-
1
-
-
0033499729
-
Cytosolic delivery of granzyme B by bacterial toxins: Evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin
-
Browne, K.A., E. Blink, V.R. Sutton, C.J. Froelich, D.A. Jans, and J.A. Trapani. 1999. Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin. Mol. Cell. Biol. 19:8604-8615.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 8604-8615
-
-
Browne, K.A.1
Blink, E.2
Sutton, V.R.3
Froelich, C.J.4
Jans, D.A.5
Trapani, J.A.6
-
2
-
-
0035136852
-
Granzyme a and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity
-
Davis, J.E., M.J. Smyth, and J.A. Trapani. 2001. Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity. Eur. J. Immunol. 31:39-47.
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 39-47
-
-
Davis, J.E.1
Smyth, M.J.2
Trapani, J.A.3
-
3
-
-
0029083438
-
Granzyme A-deficient mice retain potent cell-mediated cytotoxicity
-
Ebnet, K., M. Hausmann, F. Lehmann-Grube, A. Mullbacher, M. Kopf, M. Lamers, and M.M. Simon. 1995. Granzyme A-deficient mice retain potent cell-mediated cytotoxicity. EMBO J. 14:4230-4239.
-
(1995)
EMBO J.
, vol.14
, pp. 4230-4239
-
-
Ebnet, K.1
Hausmann, M.2
Lehmann-Grube, F.3
Mullbacher, A.4
Kopf, M.5
Lamers, M.6
Simon, M.M.7
-
4
-
-
0034655278
-
Perforin lytic activity is controlled by calreticulin
-
Fraser, S.A., R. Karimi, M. Michalak, and D. Hudig. 2000. Perforin lytic activity is controlled by calreticulin. J. Immunol. 164:4150-4155.
-
(2000)
J. Immunol.
, vol.164
, pp. 4150-4155
-
-
Fraser, S.A.1
Karimi, R.2
Michalak, M.3
Hudig, D.4
-
5
-
-
0034517367
-
A single cell analysis of apoptosis. Ordering the apoptotic phenotype
-
Goldstein, J.C., R.M. Kluck, and D.R. Green. 2000a. A single cell analysis of apoptosis. Ordering the apoptotic phenotype. Ann. NY Acad. Sci. 926:132-141.
-
(2000)
Ann. NY Acad. Sci.
, vol.926
, pp. 132-141
-
-
Goldstein, J.C.1
Kluck, R.M.2
Green, D.R.3
-
6
-
-
0033781027
-
The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
-
Goldstein, J.C., N.J. Waterhouse, P. Juin, G.I. Evan, and D.R. Green. 2000b. The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant. Nat. Cell Biol. 2:156-162.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 156-162
-
-
Goldstein, J.C.1
Waterhouse, N.J.2
Juin, P.3
Evan, G.I.4
Green, D.R.5
-
8
-
-
0028258577
-
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
-
Heusel, J.W., R.L. Wesselschmidt, S. Shresta, J.H. Russell, and T.J. Ley. 1994. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell. 76:977-987.
-
(1994)
Cell
, vol.76
, pp. 977-987
-
-
Heusel, J.W.1
Wesselschmidt, R.L.2
Shresta, S.3
Russell, J.H.4
Ley, T.J.5
-
9
-
-
0038281338
-
Cell death induced by granzyme C
-
Johnson, H., L. Scorrano, S.J. Korsmeyer, and T.J. Ley. 2003. Cell death induced by granzyme C. Blood. 101:3093-3101.
-
(2003)
Blood
, vol.101
, pp. 3093-3101
-
-
Johnson, H.1
Scorrano, L.2
Korsmeyer, S.J.3
Ley, T.J.4
-
10
-
-
0028219791
-
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
-
Kagi, D., B. Ledermann, K. Burki, P. Seiler, B. Odermatt, K.J. Olsen, E.R. Podack, R.M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature. 369:31-37.
-
(1994)
Nature
, vol.369
, pp. 31-37
-
-
Kagi, D.1
Ledermann, B.2
Burki, K.3
Seiler, P.4
Odermatt, B.5
Olsen, K.J.6
Podack, E.R.7
Zinkernagel, R.M.8
Hengartner, H.9
-
11
-
-
24944494048
-
Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis
-
Keefe, D., L. Shi, S. Feske, R. Massol, F. Navarro, T. Kirchhausen, and J. Lieberman. 2005. Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. Immunity. 23:249-262.
