Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 7, 2005, Pages 1857-1861

  Raboisson, Pierre ^a   Marugán, Juan José ^a   Schubert, Carsten ^a   Koblish, Holly K ^a   Lu, Tianbao ^a   Zhao, Shuyuan ^a   Player, Mark R ^a   Maroney, Anna C ^a   Reed, Rolanda L ^a   Huebert, Norman D ^a   Lattanze, Jennifer ^a   Parks, Daniel J ^a   Cummings, Maxwell D ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Cancer; Diazepine; HDM2 p53; Selenium

Indexed keywords

5 [3 (4 CHLOROPHENYL) 4 [1 (4 CHLOROPHENYL)ETHYL] 2,5 DIOXO 7 PHENYL 1,4 DIAZEPIN 1 YL]VALERIC ACID; 5 [7 (2 BROMOPHENYL) 3 (4 CHLOROPHENYL) 4 [1 (4 CHLOROPHENYL)ETHYL] 2,5 DIOXO 1,4 DIAZEPIN 1 YL]VALERIC ACID; DIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE;

ALPHA HELIX; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PROTEIN FOLDING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

EID: 20144382874     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.02.018     Document Type: Article

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