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Volumn 111, Issue 2, 2008, Pages 492-503

Signaling pathways governing stem-cell fate

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN; NOTCH RECEPTOR; REACTIVE OXYGEN METABOLITE; SMAD PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 38349121930     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-07-075168     Document Type: Review
Times cited : (287)

References (146)
  • 1
    • 0027325195 scopus 로고
    • Differentiation and proliferation of hematopoietic stem cells
    • Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood. 1993;81:2844-2853.
    • (1993) Blood , vol.81 , pp. 2844-2853
    • Ogawa, M.1
  • 2
    • 1642578983 scopus 로고    scopus 로고
    • Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells
    • Matsuzaki Y, Kinjo K, Mulligan RC, Okano H. Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. Immunity. 2004;20:87-93.
    • (2004) Immunity , vol.20 , pp. 87-93
    • Matsuzaki, Y.1    Kinjo, K.2    Mulligan, R.C.3    Okano, H.4
  • 3
    • 0029796633 scopus 로고    scopus 로고
    • Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell
    • Osawa M, Hanada K, Hamada H, Nakauchi H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science. 1996;273:242-245.
    • (1996) Science , vol.273 , pp. 242-245
    • Osawa, M.1    Hanada, K.2    Hamada, H.3    Nakauchi, H.4
  • 4
    • 0023922373 scopus 로고
    • Purification and characterization of mouse hematopoietic stem cells
    • Spangrude GJ, Heimfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science. 1988;241:58-62.
    • (1988) Science , vol.241 , pp. 58-62
    • Spangrude, G.J.1    Heimfeld, S.2    Weissman, I.L.3
  • 5
    • 0027092050 scopus 로고
    • In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells
    • Okada S, Nakauchi H, Nagayoshi K, Nishikawa S, Miura Y, Suda T. In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells. Blood. 1992;80:3044-3050.
    • (1992) Blood , vol.80 , pp. 3044-3050
    • Okada, S.1    Nakauchi, H.2    Nagayoshi, K.3    Nishikawa, S.4    Miura, Y.5    Suda, T.6
  • 6
    • 15944363056 scopus 로고    scopus 로고
    • Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients
    • Yang L, Bryder D, Adolfsson J, et al. Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients. Blood. 2005;105:2717-2723.
    • (2005) Blood , vol.105 , pp. 2717-2723
    • Yang, L.1    Bryder, D.2    Adolfsson, J.3
  • 7
    • 0034749999 scopus 로고    scopus 로고
    • Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity
    • Adolfsson J, Borge OJ, Bryder D, et al. Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity. 2001;15:659-669.
    • (2001) Immunity , vol.15 , pp. 659-669
    • Adolfsson, J.1    Borge, O.J.2    Bryder, D.3
  • 8
    • 0028534860 scopus 로고
    • The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
    • Morrison SJ, Weissman IL. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity. 1994;1:661-673.
    • (1994) Immunity , vol.1 , pp. 661-673
    • Morrison, S.J.1    Weissman, I.L.2
  • 9
    • 0027855043 scopus 로고
    • In vivo and in vitro characterization of long-term repopulating primitive hematopoietic cells isolated by sequential Hoechst 33342-rhodamine 123 FACS selection
    • Wolf NS, Kone A, Priestley GV, Bartelmez SH. In vivo and in vitro characterization of long-term repopulating primitive hematopoietic cells isolated by sequential Hoechst 33342-rhodamine 123 FACS selection. Exp Hematol. 1993;21:614-622.
    • (1993) Exp Hematol , vol.21 , pp. 614-622
    • Wolf, N.S.1    Kone, A.2    Priestley, G.V.3    Bartelmez, S.H.4
  • 10
    • 0029958876 scopus 로고    scopus 로고
    • Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
    • Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med. 1996;183:1797-1806.
    • (1996) J Exp Med , vol.183 , pp. 1797-1806
    • Goodell, M.A.1    Brose, K.2    Paradis, G.3    Conner, A.S.4    Mulligan, R.C.5
  • 11
    • 21244463426 scopus 로고    scopus 로고
    • SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    • Kiel MJ, Yilmaz OH, Iwashita T, Yilmaz OH, Terhorst C, Morrison SJ. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell. 2005;121:1109-1121.
    • (2005) Cell , vol.121 , pp. 1109-1121
    • Kiel, M.J.1    Yilmaz, O.H.2    Iwashita, T.3    Yilmaz, O.H.4    Terhorst, C.5    Morrison, S.J.6
  • 12
    • 33846233298 scopus 로고    scopus 로고
    • Low rhodamine 123 retention identifies long-term human hematopoietic stem cells within the Lin-CD34+CD38- population
    • McKenzie JL, Takenaka K, Gan OI, Doedens M, Dick JE. Low rhodamine 123 retention identifies long-term human hematopoietic stem cells within the Lin-CD34+CD38- population. Blood. 2007;109:543-545.
    • (2007) Blood , vol.109 , pp. 543-545
    • McKenzie, J.L.1    Takenaka, K.2    Gan, O.I.3    Doedens, M.4    Dick, J.E.5
  • 13
    • 0030685762 scopus 로고    scopus 로고
    • Assay of human stem cells by repopulation of NOD/SCID mice
    • discussion 204
    • Dick JE, Bhatia M, Gan O, Kapp U, Wang JC. Assay of human stem cells by repopulation of NOD/SCID mice. Stem Cells. 1997;15(Suppl 1):199-203; discussion 204.
    • (1997) Stem Cells , vol.15 , Issue.SUPPL. 1 , pp. 199-203
    • Dick, J.E.1    Bhatia, M.2    Gan, O.3    Kapp, U.4    Wang, J.C.5
  • 14
    • 78651158197 scopus 로고
    • A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells
    • Till JE, McCulloch EA, Siminovitch L. A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells. Proc Natl Acad Sci U S A. 1964;51:29-36.
    • (1964) Proc Natl Acad Sci U S A , vol.51 , pp. 29-36
    • Till, J.E.1    McCulloch, E.A.2    Siminovitch, L.3
  • 15
    • 0027136259 scopus 로고
    • Hematopoietic regulators: Redundancy or subtlety?
    • Metcalf D. Hematopoietic regulators: redundancy or subtlety? Blood. 1993;82:3515-3523.
    • (1993) Blood , vol.82 , pp. 3515-3523
    • Metcalf, D.1
  • 16
    • 0032527272 scopus 로고    scopus 로고
    • Do stem cells play dice?
    • discussion 352
    • Enver T, Heyworth CM, Dexter TM. Do stem cells play dice? Blood. 1998;92:348-351; discussion 352.
