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Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell. 69:1992;11-25.
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Clark EA, Brugge JS. Integrins and signal transduction pathways: the road taken. Science. 268:1995;233-239.
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Association of insulin receptor substrate-1 with integrins
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Vuori K, Ruoslahti E. Association of insulin receptor substrate-1 with integrins. Science. 266:1994;1576-1578.
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Vuori, K.1
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0029666451
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The intracellular functions of α6β4 integrin are regulated by EGF
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of outstanding interest. Evidence that α6β4 integrin is a mediator of the mitogenic (i.e. growth factor) response in keratinocytes. This paper provides key experiments indicating that α6β4 is linked to signal transduction pathways.
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Mainiero F, Pepe A, Yeon M, Ren Y, Giancotti FG. The intracellular functions of α6β4 integrin are regulated by EGF. of outstanding interest J Cell Biol. 134:1996;241-253 Evidence that α6β4 integrin is a mediator of the mitogenic (i.e. growth factor) response in keratinocytes. This paper provides key experiments indicating that α6β4 is linked to signal transduction pathways.
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J Cell Biol
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Mainiero, F.1
Pepe, A.2
Yeon, M.3
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Giancotti, F.G.5
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6
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0030980345
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The coupling of α6β4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation
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of outstanding interest. Mainiero [5] continue their studies on α6β4 integrin signaling, this time showing that Shc couples the integrin heterodimer to the Ras-MAP kinase pathway and thereby controls keratinocyte proliferation. Although intriguing, there is still controversy as to whether this integrin is the sole mediator of the mitogenic response of keratinocytes.
-
Mainiero F, Mugia C, Wary KK, Curatola AM, Pepe A, Blumenberg M, Westwick JK, Der CJ, Giancotti FG. The coupling of α6β4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. of outstanding interest EMBO J. 16:1997;2365-2375 Mainiero [5] continue their studies on α6β4 integrin signaling, this time showing that Shc couples the integrin heterodimer to the Ras-MAP kinase pathway and thereby controls keratinocyte proliferation. Although intriguing, there is still controversy as to whether this integrin is the sole mediator of the mitogenic response of keratinocytes.
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EMBO J
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Mainiero, F.1
Mugia, C.2
Wary, K.K.3
Curatola, A.M.4
Pepe, A.5
Blumenberg, M.6
Westwick, J.K.7
Der, C.J.8
Giancotti, F.G.9
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7
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0030297728
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Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation
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Juliano R. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation. Bioessays. 18:1996;911-917.
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Juliano, R.1
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8
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0028285015
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Integrin cytoplasmic domains mediate inside-out signal transduction
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O'Toole TE, Katagiri Y, Faul RJ, Peter K, Tamura R, Quaranta V, Loftus JC, Shattil SJ, Ginsberg MH. Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol. 124:1994;1047-1059.
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O'Toole, T.E.1
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Faul, R.J.3
Peter, K.4
Tamura, R.5
Quaranta, V.6
Loftus, J.C.7
Shattil, S.J.8
Ginsberg, M.H.9
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9
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0029870339
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Integrin activation by R-ras
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of outstanding interest. The authors of this pioneering paper show that activated R-ras is a novel GTPase that can activate integrins from within cells, thereby providing a mechanism for inside-out signaling.
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Zhang Z, Vuori K, Wang H, Reed JC, Ruoslahti E. Integrin activation by R-ras. of outstanding interest Cell. 85:1996;61-69 The authors of this pioneering paper show that activated R-ras is a novel GTPase that can activate integrins from within cells, thereby providing a mechanism for inside-out signaling.
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Cell
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Zhang, Z.1
Vuori, K.2
Wang, H.3
Reed, J.C.4
Ruoslahti, E.5
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10
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0030584077
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The adaptor protein Shc couples a class of integrins to the control of cell cycle progression
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of outstanding interest. These authors provide some evidence to suggest that coupling to Shc by an integrin heterodimer is a prerequisite to controlling cell cycle progression and mediating a mitogenic response. This finding suggests that Shc maybe the link between growth factor receptor and integrin pathways.
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Wary KK, Mainiero F, Isakoff SJ, Marcantonio EE, Giancotti FG. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. of outstanding interest Cell. 87:1996;733-743 These authors provide some evidence to suggest that coupling to Shc by an integrin heterodimer is a prerequisite to controlling cell cycle progression and mediating a mitogenic response. This finding suggests that Shc maybe the link between growth factor receptor and integrin pathways.