-
(2005)
Immunity
, vol.23
, pp. 249-262
-
-
Keefe, D.1
Shi, L.2
Feske, S.3
Massol, R.4
Navarro, F.5
Kirchhausen, T.6
Lieberman, J.7
-
12
-
-
2542448011
-
Granzyme M mediates a novel form of perforin-dependent cell death
-
Kelly, J.M., N.J. Waterhouse, E. Cretney, K.A. Browne, S. Ellis, J.A. Trapani, and M.J. Smyth. 2004. Granzyme M mediates a novel form of perforin-dependent cell death. J. Biol. Chem. 279:22236-22242.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 22236-22242
-
-
Kelly, J.M.1
Waterhouse, N.J.2
Cretney, E.3
Browne, K.A.4
Ellis, S.5
Trapani, J.A.6
Smyth, M.J.7
-
13
-
-
0035988243
-
The genes for perforin, granzymes A-C and IFN-gamma are differentially expressed in single CD8(+) T cells during primary activation
-
Kelso, A., E.O. Costelloe, B.J. Johnson, P. Groves, K. Buttigieg, and D.R. Fitzpatrick. 2002. The genes for perforin, granzymes A-C and IFN-gamma are differentially expressed in single CD8(+) T cells during primary activation. Int. Immunol. 14:605-613.
-
(2002)
Int. Immunol.
, vol.14
, pp. 605-613
-
-
Kelso, A.1
Costelloe, E.O.2
Johnson, B.J.3
Groves, P.4
Buttigieg, K.5
Fitzpatrick, D.R.6
-
14
-
-
0038460240
-
The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: Evidence of origin from lymphocytes involved in innate immunity
-
Krenacs, L., M.J. Smyth, E. Bagdi, T. Krenacs, L. Kopper, T. Rudiger, A. Zettl, H.K. Muller-Hermelink, E.S. Jaffe, and M. Raffeld. 2003. The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity. Blood. 101:3590-3593.
-
(2003)
Blood
, vol.101
, pp. 3590-3593
-
-
Krenacs, L.1
Smyth, M.J.2
Bagdi, E.3
Krenacs, T.4
Kopper, L.5
Rudiger, T.6
Zettl, A.7
Muller-Hermelink, H.K.8
Jaffe, E.S.9
Raffeld, M.10
-
15
-
-
0141629512
-
Nuclear war: The granzyme A-bomb
-
Lieberman, J., and Z. Fan. 2003. Nuclear war: the granzyme A-bomb. Curr. Opin. Immunol. 15:553-559.
-
(2003)
Curr. Opin. Immunol.
, vol.15
, pp. 553-559
-
-
Lieberman, J.1
Fan, Z.2
-
16
-
-
0031721557
-
Mechanisms of viral clearance in perforin-deficient mice
-
Lin, M.T., D.R. Hinton, and S.A. Stohlman. 1998. Mechanisms of viral clearance in perforin-deficient mice. Adv. Exp. Med. Biol. 440:431-436.
-
(1998)
Adv. Exp. Med. Biol.
, vol.440
, pp. 431-436
-
-
Lin, M.T.1
Hinton, D.R.2
Stohlman, S.A.3
-
17
-
-
0028352669
-
Characterization of recombinant mouse perforin expressed in insect cells using the baculovirus system
-
Liu, C.C., P.M. Persechini, and J.D. Young. 1994. Characterization of recombinant mouse perforin expressed in insect cells using the baculovirus system. Biochem. Biophys. Res. Commun. 201:318-325.
-
(1994)
Biochem. Biophys. Res. Commun.
, vol.201
, pp. 318-325
-
-
Liu, C.C.1
Persechini, P.M.2
Young, J.D.3
-
18
-
-
0028990676
-
Perforin and lymphocyte-mediated cytolysis
-
Liu, C.C., P.M. Persechini, and J.D. Young. 1995. Perforin and lymphocyte-mediated cytolysis. Immunol. Rev. 146:145-175.
-
(1995)
Immunol. Rev.
, vol.146
, pp. 145-175
-
-
Liu, C.C.1
Persechini, P.M.2
Young, J.D.3
-
19
-
-
20444445916
-
A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation
-
Ludford-Menting, M.J., J. Oliaro, F. Sacirbegovic, E.T. Cheah, N. Pedersen, S.J. Thomas, A. Pasam, R. Iazzolino, L.E. Dow, N.J. Waterhouse, et al. 2005. A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. Immunity. 22:737-748.