    • (1998) Blood , vol.92 , pp. 348-351
    • Enver, T.1    Heyworth, C.M.2    Dexter, T.M.3
  • 17
    • 0031440921 scopus 로고    scopus 로고
    • Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability
    • Miller CL, Eaves CJ. Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability. Proc Natl Acad Sci U S A. 1997;94:13648-13653.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 13648-13653
    • Miller, C.L.1    Eaves, C.J.2
  • 18
    • 0035807964 scopus 로고    scopus 로고
    • Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells
    • Christensen JL, Weissman IL. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc Natl Acad Sci U S A. 2001;98:14541-14546.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 14541-14546
    • Christensen, J.L.1    Weissman, I.L.2
  • 19
    • 0035852678 scopus 로고    scopus 로고
    • Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells
    • Audet J, Miller CL, Rose-John S, Piret JM, Eaves CJ. Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells. Proc Natl Acad Sci U S A. 2001;98:1757-1762.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1757-1762
    • Audet, J.1    Miller, C.L.2    Rose-John, S.3    Piret, J.M.4    Eaves, C.J.5
  • 20
    • 0030847329 scopus 로고    scopus 로고
    • Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis
    • Nandurkar HH, Robb L, Tarlinton D, Barnett L, Kontgen F, Begley CG. Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis. Blood. 1997;90:2148-2159.
    • (1997) Blood , vol.90 , pp. 2148-2159
    • Nandurkar, H.H.1    Robb, L.2    Tarlinton, D.3    Barnett, L.4    Kontgen, F.5    Begley, C.G.6
  • 21
    • 0032477741 scopus 로고    scopus 로고
    • Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin
    • Kimura S, Roberts AW, Metcalf D, Alexander WS. Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. Proc Natl Acad Sci U S A. 1998;95:1195-1200.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 1195-1200
    • Kimura, S.1    Roberts, A.W.2    Metcalf, D.3    Alexander, W.S.4
  • 22
    • 0032126638 scopus 로고    scopus 로고
    • Role of cmpl in early hematopoiesis
    • Solar GP, Kerr WG, Zeigler FC, et al. Role of cmpl in early hematopoiesis. Blood. 1998;92:4-10.
    • (1998) Blood , vol.92 , pp. 4-10
    • Solar, G.P.1    Kerr, W.G.2    Zeigler, F.C.3
  • 23
    • 0026500983 scopus 로고
    • Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation
    • Ikuta K, Weissman IL. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci U S A. 1992;89:1502-1506.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 1502-1506
    • Ikuta, K.1    Weissman, I.L.2
  • 24
    • 33746591727 scopus 로고    scopus 로고
    • Cytokines regulate postnatal hematopoietic stem cell expansion: Opposing roles of thrombopoietin and LNK
    • Buza-Vidas N, Antonchuk J, Qian H, et al. Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK. Genes Dev. 2006;20:2018-2023.
    • (2006) Genes Dev , vol.20 , pp. 2018-2023
    • Buza-Vidas, N.1    Antonchuk, J.2    Qian, H.3
  • 25
    • 0029858989 scopus 로고    scopus 로고
    • Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro
    • Borge OJ, Ramsfjell V, Veiby OP, Murphy MJ Jr, Lok S, Jacobsen SE. Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro. Blood. 1996;88:2859-2870.
    • (1996) Blood , vol.88 , pp. 2859-2870
    • Borge, O.J.1    Ramsfjell, V.2    Veiby, O.P.3    Murphy Jr, M.J.4    Lok, S.5    Jacobsen, S.E.6
  • 26
    • 0035496922 scopus 로고    scopus 로고
    • Mpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis
    • Pestina TI, Cleveland JL, Yang C, Zambetti GP, Jackson CW. Mpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis. Blood. 2001;98:2084-2090.
    • (2001) Blood , vol.98 , pp. 2084-2090
    • Pestina, T.I.1    Cleveland, J.L.2    Yang, C.3    Zambetti, G.P.4    Jackson, C.W.5
  • 27
    • 33847772982 scopus 로고    scopus 로고
    • Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction
    • Seita J, Ema H, Ooehara J, et al. Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction. Proc Natl Acad Sci U S A. 2007;104:2349-2354.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 2349-2354
    • Seita, J.1    Ema, H.2    Ooehara, J.3
  • 28
    • 0033637359 scopus 로고    scopus 로고
    • Control of B cell production by the adaptor protein lnk: Definition of a conserved family of signal-modulating proteins
    • Takaki S, Sauer K, Iritani BM, et al. Control of B cell production by the adaptor protein lnk: definition of a conserved family of signal-modulating proteins. Immunity. 2000;13:599-609.
    • (2000) Immunity , vol.13 , pp. 599-609
    • Takaki, S.1    Sauer, K.2    Iritani, B.M.3
  • 29
    • 20444426803 scopus 로고    scopus 로고
    • Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways
    • Tong W, Zhang J, Lodish HF. Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood. 2005;105:4604-4612.
    • (2005) Blood , vol.105 , pp. 4604-4612
    • Tong, W.1    Zhang, J.2    Lodish, H.F.3
  • 30
    • 0037124306 scopus 로고    scopus 로고
    • Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice
    • Velazquez L, Cheng AM, Fleming HE, et al. Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J Exp Med. 2002;195:1599-1611.
    • (2002) J Exp Med , vol.195 , pp. 1599-1611
    • Velazquez, L.1    Cheng, A.M.2    Fleming, H.E.3
  • 31
    • 19944400789 scopus 로고    scopus 로고
    • Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice
    • Ema H, Sudo K, Seita J, et al. Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice. Dev Cell. 2005;8:907-914.
    • (2005) Dev Cell , vol.8 , pp. 907-914
    • Ema, H.1    Sudo, K.2    Seita, J.3
  • 32
    • 0025856717 scopus 로고
    • TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    • Ellisen LW, Bird J, West DC, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell. 1991;66:649-661.
    • (1991) Cell , vol.66 , pp. 649-661
    • Ellisen, L.W.1    Bird, J.2    West, D.C.3
  • 34
    • 0028212430 scopus 로고
    • A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors
    • Milner LA, Kopan R, Martin DI, Bernstein ID. A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors. Blood. 1994;83:2057-2062.
    • (1994) Blood , vol.83 , pp. 2057-2062
    • Milner, L.A.1    Kopan, R.2    Martin, D.I.3    Bernstein, I.D.4
  • 35
    • 0034613734 scopus 로고    scopus 로고
    • The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells
    • Karanu FN, Murdoch B, Gallacher L, et al. The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells. J Exp Med. 2000;192:1365-1372.
    • (2000) J Exp Med , vol.192 , pp. 1365-1372
    • Karanu, F.N.1    Murdoch, B.2    Gallacher, L.3
  • 36
    • 0035313174 scopus 로고    scopus 로고
    • Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells
    • Karanu FN, Murdoch B, Miyabayashi T, et al. Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells. Blood. 2001;97:1960-1967.
    • (2001) Blood , vol.97 , pp. 1960-1967
    • Karanu, F.N.1    Murdoch, B.2    Miyabayashi, T.3
  • 37
    • 0037370834 scopus 로고    scopus 로고
    • Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability
    • Varnum-Finney B, Brashem-Stein C, Bernstein ID. Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability. Blood. 2003;101:1784-1789.
    • (2003) Blood , vol.101 , pp. 1784-1789
    • Varnum-Finney, B.1    Brashem-Stein, C.2    Bernstein, I.D.3
  • 38
    • 1642465517 scopus 로고    scopus 로고
    • Soluble Jagged-1 is able to inhibit the function of its multivalent form to induce hematopoietic stem cell self-renewal in a surrogate in vitro assay
    • Vas V, Szilagyi L, Paloczi K, Uher F. Soluble Jagged-1 is able to inhibit the function of its multivalent form to induce hematopoietic stem cell self-renewal in a surrogate in vitro assay. J Leukoc Biol. 2004;75:714-720.
