) 2747-2757
18. Bucher H.C., Hengstler P., Schindler C., et al. N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med 112 (2002) 298-304
19. He K., Song Y., Daviglus M.L., et al. Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation 109 (2004) 2705-2711
20. Nestel P.J. Effects of N-3 fatty acids on lipid metabolism. Annu Rev Nutr 10 (1990) 149-167
21. Harris W.S. n-3 Fatty acids and serum lipoproteins: human studies. Am J Clin Nutr 65 (1997) 1645S-1654S
22. Phillipson B.E., Rothrock D.W., Connor W.E., et al. Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia. N Engl J Med 312 (1985) 1210-1216
23. Roche H.M., and Gibney M.J. Effect of long-chain n-3 polyunsaturated fatty acids on fasting and postprandial triacylglycerol metabolism. Am J Clin Nutr 71 (2000) 232S-237S
24. Kang J.X., and Leaf A. Antiarrhythmic effects of polyunsaturated fatty acids. Recent studies. Circulation 94 (1996) 1774-1780
25. Kang J.X., and Leaf A. Prevention of fatal cardiac arrhythmias by polyunsaturated fatty acids. Am J Clin Nutr 71 (2000) 202S-207S
26. Dyerberg J., Bang H.O., Stoffersen E., et al. Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis?. Lancet 2 (1978) 117-119
27. Leaf A., and Weber P.C. Cardiovascular effects of n-3 fatty acids. N Engl J Med 318 (1988) 549-557
28. James M.J., Gibson R.A., and Cleland L.G. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 71 (2000) 343S-348S
29. Pischon T., Hankinson S.E., Hotamisligil G.S., et al. Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation 108 (2003) 155-160
30. De Caterina R., Cybulsky M.I., Clinton S.K., et al. The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells. Arterioscler Thromb 14 (1994) 1829-1836
31. De Caterina R., Bernini W., Carluccio M.A., et al. Structural requirements for inhibition of cytokine-induced endothelial activation by unsaturated fatty acids. J Lipid Res 39 (1998) 1062-1070
32. von Schacky C., Angerer P., Kothny W., et al. The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 130 (1999) 554-562
33. Erkkila A.T., Lichtenstein A.H., Mozaffarian D., et al. Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease. Am J Clin Nutr 80 (2004) 626-632
34. Morris M.C., Sacks F., and Rosner B. Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation 88 (1993) 523-533
35. Eslick G.D., Howe P.R., Smith C., et al. Benefits of fish oil supplementation in hyperlipidemia: a systematic review and meta-analysis. Int J Cardiol (2008) [Epub ahead of print]
36. Waknine Y. FDA Approvals: Omacor, Nuflexxa, Combunox, and others. Medscape Today (2004). http://www.medscape.com/viewarticle/495709 Accessed on May 28, 2009
37. Munro J.M., and Cotran R.S. The pathogenesis of atherosclerosis: atherogenesis and inflammation. Lab Invest 58 (1988) 249-261
38. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362 (1993) 801-809
39. Nieminen M.S., Mattila K., and Valtonen V. Infection and inflammation as risk factors for myocardial infarction. Eur Heart J 14 Suppl K (1993) 12-16
40. Alexander R.W. Inflammation and coronary artery disease. N Engl J Med 331 (1994) 468-469
41. Calder P.C. Polyunsaturated fatty acids, inflammation, and immunity. Lipids 36 (2001) 1007-1024
42. Sanderson P., and Calder P.C. Dietary fish oil diminishes lymphocyte adhesion to macrophage and endothelial cell monolayers. Immunology 94 (1998) 79-87
43. Hughes D.A. Pinder AC: n-3 polyunsaturated fatty acids inhibit the antigen-presenting function of human monocytes. Am J Clin Nutr 71 (2000) 357S-360S
44. Miles E.A., Wallace F.A., and Calder P.C. Dietary fish oil reduces intercellular adhesion molecule 1 and scavenger receptor expression on murine macrophages. Atherosclerosis 152 (2000) 43-50
45. Collie-Duguid E.S., and Wahle K.W. Inhibitory effect of fish oil N-3 polyunsaturated fatty acids on the expression of endothelial cell adhesion molecules. Biochem Biophys Res Commun 220 (1996) 969-974
46. Lopez-Garcia E., Schulze M.B., Manson J.E., et al. Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women. J Nutr 134 (2004) 1806-1811
