On the origin of epidermal cancers

Current Molecular Medicine

Volumn 9, Issue 3, 2009, Pages 355-364

  Lorz, Corina ^a   Segrelles, Carmen ^a   Paramio, Jesus M ^a  

^a CIEMAT   (Spain)

Author keywords

Cancer; Epidermis; Hair follicle; Mouse models; Stem cells

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; CYTOKERATIN 1; CYTOKERATIN 10; CYTOKERATIN 14; CYTOKERATIN 5; FILAGGRIN; INVOLUCRIN; LORICRIN; LYMPHOID ENHANCER FACTOR 1; N (3 METHOXYBENZYL) 3,3 DIMETHYL N [1 (3,4 METHYLENEDIOXYBENZYL) 2 (1 PIPERAZINYLCARBONYL) 4 PYRROLIDINYL]BUTYRAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN PATCHED; RAPAMYCIN; SMAD PROTEIN; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ADULT STEM CELL; BASAL CELL CARCINOMA; BASEMENT MEMBRANE; CANCER GROWTH; CANCER STEM CELL; CARCINOGENESIS; CATAGEN; CELL ACTIVATION; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINEAGE; CELL PROLIFERATION; CELL SURFACE; DEREGULATION; DOWN REGULATION; EPIDERMAL CANCER; EPIDERMAL STEM CELL; EPIDERMIS; EPIDERMIS CELL; HAIR FOLLICLE; HAIR GROWTH; HOMEOSTASIS; HUMAN; KERATINOCYTE; MEMBRANE STABILIZATION; NONHUMAN; PHENOTYPE; PILOMATRIXOMA; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TARGETING; REVIEW; SKIN CANCER; SQUAMOUS CELL CARCINOMA; STEM CELL EXPANSION; SUN EXPOSURE; TELOGEN; TISSUE GROWTH; TRICHOEPITHELIOMA; TUMOR CLASSIFICATION; ULTRAVIOLET RADIATION; WART VIRUS; ANIMAL; CELL TRANSFORMATION; CYTOLOGY; EPITHELIUM CELL; GENETICS; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SKIN TUMOR;

MUS;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; EPIDERMIS; EPITHELIAL CELLS; HAIR FOLLICLE; HUMANS; MUTATION; NEOPLASTIC STEM CELLS; SIGNAL TRANSDUCTION; SKIN NEOPLASMS;

EID: 65649128527     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652409787847227     Document Type: Review

References (114)