    • (2004) J Leukoc Biol , vol.75 , pp. 714-720
    • Vas, V.1    Szilagyi, L.2    Paloczi, K.3    Uher, F.4
  • 39
    • 0036802174 scopus 로고    scopus 로고
    • Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells
    • Ohishi K, Varnum-Finney B, Bernstein ID. Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells. J Clin Invest. 2002;110:1165-1174.
    • (2002) J Clin Invest , vol.110 , pp. 1165-1174
    • Ohishi, K.1    Varnum-Finney, B.2    Bernstein, I.D.3
  • 40
    • 27144518462 scopus 로고    scopus 로고
    • Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells
    • Delaney C, Varnum-Finney B, Aoyama K, Brashem-Stein C, Bernstein ID. Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells. Blood. 2005;106:2693-2699.
    • (2005) Blood , vol.106 , pp. 2693-2699
    • Delaney, C.1    Varnum-Finney, B.2    Aoyama, K.3    Brashem-Stein, C.4    Bernstein, I.D.5
  • 41
    • 33745892388 scopus 로고    scopus 로고
    • Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells
    • Suzuki A, Raya A, Kawakami Y, et al. Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A. 2006;103:10294-10299.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10294-10299
    • Suzuki, A.1    Raya, A.2    Kawakami, Y.3
  • 42
    • 0037369237 scopus 로고    scopus 로고
    • HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo
    • Kunisato A, Chiba S, Nakagami-Yamaguchi E, et al. HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo. Blood. 2003;101:1777-1783.
    • (2003) Blood , vol.101 , pp. 1777-1783
    • Kunisato, A.1    Chiba, S.2    Nakagami-Yamaguchi, E.3
  • 43
    • 0036529989 scopus 로고    scopus 로고
    • Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome
    • Stier S, Cheng T, Dombkowski D, Carlesso N, Scadden DT. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood. 2002;99:2369-2378.
    • (2002) Blood , vol.99 , pp. 2369-2378
    • Stier, S.1    Cheng, T.2    Dombkowski, D.3    Carlesso, N.4    Scadden, D.T.5
  • 44
    • 0033694305 scopus 로고    scopus 로고
    • Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
    • Varnum-Finney B, Xu L, Brashem-Stein C, et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med. 2000;6:1278-1281.
    • (2000) Nat Med , vol.6 , pp. 1278-1281
    • Varnum-Finney, B.1    Xu, L.2    Brashem-Stein, C.3
  • 45
    • 0242268524 scopus 로고    scopus 로고
    • Osteoblastic cells regulate the haematopoietic stem cell niche
    • Calvi LM, Adams GB, Weibrecht KW, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003;425:841-846.
    • (2003) Nature , vol.425 , pp. 841-846
    • Calvi, L.M.1    Adams, G.B.2    Weibrecht, K.W.3
  • 46
    • 20144370145 scopus 로고    scopus 로고
    • Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance
    • Duncan AW, Rattis FM, DiMascio LN, et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 2005;6:314-322.
    • (2005) Nat Immunol , vol.6 , pp. 314-322
    • Duncan, A.W.1    Rattis, F.M.2    DiMascio, L.N.3
  • 47
    • 15244346226 scopus 로고    scopus 로고
    • Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation
    • Mancini SJ, Mantei N, Dumortier A, Suter U, MacDonald HR, Radtke F. Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood. 2005;105:2340-2342.
    • (2005) Blood , vol.105 , pp. 2340-2342
    • Mancini, S.J.1    Mantei, N.2    Dumortier, A.3    Suter, U.4    MacDonald, H.R.5    Radtke, F.6
  • 48
    • 0030989287 scopus 로고    scopus 로고
    • A role for the Wnt gene family in hematopoiesis: Expansion of multilineage progenitor cells
    • Austin TW, Solar GP, Ziegler FC, Liem L, Matthews W. A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood. 1997;89:3624-3635.
    • (1997) Blood , vol.89 , pp. 3624-3635
    • Austin, T.W.1    Solar, G.P.2    Ziegler, F.C.3    Liem, L.4    Matthews, W.5
  • 49
    • 0037737726 scopus 로고    scopus 로고
    • Wnt proteins are lipid-modified and can act as stem cell growth factors
    • Willert K, Brown JD, Danenberg E, et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature. 2003;423:448-452.
    • (2003) Nature , vol.423 , pp. 448-452
    • Willert, K.1    Brown, J.D.2    Danenberg, E.3
  • 50
    • 0032212190 scopus 로고    scopus 로고
    • Role of members of the Wnt gene family in human hematopoiesis
    • Van Den Berg DJ, Sharma AK, Bruno E, Hoffman R. Role of members of the Wnt gene family in human hematopoiesis. Blood. 1998;92:3189-3202.
    • (1998) Blood , vol.92 , pp. 3189-3202
    • Van Den Berg, D.J.1    Sharma, A.K.2    Bruno, E.3    Hoffman, R.4
  • 51
    • 0037737728 scopus 로고    scopus 로고
    • A role for Wnt signalling in self-renewal of haematopoietic stem cells
    • Reya T, Duncan AW, Ailles L, et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 2003;423:409-414.
    • (2003) Nature , vol.423 , pp. 409-414
    • Reya, T.1    Duncan, A.W.2    Ailles, L.3
  • 52
    • 33748850636 scopus 로고    scopus 로고
    • Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block
    • Kirstetter P, Anderson K, Porse BT, Jacobsen SE, Nerlov C. Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol. 2006;7:1048-1056.
    • (2006) Nat Immunol , vol.7 , pp. 1048-1056
    • Kirstetter, P.1    Anderson, K.2    Porse, B.T.3    Jacobsen, S.E.4    Nerlov, C.5
  • 53
    • 1642499734 scopus 로고    scopus 로고
    • Beta-catenin is dispensable for hematopoiesis and lymphopoiesis
    • Cobas M, Wilson A, Ernst B, et al. Beta-catenin is dispensable for hematopoiesis and lymphopoiesis. J Exp Med. 2004;199:221-229.
    • (2004) J Exp Med , vol.199 , pp. 221-229
    • Cobas, M.1    Wilson, A.2    Ernst, B.3
  • 54
    • 30044444251 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation
    • Trowbridge JJ, Xenocostas A, Moon RT, Bhatia M. Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation. Nat Med. 2006;12:89-98.
    • (2006) Nat Med , vol.12 , pp. 89-98
    • Trowbridge, J.J.1    Xenocostas, A.2    Moon, R.T.3    Bhatia, M.4
  • 55
    • 0029948374 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells
    • Sitnicka E, Ruscetti FW, Priestley GV, Wolf NS, Bartelmez SH. Transforming growth factor beta 1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells. Blood. 1996;88:82-88.
    • (1996) Blood , vol.88 , pp. 82-88
    • Sitnicka, E.1    Ruscetti, F.W.2    Priestley, G.V.3    Wolf, N.S.4    Bartelmez, S.H.5
  • 56
    • 0033996341 scopus 로고    scopus 로고
    • TGF-(beta)1 maintains hematopoietic immaturity by a reversible negative control of cell cycle and induces CD34 antigen up-modulation
    • Batard P, Monier MN, Fortunel N, et al. TGF-(beta)1 maintains hematopoietic immaturity by a reversible negative control of cell cycle and induces CD34 antigen up-modulation. J Cell Sci. 2000;113(Pt 3):383-390.