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(1996)
Cell
, vol.87
, pp. 733-743
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Wary, K.K.1
Mainiero, F.2
Isakoff, S.J.3
Marcantonio, E.E.4
Giancotti, F.G.5
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11
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Hemidesmosomes: Roles in adhesion, signaling and human diseases
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Borradori L, Sonnenberg A. Hemidesmosomes: roles in adhesion, signaling and human diseases. Curr Opin Cell Biol. 8:1996;647-656.
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Borradori, L.1
Sonnenberg, A.2
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12
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Expression and function of the keratinocyte integrins
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Watt FM, Jones PH. Expression and function of the keratinocyte integrins. Development. Suppl:1993;185-192.
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Development
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Watt, F.M.1
Jones, P.H.2
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13
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0025985299
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Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and nondifferentiating keratinocytes
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Adams JC, Watt FM. Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and nondifferentiating keratinocytes. J Cell Biol. 115:1991;829-841.
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Adams, J.C.1
Watt, F.M.2
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14
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0028987192
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Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: Implications for wound healing
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Zambruno G, Marchisio PC, Marconi A, Vaschieri C, Melchiori A, Giannetti A, De Luca M. Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing. J Cell Biol. 129:1995;853-865.
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Zambruno, G.1
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Marconi, A.3
Vaschieri, C.4
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Giannetti, A.6
De Luca, M.7
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15
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0025679064
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Distinct functions for integrins alpha 3 beta 1 in focal adhesions and alpha 6 beta 4/bullous pemphigoid antigen in a new stable anchoring contacts (SAC) of keratinocytes: Relation to hemidesmosomes
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Carter WG, Kaur P, Gil SG, Gahr PJ, Wayner ER. Distinct functions for integrins alpha 3 beta 1 in focal adhesions and alpha 6 beta 4/bullous pemphigoid antigen in a new stable anchoring contacts (SAC) of keratinocytes: relation to hemidesmosomes. J Cell Biol. 111:1990;3141-3154.
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Carter, W.G.1
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Wayner, E.R.5
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16
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0025887362
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Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes
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Carter WG, Ryan MC, Gahr PJ. Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes. Cell. 65:1991;599-610.
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Carter, W.G.1
Ryan, M.C.2
Gahr, P.J.3
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0026629850
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The dermal-epidermal junction of human skin contains a novel laminin variant
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Marinkovich MP, Lunstrum GP, Keene DR, Burgeson RE. The dermal-epidermal junction of human skin contains a novel laminin variant. J Cell Biol. 119:1992;695-703.
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Marinkovich, M.P.1
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Keene, D.R.3
Burgeson, R.E.4
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18
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0027535633
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Interaction of integrins alpha 3 beta 1 and alpha 2 beta 1: Potential role in keratinocyte intercellular adhesion
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Symington BE, Takada Y, Carter WG. Interaction of integrins alpha 3 beta 1 and alpha 2 beta 1: potential role in keratinocyte intercellular adhesion. J Cell Biol. 120:1993;523-535.
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Symington, B.E.1
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Carter, W.G.3
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19
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0028316670
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Distinct and overlapping ligand specificities of the alpha 3A beta 1 and alpha 6A beta 1 integrins: Recognition of laminin isoforms
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Delwel GO, de Melker AA, Hogervorst F, Jaspars LH, Fles DL, Kuikman I, Lindblom A, Paulsson M, Timpl R, Sonnenberg A. Distinct and overlapping ligand specificities of the alpha 3A beta 1 and alpha 6A beta 1 integrins: recognition of laminin isoforms. Mol Biol Cell. 5:1994;203-215.
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Delwel, G.O.1
De Melker, A.A.2
Hogervorst, F.3
Jaspars, L.H.4
Fles, D.L.5
Kuikman, I.6
Lindblom, A.7
Paulsson, M.8
Timpl, R.9
Sonnenberg, A.10
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20
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0000710224
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Progressive kidney degeneration in mice lacking tensin
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of special interest. A report of the characterization of tensin null mice, which - in contrast to many other knockouts of focal contact genes - have viable phenotypes. The mice, however, develop tubular cysts in their kidneys, a feature which the authors suggest might be caused by a stress or fluid-induced weaking of focal contacts and subsequent loss of kidney epithelial polarity.
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Lo SH, Yu QC, Degenstein L, Chen LB, Fuchs E. Progressive kidney degeneration in mice lacking tensin. of special interest J Cell Biol. 136:1997;1349-1361 A report of the characterization of tensin null mice, which - in contrast to many other knockouts of focal contact genes - have viable phenotypes. The mice, however, develop tubular cysts in their kidneys, a feature which the authors suggest might be caused by a stress or fluid-induced weaking of focal contacts and subsequent loss of kidney epithelial polarity.