1. Bonnet, D. and Dick, J.E. (1997) Nat. Med., 3, 730-7.
2. Al-Hajj, M., Wicha, M.S., Benito-Hernandez, A., Morrison, S.J. and Clarke, M.F. (2003) Proc. Natl. Acad. Sci. USA, 100, 3983-8.
3. Singh, S.K., Hawkins, C., Clarke, I.D., Squire, J.A., Bayani, J., Hide, T., Henkelman, R. M., Cusimano, M.D. and Dirks, P.B. (2004) Nature, 432, 396-401.
4. Xin, L., Lawson, D.A. and Witte, O.N. (2005) Proc. Natl. Acad. Sci. USA, 102, 6942-7.
5. Kim, C.F., Jackson, E.L., Woolfenden, A.E., Lawrence, S., Babar, I., Vogel, S., Crowley, D., Bronson, R.T. and Jacks, T. (2005) Cell, 121, 823-35.
6. Dalerba, P., Dylla, S.J., Park, I.K., Liu, R., Wang, X., Cho, R.W., Hoey, T., Gurney, A., Huang, E.H., Simeone, D.M., Shelton, A.A., Parmiani, G., Castelli, C. and Clarke, M.F. (2007) Proc. Natl. Acad. Sci. USA, 104, 10158-63.
7. Li, C., Heidt, D.G., Dalerba, P., Burant, C.F., Zhang, L., Adsay, V., Wicha, M., Clarke, M. F. and Simeone, D.M. (2007) Cancer Res., 67, 1030-7.
8. Schatton, T., Murphy, G.F., Frank, N.Y., Yamaura, K., Waaga-Gasser, A.M., Gasser, M., Zhan, Q., Jordan, S., Duncan, L.M., Weishaupt, C., Fuhlbrigge, R.C., Kupper, T.S., Sayegh, M.H. and Frank, M.H. (2008) Nature, 451, 345-9.
9. Malanchi, I., Peinado, H., Kassen, D., Hussenet, T., Metzger, D., Chambon, P., Huber, M., Hohl, D., Cano, A., Birchmeier, W. and Huelsken, J. (2008) Nature, 452, 650-3.
10. Benitah, S.A., Frye, M., Glogauer, M. and Watt, F.M. (2005) Science, 309, 933-5.
11. Yilmaz, O.H., Valdez, R., Theisen, B.K., Guo, W., Ferguson, D.O., Wu, H. and Morrison, S.J. (2006) Nature, 441, 475-82.
12. Blank, U., Karlsson, G. and Karlsson, S. (2008) Blood, 111, 492-503.
13. Reya, T. and Clevers, H. (2005) Nature, 434, 843-50.
14. Miele, L., Golde, T. and Osborne, B. (2006) Curr. Mol. Med., 6, 905-18.
15. Rubin, L.L. and de Sauvage, F.J. (2006) Nat. Rev. Drug Discov., 5, 1026-33.
16. Watt, F.M. (2002) EMBO J., 21, 3919-26.
17. Fuchs, E., Dowling, J., Segre, J., Lo, S.H. and Yu, Q.C. (1997) Curr. Opin. Genet. Dev., 7, 672-82.
18. Marchisio, P.C., Trusolino, L. and De Luca, M. (1997) Microsc. Res. Tech., 38, 353-60.
19. Fuchs, E. (1995) Annu. Rev. Cell Dev. Biol., 11, 123-53.
20. Dai, X. and Segre, J.A. (2004) Curr. Opin. Genet. Dev., 14, 485-91.
21. Mehrel, T., Hohl, D., Rothnagel, J.A., Longley, M.A., Bundman, D., Cheng, C., Lichti, U., Bisher, M.E., Steven, A.C., Steinert, P.M., Yuspa, S.H. and Roop, D.R. (1990) Cell, 61, 1103-12.
22. Watt, F.M. (1983) J. Invest. Dermatol., 81, 100s-3s.
23. Dale, B.A., Resing, K.A. and Lonsdale-Eccles, J.D. (1985) Ann. N. Y. Acad Sci., 455, 330-42.
24. Candi, E., Schmidt, R. and Melino, G. (2005) Nat. Rev. Mol. Cell Biol., 6, 328-40.
25. Potten, C.S. (1974) Cell Tissue Kinet., 7, 77-88.
26. Mackenzie, I.C. (1997) J. Invest. Dermatol., 109, 377-83.
27. Jensen, U.B., Lowell, S. and Watt, F.M. (1999) Development, 126, 2409-18.
28. Lechler, T. and Fuchs, E. (2005) Nature, 437, 275-80.
29. Jones, P.H. and Watt, F.M. (1993) Cell, 73, 713-24.
30. Li, A., Simmons, P.J. and Kaur, P. (1998) Proc. Natl. Acad. Sci. USA, 95, 3902-7.
31. Lowell, S., Jones, P., Le Roux, I., Dunne, J. and Watt, F.M. (2000) Curr. Biol., 10, 491-500.
32. Legg, J., Jensen, U.B., Broad, S., Leigh, I. and Watt, F.M. (2003) Development, 130, 6049-63.