47. Niu K., Hozawa A., Kuriyama S., et al. Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products. Am J Clin Nutr 84 (2006) 223-229
48. Fernandez-Real J.M., Broch M., Vendrell J., et al. Insulin resistance, inflammation, and serum fatty acid composition. Diabetes Care 26 (2003) 1362-1368
49. Madsen T., Skou H.A., Hansen V.E., et al. C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease. Am J Cardiol 88 (2001) 1139-1142
50. Zampelas A., Panagiotakos D.B., Pitsavos C., et al. Fish consumption among healthy adults is associated with decreased levels of inflammatory markers related to cardiovascular disease: the ATTICA study. J Am Coll Cardiol 46 (2005) 120-124
51. He K., Liu K., Daviglus M.L., et al. Associations of dietary long-chain n-3 polyunsaturated fatty acids and fish with biomarkers of inflammation and endothelial activation (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Am J Cardiol 103 (2009) 1238-1243
52. Hjerkinn E.M., Seljeflot I., Ellingsen I., et al. Influence of long-term intervention with dietary counseling, long-chain n-3 fatty acid supplements, or both on circulating markers of endothelial activation in men with long-standing hyperlipidemia. Am J Clin Nutr 81 (2005) 583-589
53. Seierstad S.L., Seljeflot I., Johansen O., et al. Dietary intake of differently fed salmon; the influence on markers of human atherosclerosis. Eur J Clin Invest 35 (2005) 52-59
54. Grundt H., Nilsen D.W., Mansoor M.A., et al. Reduction in homocysteine by n-3 polyunsaturated fatty acids after 1 year in a randomised double-blind study following an acute myocardial infarction: no effect on endothelial adhesion properties. Pathophysiol Haemost Thromb 33 (2003) 88-95
55. Lee K.W., Blann A.D., and Lip G.Y. Effects of omega-3 polyunsaturated fatty acids on plasma indices of thrombogenesis and inflammation in patients post-myocardial infarction. Thromb Res 118 (2006) 305-312
56. Johansen O., Seljeflot I., Hostmark A.T., et al. The effect of supplementation with omega-3 fatty acids on soluble markers of endothelial function in patients with coronary heart disease. Arterioscler Thromb Vasc Biol 19 (1999) 1681-1686
57. Berstad P., Seljeflot I., Veierod M.B., et al. Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. Clin Sci (Lond) 105 (2003) 13-20
58. Reis G.J., Silverman D.I., Boucher T.M., et al. Effects of two types of fish oil supplements on serum lipids and plasma phospholipid fatty acids in coronary artery disease. Am J Cardiol 66 (1990) 1171-1175
59. Fumeron F., Brigant L., Ollivier V., et al. n-3 Polyunsaturated fatty acids raise low-density lipoproteins, high-density lipoprotein 2, and plasminogen-activator inhibitor in healthy young men. Am J Clin Nutr 54 (1991) 118-122
60. Harats D., Dabach Y., Hollander G., et al. Fish oil ingestion in smokers and nonsmokers enhances peroxidation of plasma lipoproteins. Atherosclerosis 90 (1991) 127-139
61. Whitman S.C., Fish J.R., Rand M.L., et al. n-3 Fatty acid incorporation into LDL particles renders them more susceptible to oxidation in vitro but not necessarily more atherogenic in vivo. Arterioscler Thromb 14 (1994) 1170-1176
62. Harker L.A., Kelly A.B., Hanson S.R., et al. Interruption of vascular thrombus formation and vascular lesion formation by dietary n-3 fatty acids in fish oil in nonhuman primates. Circulation 87 (1993) 1017-1029
63. Rich S., Miller Jr. J.F., Charous S., et al. Development of atherosclerosis in genetically hyperlipidemic rabbits during chronic fish-oil ingestion. Arteriosclerosis 9 (1989) 189-194
64. Fincham J.E., Gouws E., Woodroof C.W., et al. Atherosclerosis. Chronic effects of fish oil and a therapeutic diet in nonhuman primates. Arterioscler Thromb 11 (1991) 719-732
65. Sacks F.M., Stone P.H., Gibson C.M., et al. Controlled trial of fish oil for regression of human coronary atherosclerosis. HARP Research Group. J Am Coll Cardiol 25 (1995) 1492-1498