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J Cell Biol
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Lo, S.H.1
Yu, Q.C.2
Degenstein, L.3
Chen, L.B.4
Fuchs, E.5
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21
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0028983943
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Beta 1 integrins do not have a major role in keratinocyte intercellular adhesion
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Jensen PJ, Wheelock MJ. Beta 1 integrins do not have a major role in keratinocyte intercellular adhesion. Exp Cell Res. 219:1995;322-331.
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Jensen, P.J.1
Wheelock, M.J.2
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22
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0030609843
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Evidence that β1 integrins in keratinocyte cell - cell junctions are not in the ligand-occupied conformation
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Kim LT, Yamada KM. Evidence that β1 integrins in keratinocyte cell - cell junctions are not in the ligand-occupied conformation. J Invest Dermatol. 108:1997;876-880.
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J Invest Dermatol
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Kim, L.T.1
Yamada, K.M.2
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23
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0026334607
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Surface relocation of alpha 6 beta 4 integrins and assembly of hemidesmosomes in an in vitro model of wound healing
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Kurpakus MA, Quaranta V, Jones JC. Surface relocation of alpha 6 beta 4 integrins and assembly of hemidesmosomes in an in vitro model of wound healing. J Cell Biol. 115:1991;1737-1750.
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Kurpakus, M.A.1
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Jones, J.C.3
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24
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0025886308
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Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell - basement membrane adhesion
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Sonnenberg A, Calafat J, Janssen H, Daams H, van der Raaij-Helmer LM, Falcioni R, Kennel SJ, Aplin JD, Baker J, Loizidou M, et al. Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell - basement membrane adhesion. J Cell Biol. 113:1991;907-917.
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Sonnenberg, A.1
Calafat, J.2
Janssen, H.3
Daams, H.4
Van Der Raaij-Helmer, L.M.5
Falcioni, R.6
Kennel, S.J.7
Aplin, J.D.8
Baker, J.9
Loizidou, M.10
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25
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0029066406
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Gene targeting of BPAG1: Abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration
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Guo L, Degenstein L, Dowling J, Yu QC, Wollmann R, Perman B, Fuchs E. Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration. Cell. 81:1995;233-243.
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Guo, L.1
Degenstein, L.2
Dowling, J.3
Yu, Q.C.4
Wollmann, R.5
Perman, B.6
Fuchs, E.7
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26
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0029740182
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Ligand binding regulates the directed movement of beta1 integrins on fibroblasts
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of outstanding interest. These authors provide biophysical approaches to demonstrate that binding of ECM ligand in living cells induces the attachment of β1 integrins to the retrograde-moving cytoskeleton, providing interesting new mechanistic evidence to substantiate a number of prior biochemical studies implicating the β1 integrins in cellular movement.
-
Felsenfeld DP, Choquet D, Sheetz MP. Ligand binding regulates the directed movement of beta1 integrins on fibroblasts. of outstanding interest Nature. 383:1996;438-440 These authors provide biophysical approaches to demonstrate that binding of ECM ligand in living cells induces the attachment of β1 integrins to the retrograde-moving cytoskeleton, providing interesting new mechanistic evidence to substantiate a number of prior biochemical studies implicating the β1 integrins in cellular movement.
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(1996)
Nature
, vol.383
, pp. 438-440
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Felsenfeld, D.P.1
Choquet, D.2
Sheetz, M.P.3
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27
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0027301255
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Cell adhesion molecules as targets of autoantibodies in pemphigus and pemphigoid, bullous diseases due to defective epidermal cell adhesion
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Stanley JR. Cell adhesion molecules as targets of autoantibodies in pemphigus and pemphigoid, bullous diseases due to defective epidermal cell adhesion. Advan Immunol. 53:1993;291-325.
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Advan Immunol
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Stanley, J.R.1
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28
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0030598838
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An essential cytoskletal linker protein connecting actin microfilaments to intermediate filaments
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of outstanding interest. A report of the cloning and characterization of a novel cytoskeletal linker protein that has the capacity to simultaneously link actin and IF networks. When this protein is missing in sensory neurons, it leads to a disorganization of neurofilaments and rapid axonal degeneration in vivo.
-
Yang Y, Dowling J, Yu QC, Kouklis P, Cleveland DW, Fuchs E. An essential cytoskletal linker protein connecting actin microfilaments to intermediate filaments. of outstanding interest Cell. 86:1996;655-665 A report of the cloning and characterization of a novel cytoskeletal linker protein that has the capacity to simultaneously link actin and IF networks. When this protein is missing in sensory neurons, it leads to a disorganization of neurofilaments and rapid axonal degeneration in vivo.
