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Volumn 66, Issue 20, 2001, Pages 6654-6661

Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain

(4) Boger, D L a Schmitt, H W a Fink, B E a Hedrick, M P a

a SCRIPPS RESEARCH INSTITUTE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC ACTIVITIES;

ALKYLATION; CATALYSIS; DNA; SYNTHESIS (CHEMICAL);

ORGANIC COMPOUNDS;

1,2,9,9A TETRAHYDROCYCLOPROPA[C]BENZ[E]INDOL 4 ONE; DUOCARMYCIN DERIVATIVE; INDOLE DERIVATIVE; RACHELMYCIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CYTOTOXICITY; DNA ALKYLATION; DNA SEQUENCE; DRUG DNA BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; PROTEIN DEGRADATION;

ALKYLATING AGENTS; ALKYLATION; ANTIBIOTICS, ANTINEOPLASTIC; BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; CYCLOPROPANES; DNA; DNA, VIRAL; INDOLES; INHIBITORY CONCENTRATION 50; LEUCOMYCINS; PYRROLES; PYRROLIDINONES; SIMIAN VIRUS 40; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035812739 PISSN: 00223263 EISSN: None Source Type: Journal
DOI: 10.1021/jo010454u Document Type: Article

Times cited : (33)

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