Noncytotoxic lytic granule-mediated CD8+ T cell inhibition of HSV-1 reactivation from neuronal latency

Science

Volumn 322, Issue 5899, 2008, Pages 268-271

  Knickelbein, Jared E ^a   Khanna, Kamal M ^a,b   Yee, Michael B ^a   Baty, Catherine J ^a   Kinchington, Paul R ^a   Hendricks, Robert L ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON ANTIBODY; GRANZYME B; IMMEDIATE EARLY PROTEIN; IMMEDIATE EARLY PROTEIN ICP4; OKT 8; UNCLASSIFIED DRUG;

BIODEGRADATION; ENZYME ACTIVITY; GENE EXPRESSION; INHIBITION; PROTEIN; VIRAL DISEASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CD8+ T LYMPHOCYTE; CYTOLYSIS; CYTOTOXICITY; EX VIVO STUDY; GENE EXPRESSION REGULATION; HERPES SIMPLEX VIRUS 1; IN VIVO STUDY; LATENT PERIOD; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; VIRUS INACTIVATION; VIRUS REACTIVATION;

ANIMALS; APOPTOSIS; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOPLASMIC GRANULES; GRANZYMES; HERPESVIRUS 1, HUMAN; IMMEDIATE-EARLY PROTEINS; KERATITIS, HERPETIC; MICE; MICE, INBRED C57BL; NEURONS, AFFERENT; TISSUE CULTURE TECHNIQUES; TRIGEMINAL GANGLION; VIRUS ACTIVATION; VIRUS LATENCY;

HUMAN HERPESVIRUS 1; MUS; SIMPLEXVIRUS;

EID: 53749095611     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1164164     Document Type: Article

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28. We thank K. Lathrop and J. Karlsson for assistance with microscopy and preparation of figures and N. Zurowski for assistance with flow cytometry. We have no conflicting financial interests. This work was supported by NIH grants F30NS061471 (J.E.K.), R01EY05945 (R.L.H.), R01EY015291 (P.R.K.), and P30EY08098 (R.L.H.); a Research to Prevent Blindness Medical Student Eye Research Fellowship (J.E.K.); and unrestricted grants from Research to Prevent Blindness and the Eye and Ear Foundation of Pittsburgh (R.L.H.).