33. Jensen, K.B. and Watt, F.M. (2006) Proc. Natl. Acad. Sci. USA, 103, 11958-63.
34. Jones, P.H., Harper, S. and Watt, F.M. (1995) Cell, 80, 83-93.
35. Clayton, E., Doupe, D.P., Klein, A.M., Winton, D.J., Simons, B.D. and Jones, P.H. (2007) Nature, 446, 185-9.
36. Ro, S. and Rannala, B. (2004) EMBO Rep., 5, 914-20.
37. Horsley, V., O'Carroll, D., Tooze, R., Ohinata, Y., Saitou, M., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A. and Fuchs, E. (2006) Cell, 126, 597-609.
38. Cotsarelis, G., Sun, T.T. and Lavker, R.M. (1990) Cell, 61, 1329-37.
39. Taylor, G., Lehrer, M.S., Jensen, P.J., Sun, T.T. and Lavker, R.M. (2000) Cell, 102, 451-61.
40. Oshima, H., Rochat, A., Kedzia, C., Kobayashi, K. and Barrandon, Y. (2001) Cell, 104, 233-45.
41. Blanpain, C., Lowry, W.E., Geoghegan, A., Polak, L. and Fuchs, E. (2004) Cell, 118, 635-48.
42. Morris, R.J., Liu, Y., Marles, L., Yang, Z., Trempus, C., Li, S., Lin, J.S., Sawicki, J.A. and Cotsarelis, G. (2004) Nat. Biotechnol., 22, 411-7.
43. Ito, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R.J. and Cotsarelis, G. (2005) Nat. Med., 11, 1351-4.
44. Blanpain, C., Horsley, V. and Fuchs, E. (2007) Cell, 128, 445-58.
45. Lyle, S., Christofidou-Solomidou, M., Liu, Y., Elder, D.E., Albelda, S. and Cotsarelis, G. (1998) J. Cell Sci., 111( Pt 21) 3179-88.
46. Liu, Y., Lyle, S., Yang, Z. and Cotsarelis, G. (2003) J. Invest. Dermatol., 121, 963-8.
47. Trempus, C.S., Morris, R.J., Bortner, C.D., Cotsarelis, G., Faircloth, R.S., Reece, J.M. and Tennant, R.W. (2003) J. Invest. Dermatol., 120, 501-11.
48. Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W.E., Rendl, M. and Fuchs, E. (2004) Science, 303, 359-63.
49. Ohyama, M., Terunuma, A., Tock, C.L., Radonovich, M.F., Pise-Masison, C.A., Hopping, S.B., Brady, J.N., Udey, M.C. and Vogel, J.C. (2006) J. Clin. Invest., 116, 249-60.
50. Horsley, V., Aliprantis, A.O., Polak, L., Glimcher, L.H. and Fuchs, E. (2008) Cell, 132, 299-310.
51. Andl, T., Ahn, K., Kairo, A., Chu, E.Y., Wine-Lee, L., Reddy, S.T., Croft, N.J., Cebra-Thomas, J.A., Metzger, D., Chambon, P., Lyons, K.M., Mishina, Y., Seykora, J.T., Crenshaw, E.B. and Millar, S.E. (2004) Development, 131, 2257-68.
52. Foundation, S.C. (Last accessed, 31st March 2008) http://www.skincancer.org/.
53. Brash, D.E. (1997) Trends Genet., 13, 410-4.
54. zur Hausen, H. (2002) Nat. Rev. Cancer, 2, 342-50.
55. Harwood, C.A. and Proby, C.M. (2002) Curr. Opin. Infect. Dis., 15, 101-14.
56. Boukamp, P. (2005) Carcinogenesis, 26, 1657-67.
57. Hahn, W.C. and Weinberg, R.A. (2002) Nat. Rev. Cancer, 2, 331-41.
58. Preston, D.L., Ron, E., Tokuoka, S., Funamoto, S., Nishi, N., Soda, M., Mabuchi, K., and Kodama, K. (2007) Radiat. Res., 168, 1-64.
59. Van Duuren, B.L., Sivak, A., Katz, C., Seidman, I. and Melchionne, S. (1975) Cancer Res., 35, 502-5.
60. Bailleul, B., Surani, M.A., White, S., Barton, S.C., Brown, K., Blessing, M., Jorcano, J., and Balmain, A. (1990) Cell, 62, 697-708.
61. Brown, K., Strathdee, D., Bryson, S., Lambie, W. and Balmain, A. (1998) Curr. Biol., 8, 516-24.
62. Morris, R.J., Tryson, K.A. and Wu, K.Q. (2000) Cancer Res., 60, 226-9.
63. Trempus, C.S., Morris, R.J., Ehinger, M., Elmore, A., Bortner, C.D., Ito, M., Cotsarelis, G., Nijhof, J.G., Peckham, J., Flagler, N., Kissling, G., Humble, M.M., King, L.C., Adams, L.D., Desai, D., Amin, S. and Tennant, R.W. (2007) Cancer Res., 67, 4173-81.
