Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions

Journal of the American Chemical Society

Volumn 128, Issue 6, 2006, Pages 1995-2004

  Hara, Toshiaki ^a   Durell, Stewart R ^a   Myers, Michael C ^b   Appella, Daniel H ^c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DISEASES; DRUG PRODUCTS; TUMORS;

PEPTOIDS; PROTEIN-PROTEIN INTERACTIONS; THERAPIES;

PROTEINS;

HUMAN DOUBLE MINUTE 2 PROTEIN; OLIGOMER; PEPTOID; PROTEIN; PROTEIN INHIBITOR; PROTEIN P53; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER; CANCER GROWTH; CANCER RESISTANCE; DRUG DESIGN; DRUG SYNTHESIS; DRUG TARGETING; GENE OVEREXPRESSION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RIGIDITY;

CALORIMETRY; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; PEPTOIDS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS C-MDM2; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53; WATER;

EID: 33244473080     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja056344c     Document Type: Article

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