n-3 Fatty acids and serum lipoproteins: Human studies

American Journal of Clinical Nutrition

Volumn 65, Issue 5 SUPPL., 1997, Pages

  Harris, William S ^a,b  

^a SAINT LUKE S MID AMERICA HEART INSTITUTE   (United States)

^b ST LUKE S HOSPITAL   (United States)

Author keywords

cholesterol; docosahexaenoic acid; Eicosapentaenoic acid; fish oil; high density lipoproteins; low density lipoproteins; marine oil; n 3 fatty acids; plant oil; triacylglycerol

Indexed keywords

CHOLESTEROL; DOCOSAHEXAENOIC ACID; FATTY ACID; FISH OIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ICOSAPENTAENOIC ACID; LINOLENIC ACID; LINSEED OIL; LIPID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; SAFFLOWER OIL; SUNFLOWER OIL; TRIACYLGLYCEROL; VEGETABLE OIL;

CLINICAL TRIAL; CONFERENCE PAPER; CROSSOVER PROCEDURE; FAT INTAKE; HUMAN; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM;

CARTHAMUS TINCTORIUS; HELIANTHUS;

EID: 0030974010     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/65.5.1645S     Document Type: Conference Paper

References (83)

1. Bang HO, Dyerberg J. Lipid metabolism and ischemic heart disease in Greenland Eskimos. In: Draper H, ed. Advances in nutrition research. New York: Plenum Press, 1980:1-22.
2. Bronsgeest-Schoute HC, van Gent CM, Luten JB, Ruiter A. The effect of various intakes of ω3 fatty acids on the blood lipid composition in healthy human subjects. Am J Clin Nutr 1981;34:1752-7.
3. Harris WS, Connor WE. The effects of salmon oil upon plasma lipids, lipoproteins and triglyceride clearance. Trans Assoc Am Physicians 1980;43:148-55.
4. Harris WS, Connor WE, McMurry MP. The comparative reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats: salmon oil versus vegetable oils. Metabolism 1983;32:179-84.
5. Siscovick DS, Raghunathan TE, King I, et al. Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. JAMA 1995;274:1363-7.
6. Shekelle RB, Missell LV, Paul O, Shryock AM, Stamler J. Fish consumption and mortality from coronary heart disease. N Engl J Med 1985;313:820 (letter).
7. Burr ML, Fehily AM, Gilbert JF, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 1989;2:757-61.
8. Mantzioris E, James MJ, Gibson RA, Cleland LG. Dietary substitution with an α-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. Am J Clin Nutr 1994;59:1304-9.
9. Singer P, Berger I, Wirth M, Godicke W, Jaeger W, Voigt S. Slow desaturation and elongation of linoleic and α-linolenic acids as a rationale of eicosapentaenoic acid-rich diet to lower blood pressure and serum lipids in normal, hypertensive and hyperlipemic subjects. Prostaglandins Leukot Med 1986;24:173-93.
10. Abbey M, Clifton P, Kestin M, Belling B, Nestel P. Effect of fish oil on lipoproteins, lecithin:cholesterol acyltransferase, and lipid transfer protein activity in humans. Arteriosclerosis 1990;10:85-94.
11. Harris WS. Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review. J Lipid Res 1989;30:785-807.
12. Leaf DA, Connor WE, Illingworth DR, Bacon SP, Sexton G. The hypolipidemic effects of gemfibrozil in type V hyperlipidemia. JAMA 1989;262:3154-60.
13. Dolecek TA, Grandits G. Dietary polyunsaturated fatty acids and mortality in the Multiple Risk Factor Intervention Trial. World Rev Nutr Diet 1991;66:205-16.
14. Leaf A, Weber PC. Cardiovascular effects of omega-3 fatty acids. N Engl J Med 1988;318:549-57.
15. Endres S, Ghorbani R, Kelley VE, et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989;320:265-71.
16. Knapp HR, Miller AJ, Lawson JA. Urinary excretion of diols derived from eicosapentaenoic acid during n-3 fatty acid ingestion by man. Prostaglandins 1991;42:47-54.
17. von Schacky C. Prophylaxis of atherosclerosis with marine omega-3 fatty acids. Ann Intern Med 1987;107:890-9.
18. Eritsland J, Arnesen H, Seljeflot I, Høstmark AT. Long-term metabolic effects of n-3 polyunsaturated fatty acids in patients with coronary artery disease. Am J Clin Nutr 1994;61:831-6.