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(1996)
Cell
, vol.86
, pp. 655-665
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Yang, Y.1
Dowling, J.2
Yu, Q.C.3
Kouklis, P.4
Cleveland, D.W.5
Fuchs, E.6
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29
-
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0027159977
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Expression of plectin mutant cDNA in cultured cells indicates a role of COOH-terminal domain in intermediate filament association
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Wiche G, Gromov D, Donovan A, Castanon MJ, Fuchs E. Expression of plectin mutant cDNA in cultured cells indicates a role of COOH-terminal domain in intermediate filament association. J Cell Biol. 121:1993;607-619.
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J Cell Biol
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Wiche, G.1
Gromov, D.2
Donovan, A.3
Castanon, M.J.4
Fuchs, E.5
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30
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0029620499
-
Distribution and ultrastructure of plectin arrays in subclones of rat glioma C6 cells differing in intermediate filament protein (vimentin) expression
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Foisner R, Bohn W, Mannweiler K, Wiche G. Distribution and ultrastructure of plectin arrays in subclones of rat glioma C6 cells differing in intermediate filament protein (vimentin) expression. J Struct Biol. 115:1995;304-317.
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Foisner, R.1
Bohn, W.2
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Wiche, G.4
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31
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0029666420
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Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival
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of outstanding interest. See annotation [33].
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Dowling J, Yu QC, Fuchs E. Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. of outstanding interest J Cell Biol. 134:1996;559-572 See annotation [33].
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Dowling, J.1
Yu, Q.C.2
Fuchs, E.3
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32
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0030015434
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Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice
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of outstanding interest. See annotation [33].
-
Van der Neut R, Krimpenfort P, Calafat J, Niessen CM, Sonnenberg A. Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice. of outstanding interest Nat Genet. 13:1996;366-369 See annotation [33].
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(1996)
Nat Genet
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, pp. 366-369
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Van Der Neut, R.1
Krimpenfort, P.2
Calafat, J.3
Niessen, C.M.4
Sonnenberg, A.5
-
33
-
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0029908558
-
Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice
-
of outstanding interest. In July 1996, three groups (including our own) [31-33] reported the knockouts of either β4 integrin or its partner α6. All mice exhibited gross skin blistering as a result of detachment of the epidermis from the underlying basement membrane. These studies underscore the importance of this integrin heterodimer in providing cell - substratum attachment, a function that the other epidermal integrins can apparently only perform weakly. In addition, these mice provided functional evidence that defects in α6β4 integrins (and by inference, their ligand) are indeed responsible for the junctional epidermolysis bullosa (JEB) phenotype.
-
Georges-Labouesse E, Messaddeq N, Yehia G, Cadalbert L, Dierich A, Le Meur M. Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice. of outstanding interest Nat Genet. 13:1996;370-373 In July 1996, three groups (including our own) [31-33] reported the knockouts of either β4 integrin or its partner α6. All mice exhibited gross skin blistering as a result of detachment of the epidermis from the underlying basement membrane. These studies underscore the importance of this integrin heterodimer in providing cell - substratum attachment, a function that the other epidermal integrins can apparently only perform weakly. In addition, these mice provided functional evidence that defects in α6β4 integrins (and by inference, their ligand) are indeed responsible for the junctional epidermolysis bullosa (JEB) phenotype.
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(1996)
Nat Genet
, vol.13
, pp. 370-373
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-
Georges-Labouesse, E.1
Messaddeq, N.2
Yehia, G.3
Cadalbert, L.4
Dierich, A.5
Le Meur, M.6
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34
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0030070588
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Molecular complexity of the cutaneous basement membrane zone. Revelations from the paradigms of epidermolysis bullosa
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Christiano AM, Uitto J. Molecular complexity of the cutaneous basement membrane zone. Revelations from the paradigms of epidermolysis bullosa. Exper Dermatol. 5:1996;1-11.
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Exper Dermatol
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Christiano, A.M.1
Uitto, J.2
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35
-
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0028989243
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Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia
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Vidal F, Aberdam D, Miquel C, Christiano AM, Pulkkinen L, Uitto J, Ortonne JP, Meneguzzi G. Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia. Nat Genet. 10:1995;229-234.
