The effect of dietary ω-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial

Annals of Internal Medicine

Volumn 130, Issue 7, 1999, Pages 554-562

  Von Schacky, Clemens ^a,b   Angerer, Peter ^a,b   Kothny, Wolfgang ^a,b   Theisen, Karl ^a,b   Mudra, Harald ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GLYCERYL TRINITRATE; LOW DENSITY LIPOPROTEIN; NITRATE; OMEGA 3 FATTY ACID;

ADULT; ANGIOCARDIOGRAPHY; ARTICLE; ATHEROGENESIS; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; DISEASE COURSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; FAT INTAKE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT SELECTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REMISSION; TREATMENT OUTCOME;

EID: 0033528646     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-130-7-199904060-00003     Document Type: Article

References (35)

1. von Schacky C. Prophylaxis of atherosclerosis with marine omega-3 fatty acids. A comprehensive strategy. Ann Intern Med. 1987;107:890-9.
2. Dolecek TA. Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the multiple risk factor intervention trial. Proc Soc Exp Biol Med. 1992;200:177-82.
3. Albert CM, Hennekens CH, O'Donnell CJ, Ajani UA, Carey VJ, Willett WC, et al. Fish consumption and risk of sudden cardiac death. JAMA. 1998; 279:23-8.
4. Siscovick DS, Raghunathan TE, King I, Weinmann S, Wicklund KG, Albright J, et al. Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. JAMA. 1995;274:1363-7.
5. Daviglus ML, Stamler J, Orencia AJ, Dyer AR, Liu K, Greenland P, et al. Fish consumption and the 30-year risk of fatal myocardial infarction. N Engl J Med. 1997;336:1046-53.
6. Dyerberg J, Bang HO. Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet. 1979;324:433-5
7. Kaminski WE, Jendraschak E, Kiefl R, von Schacky C. Dietary omega-3 fatty acids lower levels of platelet-derived growth factor mRNA in human mononuclear cells. Blood. 1993;81:1871-9.
8. Endres S, von Schacky C. n-3 polyunsaturated fatty acids and human cytokine synthesis. Curr Opin Lipidol. 1996;7:48-52.
9. von Schacky C. Cardiovascular effects of n-3 fatty acids. In: Frölich JC, von Schacky C, eds. Fish, Fish Oil, and Human Health. Munich: Zuckschwerdt Verlag; 1992:157-78.
10. Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, Sweetnam PM, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet. 1989;334:757-61.
11. Gapinski JP, VanRuiswyk JV, Heudebert GR, Schectman GS. Preventing restenosis with fish oils following coronary angioplasty. A meta-analysis. Arch Intern Med. 1993;153:1595-1601.
12. Leaf A, Jorgensen MB, Jacobs AK, Cote G, Schoenfeld DA, Scheer J, et al. Do fish oils prevent restenosis after coronary angioplasty? Circulation. 1994;90:2248-57.
13. Cairns JA, Gill J, Morton B, Roberts R, Gent M, Hirsh J, et al. Fish oils and low-molecular-weight heparin for the reduction of restenosis after percutaneous transluminal coronary angioplasty. The EMPAR Study. Circulation 1996;94:1553-60.
14. Eritsland J, Arnesen H, Gronseth K, Fjeld NB, Abdelnoor M. Effect of dietary supplementation with n-3 fatty acids on coronary artery bypass graft patency. Am J Cardiol. 1996;77:31-6.
15. Sacks FM, Stone PH, Gibson CM, Silverman DI, Rosner B, Pasternak RC. Controlled trial of fish oil for regression of human coronary atherosclerosis. HARP Research Group. J Am Coll Cardiol. 1995;25:1492-8.
16. Bull ML, Day MJ, Burt R, Buss DH. Individual fatty acids in the British household food supply. Hum Nutr Appl Nutr. 1983;37:373-7.
17. Mudra H, Klauss V, Blasini R, Kroetz M, Rieber J, Regar E, et al. Ultrasound guidance of Palmaz-Schatz intracoronary stenting with a combined intravascular ultrasound balloon catheter. Circulation. 1994;90:1252-61.