-
(2005)
Immunity
, vol.22
, pp. 737-748
-
-
Ludford-Menting, M.J.1
Oliaro, J.2
Sacirbegovic, F.3
Cheah, E.T.4
Pedersen, N.5
Thomas, S.J.6
Pasam, A.7
Iazzolino, R.8
Dow, L.E.9
Waterhouse, N.J.10
-
20
-
-
0033521626
-
Mitochondria-dependent and -independent regulation of granzyme B-induced apoptosis
-
MacDonald, G., L. Shi, C. Vande Velde, J. Lieberman, and A.H. Greenberg. 1999. Mitochondria-dependent and -independent regulation of granzyme B-induced apoptosis. J. Exp. Med. 189:131-144.
-
(1999)
J. Exp. Med.
, vol.189
, pp. 131-144
-
-
MacDonald, G.1
Shi, L.2
Vande Velde, C.3
Lieberman, J.4
Greenberg, A.H.5
-
21
-
-
0028800947
-
Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
-
Martin, S.J., C.P. Reutelingsperger, A.J. McGahon, J.A. Rader, R.C. van Schie, D.M. LaFace, and D.R. Green. 1995. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med. 182:1545-1556.
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1545-1556
-
-
Martin, S.J.1
Reutelingsperger, C.P.2
McGahon, A.J.3
Rader, J.A.4
Van Schie, R.C.5
LaFace, D.M.6
Green, D.R.7
-
22
-
-
9344261615
-
The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism
-
Martin, S.J., G.P. Amarante-Mendes, L. Shi, T.H. Chuang, C.A. Casiano, G.A. O'Brien, P. Fitzgerald, E.M. Tan, G.M. Bokoch, A.H. Greenberg, and D.R. Green. 1996. The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism. EMBO J. 15:2407-2416.
-
(1996)
EMBO J.
, vol.15
, pp. 2407-2416
-
-
Martin, S.J.1
Amarante-Mendes, G.P.2
Shi, L.3
Chuang, T.H.4
Casiano, C.A.5
O'Brien, G.A.6
Fitzgerald, P.7
Tan, E.M.8
Bokoch, G.M.9
Greenberg, A.H.10
Green, D.R.11
-
23
-
-
0033598718
-
Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes
-
Mullbacher, A., P. Waring, R. Tha Hla, T. Tran, S. Chin, T. Stehle, C. Museteanu, and M.M. Simon. 1999. Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc. Natl. Acad. Sci. USA. 96:13950-13955.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 13950-13955
-
-
Mullbacher, A.1
Waring, P.2
Tha Hla, R.3
Tran, T.4
Chin, S.5
Stehle, T.6
Museteanu, C.7
Simon, M.M.8
-
24
-
-
0026526548
-
Direct evidence for release of pore-forming protein during NK cellular lysis
-
Ortaldo, J.R., R.T. Winkler-Pickett, K. Nagashima, H. Yagita, and K. Okumura. 1992. Direct evidence for release of pore-forming protein during NK cellular lysis. J. Leukoc. Biol. 52:483-488.
-
(1992)
J. Leukoc. Biol.
, vol.52
, pp. 483-488
-
-
Ortaldo, J.R.1
Winkler-Pickett, R.T.2
Nagashima, K.3
Yagita, H.4
Okumura, K.5
-
25
-
-
0036312429
-
The differential contribution of granzyme a and granzyme B in cytotoxic T lymphocyte-mediated apoptosis is determined by the quality of target cells
-
Pardo, J., S. Balkow, A. Anel, and M.M. Simon. 2002. The differential contribution of granzyme A and granzyme B in cytotoxic T lymphocyte-mediated apoptosis is determined by the quality of target cells. Eur. J. Immunol. 32:1980-1985.
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 1980-1985
-
-
Pardo, J.1
Balkow, S.2
Anel, A.3
Simon, M.M.4
-
26
-
-
8444249247
-
Apoptotic pathways are selectively activated by granzyme a and/or granzyme B in CTL-mediated target cell lysis
-
Pardo, J., A. Bosque, R. Brehm, R. Wallich, J. Naval, A. Mullbacher, A. Anel, and M.M. Simon. 2004. Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis. J. Cell Biol. 167:457-468.
-
(2004)
J. Cell Biol.
, vol.167
, pp. 457-468
-
-
Pardo, J.1
Bosque, A.2
Brehm, R.3
Wallich, R.4
Naval, J.5
Mullbacher, A.6
Anel, A.7
Simon, M.M.8
-
27
-
-
0025905925
-
Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes
-
Peters, P.J., J. Borst, V. Oorschot, M. Fukuda, O. Krahenbuhl, J. Tschopp, J.W. Slot, and H.J. Geuze. 1991. Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes. J. Exp. Med. 173:1099-1109.
