The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation

Microbes and Infection

Volumn 11, Issue 4, 2009, Pages 452-459

  Pardo, Julián ^a,b   Aguilo, Juan Ignacio ^a   Anel, Alberto ^a   Martin, Praxedis ^c   Joeckel, Lars ^c,d   Borner, Christoph ^d   Wallich, Reiner ^e   Müllbacher, Arno ^f   Froelich, Christopher J ^g   Simon, Markus M ^c  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b CENTRO DE INVESTIGACIÓN Y TECNOLOGÍA AGROALIMENTARIA DE ARAGÓN CITA   (Spain)

^c MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^d UNIVERSITY OF FREIBURG   (Germany)

^e UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^f Biology and Environment   (Australia)

^g NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

Author keywords

Cell death; Granule exocytosis; Granzymes; Inflammation; Perforin

Indexed keywords

CYTOKINE; GRANZYME; GRANZYME A; GRANZYME B; GRANZYME C; GRANZYME H; GRANZYME K; GRANZYME M; UNCLASSIFIED DRUG;

APOPTOSIS; CELL DEATH; CELL GRANULE; CELL TYPE; CYTOKINE RELEASE; CYTOTOXIC LYMPHOCYTE; ENZYME RELEASE; EX VIVO STUDY; EXOCYTOSIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT SURVEY; T LYMPHOCYTE;

CELL DEATH; EXOCYTOSIS; GRANZYMES; INFLAMMATION; KILLER CELLS, NATURAL; T-LYMPHOCYTES, CYTOTOXIC;

EID: 64549090599     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2009.02.004     Document Type: Short Survey

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