    • (2000) J Cell Sci , vol.113 , Issue.PART 3 , pp. 383-390
    • Batard, P.1    Monier, M.N.2    Fortunel, N.3
  • 57
    • 0031456790 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 delays formation of granulocyte-macrophage colony-forming cells, but spares more primitive progenitors during ex vivo expansion of CD34+ haemopoietic progenitor cells
    • Garbe A, Spyridonidis A, Mobest D, Schmoor C, Mertelsmann R, Henschler R. Transforming growth factor-beta 1 delays formation of granulocyte-macrophage colony-forming cells, but spares more primitive progenitors during ex vivo expansion of CD34+ haemopoietic progenitor cells. Br J Haematol. 1997;99:951-958.
    • (1997) Br J Haematol , vol.99 , pp. 951-958
    • Garbe, A.1    Spyridonidis, A.2    Mobest, D.3    Schmoor, C.4    Mertelsmann, R.5    Henschler, R.6
  • 58
    • 0025940505 scopus 로고
    • Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides
    • Hatzfeld J, Li ML, Brown EL, et al. Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides. J Exp Med. 1991;174:925-929.
    • (1991) J Exp Med , vol.174 , pp. 925-929
    • Hatzfeld, J.1    Li, M.L.2    Brown, E.L.3
  • 59
    • 0031851630 scopus 로고    scopus 로고
    • High proliferative potential-quiescent cells: A working model to study primitive quiescent hematopoietic cells
    • Fortunel N, Batard P, Hatzfeld A, et al. High proliferative potential-quiescent cells: a working model to study primitive quiescent hematopoietic cells. J Cell Sci. 1998;111(Pt 13):1867-1875.
    • (1998) J Cell Sci , vol.111 , Issue.PART 13 , pp. 1867-1875
    • Fortunel, N.1    Batard, P.2    Hatzfeld, A.3
  • 60
    • 9044237272 scopus 로고    scopus 로고
    • Maintenance of murine long-term repopulating stem cells in ex vivo culture is affected by modulation of transforming growth factor-beta but not macrophage inflammatory protein-1 alpha activities
    • Soma T, Yu JM, Dunbar CE. Maintenance of murine long-term repopulating stem cells in ex vivo culture is affected by modulation of transforming growth factor-beta but not macrophage inflammatory protein-1 alpha activities. Blood. 1996;87:4561-4567.
    • (1996) Blood , vol.87 , pp. 4561-4567
    • Soma, T.1    Yu, J.M.2    Dunbar, C.E.3
  • 61
    • 0025803697 scopus 로고
    • Transforming growth factor-beta trans-modulates the expression of colony stimulating factor receptors on murine hematopoietic progenitor cell lines
    • Jacobsen SE, Ruscetti FW, Dubois CM, Lee J, Boone TC, Keller JR. Transforming growth factor-beta trans-modulates the expression of colony stimulating factor receptors on murine hematopoietic progenitor cell lines. Blood. 1991;77:1706-1716.
    • (1991) Blood , vol.77 , pp. 1706-1716
    • Jacobsen, S.E.1    Ruscetti, F.W.2    Dubois, C.M.3    Lee, J.4    Boone, T.C.5    Keller, J.R.6
  • 62
    • 0024988543 scopus 로고
    • Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: Proposed mechanism of inhibition of IL-1 action
    • Dubois CM, Ruscetti FW, Palaszynski EW, Falk LA, Oppenheim JJ, Keller JR. Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action. J Exp Med. 1990;172:737-744.
    • (1990) J Exp Med , vol.172 , pp. 737-744
    • Dubois, C.M.1    Ruscetti, F.W.2    Palaszynski, E.W.3    Falk, L.A.4    Oppenheim, J.J.5    Keller, J.R.6
  • 63
    • 0028177911 scopus 로고
    • Transforming growth factor-beta regulates c-kit message stability and cell-surface protein expression in hematopoietic progenitors
    • Dubois CM, Ruscetti FW, Stankova J, Keller JR. Transforming growth factor-beta regulates c-kit message stability and cell-surface protein expression in hematopoietic progenitors. Blood. 1994;83:3138-3145.
    • (1994) Blood , vol.83 , pp. 3138-3145
    • Dubois, C.M.1    Ruscetti, F.W.2    Stankova, J.3    Keller, J.R.4
  • 64
    • 0028982214 scopus 로고
    • Early CD34high cells can be separated into KIThigh cells in which transforming growth factor-beta (TGF-beta) downmodulates c-kit and KITlow cells in which anti-TGF-beta upmodulates c-kit
    • Sansilvestri P, Cardoso AA, Batard P, et al. Early CD34high cells can be separated into KIThigh cells in which transforming growth factor-beta (TGF-beta) downmodulates c-kit and KITlow cells in which anti-TGF-beta upmodulates c-kit. Blood. 1995;86:1729-1735.
    • (1995) Blood , vol.86 , pp. 1729-1735
    • Sansilvestri, P.1    Cardoso, A.A.2    Batard, P.3
  • 65
    • 0034040637 scopus 로고    scopus 로고
    • p21(cip1) mRNA is controlled by endogenous transforming growth factor-beta1 in quiescent human hematopoietic stem/progenitor cells
    • Ducos K, Panterne B, Fortunel N, Hatzfeld A, Monier MN, Hatzfeld J. p21(cip1) mRNA is controlled by endogenous transforming growth factor-beta1 in quiescent human hematopoietic stem/progenitor cells. J Cell Physiol. 2000;184:80-85.
    • (2000) J Cell Physiol , vol.184 , pp. 80-85
    • Ducos, K.1    Panterne, B.2    Fortunel, N.3    Hatzfeld, A.4    Monier, M.N.5    Hatzfeld, J.6
  • 66
    • 0035895046 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21(Cip1/Waf1) or p27(Kip1)
    • Cheng T, Shen H, Rodrigues N, Stier S, Scadden DT. Transforming growth factor beta 1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21(Cip1/Waf1) or p27(Kip1). Blood. 2001;98:3643-3649.
    • (2001) Blood , vol.98 , pp. 3643-3649
    • Cheng, T.1    Shen, H.2    Rodrigues, N.3    Stier, S.4    Scadden, D.T.5
  • 67
    • 0032573177 scopus 로고    scopus 로고
    • Reduction in levels of the cyclin-dependent kinase inhibitor p27(kip-1) coupled with transforming growth factor beta neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells
    • Dao MA, Taylor N, Nolta JA. Reduction in levels of the cyclin-dependent kinase inhibitor p27(kip-1) coupled with transforming growth factor beta neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells. Proc Natl Acad Sci U S A. 1998;95:13006-13011.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13006-13011
    • Dao, M.A.1    Taylor, N.2    Nolta, J.A.3
  • 68
    • 0037079726 scopus 로고    scopus 로고
    • Molecular mechanism of transforming growth factor beta-mediated cellcycle modulation in primary human CD34(+) progenitors
    • Dao MA, Hwa J, Nolta JA. Molecular mechanism of transforming growth factor beta-mediated cellcycle modulation in primary human CD34(+) progenitors. Blood. 2002;99:499-506.
