Evidence that the epidermal targets of carcinogen action are found in the interfollicular epidermis or infundibulum as well as in the hair follicles

Cancer Research

Volumn 60, Issue 2, 2000, Pages 226-229

  Morris, Rebecca J ^a   Tryson, Kimberly A ^a   Wu, Kai Q ^a  

^a LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; EPIDERMIS CELL; FEMALE; HAIR FOLLICLE; INFUNDIBULUM; MOUSE; NONHUMAN; PAPILLOMA; PRIORITY JOURNAL; SKIN ABRASION; SKIN TUMOR; STEM CELL;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CARCINOGENS; EPIDERMIS; FEMALE; HAIR FOLLICLE; MICE; MICE, INBRED SENCAR; PAPILLOMA; REGENERATION; SKIN; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS;

EID: 0034650889     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Boutwell, R. K. The function and mechanism of promoters of carcinogenesis. CRC Crit. Rev. Toxicol., 2: 419-443, 1974.
2. Scribner, J. D., and Suss, R. Tumor initiation and promotion. Int. Rev. Exp. Pathol., 18: 137-198, 1978.
3. Slaga, T. J. Mechanisms involved in two-stage carcinogenesis in mouse skin. In: T. J. Slaga (ed.), Mechanisms of Tumor Promotion, Vol. 2. pp. 1-16. Boca Raton: CRC Press, Inc., 1984.
4. Miller, S. J., Sun, T-T., and Lavker, R. M. Hair follicles, stem cells, and cancer, J. Investig. Dermatol., 100 (Suppl.): 288S-294S, 1993.
5. Morris, R. J. Epidermal stem cells: targets for carcinogenic chemicals. Semin. Dev. Biol., 4: 251-259, 1994.
6. Binder, R. L., Johnson, G. R., Gallagher, P. M., Stockman, S. L., Sundberg, J. P., and Conti, C. J. Squamous cell hyperplastic foci: precursors of cutaneous papillomas induced in SENCAR mice by a two-stage carcinogenesis regimen. Cancer Res., 58: 4314-4323, 1998.
7. Argyris, T. S. Tumor promotion by abrasion induced epidermal hyperplasia in the skin of mice. J. Invest. Dermatol., 75: 360-362, 1980.
8. Argyris, T. S., and Slaga, T. J. Promotion of carcinomas by repeated abrasion in initiated skin of mice. Cancer Res., 41: 5193-5195, 1981.
9. Miller, S. J., Lava, R. M., and Sun, T-T. Keratinocyte stem cells of cornea, skin, and hair follicles. In: C.S. Potten (ed.), Stem Cells, pp. 331-362, San Diego, CA: Academic Press, 1997.
10. Morris, R. J., and Argyris, T. S. Epidermal cell cycle and transit times during hyperplastic growth induced by abrasion or treatment with 12-O-tetradecanoylphorbol-13-acetate. Cancer Res., 43: 4935-4942, 1983.
11. Morris, R. J., Coulter, K., Tryson, K., and Steinberg, S. R. Evidence that cutaneous carcinogen-initiated epithelial cells from mice are quiescent rather than actively cycling. Cancer Res., 57: 3436-3443, 1997.
12. Hansen, L. A., and Tennant, R. W. Follicular origin of epidermal papillomas in v-Ha-ras transgenic TG.AC mouse skin. Proc. Natl. Acad. Sci. USA, 91: 7822-7826, 1994.
13. Hansen, L. A., and Tennant, R. Focal transgene expression associated with papilloma development in v-Ha-ras-transgenic mice. Mol. Carcinog., 9: 143-154, 1994.