Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA

FASEB Journal

Volumn 10, Issue 2, 1996, Pages 333-338

  Garcia De La Asuncion, José ^a   Millan, Arantxa ^a   Pla, Rosa ^a   Bruseghini, Leo ^a   Esteras, Antonio ^a   Pallardo, Federico V ^a   Sastre, Juan ^a   Viña, José ^a,b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

aging; antioxidants; free radicals; oxidative stress; vitamins

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; FREE RADICAL; GLUTATHIONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DIETARY INTAKE; DNA DAMAGE; ENZYME ASSAY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPECIES DIFFERENTIATION;

EID: 0000350066     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.10.2.8641567     Document Type: Article

References (35)

1. Timiras, P. S. (1988) Physiological Basis of Aging and Geriatrics, pp. 1-5, McMillan Publishing Company, New York
2. Medvedev, Z. A.(1990) An attempt at a rational classification of theories of ageing. Biol. Rev. Cambridge Phil. Soc. 65, 375-398
3. Harman, D. (1956) Aging: a theory based on free radical and radiation chemistry. J. Gerontol 11, 298-300
4. Miquel, J., Economos, A. C., Fleming, J. A., and Johnson, J. E., Jr. (1980) Mitochondrial role in cell aging. Exp. Gerontol. 15, 575-591
5. Ames, B. N., Shigenaga, M. K., and Hagen, T. M. (1993) Oxidants, antioxidants, and the degenerative diseases of aging, Proc, Natl. Acad. Sci. USA 90, 7915-7922
6. Shigenaga, H. K., Hagen. T. M., and Ames, H. N. (1994) Oxidative damage and mitochondrial decay in aging. Proc. Nal. Acad. Sci. USA 91, 10771-10778
7. Vina, J. (1990) Glutathione: Metabolism and Physiological Functions, CRC Press, Boca Raton, Florida
8. Wahllander, A., Soboll, S., and Sies, H. (1979) Hepatic mitochondrial and cytosolic glutathione content and the subcellular distribution of GSH S-transferases. FEBS Lett 97, 138-140
9. Meredith, M. J., and Reed, D. J (1982) Status of the mitochondrial pool of glutathione in the isolated hepatocyte.J. Biol. Chem. 257, 3747-3753
10. Sies, H. (1986) Biochemistry of oxidative stress. Angewandte Chemie 25, 1058-1071
11. Reed, D. J., Babson, J. R., Beatty, P. W., Brodie, A. E., Ellis, W. W., and Potter, D. W (1980) High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides. Anal. Biochem. 106, 55-62
12. Asensi, M., Sastre, J., and Pallardó, F. V., Garcia de la Asunción, J., Estrela, J. M., and Vina, J. (1994) A high-performance liquid chromatography method for measurement of oxidized glutathione in biological samples. Anal. Biochem. 217, 323-328
13. Vina, J., J. Sastre, J., M. Asensi, M., and Packer, L. (1995) Assay of blood glutathione oxidation during physical exercise Methods Enzymol. 251, 237-243
14. Rickwood, D. W., Wilson, M. T., and Darley-Usmar, V. M. Isolation and characteristics of intact mitochondria (1987) In Mitochondria: A Practical Approach (Darley-Ulmar, V. M., Wilson, M. T., Rickwood, D., eds) pp. 4-6, IRL PRESS, Oxford
15. Brigelius, R., Muckel, C., Akerboom, T. P. M., and Sies, H. (1983) Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide. Biochem. Pharm. 32, 2526-2534
16. Latorre, A., Moya, A.,and Ayala, F. J.(1986) Evolution of mitochondrial DNA in Drosophila subobscura. Proc. Natl. Acad. Sci. USA 83, 8649-8653
17. Richter, C., Park, J. W., and Ames, B. (1988) Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc. Natl. Acad. Sci. USA 85, 6465-6467
18. Shigenaga, M. K., Park, J. W., Cundy, K. C., Gimeno, C., and Ames, B. (1990) In vivo Oxidative DNA damage: measurement of 8 hydroxy-2′deoxyguanosine in DNA and in urine by high performance liquid chromatography with electrochemical detection. Methods Enzymol. 186, 521-530
19. Fraga, C. G., Motehnik, P. A., Shigenaga, M. K., Helbrock H. J., Jacob, R. A., and Ames B. (1991) Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc. Natl. Acad. Sci. USA 88, 11003-11006
20. Kasai, H., and Nishimura, S. (1984) Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents. Nucleic Acids Res. 12, 2137-3145
21. Wlodek, L., Rommelspaeher, H., Susilo, R., Radomski, J., and Hofle, C. (1993) Thiazolidine derivatives as source of free L-cysteine in rat tissue. Biochem. Pharm. 46, 1917-1928
22. Miquel, J., and Economos, A. C. (1979) Favorable effects of the antioxidants sodium and magnesium thiazolidine carboxylate on the vitality and life span of Drosophila and mice. Exp. Gerontol. 14, 279-285
23. Weber, H. U., Fleming, J. F., and Miquel, J. (1982) Thiazolidine4-carboxylic acid, a physiologic sulfhydryl antioxidant with potential value in geriatric medicine. Arch. Gerontol. Geriatr. 1, 299-310
24. Vina, J., Sastre, J., Anton, V., Bruseghini, L., Esteras, A., and Asensi, M. (1992) Effect of aging on glutathione metabolism. Protection by antioxidants. In Free Radicals and Aging (Emerit, I., Chance, B., eds) pp. 136-144, Birkhauser Verlag, Basel, Switzerland
25. Oshino, N., and Chance, B. (1976) Properties of glutathione release observed during reduction of organic hydroperoxide, demethylation of aminopyrine and oxidation of some substances in perfused rat liver, and their implications for the physiological functions of catalase. Biochem. J. 162, 509-525
26. Sohal, R. S., and Dubey, A. (1994) Mitochondrial Oxidative Damage, Hydrogen Peroxide Release, and Aging. Free Rad. Biol. Med. 16, 621-626
27. Miquel, J., and Economos, A. C. (1979) Favorable effects of the antioxidants sodium and magnesium thiazolidine carboxylate on the vitality and life span of Drosophila and mice. Exp. Geront. 14, 279-285
28. Cutler, R. G. (1991) Antioxidants and Aging. Am. J.Clin. Nutr. 53, S373-S379
29. Ames, B. N., Shigenaga, M., and Hagen, T. M. (1993) Oxidants, antioxidants and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA 90, 7915-7922
30. Richie, J. P., Leutzinger, Y., Partharsarathy, S., Malloy, V., Orentreich, N., and Zimmerman, J. A.(1994) Methionine restriction increases blood glutathione and longevity in F344 rats. FASER J. 8, 1302-1307
31. Loft, S., Astrup, A., Buemann, B., and Poulsen, H. E. (1994) Oxidative DNA damage correlates with oxygen consumption in humans. FASEB J. 8, 534-537
32. Cutler, R. G (1991) Antioxidants and aging Am. J. Clin. Nutr. 53, S373-S379
33. 2 and basal and maximum aerobic capacity Mech Aging Dev. 70, 177-179
34. Gohil, K., Viguie, C.,Stanley, W. C., Brooks, G., and Packer, L. (1988) Blood glutathione oxidation during human exercise. J. Appl. Physiol. 64, 115-119
35. Mills, B. J, Richie J. P., and Lang, C. A. (1990) Sample processing alters glutathione and cysteine values in blood. Anal. Biochem. 184, 263-267