19. Haines AP, Sanders TAB, Imeson JD, et al. Effects of a fish oil supplement on platelet function, haemostatic variables and albuminuria in insulin-dependent diabetics. Thromb Res 1986;43:643-55.
20. Bhathena SJ, Berlin E, Judd JT, et al. Effects of ω3 fatty acids and vitamin E on hormones involved in carbohydrate and lipid metabolism in men. Am J Clin Nutr 1991;54:684-8.
21. Sanders TAB, Hochland MC. A comparison of the influence on plasma lipids and platelet function of supplements of ω3 and ω6 poylunsaturated fatty acids. Br J Nutr 1983;50:521-9.
22. Fehily AM, Burr ML, Phillips KM, Deadman NM. The effect of fatty fish on plasma lipid and lipoprotein concentrations. Am J Clin Nutr 1983;38:349-51.
23. Lindgren FT, Adamson GL, Shore VG, Nelson GJ, Schmidt PC. Effect of a salmon diet on the distribution of plasma lipoproteins and apolipoproteins in normolipidemic adult men. Lipids 1991;26:97-101.
24. von Lossonczy TO, Ruiter A, Bronsgeest-Schoute HC, van Gent CM, Hermus RJJ. The effect of a fish diet on serum lipids in healthy human subjects. Am J Clin Nutr 1978;31:1340-6.
25. Tidwell DK, McNaughton JP, Pellum LK, McLaurin BP, Chen SC. Comparison of the effects of adding fish high or low in n-3 fatty acids to a diet conforming to the dietary guidelines for Americans. J Am Diet Assoc 1991;93:1124-8.
26. Atkinson PM, Wheeler MC, Mendelsohn D, Pienaar N, Chetty N. Effects of a 4-week freshwater fish (trout) diet on platelet aggregation, platelet fatty acids, serum lipids and coagulation factors. Am J Hematol 1987;24:143-9.
27. Jacques H, Noreau L, Moorjani S. Effects on plasma lipoproteins and endogenous sex hormones of substituting lean white fish for other animal-protein sources in diets of postmenopausal women. Am J Clin Nutr 1992;55:896-901.
28. Bang HO, Dyerberg J. Letter to the editor. N Engl J Med 1985;313:822-3.
29. Sztern MI, Harris WS. Short-term effects of fish oil on human plasma lipid levels. J Nutr Biochem 1991;2:255-9.
30. Clark WF, Parbtani A, Naylor CD, et al. Fish oil in lupus nephritis: clinical findings and methodological implications. Kidney Int 1993;44:75-86.
31. Hughes GS, Ringer TV, Watts KC, DeLoof MJ, Francom SF, Spillers CR. Fish oil produces an atherogenic lipid profile in hypertensive men. Atherosclerosis 1990;84:229-37.
32. Jensen T, Stender S, Goldstein K, Holmer G, Deckert T. Partial normalization by dietary cod-liver oil of increased microvascular albumin leakage in patients with insulin-dependent diabetes and albuminuria. N Engl J Med 1989;321:1572-7.
33. Lungerhausen YK, Abbey M, Nestel PJ, Howe PRC. Reduction of blood pressure and plasma triglycerides by omega-3 fatty acids in treated hypertensives. J Hypertens 1994;12:1041-5.
34. Oosthuizen W, Vorster HH, Jerling JC, et al. Both fish oil and olive oil lowered plasma fibrinogen in women with high baseline fibrinogen levels. Thromb Haemost 1994;72:557-62.
35. Rillaerts EG, Engelmann GJ, Van Camp KM, De Leeuw I. Effect of omega-3 fatty acids in diet of type I diabetic subjects on lipid values and hemorheological parameters. Diabetes 1989;38:1412-6.
36. Valdini AF, Glenn MA, Greenblatt L, Steinhardt S. Efficacy of fish oil supplementation for treatment of moderate elevation of serum cholesterol. J Fam Pract 1990;30:55-9.
37. Wilt TJ, Lofgren RP, Nichol KL, et al. Fish oil supplementation does not lower plasma cholesterol in men with hypercholesterolemia. Ann Intern Med 1989;111:900-5.
38. Wojenski CM, Silver MJ, Walker J. Eicosapentaenoic acid ethyl ester as an antithrombotic agent: comparison to an extract of fish oil. Biochim Biophys Acta 1991;1081:33-8.
39. Zucker ML, Bilyeu DS, Helmkamp GM, Harris WS, Dujovne CA. The effects of dietary fish oil on platelet function and plasma lipids in hyperlipoproteinemic and normal subjects. Atherosclerosis 1988;73:13-22.
40. Annuzzi G, Rivellese A, Capaldo B, et al. A controlled study on the effects on n-3 fatty acids on lipid and glucose metabolism in non-insulin-dependent diabetic patients. Atherosclerosis 1991;87:65-73.