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(1995)
Nat Genet
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Vidal, F.1
Aberdam, D.2
Miquel, C.3
Christiano, A.M.4
Pulkkinen, L.5
Uitto, J.6
Ortonne, J.P.7
Meneguzzi, G.8
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36
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0029990621
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Deficiency of the integrin β4 subunit in junctional epidermolysis bullosa with pyloric atresia: Consequences for hemidesmosome formation and adhesion properties
-
Niessen CM, van der Raaij-Helmer LM, Hulsman EH, van der Neut R, Jonkman MF, Sonnenberg A. Deficiency of the integrin β4 subunit in junctional epidermolysis bullosa with pyloric atresia: consequences for hemidesmosome formation and adhesion properties. J Cell Sci. 109:1996;1695-1706.
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(1996)
J Cell Sci
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, pp. 1695-1706
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Niessen, C.M.1
Van Der Raaij-Helmer, L.M.2
Hulsman, E.H.3
Van Der Neut, R.4
Jonkman, M.F.5
Sonnenberg, A.6
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37
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0029005210
-
Molecular genetic studies of a human epidermal autoantigen (the 180-kD bullous pemphigoid antigen/BP180): Identification of functionally important sequences with the BP180 molecule and evidence for an interaction between BP180 and alpha 6 integrin
-
Hopkinson SB, Baker SE, Jones JC. Molecular genetic studies of a human epidermal autoantigen (the 180-kD bullous pemphigoid antigen/BP180): identification of functionally important sequences with the BP180 molecule and evidence for an interaction between BP180 and alpha 6 integrin. J Cell Biol. 130:1995;117-125.
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(1995)
J Cell Biol
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, pp. 117-125
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Hopkinson, S.B.1
Baker, S.E.2
Jones, J.C.3
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38
-
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0030773865
-
The localization of Bullous Pemphigoid Antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic doman and seems to be regulated by the β4 integrin subunit
-
of special interest. These authors provide surprising evidence that BPAG2 localizes to hemidesmosomes through an interaction with β4 integrin's cytoplasmic domain.
-
Borradori L, Koch PJ, Niessen CM, Erkeland S, van Leusden MR, Sonnenbrg A. The localization of Bullous Pemphigoid Antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic doman and seems to be regulated by the β4 integrin subunit. of special interest J Cell Biol. 136:1997;1333-1347 These authors provide surprising evidence that BPAG2 localizes to hemidesmosomes through an interaction with β4 integrin's cytoplasmic domain.
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(1997)
J Cell Biol
, vol.136
, pp. 1333-1347
-
-
Borradori, L.1
Koch, P.J.2
Niessen, C.M.3
Erkeland, S.4
Van Leusden, M.R.5
Sonnenbrg, A.6
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39
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0029616073
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Keratins and the skin
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Fuchs E. Keratins and the skin. Annu Rev Cell Dev Biol. 11:1995;123-153.
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Annu Rev Cell Dev Biol
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Fuchs, E.1
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40
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0029035706
-
The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1
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Brown A, Bernier G, Mathieu M, Rossant J, Kothary R. The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1. Nat Genet. 10:1995;301-306.
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Nat Genet
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Brown, A.1
Bernier, G.2
Mathieu, M.3
Rossant, J.4
Kothary, R.5
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41
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0030611639
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Developmental expression of BPAG1-n: Insights into the spastic ataxia and gross neurologic degeneration in dystonia musculorum mice
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in press
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Dowling J, Yang Y, Wollman R, Reichardt L, Fuchs E. Developmental expression of BPAG1-n: Insights into the spastic ataxia and gross neurologic degeneration in dystonia musculorum mice. Dev Biol. 1997;. in press.
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(1997)
Dev Biol
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Dowling, J.1
Yang, Y.2
Wollman, R.3
Reichardt, L.4
Fuchs, E.5
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42
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9344248374
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Plectin deficiency results in muscular dystrophy with epidermolysis bullosa
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of outstanding interest. See annotation [44].
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Smith FJ, Eady RA, Leigh IM, McMillan JR, Rugg EL, Kelsell DP, Bryant SP, Spurr NK, Geddes JF, Kirtschig G, et al. Plectin deficiency results in muscular dystrophy with epidermolysis bullosa. of outstanding interest Nat Genet. 13:1996;450-457 See annotation [44].
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(1996)
Nat Genet
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Smith, F.J.1
Eady, R.A.2
Leigh, I.M.3
McMillan, J.R.4
Rugg, E.L.5
Kelsell, D.P.6
Bryant, S.P.7
Spurr, N.K.8
Geddes, J.F.9
Kirtschig, G.10
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43
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9444272226
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Loss of plectin causes epidermolysis bullosa with muscular dystrophy: CDNA cloning and genomic organization
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of outstanding interest. See annotation [44].