66. Angerer P., Kothny W., Stork S., et al. Effect of dietary supplementation with omega-3 fatty acids on progression of atherosclerosis in carotid arteries. Cardiovasc Res 54 (2002) 183-190
67. Yamada T., Strong J.P., Ishii T., et al. Atherosclerosis and omega-3 fatty acids in the populations of a fishing village and a farming village in Japan. Atherosclerosis 153 (2000) 469-481
68. He K., Liu K., Daviglus M.L., et al. Intakes of long-chain n-3 polyunsaturated fatty acids and fish in relation to measurements of subclinical atherosclerosis. Am J Clin Nutr 88 (2008) 1111-1118
69. De Caterina R., Spiecker M., Solaini G., et al. The inhibition of endothelial activation by unsaturated fatty acids. Lipids 34 Suppl (1993) S191-S194
70. De Caterina R., and Zampolli A. n-3 Fatty acids: antiatherosclerotic effects. Lipids 36 Suppl (2001) S69-S78
71. Kristensen S.D., Schmidt E.B., and Dyerberg J. Dietary supplementation with n-3 polyunsaturated fatty acids and human platelet function: a review with particular emphasis on implications for cardiovascular disease. J Intern Med Suppl 225 (1989) 141-150
72. Scheurlen M., Kirchner M., Clemens M.R., et al. Fish oil preparations rich in docosahexaenoic acid modify platelet responsiveness to prostaglandin-endoperoxide/thromboxane A2 receptor agonists. Biochem Pharmacol 46 (1993) 245-249
73. Huikuri H.V., Castellanos A., and Myerburg R.J. Sudden death due to cardiac arrhythmias. N Engl J Med 345 (2001) 1473-1482
74. Das U.N. Prostacyclin as an endogenous anti-arrhythmic agent. Basic Res Cardiol 78 (1983) 716-718
75. McMillin J.B., Bick R.J., and Benedict C.R. Influence of dietary fish oil on mitochondrial function and response to ischemia. Am J Physiol 263 (1992) H1479-H1485
76. Matthan N.R., Jordan H., Chung M., et al. A systematic review and meta-analysis of the impact of omega-3 fatty acids on selected arrhythmia outcomes in animal models. Metabolism 54 (2005) 1557-1565
77. Hock C.E., Beck L.D., Bodine R.C., et al. Influence of dietary n-3 fatty acids on myocardial ischemia and reperfusion. Am J Physiol 259 (1990) H1518-H1526
78. Otsuji S., Shibata N., Hirota H., et al. Highly purified eicosapentaenoic acid attenuates tissue damage in experimental myocardial infarction. Jpn Circ J 57 (1993) 335-343
79. Hock C.E., Holahan M.A., and Reibel D.K. Effect of dietary fish oil on myocardial phospholipids and myocardial ischemic damage. Am J Physiol 252 (1987) H554-H560
80. Culp B.R., Lands W.E., Lucches B.R., et al. The effect of dietary supplementation of fish oil on experimental myocardial infarction. Prostaglandins 20 (1980) 1021-1031
81. Hartog J.M., Lamers J.M., Achterberg P.W., et al. The effects of dietary mackerel oil on the recovery of cardiac function after acute ischaemic events in the pig. Basic Res Cardiol 82 (1987) S223-S234
82. McLennan P.L., Abeywardena M.Y., and Charnock J.S. Dietary fish oil prevents ventricular fibrillation following coronary artery occlusion and reperfusion. Am Heart J 116 (1988) 709-717
83. McLennan P.L., Abeywardena M.Y., and Charnock J.S. Reversal of the arrhythmogenic effects of long-term saturated fatty acid intake by dietary n-3 and n-6 polyunsaturated fatty acids. Am J Clin Nutr 51 (1990) 53-58
84. McLennan P.L. Relative effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on cardiac arrhythmias in rats. Am J Clin Nutr 57 (1993) 207-212
85. Chen M.F., Hsu H.C., and Lee Y.T. Effects of fish oil supplementation on the changes in myocardial cyclic adenosine monophosphate, inositol 1,4,5-triphosphate and mitochondrial calcium levels during acute coronary occlusion-reperfusion in cholesterol-fed rabbits. Int J Cardiol 46 (1994) 23-31
86. Whelton S.P., He J., and Whelton P.K. Meta-analysis of observational studies on fish intake and coronary heart disease. Am J Cardiol 93 (2004) 1119-1123
87. Albert C.M., Hennekens C.H., O'Donnell C.J., et al. Fish consumption and risk of sudden cardiac death. Jama 279 (1998) 23-28
88. Albert C.M., Campos H., Stampfer M.J., et al. Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med 346 (2002) 1113-1118