64. Mimeault, M., Hauke, R., Mehta, P.P. and Batra, S.K. (2007) J. Cell Mol. Med., 11, 981-1011.
65. Polakis, P. (2007) Curr. Opin. Genet. Dev., 17, 45-51.
66. Fodde, R. and Brabletz, T. (2007) Curr. Opin. Cell Biol., 19, 150-8.
67. Alonso, L. and Fuchs, E. (2003) Genes Dev., 17, 1189-200.
68. Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G. and Birchmeier, W. (2001) Cell, 105, 533-45.
69. Niemann, C., Owens, D.M., Hulsken, J., Birchmeier, W. and Watt, F.M. (2002) Development, 129, 95-109.
70. DasGupta, R., Rhee, H. and Fuchs, E. (2002) J. Cell Biol., 158, 331-44.
71. Gat, U., DasGupta, R., Degenstein, L. and Fuchs, E. (1998) Cell, 95, 605-14.
72. Lo Celso, C., Prowse, D.M. and Watt, F.M. (2004) Development, 131, 1787-99.
73. Chan, E.F., Gat, U., McNiff, J.M. and Fuchs, E. (1999) Nat. Genet., 21, 410-3.
74. Morin, P.J., Sparks, A.B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B. and Kinzler, K.W. (1997) Science, 275, 1787-90.
75. Korinek, V., Barker, N., Morin, P.J., van Wichen, D., de Weger, R., Kinzler, K.W., Vogelstein, B. and Clevers, H. (1997) Science, 275, 1784-7.
76. Lin, S.Y., Xia, W., Wang, J.C., Kwong, K.Y., Spohn, B., Wen, Y., Pestell, R.G. and Hung, M.C. (2000) Proc. Natl. Acad. Sci. USA, 97, 4262-6.
77. Niemann, C., Owens, D.M., Schettina, P. and Watt, F.M. (2007) Cancer Res., 67, 2916-21.
78. Takeda, H., Lyle, S., Lazar, A.J., Zouboulis, C.C., Smyth, I. and Watt, F.M. (2006) Nat. Med., 12, 395-7.
79. Barker, N. and Clevers, H. (2006) Nat. Rev. Drug Discov., 5, 997-1014.
80. Botchkarev, V.A. and Sharov, A.A. (2004) Differentiation, 72, 512-26.
81. Plikus, M.V., Mayer, J.A., de la Cruz, D., Baker, R.E., Maini, P.K., Maxson, R. and Chuong, C.M. (2008) Nature, 451, 340-4.
82. Howe, J.R., Bair, J.L., Sayed, M.G., Anderson, M.E., Mitros, F.A., Petersen, G.M., Velculescu, V.E., Traverso, G. and Vogelstein, B. (2001) Nat. Genet., 28, 184-7.
83. Howe, J.R., Roth, S., Ringold, J.C., Summers, R.W., Jarvinen, H.J., Sistonen, P., Tomlinson, I.P., Houlston, R.S., Bevan, S., Mitros, F.A., Stone, E.M. and Aaltonen, L. A. (1998) Science, 280, 1086-8.
84. He, X.C., Zhang, J., Tong, W.G., Tawfik, O., Ross, J., Scoville, D.H., Tian, Q., Zeng, X., He, X., Wiedemann, L.M., Mishina, Y. and Li, L. (2004) Nat. Genet., 36, 1117-21.
85. Ming Kwan, K., Li, A.G., Wang, X.J., Wurst, W. and Behringer, R.R. (2004) Genesis, 39, 10-25.
86. Kobielak, K., Stokes, N., de la Cruz, J., Polak, L. and Fuchs, E. (2007) Proc. Natl. Acad. Sci. USA, 104, 10063-8.
87. Zhang, J., Niu, C., Ye, L., Huang, H., He, X., Tong, W. G., Ross, J., Haug, J., Johnson, T., Feng, J.Q., Harris, S., Wiedemann, L.M., Mishina, Y. and Li, L. (2003) Nature, 425, 836-41.
88. Zhang, J., He, X.C., Tong, W.G., Johnson, T., Wiedemann, L.M., Mishina, Y., Feng, J. Q. and Li, L. (2006) Stem Cells, 24, 2826-39.
89. Manning, B.D. and Cantley, L.C. (2007) Cell, 129, 1261-74.
90. Vivanco, I. and Sawyers, C.L. (2002) Nat. Rev. Cancer, 2, 489-501.
91. He, X.C., Yin, T., Grindley, J.C., Tian, Q., Sato, T., Tao, W.A., Dirisina, R., Porter-Westpfahl, K.S., Hembree, M., Johnson, T., Wiedemann, L.M., Barrett, T.A., Hood, L., Wu, H. and Li, L. (2007) Nat. Genet., 39, 189-98.
