Small molecule inhibitors of the MDM2-p53 interaction discovered by ensemble-based receptor models

Journal of the American Chemical Society

Volumn 129, Issue 42, 2007, Pages 12809-12814

  Bowman, Anna L ^a   Nikolovska Coleska, Zaneta ^a,b   Zhong, Haizhen ^a,c   Wang, Shaomeng ^a,b   Carlson, Heather A ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; HYDROGEN BONDS; HYDROPHOBICITY; MOLECULAR INTERACTIONS; MOLECULAR MODELING; SCAFFOLDS;

BINDING RESIDUES; MULTIPLE PROTEIN STRUCTURE (MPS) METHOD; RECEPTOR MODELS; SMALL-MOLECULE INHIBITORS;

ENZYME INHIBITION;

PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN P53; SCAFFOLD PROTEIN;

ARTICLE; DATA BASE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; PHARMACOPHORE; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

BINDING, COMPETITIVE; CLUSTER ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MOLECULAR CONFORMATION; NORMAL DISTRIBUTION; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS C-MDM2; SOFTWARE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 35548942306     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja073687x     Document Type: Article

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