41. Boberg M, Pollare T, Siegbahn A, Vessby B. Supplementation with n-3 fatty acids reduces triglycerides but increases PAI-1 in non-insulin-dependent diabetic mellitus. Eur J Clin Invest 1992;22:645-50.
42. Connor WE, Prince MJ, Ullmann D, et al. The hypotriglyceridemic effect of fish oil in adult-onset diabetes without adverse glucose control. Ann N Y Acad Sci 1993:683:337-40.
43. Donnelly SM, Ali MAM, Churchill DN. Effect of n-3 fatty acids from fish oil on hemostasis, blood pressure, and lipid profile of dialysis patients. J Am Soc Nephrol 1992;2:1634-9.
44. Green D, Barreres L, Borensztajn J, et al. A double-blind, placebo-controlled trial of fish oil concentrate (MaxEpa) in stroke patients. Stroke 1985;16:706-9.
45. Green P, Fuchs J, Schoenfeld N, et al. Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study. Am J Clin Nutr 1990;52:1118-24.
46. Harris WS, Windsor SL, Caspermeyer JJ. Modification of lipid-related atherosclerosis risk factors by ω3 fatty acid ethyl esters in hypertriglyceridemic patients. J Nutr Biochem 1993;4:706-12.
47. Harris WS, Dujovne CA, Zucker M, Johnson B. Effects of a low saturated fat, low cholesterol fish oil supplement in hypertriglyceridemic patients: a placebo-controlled trial. Ann Intern Med 1988; 109:465-70.
48. Harris WS, Zucker ML, Dujovne CA. ω-3 Fatty acids in hypertriglyceridemic patients: triglycerides vs methyl esters. Am J Clin Nutr 1988;48:992-7.
49. Molgaard J, von Schenck H, Lassvik C, Kuusi T, Olsson AG. Effect of fish oil treatment on plasma lipoproteins in type III hyperlipoproteinaemia. Atherosclerosis 1990;81:1-9.
50. Nikkila M. Influence of fish oil on blood lipids in coronary artery disease. Eur J Clin Nutr 1991;45:209-13.
51. Olszewski AJ, McCully KS. Fish oil decreases serum homocysteine in hyperlipemic men. Coron Artery Dis 1993;4:53-60.
52. Puhakainen I, Ahola I, Yki-Järvinen H. Dietary supplementation with n-3 fatty acids increases gluconeogenesis from glycerol but not hepatic glucose production in patients with non-insulin-dependent diabetes mellitus. Am J Clin Nutr 1995;61:121-6.
53. Schectman G, Kaul S, Kissebah AH. Effect of fish oil concentrate on lipoprotein composition in NIDDM. Diabetes 1988;37:1567-73.
54. Schectman G, Kaul S, Kissebah A. Heterogeneity of low density lipoprotein responses to fish-oil supplementation in hypertriglyceridemic subjects. Arteriosclerosis 1989;9:345-54.
55. Vessby B, Boberg M. Dietary supplementation with n-3 fatty acids may impair glucose homeostasis in patients with non-insulin-dependent diabetes mellitus. J Intern Med 1990;228:165-71.
56. BSlashed n signaa KH, Bjerve KS, Nordoy A. Docosahexaenoic and eicosapentaenoic acids in plasma phospholipids are divergently associated with high density lipoprotein in humans. Arterioscler Thromb 1992;12:675-81.
57. Brown AJ, Roberts DCK. Moderate fish oil intake improves lipemic response to a standard fat meal: a study in 25 healthy men. Arterioscler Thromb 1991;11:457-66.
58. Bruckner G, Webb P, Greenwell L, Chow C, Richardson D. Fish oil increases peripheral capillary blood cell velocity in humans. Atherosclerosis 1987;66:237-45.
59. Demke DM, Peters GR, Linet OI, Metzler CM, Klott KA. Effects of a fish oil concentrate in patients with hypercholesterolemia. Atherosclerosis 1988;70:73-80.
60. Flaten H, Høstmark AT, Kierulf P, et al. Fish-oil concentrate: effects on variables related to cardiovascular disease. Am J Clin Nutr 1990;52:300-6.
61. Franzen D, Schannwell M, Oette K, Hopp HW. A prospective, randomized and double-blind trial on the effect of fish oil on the incidence of restenosis following PTCA. Cathet Cardiovasc Diagn 1993;28:301-10.
62. Gans ROB, Bilo HJG, Weersink EGL, et al. Fish oil supplementation in patients with stable claudication. Am J Surg 1990;160:490-5.