89. Engler M.M., Engler M.B., Pierson D.M., et al. Effects of docosahexaenoic acid on vascular pathology and reactivity in hypertension. Exp Biol Med (Maywood) 228 (2003) 299-307
90. Engler M.M., Engler M.B., Goodfriend T.L., et al. Docosahexaenoic acid is an antihypertensive nutrient that affects aldosterone production in SHR. Proc Soc Exp Biol Med 221 (1999) 32-38
91. Appel L.J., Miller III E.R., Seidler A.J., et al. Does supplementation of diet with 'fish oil' reduce blood pressure? A meta-analysis of controlled clinical trials. Arch Intern Med 153 (1993) 1429-1438
92. Geleijnse J.M., Giltay E.J., Grobbee D.E., et al. Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens 20 (2002) 1493-1499
93. Salonen J.T., Salonen R., Ihanainen M., et al. Blood pressure, dietary fats, and antioxidants. Am J Clin Nutr 48 (1988) 1226-1232
94. Ueshima H., Stamler J., Elliott P., et al. Food omega-3 fatty acid intake of individuals (total, linolenic acid, long-chain) and their blood pressure: INTERMAP study. Hypertension 50 (2007) 313-319
95. Gramenzi A., Gentile A., Fasoli M., et al. Association between certain foods and risk of acute myocardial infarction in women. BMJ 300 (1990) 771-773
96. Sasazuki S. Case-control study of nonfatal myocardial infarction in relation to selected foods in Japanese men and women. Jpn Circ J 65 (2001) 200-206
97. Tavani A., Pelucchi C., Negri E., et al. n-3 Polyunsaturated fatty acids, fish, and nonfatal acute myocardial infarction. Circulation 104 (2001) 2269-2272
98. Martinez-Gonzalez M.A., Fernandez-Jarne E., Serrano-Martinez M., et al. Mediterranean diet and reduction in the risk of a first acute myocardial infarction: an operational healthy dietary score. Eur J Nutr 41 (2002) 153-160
99. Järvinen R., Knekt P., Rissanen H., et al. Intake of fish and long-chain n-3 fatty acids and the risk of coronary heart mortality in men and women. Br J Nutr 95 (2006) 824-829
100. Mozaffarian D., Lemaitre R.N., Kuller L.H., et al. Cardiac benefits of fish consumption may depend on the type of fish meal consumed: the Cardiovascular Health Study. Circulation 107 (2003) 1372-1377
101. Daviglus M.L., Stamler J., Orencia A.J., et al. Fish consumption and the 30-year risk of fatal myocardial infarction. N Engl J Med 336 (1997) 1046-1053
102. Dolecek T.A., and Granditis G. Dietary polyunsaturated fatty acids and mortality in the Multiple Risk Factor Intervention Trial (MRFIT). World Rev Nutr Diet 66 (1991) 205-216
103. Kromhout D., Feskens E.J., and Bowles C.H. The protective effect of a small amount of fish on coronary heart disease mortality in an elderly population. Int J Epidemiol 24 (1995) 340-345
104. Rodriguez B.L., Sharp D.S., Abbott R.D., et al. Fish intake may limit the increase in risk of coronary heart disease morbidity and mortality among heavy smokers. The Honolulu Heart Program. Circulation 94 (1996) 952-956
105. Yuan J.M., Ross R.K., Gao Y.T., et al. Fish and shellfish consumption in relation to death from myocardial infarction among men in Shanghai, China. Am J Epidemiol 154 (2001) 809-816
106. Hu F.B., Bronner L., Willett W.C., et al. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. Jama 287 (2002) 1815-1821
107. Kromhout D., Bosschieter E.B., and de Lezenne Coulander C. The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med 312 (1985) 1205-1209
108. Norell S.E., Ahlbom A., Feychting M., et al. Fish consumption and mortality from coronary heart disease. Br Med J (Clin Res Ed) 293 (1986) 426
109. Fraser G.E., Sabate J., Beeson W.L., et al. A possible protective effect of nut consumption on risk of coronary heart disease. The Adventist Health Study. Arch Intern Med 152 (1992) 1416-1424
110. Ascherio A., Rimm E.B., Stampfer M.J., et al. Dietary intake of marine n-3 fatty acids, fish intake, and the risk of coronary disease among men. N Engl J Med 332 (1995) 977-982
111. Mann J.I., Appleby P.N., Key T.J., et al. Dietary determinants of ischaemic heart disease in health conscious individuals. Heart 78 (1997) 450-455