    • (2002) Blood , vol.99 , pp. 499-506
    • Dao, M.A.1    Hwa, J.2    Nolta, J.A.3
  • 69
    • 6344293545 scopus 로고    scopus 로고
    • Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation
    • Scandura JM, Boccuni P, Massague J, Nimer SD. Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation. Proc Natl Acad Sci U S A. 2004;101:15231-15236.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 15231-15236
    • Scandura, J.M.1    Boccuni, P.2    Massague, J.3    Nimer, S.D.4
  • 70
    • 24644495693 scopus 로고    scopus 로고
    • The role of Smad signaling in hematopoiesis
    • Larsson J, Karlsson S. The role of Smad signaling in hematopoiesis. Oncogene. 2005;24:5676-5692.
    • (2005) Oncogene , vol.24 , pp. 5676-5692
    • Larsson, J.1    Karlsson, S.2
  • 71
    • 24644475227 scopus 로고    scopus 로고
    • Autocrine transforming growth factor-beta regulation of hematopoiesis: Many outcomes that depend on the context
    • Ruscetti FW, Akel S, Bartelmez SH. Autocrine transforming growth factor-beta regulation of hematopoiesis: many outcomes that depend on the context. Oncogene. 2005;24:5751-5763.
    • (2005) Oncogene , vol.24 , pp. 5751-5763
    • Ruscetti, F.W.1    Akel, S.2    Bartelmez, S.H.3
  • 72
    • 0034665777 scopus 로고    scopus 로고
    • Transforming growth factor-beta: Pleiotropic role in the regulation of hematopoiesis
    • Fortunel NO, Hatzfeld A, Hatzfeld JA. Transforming growth factor-beta: pleiotropic role in the regulation of hematopoiesis. Blood. 2000;96:2022-2036.
    • (2000) Blood , vol.96 , pp. 2022-2036
    • Fortunel, N.O.1    Hatzfeld, A.2    Hatzfeld, J.A.3
  • 73
    • 0030063832 scopus 로고    scopus 로고
    • Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse
    • Yaswen L, Kulkarni AB, Fredrickson T, et al. Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse. Blood. 1996;87:1439-1445.
    • (1996) Blood , vol.87 , pp. 1439-1445
    • Yaswen, L.1    Kulkarni, A.B.2    Fredrickson, T.3
  • 74
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-beta
    • Letterio JJ, Roberts AB. Regulation of immune responses by TGF-beta. Annu Rev Immunol. 1998;16:137-161.
    • (1998) Annu Rev Immunol , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 75
    • 0037100520 scopus 로고    scopus 로고
    • Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable
    • Levéen P, Larsson J, Ehinger M, et al. Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. Blood. 2002;100:560-568.
    • (2002) Blood , vol.100 , pp. 560-568
    • Levéen, P.1    Larsson, J.2    Ehinger, M.3
  • 76
    • 0029907123 scopus 로고    scopus 로고
    • Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression
    • Letterio JJ, Geiser AG, Kulkarni AB, et al. Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression. J Clin Invest. 1996;98:2109-2119.
    • (1996) J Clin Invest , vol.98 , pp. 2109-2119
    • Letterio, J.J.1    Geiser, A.G.2    Kulkarni, A.B.3
  • 77
    • 0142245613 scopus 로고    scopus 로고
    • TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro
    • Larsson J, Blank U, Helgadottir H, et al. TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro. Blood. 2003;102:3129-3135.
    • (2003) Blood , vol.102 , pp. 3129-3135
    • Larsson, J.1    Blank, U.2    Helgadottir, H.3
  • 78
    • 17844384518 scopus 로고    scopus 로고
    • Quiescence of hematopoietic stem cells and maintenance of the stem cell pool is not dependent on TGF-beta signaling in vivo
    • Larsson J, Blank U, Klintman J, Magnusson M, Karlsson S. Quiescence of hematopoietic stem cells and maintenance of the stem cell pool is not dependent on TGF-beta signaling in vivo. Exp Hematol. 2005;33:592-596.
    • (2005) Exp Hematol , vol.33 , pp. 592-596
    • Larsson, J.1    Blank, U.2    Klintman, J.3    Magnusson, M.4    Karlsson, S.5
  • 79
    • 0032402116 scopus 로고    scopus 로고
    • Cooperative effects of growth factors involved in the induction of hematopoietic mesoderm
    • Huber TL, Zhou Y, Mead PE, Zon LI. Cooperative effects of growth factors involved in the induction of hematopoietic mesoderm. Blood. 1998;92:4128-4137.
    • (1998) Blood , vol.92 , pp. 4128-4137
    • Huber, T.L.1    Zhou, Y.2    Mead, P.E.3    Zon, L.I.4
  • 80
    • 0029793060 scopus 로고    scopus 로고
    • The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis
    • Maeno M, Mead PE, Kelley C, et al. The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis. Blood. 1996;88:1965-1972.
    • (1996) Blood , vol.88 , pp. 1965-1972
    • Maeno, M.1    Mead, P.E.2    Kelley, C.3
  • 81
    • 0343674772 scopus 로고    scopus 로고
    • Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation
    • Schmid B, Furthauer M, Connors SA, et al. Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation. Development. 2000;127:957-967.
    • (2000) Development , vol.127 , pp. 957-967
    • Schmid, B.1    Furthauer, M.2    Connors, S.A.3
  • 82
    • 0142152445 scopus 로고    scopus 로고
    • Primitive erythropoiesis is regulated by Smad-dependent signaling in postgastrulation mesoderm
    • Schmerer M, Evans T. Primitive erythropoiesis is regulated by Smad-dependent signaling in postgastrulation mesoderm. Blood. 2003;102:3196-3205.
    • (2003) Blood , vol.102 , pp. 3196-3205
    • Schmerer, M.1    Evans, T.2
  • 83
    • 0029149656 scopus 로고
    • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    • Winnier G, Blessing M, Labosky PA, Hogan BL. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 1995;9:2105-2116.
    • (1995) Genes Dev , vol.9 , pp. 2105-2116
    • Winnier, G.1    Blessing, M.2    Labosky, P.A.3    Hogan, B.L.4
  • 84
    • 0033526067 scopus 로고    scopus 로고
    • Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells
    • Bhatia M, Bonnet D, Wu D, et al. Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells. J Exp Med. 1999;189:1139-1148.
    • (1999) J Exp Med , vol.189 , pp. 1139-1148
    • Bhatia, M.1    Bonnet, D.2    Wu, D.3
  • 85
    • 0035257660 scopus 로고    scopus 로고
    • Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
    • Bhardwaj G, Murdoch B, Wu D, et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol. 2001;2:172-180.
    • (2001) Nat Immunol , vol.2 , pp. 172-180
    • Bhardwaj, G.1    Murdoch, B.2    Wu, D.3
  • 87
    • 0037222682 scopus 로고    scopus 로고
    • Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis
    • Liu B, Sun Y, Jiang F, et al. Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis. Blood. 2003;101:124-133.