18. Reiber JH, Serruys PW. Quantitative coronary angiography. In: Marcus ML, Schelbert HR, Skorton DJ, Wolf GL, eds. Cardiac Imaging: A Companion to Braunwald's Heart Disease. Philadelphia: WB Saunders; 1991:211-80.
19. Rozenman Y, Gilon D, Welber S, Sapoznikov D, Lotan C, Mosseri M, et al. Influence of coronary angioplasty on the progression of coronary atherosclerosis. Am J Cardiol. 1995;76:1126-30.
20. Blankenhorn DH, Selzer RH, Mack WJ, Crawford DW, Pogoda J, Lee PL, et al. Evaluation of colestipol/niacin therapy with computer-derived coronary end point measures. A comparison of different measures of treatment effect. Circulation. 1992;86:1701-9.
21. Hausleiter J, Jost S, Nohe CW, Dirschinger J, Kastrati A, Stiel GM, et al. Comparative in-vitro validation of eight first- and second-generation quantitative coronary angiography systems. Coron Artery Dis. 1997;8:83-90.
22. von Schacky C, Fischer S, Weber PC. Long-term effects of dietary marine ω-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. J Clin Invest. 1985;76:1626-31.
23. Olsen SF, Hansen HS, Sandstrom B, Jensen B. Erythrocyte levels compared with reported dietary intake of marine n-3 fatty acids in pregnant women. Br J Nutr. 1995;73:387-95.
24. Blankenhorn DH, Nessim SA, Johnson RL, Sanmarco ME, Azen SP, Cashin-Hemphill L. Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts. JAMA. 1987; 257:3233-40.
25. Waters D, Higginson L, Gladstone P, Kimball B, Le May M, Boccuzzi SJ, et al. Effects of monotherapy with an HMG-CoA reductase inhibitor on the progression of coronary atherosclerosis as assessed by serial quantitative arteriography. The Canadian Coronary Atherosclerosis Intervention Trial. Circulation. 1994;89:959-69.
26. Brown BG, Zhao XQ, Poulin D, Albers JJ. Regression of atherosclerosis Does it occur and does it have clinical meaning? Eur Heart J. 1995;16(Suppl E):2-5.
27. Jukema JW, Bruschke AV, van Boven AJ, Reiber JH, Bal ET, Zwinderman AH, et al. Effects of lipid lowering by pravastatin on progression and regression of coronary artery disease in symptomatic men with normal to moderately elevated serum cholesterol levels. The Regression Growth Evaluation Statin Study (REGRESS). Circulation. 1995;91:2528-40.
28. Ornish D, Brown SE, Scherwitz LW, Billings JH, Armstrong WT, Ports TA, et al. Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial. Lancet. 1990;336:129-33.
29. Haskell WL, Alderman EL, Fair JM, Maron DJ, Mackey SF, Superko HR, et al. Effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease. The Standford Risk Intervention Project (SCRIP). Circulation. 1994;89: 975-90.
30. Hambrecht R, Niebauer J, Marburger C, Grunze M, Kalberer B, Hauer K, et al. Various intensities of leisure time physical activity in patients with coronary artery disease: effects on cardiorespiratory fitness and progression of coronary atherosclerotic lesions. J Am Coll Cardiol. 1993;22:468-77.
31. Kothny W, Angerer P, Störk S, von Schacky C. Short term effects of ω-3 fatty acids on the radial artery of patients with coronary artery disease. Atherosclerosis. 1998;140:181-6.
32. Smith SC Jr, Blair SN, Criqui MH, Fletcher GF, Fuster V, Gersh BJ, et al. Preventing heart attack and death in patients with coronary disease. Circulation. 1995;92:2-4.
33. Harris WS. n-3 fatty acids and serum lipoproteins: human studies. Am J Clin Nutr. 1997;65:1645S-54S.
34. Baumann KH, Hessel F, Larass I, Müller T, Angerer P, Kiefl R, et al. Dietary ω-3, ω-6, and ω-9 unsaturated fatty acids and growth factor and cytokine gene expression in unstimulated and stimulated monocytes: a randomized volunteer study. Arterioscler Thromb Vasc Biol. 1999;19:59-66.
35. Fox PL, DiCorleto PE. Fish oils inhibit endothelial cell production of platelet-derived growth factor-like protein. Science. 1988;241:453-6.