112. Oomen C.M., Feskens E.J., Rasanen L., et al. Fish consumption and coronary heart disease mortality in Finland, Italy, and The Netherlands. Am J Epidemiol 151 (2000) 999-1006
113. Osler M., Andreasen A.H., and Hoidrup S. No inverse association between fish consumption and risk of death from all-causes, and incidence of coronary heart disease in middle-aged, Danish adults. J Clin Epidemiol 56 (2003) 274-279
114. Folsom A.R., and Demissie Z. Fish intake, marine omega-3 fatty acids, and mortality in a cohort of postmenopausal women. Am J Epidemiol 160 (2004) 1005-1010
115. Nakamura Y., Ueshima H., Okamura T., et al. Association between fish consumption and all-cause and cause-specific mortality in Japan: NIPPON DATA80, 1980-99. Am J Med 118 (2005) 239-245
116. Iso H., Kobayashi M., Ishihara J., et al. Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese: the Japan Public Health Center-Based (JPHC) Study Cohort I. Circulation 113 (2006) 195-202
117. Streppel M.T., Ocke M.C., Boshuizen H.C., et al. Long-term fish consumption and n-3 fatty acid intake in relation to (sudden) coronary heart disease death: the Zutphen study. Eur Heart J 29 (2008) 2024-2030
118. Salonen J.T., Nyyssonen K., and Salonen R. Fish intake and the risk of coronary disease. N Engl J Med 333 (1995) 937
119. Konig A., Bouzan C., Cohen J.T., et al. A quantitative analysis of fish consumption and coronary heart disease mortality. Am J Prev Med 29 (2005) 335-346
120. Hooper L., Thompson R.L., Harrison R.A., et al. Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. BMJ 332 (2005) 752-760
121. He K., and Song Y.Q. Risks and benefits of omega 3 fats: a few thoughts on systematic review. BMJ 332 (2006) 915-916
122. Geleijnse J.M., Brouwer I.A., and Feskens E.J. Risks and benefits of omega 3 fats: health benefits of omega 3 fats are in doubt. BMJ 332 (2006) 915-916
123. Burr M.L., Fehily A.M., Gilbert J.F., et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 2 (1989) 757-761
124. Burr M.L., Ashfield-Watt P.A., Dunstan F.D., et al. Lack of benefit of dietary advice to men with angina: results of a controlled trial. Eur J Clin Nutr 57 (2003) 193-200
125. Marchioli R., Barzi F., Bomba E., et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation 105 (2002) 1897-1903
126. Yokoyama M., Origasa H., Matsuzaki M., et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 369 (2007) 1090-1098
127. Hamazaki T. The first randomized clinical trial of 2 y to prevent reinfarction with fish oil. Eur J Clin Nutr 58 (2004) 1557
128. Kris-Etherton P.M., and Harris W.S. Adverse effect of fish oils in patients with angina?. Curr Atheroscler Rep 6 (2004) 413-414
129. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet 354 (1999) 447-455
130. Gillum R.F., Mussolino M.E., and Madans J.H. The relationship between fish consumption and stroke incidence. The NHANES I Epidemiologic Follow-up Study (National Health and Nutrition Examination Survey). Arch Intern Med 156 (1996) 537-542
131. Iso H., Rexrode K.M., Stampfer M.J., et al. Intake of fish and omega-3 fatty acids and risk of stroke in women. Jama 285 (2001) 304-312
132. He K., Rimm E.B., Merchant A., et al. Fish consumption and risk of stroke in men. Jama 288 (2002) 3130-3136
133. Sauvaget C., Nagano J., Allen N., et al. Intake of animal products and stroke mortality in the Hiroshima/Nagasaki Life Span Study. Int J Epidemiol 32 (2003) 536-543
134. Mozaffarian D., Longstreth Jr. W.T., Lemaitre R.N., et al. Fish consumption and stroke risk in elderly individuals: the cardiovascular health study. Arch Intern Med 165 (2005) 200-206
135. Keli S.O., Feskens E.J., and Kromhout D. Fish consumption and risk of stroke. The Zutphen Study. Stroke 25 (1994) 328-332
136. Morris M.C., Manson J.E., Rosner B., et al. Fish consumption and cardiovascular disease in the physicians' health study: a prospective study. Am J Epidemiol 142 (1995) 166-175
137. Orencia A.J., Daviglus M.L., Dyer A.R., et al. Fish consumption and stroke in men. 30-year findings of the Chicago Western Electric Study. Stroke 27 (1996) 204-209