    • (2003) Blood , vol.101 , pp. 124-133
    • Liu, B.1    Sun, Y.2    Jiang, F.3
  • 88
    • 33845245178 scopus 로고    scopus 로고
    • Smad5 is dispensable for adult murine hematopoiesis
    • Singbrant S, Moody JL, Blank U, et al. Smad5 is dispensable for adult murine hematopoiesis. Blood. 2006;108:3707-3712.
    • (2006) Blood , vol.108 , pp. 3707-3712
    • Singbrant, S.1    Moody, J.L.2    Blank, U.3
  • 89
    • 33845482880 scopus 로고    scopus 로고
    • Smad7 promotes self-renewal of hematopoietic stem cells in vivo
    • Blank U, Karlsson G, Moody JL, et al. Smad7 promotes self-renewal of hematopoietic stem cells in vivo. Blood. 2006;108:4246-4254.
    • (2006) Blood , vol.108 , pp. 4246-4254
    • Blank, U.1    Karlsson, G.2    Moody, J.L.3
  • 90
    • 14944369329 scopus 로고    scopus 로고
    • Smad7 alters cell fate decisions of human hematopoietic repopulating cells
    • Chadwick K, Shojaei F, Gallacher L, Bhatia M. Smad7 alters cell fate decisions of human hematopoietic repopulating cells. Blood. 2005;105:1905-1915.
    • (2005) Blood , vol.105 , pp. 1905-1915
    • Chadwick, K.1    Shojaei, F.2    Gallacher, L.3    Bhatia, M.4
  • 91
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-beta signals
    • Moustakas A, Heldin CH. Non-Smad TGF-beta signals. J Cell Sci. 2005;118:3573-3584.
    • (2005) J Cell Sci , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 92
    • 33947419709 scopus 로고    scopus 로고
    • Smad4 is critical for self-renewal of hematopoietic stem cells
    • Karlsson G, Blank U, Moody JL, et al. Smad4 is critical for self-renewal of hematopoietic stem cells. J Exp Med. 2007;204:467-474.
    • (2007) J Exp Med , vol.204 , pp. 467-474
    • Karlsson, G.1    Blank, U.2    Moody, J.L.3
  • 93
    • 0034677494 scopus 로고    scopus 로고
    • Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer
    • Nishita M, Hashimoto MK, Ogata S, et al. Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer. Nature. 2000;403:781-785.
    • (2000) Nature , vol.403 , pp. 781-785
    • Nishita, M.1    Hashimoto, M.K.2    Ogata, S.3
  • 94
    • 0034682515 scopus 로고    scopus 로고
    • Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways
    • Labbé E, Letamendia A, Attisano L. Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways. Proc Natl Acad Sci U S A. 2000;97:8358-8363.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 8358-8363
    • Labbé, E.1    Letamendia, A.2    Attisano, L.3
  • 95
    • 10744231139 scopus 로고    scopus 로고
    • Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells
    • Itoh F, Itoh S, Goumans MJ, et al. Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J. 2004;23:541-551.
    • (2004) EMBO J , vol.23 , pp. 541-551
    • Itoh, F.1    Itoh, S.2    Goumans, M.J.3
  • 96
    • 33646876973 scopus 로고    scopus 로고
    • Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway
    • He W, Dorn DC, Erdjument-Bromage H, Tempst P, Moore MA, Massague J. Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell. 2006;125:929-941.
    • (2006) Cell , vol.125 , pp. 929-941
    • He, W.1    Dorn, D.C.2    Erdjument-Bromage, H.3    Tempst, P.4    Moore, M.A.5    Massague, J.6
  • 97
    • 19344371219 scopus 로고    scopus 로고
    • The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis
    • Ransom DG, Bahary N, Niss K, et al. The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol. 2004;2:E237.
    • (2004) PLoS Biol , vol.2
    • Ransom, D.G.1    Bahary, N.2    Niss, K.3
  • 98
    • 17044365440 scopus 로고    scopus 로고
    • Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase
    • Dupont S, Zacchigna L, Cordenonsi M, et al. Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell. 2005;121:87-99.
    • (2005) Cell , vol.121 , pp. 87-99
    • Dupont, S.1    Zacchigna, L.2    Cordenonsi, M.3
  • 99
    • 0032126633 scopus 로고    scopus 로고
    • Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
    • Kroon E, Krosl J, Thorsteinsdottir U, Baban S, Buchberg AM, Sauvageau G. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J. 1998;17:3714-3725.
    • (1998) EMBO J , vol.17 , pp. 3714-3725
    • Kroon, E.1    Krosl, J.2    Thorsteinsdottir, U.3    Baban, S.4    Buchberg, A.M.5    Sauvageau, G.6
  • 100
    • 33645740881 scopus 로고    scopus 로고
    • TGFbeta/BMP inhibits the bone marrow transformation capability of Hoxa9 by repressing its DNA-binding ability
    • Wang N, Kim HG, Cotta CV, et al. TGFbeta/BMP inhibits the bone marrow transformation capability of Hoxa9 by repressing its DNA-binding ability. EMBO J. 2006;25:1469-1480.
    • (2006) EMBO J , vol.25 , pp. 1469-1480
    • Wang, N.1    Kim, H.G.2    Cotta, C.V.3
  • 101
    • 32244436673 scopus 로고    scopus 로고
    • Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells
    • Zhang CC, Kaba M, Ge G, et al. Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat Med. 2006;12:240-245.
    • (2006) Nat Med , vol.12 , pp. 240-245
    • Zhang, C.C.1    Kaba, M.2    Ge, G.3
  • 102
    • 0016822122 scopus 로고
    • The relative spatial distributions of CFUs and CFUc in the normal mouse femur
    • Lord BI, Testa NG, Hendry JH. The relative spatial distributions of CFUs and CFUc in the normal mouse femur. Blood.1975;46:65-72.
    • (1975) Blood , vol.46 , pp. 65-72
    • Lord, B.I.1    Testa, N.G.2    Hendry, J.H.3
  • 103
    • 0017834345 scopus 로고
    • Endosteal marrow: A rich source of hematopoietic stem cells
    • Gong JK. Endosteal marrow: a rich source of hematopoietic stem cells. Science. 1978;199:1443-1445.
    • (1978) Science , vol.199 , pp. 1443-1445
    • Gong, J.K.1
  • 104
    • 0018102359 scopus 로고
    • The relationship between the spleen colony-forming cell and the haemopoietic stem cell
    • Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells. 1978;4:7-25.
    • (1978) Blood Cells , vol.4 , pp. 7-25
    • Schofield, R.1
  • 105
    • 33644827383 scopus 로고    scopus 로고
    • Bone-marrow haematopoietic-stem-cell niches
    • Wilson A, Trumpp A. Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol. 2006;6:93-106.
    • (2006) Nat Rev Immunol , vol.6 , pp. 93-106
    • Wilson, A.1    Trumpp, A.2
  • 106
    • 0242363225 scopus 로고    scopus 로고
    • Identification of the haematopoietic stem cell niche and control of the niche size
    • Zhang J, Niu C, Ye L, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003;425:836-841.
    • (2003) Nature , vol.425 , pp. 836-841
    • Zhang, J.1    Niu, C.2    Ye, L.3
  • 107
    • 1942457308 scopus 로고    scopus 로고
    • Hematopoiesis is severely altered in mice with an induced osteoblast deficiency
    • Visnjic D, Kalajzic Z, Rowe DW, Katavic V, Lorenzo J, Aguila HL. Hematopoiesis is severely altered in mice with an induced osteoblast deficiency. Blood. 2004;103:3258-3264.