-
(1991)
J. Exp. Med.
, vol.173
, pp. 1099-1109
-
-
Peters, P.J.1
Borst, J.2
Oorschot, V.3
Fukuda, M.4
Krahenbuhl, O.5
Tschopp, J.6
Slot, J.W.7
Geuze, H.J.8
-
28
-
-
0029847228
-
Long-range disruption of gene expression by a selectable marker cassette
-
Pham, C.T., D.M. MacIvor, B.A. Hug, J.W. Heusel, and T.J. Ley. 1996. Long-range disruption of gene expression by a selectable marker cassette. Proc. Natl. Acad. Sci. USA. 93:13090-13095.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13090-13095
-
-
Pham, C.T.1
MacIvor, D.M.2
Hug, B.A.3
Heusel, J.W.4
Ley, T.J.5
-
29
-
-
0035853855
-
Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway
-
Pinkoski, M.J., N.J. Waterhouse, J.A. Heibein, B.B. Wolf, T. Kuwana, J.C. Goldstein, D.D. Newmeyer, R.C. Bleackley, and D.R. Green. 2001. Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway. J. Biol. Chem. 276:12060-12067.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 12060-12067
-
-
Pinkoski, M.J.1
Waterhouse, N.J.2
Heibein, J.A.3
Wolf, B.B.4
Kuwana, T.5
Goldstein, J.C.6
Newmeyer, D.D.7
Bleackley, R.C.8
Green, D.R.9
-
30
-
-
33644841604
-
Mitochondria, apoptosis and autoimmunity
-
Pinkoski, M.J., N.J. Waterhouse, and D.R. Green. 2006. Mitochondria, apoptosis and autoimmunity. Curr. Dir. Autoimmun. 9:55-73.
-
(2006)
Curr. Dir. Autoimmun.
, vol.9
, pp. 55-73
-
-
Pinkoski, M.J.1
Waterhouse, N.J.2
Green, D.R.3
-
31
-
-
0021270576
-
Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization
-
Podack, E.R., and P.J. Konigsberg. 1984. Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization. J. Exp. Med. 160:695-710.
-
(1984)
J. Exp. Med.
, vol.160
, pp. 695-710
-
-
Podack, E.R.1
Konigsberg, P.J.2
-
32
-
-
0030796734
-
Dependence of the lytic activity of the N-terminal domain of human perforin on membrane lipid composition-implications for T-cell self-preservation
-
Rochel, N., and J.A. Cowan. 1997. Dependence of the lytic activity of the N-terminal domain of human perforin on membrane lipid composition-implications for T-cell self-preservation. Eur. J. Biochem. 249:223-231.
-
(1997)
Eur. J. Biochem.
, vol.249
, pp. 223-231
-
-
Rochel, N.1
Cowan, J.A.2
-
33
-
-
0036838596
-
Perforin-mediated CTL cytolysis counteracts direct cell-cell spread of Listeria monocytogenes
-
San Mateo, L.R., M.M. Chua, S.R. Weiss, and H. Shen. 2002. Perforin-mediated CTL cytolysis counteracts direct cell-cell spread of Listeria monocytogenes. J. Immunol. 169:5202-5208.
-
(2002)
J. Immunol.
, vol.169
, pp. 5202-5208
-
-
San Mateo, L.R.1
Chua, M.M.2
Weiss, S.R.3
Shen, H.4
-
34
-
-
2942700101
-
Discordant regulation of granzyme H and granzyme B expression in human lymphocytes
-
Sedelies, K.A., T.J. Sayers, K.M. Edwards, W. Chen, D.G. Pellicci, D.I. Godfrey, and J.A. Trapani. 2004. Discordant regulation of granzyme H and granzyme B expression in human lymphocytes. J. Biol. Chem. 279:26581-26587.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 26581-26587
-
-
Sedelies, K.A.1
Sayers, T.J.2
Edwards, K.M.3
Chen, W.4
Pellicci, D.G.5
Godfrey, D.I.6
Trapani, J.A.7
-
35
-
-
0026532606
-
A natural killer cell granule protein that induces DNA fragmentation and apoptosis
-
Shi, L., R.P. Kraut, R. Aebersold, and A.H. Greenberg. 1992. A natural killer cell granule protein that induces DNA fragmentation and apoptosis. J. Exp. Med. 175:553-566.