92. Groszer, M., Erickson, R., Scripture-Adams, D.D., Dougherty, J.D., Le Belle, J., Zack, J.A., Geschwind, D.H., Liu, X., Kornblum, H.I. and Wu, H. (2006) Proc. Natl. Acad. Sci. USA, 103, 111-6.
93. Wang, S., Garcia, A.J., Wu, M., Lawson, D.A., Witte, O.N. and Wu, H. (2006) Proc. Natl. Acad. Sci. USA, 103, 1480-5.
94. Zhang, J., Grindley, J.C., Yin, T., Jayasinghe, S., He, X.C., Ross, J.T., Haug, J.S., Rupp, D., Porter-Westpfahl, K.S., Wiedemann, L.M., Wu, H. and Li, L. (2006) Nature, 441, 518-22.
95. Murayama, K., Kimura, T., Tarutani, M., Tomooka, M., Hayashi, R., Okabe, M., Nishida, K., Itami, S., Katayama, I. and Nakano, T. (2007) Oncogene, 26, 4882-8.
96. Segrelles, C., Moral, M., Lorz, C., Santos, M., Lu, J., Cascallana, J.L., Lara, M.F., Carbajal, S., Martinez-Cruz, A.B., Garcia-Escudero, R., Beltran, L., Segovia, J.C., Bravo, A., Digiovanni, J. and Paramio, J.M. (2008) Mol. Biol. Cell, 19, 137-49.
97. Liaw, D., Marsh, D.J., Li, J., Dahia, P.L., Wang, S.I., Zheng, Z., Bose, S., Call, K.M., Tsou, H.C., Peacocke, M., Eng, C. and Parsons, R. (1997) Nat. Genet., 16, 64-7.
98. Waite, K.A. and Eng, C. (2003) Hum. Mol. Genet., 12, 679-84.
99. Marone, R., Cmiljanovic, V., Giese, B. and Wymann, M.P. (2008) Biochim. Biophys. Acta, 1784, 159-85.
100. Evangelista, M., Tian, H. and de Sauvage, F.J. (2006) Clin. Cancer Res., 12, 5924-8.
101. Watt, F.M. (2004) Trends Mol. Med., 10, 577-80.
102. Oro, A.E., Higgins, K.M., Hu, Z., Bonifas, J.M., Epstein, E.H.Jr. and Scott, M.P. (1997) Science, 276, 817-21.
103. Oro, A.E. and Higgins, K. (2003) Dev. Biol., 255, 238-48.
104. Hutchin, M.E., Kariapper, M.S., Grachtchouk, M., Wang, A., Wei, L., Cummings, D., Liu, J., Michael, L.E., Glick, A. and Dlugosz, A.A. (2005) Genes. Dev., 19, 214-23.
105. Fan, H., Oro, A.E., Scott, M.P. and Khavari, P.A. (1997) Nat. Med., 3, 788-92.
106. Gailani, M.R., Stahle-Backdahl, M., Leffell, D.J., Glynn, M., Zaphiropoulos, P.G., Pressman, C., Unden, A.B., Dean, M., Brash, D.E., Bale, A.E. and Toftgard, R. (1996) Nat. Genet., 14, 78-81.
107. Hahn, H., Wicking, C., Zaphiropoulous, P.G., Gailani, M.R., Shanley, S., Chidambaram, A., Vorechovsky, I., Holmberg, E., Unden, A.B., Gillies, S., Negus, K., Smyth, I., Pressman, C., Leffell, D.J., Gerrard, B., Goldstein, A.M., Dean, M., Toftgard, R., Chenevix-Trench, G., Wainwright, B. and Bale, A.E. (1996) Cell, 85, 841-51.
108. Johnson, R.L., Rothman, A.L., Xie, J., Goodrich, L.V., Bare, J.W., Bonifas, J.M., Quinn, A.G., Myers, R.M., Cox, D.R., Epstein, E.H.Jr. and Scott, M.P. (1996) Science, 272, 1668-71.
109. Reifenberger, J., Wolter, M., Weber, R.G., Megahed, M., Ruzicka, T., Lichter, P. and Reifenberger, G. (1998) Cancer Res., 58, 1798-803.
110. Wakabayashi, Y., Mao, J.H., Brown, K., Girardi, M. and Balmain, A. (2007) Nature, 445, 761-5.
111. Lauth, M., Bergstrom, A., Shimokawa, T. and Toftgard, R. (2007) Proc. Natl. Acad. Sci. USA, 104, 8455-60.
112. Athar, M., Tang, X., Lee, J.L., Kopelovich, L. and Kim, A.L. (2006) Exp. Dermatol., 15, 667-77.
113. Genentech (Last accessed April 2008).
114. Williams, J.A., Guicherit, O.M., Zaharian, B.I., Xu, Y., Chai, L., Wichterle, H., Kon, C., Gatchalian, C., Porter, J.A., Rubin, L.L. and Wang, F.Y. (2003) Proc. Natl. Acad. Sci. USA, 100, 4616-21.