    • (2004) Blood , vol.103 , pp. 3258-3264
    • Visnjic, D.1    Kalajzic, Z.2    Rowe, D.W.3    Katavic, V.4    Lorenzo, J.5    Aguila, H.L.6
  • 108
    • 3242669145 scopus 로고    scopus 로고
    • Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
    • Arai F, Hirao A, Ohmura M, et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell. 2004;118:149-161.
    • (2004) Cell , vol.118 , pp. 149-161
    • Arai, F.1    Hirao, A.2    Ohmura, M.3
  • 109
    • 21244472780 scopus 로고    scopus 로고
    • Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size
    • Stier S, Ko Y, Forkert R, et al. Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Exp Med. 2005;201:1781-1791.
    • (2005) J Exp Med , vol.201 , pp. 1781-1791
    • Stier, S.1    Ko, Y.2    Forkert, R.3
  • 110
    • 21344474104 scopus 로고    scopus 로고
    • Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells
    • Nilsson SK, Johnston HM, Whitty GA, et al. Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood. 2005;106:1232-1239.
    • (2005) Blood , vol.106 , pp. 1232-1239
    • Nilsson, S.K.1    Johnston, H.M.2    Whitty, G.A.3
  • 111
    • 31844449374 scopus 로고    scopus 로고
    • Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor
    • Adams GB, Chabner KT, Alley IR, et al. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature. 2006;439:599-603.
    • (2006) Nature , vol.439 , pp. 599-603
    • Adams, G.B.1    Chabner, K.T.2    Alley, I.R.3
  • 112
    • 34250331610 scopus 로고    scopus 로고
    • A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency
    • Walkley CR, Olsen GH, Dworkin S, et al. A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell. 2007;129:1097-1110.
    • (2007) Cell , vol.129 , pp. 1097-1110
    • Walkley, C.R.1    Olsen, G.H.2    Dworkin, S.3
  • 113
    • 34250363611 scopus 로고    scopus 로고
    • Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment
    • Walkley CR, Shea JM, Sims NA, Purton LE, Orkin SH. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell. 2007;129:1081-1095.
    • (2007) Cell , vol.129 , pp. 1081-1095
    • Walkley, C.R.1    Shea, J.M.2    Sims, N.A.3    Purton, L.E.4    Orkin, S.H.5
  • 114
    • 34248359065 scopus 로고    scopus 로고
    • Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
    • Parmar K, Mauch P, Vergilio JA, Sackstein R, Down JD. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci U S A. 2007;104:5431-5436.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 5431-5436
    • Parmar, K.1    Mauch, P.2    Vergilio, J.A.3    Sackstein, R.4    Down, J.D.5
  • 115
    • 7244250309 scopus 로고    scopus 로고
    • Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
    • Ito K, Hirao A, Arai F, et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature. 2004;431:997-1002.
    • (2004) Nature , vol.431 , pp. 997-1002
    • Ito, K.1    Hirao, A.2    Arai, F.3
  • 116
    • 33645730667 scopus 로고    scopus 로고
    • Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
    • Ito K, Hirao A, Arai F, et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med. 2006;12:446-451.
    • (2006) Nat Med , vol.12 , pp. 446-451
    • Ito, K.1    Hirao, A.2    Arai, F.3
  • 117
    • 33846419112 scopus 로고    scopus 로고
    • FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    • Tothova Z, Kollipara R, Huntly BJ, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 2007;128:325-339.
    • (2007) Cell , vol.128 , pp. 325-339
    • Tothova, Z.1    Kollipara, R.2    Huntly, B.J.3
  • 118
    • 0029965412 scopus 로고    scopus 로고
    • The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts
    • Rebel VI, Miller CL, Eaves CJ, Lansdorp PM. The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts. Blood. 1996;87:3500-3507.
    • (1996) Blood , vol.87 , pp. 3500-3507
    • Rebel, V.I.1    Miller, C.L.2    Eaves, C.J.3    Lansdorp, P.M.4
  • 119
    • 33749452454 scopus 로고    scopus 로고
    • Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect
    • Bowie MB, McKnight KD, Kent DG, McCaffrey L, Hoodless PA, Eaves CJ. Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect. J Clin Invest. 2006;116:2808-2816.
    • (2006) J Clin Invest , vol.116 , pp. 2808-2816
    • Bowie, M.B.1    McKnight, K.D.2    Kent, D.G.3    McCaffrey, L.4    Hoodless, P.A.5    Eaves, C.J.6
  • 120
    • 34249679309 scopus 로고    scopus 로고
    • Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties
    • Bowie MB, Kent DG, Dykstra B, et al. Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties. Proc Natl Acad Sci U S A. 2007;104:5878-5882.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 5878-5882
    • Bowie, M.B.1    Kent, D.G.2    Dykstra, B.3
  • 121
    • 34249711353 scopus 로고    scopus 로고
    • Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells
    • Bowie MB, Kent DG, Copley MR, Eaves CJ. Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells. Blood. 2007;109:5043-5048.
    • (2007) Blood , vol.109 , pp. 5043-5048
    • Bowie, M.B.1    Kent, D.G.2    Copley, M.R.3    Eaves, C.J.4
  • 122
    • 0024396816 scopus 로고
    • Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical cord blood from an HLA-identical sibling
    • Gluckman E, Broxmeyer HA, Auerbach AD, et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical cord blood from an HLA-identical sibling. N Engl J Med. 1989;321:1174-1178.
    • (1989) N Engl J Med , vol.321 , pp. 1174-1178
    • Gluckman, E.1    Broxmeyer, H.A.2    Auerbach, A.D.3
  • 123
    • 8844251482 scopus 로고    scopus 로고
    • Regulation of hematopoietic stem cell growth
    • Attar EC, Scadden DT. Regulation of hematopoietic stem cell growth. Leukemia. 2004;18:1760-1768.
    • (2004) Leukemia , vol.18 , pp. 1760-1768
    • Attar, E.C.1    Scadden, D.T.2
  • 124
    • 8544252411 scopus 로고    scopus 로고
    • Clinical strategies for expansion of haematopoietic stem cells
    • Sorrentino BP. Clinical strategies for expansion of haematopoietic stem cells. Nat Rev Immunol. 2004;4:878-888.
    • (2004) Nat Rev Immunol , vol.4 , pp. 878-888
    • Sorrentino, B.P.1
  • 125
    • 0037443457 scopus 로고    scopus 로고
    • Side effects of retroviral gene transfer into hematopoietic stem cells
    • Baum C, Dullmann J, Li Z, et al. Side effects of retroviral gene transfer into hematopoietic stem cells. Blood. 2003;101:2099-2114.
    • (2003) Blood , vol.101 , pp. 2099-2114
    • Baum, C.1    Dullmann, J.2    Li, Z.3
  • 126
    • 0142084745 scopus 로고    scopus 로고
    • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    • Hacein-Bey-Abina S, Von Kalle C, Schmidt M, et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science. 2003;302:415-419.