63. Grigg LE, Kay TWH, Valentine PA, et al. Determinants of restenosis and lack of effect of dietary supplementation with eicosapentaenoic acid on the incidence of cornary artery restenosis after angioplasty. J Am Coll Cardiol 1989;13:665-72.
64. Hansen JB, Olsen JO, Wilsgard L, Lyngmo V, Svensson B. Comparative effects of prolonged intake of highly purified fish oils as ethyl ester or triglyceride on lipids, haemostasis and platelet function in normolipaemic men. Eur J Clin Nutr 1993;47:497-507.
65. Holub BJ, Bakker DJ, Skeaff CM. Alterations in molecular species of cholesterol esters formed via plasma lecithin-cholesterol acyltransferase in human subjects consuming fish oil. Atherosclerosis 1987;66:11-8.
66. Kestin M, Clifton P, Belling GB, Nestel PJ. n-3 Fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. Am J Clin Nutr 1990;51:1028-34.
67. Mori TA, Vandongen R, Masarei JRL, Rouse IL, Dunbar D. Comparison of diets supplemented with fish oil or olive oil on plasma lipoproteins in insulin-dependent diabetics. Metabolism 1991;40: 241-6.
68. Rogers S, James KS, Rutland BK, Etherington MD, O'Brien JR, Jones JG. Effects of a fish oil supplement on serum lipids, blood pressure, bleeding time, haemostatic and rheological variables - a double blind randomised controlled trial in healthy volunteers. Atherosclerosis 1987;63:137-43.
69. Bairati I, Roy L, Meyer F. Double-blind, randomized, controlled trial of fish oil supplements in prevention of recurrence of stenosis after coronary angioplasty. Circulation 1992;85:950-6.
70. Beil FU, Terres W, Orgass M, Greten H. Dietary fish oil lowers lipoprotein(a) in primary hypertriglyceridemia. Atherosclerosis 1991; 90-95-7.
71. Simons LA. Dietary fish oil and Lp(a). Atherosclerosis 1992;93: 169-70.
72. Hendra TJ, Britton ME, Roper DR, et al. Effects of fish oil supplements in NIDDM subjects: controlled study. Diabetes Care 1990;13:821-9.
73. Leaf A, Jorgensen MB, Jacobs AK, et al. Do fish oils prevent restenosis after coronary angioplasty? Circulation 1994;90:2248-57.
74. Mackness MI, Bhatnagar D, Durrington PN, et al. Effects of a new fish oil concentrate on plasma lipids and lipoproteins in patients with hypertriglyceridaemia. Eur J Clin Nutr 1994;48:859-65.
75. Miller JP, Heath ID, Choraria SK, et al. Triglyceride lowering effect of MaxEPA fish lipid concentrate: a multicentre placebo controlled double blind study. Clin Chim Acta 1988;178:251-60.
76. Mori TA, Vandongen R, Mahanian F, Douglas A. The effect of fish oil on plasma lipids, platelet and neutrophil function in patients with vascular disease. Adv Prostaglandin Thromboxane Leukot Res 1990;21:229-36.
77. Nye ER, Ablett MB, Robertson MC, Ilsley CDJ, Sutherland WHF. Effect of eicosapentaenoic acid on restenosis rate, clinical course and blood lipids in patients after percutaneous transluminal coronary angioplasty. Aust N Z J Med 1990;20:549-52.
78. Radack KL, Deck CC, Huster GA. n-3 Fatty acid effects on lipids, lipoproteins, and apolipoproteins at very low doses: results of a randomized controlled trial in hypertriglyceridemic subjects. Am J Clin Nutr 1990;51:599-605.
79. Reis GJ, Silverman DI, Boucher TM, et al. Effects of two types of fish oil supplements on serum lipids and plasma phospholipid fatty acids in coronary artery disease. Am J Cardiol 1990;66:1171-5.
80. Salachas A, Papadopoulos C, Sakadamis G, et al. Effects of a low-dose fish oil concentrate on angina, exercise tolerance time, serum triglycerides, and platelet function. Angiology 1994;45:1023-31.
81. Sanders TAB, Sullivan DR, Reeve J, Thompson GR. Triglyceridelowering effect of marine polyunsaturates in patients with hypertriglyceridemia. Arteriosclerosis 1985;5:459-65.
82. Herzberg GR. The influence of dietary fatty acid composition of lipogenesis. In: Draper HH, ed. Advances in nutritional research. New York: Plenum Press, 1983:221-53.
83. Dagnelie PC. Rietveld T, Swart GR, Stijnen T, van den Berg JWO. Effect of dietary fish oil on blood levels of free fatty acids, ketone bodies and triacylglycerol in humans. Lipids 1994;29:41-5.