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McLean WH, Pulkkinen L, Smith FJ, Rugg EL, Lane EB, Bullrich F, Burgeson RE, Amano S, Hudson DL, Owaribe K, et al. Loss of plectin causes epidermolysis bullosa with muscular dystrophy: cDNA cloning and genomic organization. of outstanding interest Genes Dev. 10:1996;1724-1735 See annotation [44].
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(1996)
Genes Dev
, vol.10
, pp. 1724-1735
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McLean, W.H.1
Pulkkinen, L.2
Smith, F.J.3
Rugg, E.L.4
Lane, E.B.5
Bullrich, F.6
Burgeson, R.E.7
Amano, S.8
Hudson, D.L.9
Owaribe, K.10
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44
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0029970098
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Defective expression of plectin/HD1 in epidermolysis bullosa simplex with muscular dystrophy
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of outstanding interest. These three papers [142-44] report the existence of mutations in the plectin gene in patients that suffer from the rare genetic disease, epidermolysis bullosa simplex (EBS) with muscular dystrophy. PLECTIN emerged as a candidate gene for this disease, after it was found that mice targeted for a related gene (BPAG1) develop EBS with spastic ataxia, eventually leading to indirect muscle wasting. Both plectin and BPAG1 localize to hemidesmosomes in the epidermis; whereas BPAG1 is expressed in neurons, plectin is expressed in skeletal muscle.
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Gache Y, Chavanas S, Lacour JP, Wiche G, Owaribe K, Meneguzzi G, Ortonne JP. Defective expression of plectin/HD1 in epidermolysis bullosa simplex with muscular dystrophy. of outstanding interest J Clin Invest. 97:1996;2289-2298 These three papers [142-44] report the existence of mutations in the plectin gene in patients that suffer from the rare genetic disease, epidermolysis bullosa simplex (EBS) with muscular dystrophy. PLECTIN emerged as a candidate gene for this disease, after it was found that mice targeted for a related gene (BPAG1) develop EBS with spastic ataxia, eventually leading to indirect muscle wasting. Both plectin and BPAG1 localize to hemidesmosomes in the epidermis; whereas BPAG1 is expressed in neurons, plectin is expressed in skeletal muscle.
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(1996)
J Clin Invest
, vol.97
, pp. 2289-2298
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Gache, Y.1
Chavanas, S.2
Lacour, J.P.3
Wiche, G.4
Owaribe, K.5
Meneguzzi, G.6
Ortonne, J.P.7
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45
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0027195638
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Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression
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Jones PH, Watt FM. Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell. 73:1993;713-724.
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(1993)
Cell
, vol.73
, pp. 713-724
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Jones, P.H.1
Watt, F.M.2
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46
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0028888316
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Stem cell patterning and fate in human epidermis
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Jones PH, Harper S, Watt FM. Stem cell patterning and fate in human epidermis. Cell. 80:1995;83-93.
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(1995)
Cell
, vol.80
, pp. 83-93
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Jones, P.H.1
Harper, S.2
Watt, F.M.3
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47
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0029565083
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Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis
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Carroll JM, Romero MR, Watt FM. Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Cell. 83:1995;957-968.
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(1995)
Cell
, vol.83
, pp. 957-968
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Carroll, J.M.1
Romero, M.R.2
Watt, F.M.3
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48
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0028979154
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Consequences of lack of beta 1 integrin gene expression in mice
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Fassler R, Meyer M. Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev. 9:1995;1896-1908.
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(1995)
Genes Dev
, vol.9
, pp. 1896-1908
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Fassler, R.1
Meyer, M.2
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49
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0028979153
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Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality
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Stephens LE, Sutherland AE, Klimanskaya IV, Andrieux A, Meneses J, Pedersen RA, Damsky CH. Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes Dev. 9:1995;1883-1895.
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(1995)
Genes Dev
, vol.9
, pp. 1883-1895
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Stephens, L.E.1
Sutherland, A.E.2
Klimanskaya, I.V.3
Andrieux, A.4
Meneses, J.5
Pedersen, R.A.6
Damsky, C.H.7
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50
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0030579185
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Differentiation of embryonal stem cells into keratinocytes: Comparison of wild-type and beta 1 integrin-deficient cells
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of special interest. An intriguing report of the characterization of the skin or chimeric mice made from wild-type blastocysts and β1 null embryonic stem cells. The epidermis was normal, despite the existence of β1 null keratinocytes mixed with wild-type cells. The authors propose that the function of β1 and its partners in the epidermis might be to organize extracellular matrix and, if this is accomplished by the surrounding wild-type keratinocytes, the β1 null cells can survive.