-
(1992)
J. Exp. Med.
, vol.175
, pp. 553-566
-
-
Shi, L.1
Kraut, R.P.2
Aebersold, R.3
Greenberg, A.H.4
-
36
-
-
0030723209
-
In vitro- And ex vivo-derived cytolytic leukocytes from granzyme a x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells
-
Simon, M.M., M. Hausmann, T. Tran, K. Ebnet, J. Tschopp, R. ThaHla, and A. Mullbacher. 1997. In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells. J. Exp. Med. 186:1781-1786.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 1781-1786
-
-
Simon, M.M.1
Hausmann, M.2
Tran, T.3
Ebnet, K.4
Tschopp, J.5
ThaHla, R.6
Mullbacher, A.7
-
37
-
-
0034605122
-
Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma
-
Smyth, M.J., K.Y. Thia, S.E. Street, D. MacGregor, D.I. Godfrey, and J.A. Trapani. 2000. Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma. J. Exp. Med. 192:755-760.
-
(2000)
J. Exp. Med.
, vol.192
, pp. 755-760
-
-
Smyth, M.J.1
Thia, K.Y.2
Street, S.E.3
MacGregor, D.4
Godfrey, D.I.5
Trapani, J.A.6
-
38
-
-
0038107576
-
Cutting edge: Granzymes a and B are not essential for perforin-mediated tumor rejection
-
Smyth, M.J., S.E. Street, and J.A. Trapani. 2003. Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection. J. Immunol. 171:515-518.
-
(2003)
J. Immunol.
, vol.171
, pp. 515-518
-
-
Smyth, M.J.1
Street, S.E.2
Trapani, J.A.3
-
39
-
-
0036645530
-
Suppression of lymphoma and epithelial malignancies effected by interferon γ
-
Street, S.E., J.A. Trapani, D. MacGregor, and M.J. Smyth. 2002. Suppression of lymphoma and epithelial malignancies effected by interferon γ. J. Exp. Med. 196:129-134.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 129-134
-
-
Street, S.E.1
Trapani, J.A.2
MacGregor, D.3
Smyth, M.J.4
-
40
-
-
0033516994
-
Expression and purification of recombinant human granzyme B from Pichia pastoris
-
Sun, J., C.H. Bird, M.S. Buzza, K.E. McKee, J.C. Whisstock, and P.I. Bird. 1999. Expression and purification of recombinant human granzyme B from Pichia pastoris. Biochem. Biophys. Res. Commun. 261:251-255.
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.261
, pp. 251-255
-
-
Sun, J.1
Bird, C.H.2
Buzza, M.S.3
McKee, K.E.4
Whisstock, J.C.5
Bird, P.I.6
-
41
-
-
0031570536
-
Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes
-
Sutton, V.R., D.L. Vaux, and J.A. Trapani. 1997. Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes. J. Immunol. 158:5783-5790.
-
(1997)
J. Immunol.
, vol.158
, pp. 5783-5790
-
-
Sutton, V.R.1
Vaux, D.L.2
Trapani, J.A.3
-
42
-
-
0034694091
-
Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation
-
Sutton, V.R., J.E. Davis, M. Cancilla, R.W. Johnstone, A.A. Ruefli, K. Sedelies, K.A. Browne, and J.A. Trapani. 2000. Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation. J. Exp. Med. 192:1403-1414.
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1403-1414
-
-
Sutton, V.R.1
Davis, J.E.2
Cancilla, M.3
Johnstone, R.W.4
Ruefli, A.A.5
Sedelies, K.6
Browne, K.A.7
Trapani, J.A.8
-
43
-
-
0037341354
-
Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors
-
Sutton, V.R., M.E. Wowk, M. Cancilla, and J.A. Trapani. 2003. Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors. Immunity. 18:319-329.
-
(2003)
Immunity
, vol.18
, pp. 319-329
-
-
Sutton, V.R.1
Wowk, M.E.2
Cancilla, M.3
Trapani, J.A.4
-
44
-
-
0027318806
-
Killing by cytotoxic T cells and natural killer cells: Multiple granule serine proteases as initiators of DNA fragmentation
-
Trapani, J.A., and M.J. Smyth. 1993. Killing by cytotoxic T cells and natural killer cells: multiple granule serine proteases as initiators of DNA fragmentation. Immunol. Cell Biol. 71:201-208.
-
(1993)
Immunol. Cell Biol.