    • (2003) Science , vol.302 , pp. 415-419
    • Hacein-Bey-Abina, S.1    Von Kalle, C.2    Schmidt, M.3
  • 127
    • 0037441587 scopus 로고    scopus 로고
    • Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: Risk of insertional mutagenesis
    • Woods NB, Muessig A, Schmidt M, et al. Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis. Blood. 2003;101:1284-1289.
    • (2003) Blood , vol.101 , pp. 1284-1289
    • Woods, N.B.1    Muessig, A.2    Schmidt, M.3
  • 128
    • 0037023528 scopus 로고    scopus 로고
    • HOXB4-induced expansion of adult hematopoietic stem cells ex vivo
    • Antonchuk J, Sauvageau G, Humphries RK. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell. 2002;109:39-45.
    • (2002) Cell , vol.109 , pp. 39-45
    • Antonchuk, J.1    Sauvageau, G.2    Humphries, R.K.3
  • 129
    • 0345708270 scopus 로고    scopus 로고
    • Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein
    • Amsellem S, Pflumio F, Bardinet D, et al. Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein. Nat Med. 2003;9:1423-1427.
    • (2003) Nat Med , vol.9 , pp. 1423-1427
    • Amsellem, S.1    Pflumio, F.2    Bardinet, D.3
  • 130
    • 0344413639 scopus 로고    scopus 로고
    • In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein
    • Krosl J, Austin P, Beslu N, Kroon E, Humphries RK, Sauvageau G. In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nat Med. 2003;9:1428-1432.
    • (2003) Nat Med , vol.9 , pp. 1428-1432
    • Krosl, J.1    Austin, P.2    Beslu, N.3    Kroon, E.4    Humphries, R.K.5    Sauvageau, G.6
  • 131
    • 0037322190 scopus 로고    scopus 로고
    • In vitro generation of long-term repopulating hematopoietic stem cells by fibroblast growth factor-1
    • de Haan G, Weersing E, Dontje B, et al. In vitro generation of long-term repopulating hematopoietic stem cells by fibroblast growth factor-1. Dev Cell. 2003;4:241-251.
    • (2003) Dev Cell , vol.4 , pp. 241-251
    • de Haan, G.1    Weersing, E.2    Dontje, B.3
  • 132
    • 33747616838 scopus 로고    scopus 로고
    • Fibroblast growth factor-1 and -2 preserve long-term repopulating ability of hematopoietic stem cells in serum-free cultures
    • Yeoh JS, van Os R, Weersing E, et al. Fibroblast growth factor-1 and -2 preserve long-term repopulating ability of hematopoietic stem cells in serum-free cultures. Stem Cells. 2006;24:1564-1572.
    • (2006) Stem Cells , vol.24 , pp. 1564-1572
    • Yeoh, J.S.1    van Os, R.2    Weersing, E.3
  • 133
    • 19444386119 scopus 로고    scopus 로고
    • Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion
    • Zhang CC, Lodish HF. Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion. Blood. 2005;105:4314-4320.
    • (2005) Blood , vol.105 , pp. 4314-4320
    • Zhang, C.C.1    Lodish, H.F.2
  • 134
    • 34247623492 scopus 로고    scopus 로고
    • NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells
    • Gupta R, Hong D, Iborra F, Sarno S, Enver T. NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells. Science. 2007;316:590-593.
    • (2007) Science , vol.316 , pp. 590-593
    • Gupta, R.1    Hong, D.2    Iborra, F.3    Sarno, S.4    Enver, T.5
  • 135
    • 20144388533 scopus 로고    scopus 로고
    • Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells
    • Bug G, Gul H, Schwarz K, et al. Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells. Cancer Res. 2005;65:2537-2541.
    • (2005) Cancer Res , vol.65 , pp. 2537-2541
    • Bug, G.1    Gul, H.2    Schwarz, K.3
  • 136
    • 13944263926 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor valproic acid enhances the cytokine-induced expansion of human hematopoietic stem cells
    • De Felice L, Tatarelli C, Mascolo MG, et al. Histone deacetylase inhibitor valproic acid enhances the cytokine-induced expansion of human hematopoietic stem cells. Cancer Res. 2005;65:1505-1513.
    • (2005) Cancer Res , vol.65 , pp. 1505-1513
    • De Felice, L.1    Tatarelli, C.2    Mascolo, M.G.3
  • 137
    • 34250883337 scopus 로고    scopus 로고
    • Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
    • North TE, Goessling W, Walkley CR, et al. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007;447:1007-1011.
    • (2007) Nature , vol.447 , pp. 1007-1011
    • North, T.E.1    Goessling, W.2    Walkley, C.R.3
  • 138
    • 33747179585 scopus 로고    scopus 로고
    • Normal and deregulated notch signaling in regulation of hematopoietic stem cells and development of leukemia [in Japanese]
    • Chiba S. Normal and deregulated notch signaling in regulation of hematopoietic stem cells and development of leukemia [in Japanese]. Rinsho Ketsueki. 2006;47:371-378.
    • (2006) Rinsho Ketsueki , vol.47 , pp. 371-378
    • Chiba, S.1
  • 139
    • 33751530490 scopus 로고    scopus 로고
    • Mining the Wnt pathway for cancer therapeutics
    • Barker N, Clevers H. Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov. 2006;5:997-1014.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 997-1014
    • Barker, N.1    Clevers, H.2
  • 140
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell. 2006;127:469-480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 141
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • Massagué J. TGF-beta signal transduction. Annu Rev Biochem. 1998;67:753-791.
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massagué, J.1
  • 142
    • 0031438047 scopus 로고    scopus 로고
    • TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    • Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature. 1997;390:465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    ten Dijke, P.3
  • 143
    • 0030611757 scopus 로고    scopus 로고
    • Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
    • Nakao A, Afrakhte M, Moren A, et al. Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature. 1997;389:631-635.
    • (1997) Nature , vol.389 , pp. 631-635
    • Nakao, A.1    Afrakhte, M.2    Moren, A.3
  • 144
    • 0031587828 scopus 로고    scopus 로고
    • The MAD-related protein Smad7 associates with the TGF-beta receptor and functions as an antagonist of TGFbeta signaling
    • Hayashi H, Abdollah S, Qiu Y, et al. The MAD-related protein Smad7 associates with the TGF-beta receptor and functions as an antagonist of TGFbeta signaling. Cell. 1997;89:1165-1173.
    • (1997) Cell , vol.89 , pp. 1165-1173
    • Hayashi, H.1    Abdollah, S.2    Qiu, Y.3
  • 145
    • 0032566611 scopus 로고    scopus 로고
    • Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors
    • Souchelnytskyi S, Nakayama T, Nakao A, et al. Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors. J Biol Chem. 1998;273:25364-25370.
    • (1998) J Biol Chem , vol.273 , pp. 25364-25370
    • Souchelnytskyi, S.1    Nakayama, T.2    Nakao, A.3
  • 146
    • 34249882777 scopus 로고    scopus 로고
    • Foxo3a is essential for maintenance of the hematopoietic stem cell pool
    • Miyamoto K, Araki KY, Naka K, et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem. 2007;1:101-112.
    • (2007) Cell Stem , vol.1 , pp. 101-112
    • Miyamoto, K.1    Araki, K.Y.2    Naka, K.3


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