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Bagutti C, Wobus AM, Fassler R, Watt FM. Differentiation of embryonal stem cells into keratinocytes: comparison of wild-type and beta 1 integrin-deficient cells. of special interest Dev Biol. 179:1996;184-196 An intriguing report of the characterization of the skin or chimeric mice made from wild-type blastocysts and β1 null embryonic stem cells. The epidermis was normal, despite the existence of β1 null keratinocytes mixed with wild-type cells. The authors propose that the function of β1 and its partners in the epidermis might be to organize extracellular matrix and, if this is accomplished by the surrounding wild-type keratinocytes, the β1 null cells can survive.
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(1996)
Dev Biol
, vol.179
, pp. 184-196
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Bagutti, C.1
Wobus, A.M.2
Fassler, R.3
Watt, F.M.4
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51
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0030610163
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α3β1 integrin is required for normal development of the epidermal basement membrane
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of outstanding interest. This paper provides the best evidence to date that the function of α3β1 integrin is to organize ECM in the epidermis. Thus, mice that are null for α3 display a mild mechanically induced skin blistering caused by rifts within the basement membrane that separates the epidermis from dermis. The phenotype is strikingly different from that seen in the α6β4 knockouts, underscoring the unique functions attributed to these different epidermal integrins.
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DiPersio CM, Hodivala-Dilke KM, Jaenisch R, Kreidberg JA, Hynes RO. α3β1 integrin is required for normal development of the epidermal basement membrane. of outstanding interest J Cell Biol. 137:1997;729-742 This paper provides the best evidence to date that the function of α3β1 integrin is to organize ECM in the epidermis. Thus, mice that are null for α3 display a mild mechanically induced skin blistering caused by rifts within the basement membrane that separates the epidermis from dermis. The phenotype is strikingly different from that seen in the α6β4 knockouts, underscoring the unique functions attributed to these different epidermal integrins.
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(1997)
J Cell Biol
, vol.137
, pp. 729-742
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Dipersio, C.M.1
Hodivala-Dilke, K.M.2
Jaenisch, R.3
Kreidberg, J.A.4
Hynes, R.O.5
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52
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0029671372
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Beta 1 integrin- dependent and -independent polymerization of fibronectin
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of special interest. An examination of the role of β1 in orchestrating fibronectin polymerization in fibroblasts.
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Wennerberg K, Lohikangas L, Gullberg D, Pfaff M, Johansson S, Fassler R. Beta 1 integrin- dependent and -independent polymerization of fibronectin. of special interest J Cell Biol. 132:1996;227-238 An examination of the role of β1 in orchestrating fibronectin polymerization in fibroblasts.
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(1996)
J Cell Biol
, vol.132
, pp. 227-238
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Wennerberg, K.1
Lohikangas, L.2
Gullberg, D.3
Pfaff, M.4
Johansson, S.5
Fassler, R.6
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53
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0028987190
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Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin
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Huhtala P, Humphries MJ, McCarthy JB, Tremble PM, Werb Z, Damsky CH. Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. J Cell Biol. 129:1995;867-879.
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(1995)
J Cell Biol
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Huhtala, P.1
Humphries, M.J.2
McCarthy, J.B.3
Tremble, P.M.4
Werb, Z.5
Damsky, C.H.6
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54
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0030994017
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Extracellular matrix rigidity causes strengthening of integrin-cytoskleleton linkages
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of outstanding interest. This pioneering paper provides evidence that the rigidity of ECM is important in determining the strength of integrin - cytoskeletal linkages. These biophysical measurements have implications for the importance of ECM organization and deposition in cell architecture and function.
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Choquet D, Felsenfeld DP, Sheetz MP. Extracellular matrix rigidity causes strengthening of integrin-cytoskleleton linkages. of outstanding interest Cell. 88:1997;39-48 This pioneering paper provides evidence that the rigidity of ECM is important in determining the strength of integrin - cytoskeletal linkages. These biophysical measurements have implications for the importance of ECM organization and deposition in cell architecture and function.
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(1997)
Cell
, vol.88
, pp. 39-48
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Choquet, D.1
Felsenfeld, D.P.2
Sheetz, M.P.3
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55
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0030971756
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BCL-X expression influences keratinocyte cell survival but not terminal differentiation
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in press
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Pena JC, Fuchs E, Thompson CB. BCL-X expression influences keratinocyte cell survival but not terminal differentiation. Cell Growth Differ. 1997;. in press.
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(1997)
Cell Growth Differ
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Pena, J.C.1
Fuchs, E.2
Thompson, C.B.3
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56
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0028057613
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Disruption of epithelial cell-matrix interactions induces apoptosis
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Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol. 124:1994;619-626.
