Structure-based design of potent non-peptide MDM2 inhibitors

Journal of the American Chemical Society

Volumn 127, Issue 29, 2005, Pages 10130-10131

  Ding, Ke ^a   Lu, Yipin ^a   Nikolovska Coleska, Zaneta ^a   Qiu, Su ^a   Ding, Yousong ^a   Gao, Wei ^a   Stuckey, Jeanne ^b   Krajewski, Krzysztof ^c   Roller, Peter P ^c   Tomita, York ^d   Parrish, Damon A ^e   Deschamps, Jeffrey R ^e   Wang, Shaomeng ^a  

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d GEORGETOWN UNIVERSITY   (United States)

^e NAVAL RESEARCH LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALSTONISINE; ANTINEOPLASTIC AGENT; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN MDM2 INHIBITOR; PROTEIN P53; SPIROTRYPROSTATIN A; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; FLUORESCENCE POLARIZATION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; IC 50; MOLECULAR MODEL; PROTEIN PROTEIN INTERACTION; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BIOMIMETIC MATERIALS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; INDOLE ALKALOIDS; MODELS, MOLECULAR; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 22944473048     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja051147z     Document Type: Article

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