138. Myint P.K., Welch A.A., Bingham S.A., et al. Habitual fish consumption and risk of incident stroke: the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study. Public Health Nutr 9 (2006) 882-888
139. Yamagishi K., Iso H., Date C., et al. Fish, omega-3 polyunsaturated fatty acids, and mortality from cardiovascular diseases in a nationwide community-based cohort of Japanese men and women the JACC (Japan Collaborative Cohort Study for Evaluation of Cancer Risk) Study. J Am Coll Cardiol 52 (2008) 988-996
140. Montonen J., Jarvinen R., Reunanen A., et al. Fish consumption and the incidence of cerebrovascular disease. Br J Nutr 100 (2009) 1-7
141. Caicoya M. Fish consumption and stroke: a community case-control study in Asturias, Spain. Neuroepidemiology 21 (2002) 107-114
142. Wennberg M., Bergdahl I.A., Stegmayr B., et al. Fish intake, mercury, long-chain n-3 polyunsaturated fatty acids and risk of stroke in northern Sweden. Br J Nutr 98 (2007) 1038-1045
143. Bravata D.M., Wells C.K., Brass L.M., et al. Dietary fish or seafood consumption is not related to cerebrovascular disease risk in twin veterans. Neuroepidemiology 28 (2007) 186-190
144. He K., Song Y., Daviglus M.L., et al. Fish consumption and incidence of stroke: a meta-analysis of cohort studies. Stroke 35 (2004) 1538-1542
145. Sabry J.H. Nutritional aspects of fish consumption. A report prepared for the National Institute of Nutrition (1990) Ottawa, Canada
146. Sheeshka J., and Murkin E. Nutritional aspects of fish compared with other protein sources. Comments Toxicol 8 (2002) 375-397
147. Liu L., Mizushima S., Ikeda K., et al. Comparative studies of diet-related factors and blood pressure among Chinese and Japanese: results from the China-Japan Cooperative Research of the WHO-CARDIAC Study. Cardiovascular disease and alimentary comparison. Hypertens Res 23 (2000) 413-420
148. Oudit G.Y., Trivieri M.G., Khaper N., et al. Taurine supplementation reduces oxidative stress and improves cardiovascular function in an iron-overload murine model. Circulation 109 (2004) 1877-1885
149. Chen W., Matuda K., Nishimura N., et al. The effect of taurine on cholesterol degradation in mice fed a high-cholesterol diet. Life Sci 74 (2004) 1889-1898
150. Militante J.D., and Lombardini J.B. Treatment of hypertension with oral taurine: experimental and clinical studies. Amino Acids 23 (2002) 381-393
151. Yamori Y., Liu L., Ikeda K., et al. Distribution of twenty-four hour urinary taurine excretion and association with ischemic heart disease mortality in 24 populations of 16 countries: results from the WHO-CARDIAC study. Hypertens Res 24 (2001) 453-457
152. Moncada S., and Higgs A. The l-arginine-nitric oxide pathway. N Engl J Med 329 (1993) 2002-2012
153. Hansen J.C., Pedersen H.S., and Mulvad G. Fatty acids and antioxidants in the Inuit diet. Their role in ischemic heart disease (IHD) and possible interactions with other dietary factors. A review. Arctic Med Res 53 (1994) 4-17
154. van Mierlo L.A., Arends L.R., Streppel M.T., et al. Blood pressure response to calcium supplementation: a meta-analysis of randomized controlled trials. J Hum Hypertens 20 (2006) 571-580
155. US Department of Agriculture. Agricultural Research Service. USDA National Nutrient Database for Standard Reference - Release 18 (2006), US Department of Agriculture, Washington DC
156. Hites R.A., Foran J.A., Carpenter D.O., et al. Global assessment of organic contaminants in farmed salmon. Science 303 (2004) 226-229
157. USDA: Nutrient Data Laboratory. Agricultural Research Service, Beltsville Human Nutrition Research Center, 2006, http://www.nal.usda.gov/fnic/foodcomp/, Accessed on May 27, 2009.
158. Mozaffarian D., Psaty B.M., Rimm E.B., et al. Fish intake and risk of incident atrial fibrillation. Circulation 110 (2004) 368-373
159. Echarte M., Zulet M.A., and Astiasaran I. Oxidation process affecting fatty acids and cholesterol in fried and roasted salmon. J Agric Food Chem 49 (2001) 5662-5667