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(1994)
J Cell Biol
, vol.124
, pp. 619-626
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Frisch, S.M.1
Francis, H.2
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57
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0028927484
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Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix
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Boudreau N, Sympson CJ, Werb Z, Bissell MJ. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science. 267:1995;891-893.
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(1995)
Science
, vol.267
, pp. 891-893
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Boudreau, N.1
Sympson, C.J.2
Werb, Z.3
Bissell, M.J.4
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58
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0028949575
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Regulation of cell surface beta 1 integrin levels during keratinocyte terminal differentiation
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Hotchin NA, Gandarillas A, Watt FM. Regulation of cell surface beta 1 integrin levels during keratinocyte terminal differentiation. J Cell Biol. 128:1995;1209-1219.
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(1995)
J Cell Biol
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, pp. 1209-1219
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Hotchin, N.A.1
Gandarillas, A.2
Watt, F.M.3
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59
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0027977117
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Basal detachment of the epidermis using dispase: Tissue spatial oganization and fate of integrin alpha 6 beta 4 and hemidesmosomes
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Poumay Y, Roland IH, Leclercq-Smekens M, Leloup R. Basal detachment of the epidermis using dispase: tissue spatial oganization and fate of integrin alpha 6 beta 4 and hemidesmosomes. J Invest Dermatol. 102:1994;111-117.
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(1994)
J Invest Dermatol
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, pp. 111-117
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Poumay, Y.1
Roland, I.H.2
Leclercq-Smekens, M.3
Leloup, R.4
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60
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0030953763
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Geometric control of cell life and death
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of outstanding interest. This exciting paper demonstrates that, by altering the distance between ECM ligand contacts, a cell can have dramatically different properties, including changes in proliferative responses.
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Chen CS, Mrksich M, Huang S, Whitesides GM, Ingber DE. Geometric control of cell life and death. of outstanding interest Science. 276:1997;1425-1428 This exciting paper demonstrates that, by altering the distance between ECM ligand contacts, a cell can have dramatically different properties, including changes in proliferative responses.
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(1997)
Science
, vol.276
, pp. 1425-1428
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Chen, C.S.1
Mrksich, M.2
Huang, S.3
Whitesides, G.M.4
Ingber, D.E.5
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61
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0029115343
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Signal transduction by the alpha 6 beta 4 integrin: Distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes
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Mainiero F, Pepe A, Wary KK, Spinardi L, Mohammadi M, Schlessinger J, Giancotti FG. Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J. 14:1995;4470-4481.
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(1995)
EMBO J
, vol.14
, pp. 4470-4481
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Mainiero, F.1
Pepe, A.2
Wary, K.K.3
Spinardi, L.4
Mohammadi, M.5
Schlessinger, J.6
Giancotti, F.G.7
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62
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0028901094
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Stimulation of tyrosine phosphorylation of distinct proteins in response to antibody-mediated ligation and clustering of alpha 3 and alpha 6 integrins
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Jewell K, Kapron-Bras C, Jeevaratnam P, Dedhar S. Stimulation of tyrosine phosphorylation of distinct proteins in response to antibody-mediated ligation and clustering of alpha 3 and alpha 6 integrins. J Cell Sci. 108:1995;1165-1174.
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(1995)
J Cell Sci
, vol.108
, pp. 1165-1174
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Jewell, K.1
Kapron-Bras, C.2
Jeevaratnam, P.3
Dedhar, S.4
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63
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0030046992
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Anchorage mediated by integrin α6β4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kD protein
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of special interest. In this work, the Carter group shows that, upon α6β4 activation, proteins can become tyrosine phosphorylated, thereby providing evidence for signal transduction mechanisms similar to those well established for the β1 integrins.
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Xia Y, Gil SG, Carter WG. Anchorage mediated by integrin α6β4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kD protein. of special interest J Cell Biol. 132:1996;727-740 In this work, the Carter group shows that, upon α6β4 activation, proteins can become tyrosine phosphorylated, thereby providing evidence for signal transduction mechanisms similar to those well established for the β1 integrins.
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(1996)
J Cell Biol
, vol.132
, pp. 727-740
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Xia, Y.1
Gil, S.G.2
Carter, W.G.3
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64
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0028533592
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Tensin: A potential link between the cytoskeleton and signal transduction
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Lo SH, Weisberg E, Chen LB. Tensin: a potential link between the cytoskeleton and signal transduction. Bioessays. 16:1994;817-823.
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(1994)
Bioessays
, vol.16
, pp. 817-823
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Lo, S.H.1
Weisberg, E.2
Chen, L.B.3
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