, vol.71
, pp. 201-208
-
-
Trapani, J.A.1
Smyth, M.J.2
-
45
-
-
0036779576
-
Functional significance of the perforin/granzyme cell death pathway
-
Trapani, J.A., and M.J. Smyth. 2002. Functional significance of the perforin/granzyme cell death pathway. Nat. Rev. Immunol. 2:735-747.
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 735-747
-
-
Trapani, J.A.1
Smyth, M.J.2
-
46
-
-
0032561352
-
Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspasedependent, but cell death is caspase-independent
-
Trapani, J.A., D.A. Jans, P.J. Jans, M.J. Smyth, K.A. Browne, and V.R. Sutton. 1998. Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspasedependent, but cell death is caspase-independent. J. Biol. Chem. 273:27934-27938.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 27934-27938
-
-
Trapani, J.A.1
Jans, D.A.2
Jans, P.J.3
Smyth, M.J.4
Browne, K.A.5
Sutton, V.R.6
-
47
-
-
0029804782
-
Decreased tumor surveillance in perforin-deficient mice
-
van den Broek, M.E., D. Kagi, F. Ossendorp, R. Toes, S. Vamvakas, W.K. Lutz, C.J. Melief, R.M. Zinkernagel, and H. Hengartner. 1996. Decreased tumor surveillance in perforin-deficient mice. J. Exp. Med. 184:1781-1790.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 1781-1790
-
-
Van Den Broek, M.E.1
Kagi, D.2
Ossendorp, F.3
Toes, R.4
Vamvakas, S.5
Lutz, W.K.6
Melief, C.J.7
Zinkernagel, R.M.8
Hengartner, H.9
-
48
-
-
0035987541
-
CTL: Caspases terminate life, but that's not the whole story
-
Waterhouse, N.J., and J.A. Trapani. 2002. CTL: caspases terminate life, but that's not the whole story. Tissue Antigens. 59:175-183.
-
(2002)
Tissue Antigens
, vol.59
, pp. 175-183
-
-
Waterhouse, N.J.1
Trapani, J.A.2
-
49
-
-
4143136628
-
Cytotoxic lymphocytes; instigators of dramatic target cell death
-
Waterhouse, N.J., C.J. Clarke, K.A. Sedelies, M.W. Teng, and J.A. Trapani. 2004. Cytotoxic lymphocytes; instigators of dramatic target cell death. Biochem. Pharmacol. 68:1033-1040.
-
(2004)
Biochem. Pharmacol.
, vol.68
, pp. 1033-1040
-
-
Waterhouse, N.J.1
Clarke, C.J.2
Sedelies, K.A.3
Teng, M.W.4
Trapani, J.A.5
-
50
-
-
20044381271
-
A central role for Bid in granzyme B-induced apoptosis
-
Waterhouse, N.J., K.A. Sedelies, K.A. Browne, M.E. Wowk, A. Newbold, V.R. Sutton, C.J. Clarke, J. Oliaro, R.K. Lindemann, P.I. Bird, et al. 2005. A central role for Bid in granzyme B-induced apoptosis. J. Biol. Chem. 280:4476-4482.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 4476-4482
-
-
Waterhouse, N.J.1
Sedelies, K.A.2
Browne, K.A.3
Wowk, M.E.4
Newbold, A.5
Sutton, V.R.6
Clarke, C.J.7
Oliaro, J.8
Lindemann, R.K.9
Bird, P.I.10
-
51
-
-
0034292404
-
Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway
-
Wei, S., D.L. Gilvary, B.C. Corliss, S. Sebti, J. Sun, D.B. Straus, P.J. Leibson, J.A. Trapani, A.D. Hamilton, M.J. Weber, and J.Y. Djeu. 2000. Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway. J. Immunol. 165:3811-3819.
-
(2000)
J. Immunol.
, vol.165
, pp. 3811-3819
-
-
Wei, S.1
Gilvary, D.L.2
Corliss, B.C.3
Sebti, S.4
Sun, J.5
Straus, D.B.6
Leibson, P.J.7
Trapani, J.A.8
Hamilton, A.D.9
Weber, M.J.10
Djeu, J.Y.11
-
52
-
-
0022497854
-
Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity
-
Young, J.D., H. Hengartner, E.R. Podack, and Z.A. Cohn. 1986. Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity. Cell. 44:849-859.
-
(1986)
Cell
, vol.44
, pp. 849-859
-
-
Young, J.D.1
Hengartner, H.2
Podack, E.R.3
Cohn, Z.A.4
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