Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice

Viral Immunology

Volumn 21, Issue 3, 2008, Pages 341-346

  Jenkins, Misty R ^a,d   Trapani, Joseph A ^c   Doherty, Peter C ^a,b   Turner, Stephen J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c PETER MACCALLUM CANCER CENTRE   (Australia)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMIUM 51; GRANZYME; GRANZYME A; GRANZYME B; GRANZYME K; TETRAMER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; INFLUENZA; INFLUENZA VIRUS; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PNEUMONIA; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WILD TYPE;

ANIMALS; CELLS, CULTURED; GENE EXPRESSION; GRANZYMES; INFLUENZA A VIRUS; MICE; MICE, KNOCKOUT; ORTHOMYXOVIRIDAE INFECTIONS; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC;

INFLUENZA A VIRUS; MUS; ORTHOMYXOVIRIDAE;

EID: 51849108216     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/vim.2008.0036     Document Type: Conference Paper

References (35)

1. Belz GT, Wodarz D, Diaz G, Nowak MA, and P. C. Doherty: Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice. J Virol 2002;76:12388-12393.
2. Bolitho P, Voskoboinik I, Trapani JA, and Smyth MJ: Apoptosis induced by the lymphocyte effector molecule perforin. Curr Opin Immunol 2007;19:339-347.
3. Bratke K, Kuepper M, Bade B, Virchow JC Jr., and Luttmann W: Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood. Eur J Immunol 2005;35:2608-2616.
4. Chowdhury D, and Lieberman J: Death by a thousand cuts: Granzyme pathways of programmed cell death. Annu Rev Immunol 2008;26:389-420.
5. Darmon AJ, Nicholson DW, and Bleackley RC: Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature 1995;377:446-448.
6. Day EB, Zeng W, Doherty PC, Jackson DC, Kedzierska K, and Turner SJ: The context of epitope presentation can influence functional quality of recalled influenza A virus-specific memory CD8+ T cells. J Immunol 2007;179:2187-2194.
7. Deliyannis G, Jackson DC, Ede NJ, Zeng W, Hourdakis I, Sakabetis E, and Brown LE: Induction of long-term memory CD8(+) T cells for recall of viral clearing responses against influenza virus. J Virol 2002;76: 4212-4221.
8. Doherty PC, Topham DJ, Tripp RA, Cardin RD, Brooks JW, and Stevenson PG: Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections. Immunol Rev 1997;159:105-117.
9. Eichelberger M, Allan W, Zijlstra M, Jaenisch R, and Doherty PC: Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells. J Exp Med 1991;174:875-880.
10. Fan Z, Beresford PJ, Zhang D, and Lieberman J: HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol Cell Biol 2002;22:2810-2820.
11. Fan Z, Beresford PJ, Zhang D, et al.: Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nat Immunol 2003;4:145-153.
12. Grossman WJ, Revell PA, Lu ZH, Johnson H, Bredemeyer AJ, and Ley TJ: The orphan granzymes of humans and mice. Curr Opin Immunol 2003;15:544-552.
13. Jenkins MR, Kedzierska K, Doherty PC, and Turner SJ: Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL. J Immunol 2007;179:64-70.
14. Jenkins MR, Webby R, Doherty PC, and Turner SJ: Addition of a prominent epitope affects influenza A virus-specific CD8+ T cell immunodominance hierarchies when antigen is limiting. J Immunol 2006;177:2917-2925.
15. Jenne D, Rey C, Haefliger JA, Qiao BY, Groscurth P, and Tschopp J: Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes. Proc Natl Acad Sci USA 1988;85:4814-4818.
16. Kelly JM, Waterhouse NJ, Cretney E, Browne KA, Ellis S, Trapani JA, and Smyth MJ: Granzyme M mediates a novel form of perforin-dependent cell death. J Biol Chem 2004;279:22236-22242.
17. La Gruta NL, Kedzierska K, Pang K, et al.: A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies. Proc Natl Acad Sci USA 2006;103:994-999.
18. La Gruta NL, Turner SJ, and Doherty PC: Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8+ T cell responses: correlation of cytokine profile and TCR avidity. J Immunol 2004;172:5553-5560.
19. Mintern JD, Guillonneau C, Carbone FR, Doherty PC, and Turner SJ: Cutting edge: Tissue-resident memory CTL down-regulate cytolytic molecule expression following virus clearance. J Immunol 2007;179:7220-7204.
20. Mullbacher A, Waring P, Tha Hla R, et al.: Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc Natl Acad Sci USA 1999;96:13950-13955.
21. Pao LI, Sumaria N, Kelly JM, et al.: Functional analysis of granzyme M and its role in immunity to infection. J Immunol 2005;175:3235-3243.
22. Pardo J, Bosque A, Brehm R, et al.: Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis. J Cell Biol 2004;167:457-468.
23. Pham CT, MacIvor DM, Hug BA, Heusel JW, and Ley TJ: Long-range disruption of gene expression by a selectable marker cassette. Proc Natl Acad Sci USA 1996;93:13090-13095.
24. Revell PA, Grossman WJ, Thomas DA, et al.: Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions. J Immunol 2005;174:2124-2131.
25. Smyth MJ, O'Connor MD, and Trapani JA: Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies. J Leukoc Biol 1996;60:555-562.
26. Smyth MJ, Street SE, and Trapani JA: Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection. J Immunol 2003;171:515-518.
27. Smyth MJ, Thia KY, Street SE, MacGregor D, Godfrey DI, and Trapani JA: Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma. J Exp Med 2000;192:755-760.
28. Smyth MJ, and Trapani JA: The relative role of lymphocyte granule exocytosis versus death receptor-mediated cytotoxicity in viral pathophysiology. J Virol 1998;72:1-9.
29. Takano N, Matusi H, and Takahashi T: Granzyme N, a novel granzyme, is expressed in spermatocytes and spermatids of the mouse testis. Biol Reprod 2004;71:1785-1795.
30. Thomas PG, Brown SA, Keating R, et al.: Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses. J Immunol 2007;178:3091-3098.
31. Topham DJ, Tripp RA, Hamilton-Easton AM, Sarawar SR, and Doherty PC: Quantitative analysis of the influenza virus-specific CD4+ T cell memory in the absence of B cells and Ig. J Immunol 1996;157:2947-2952.
32. Trapani JA, and Smyth MJ: Functional significance of the perforin/granzyme cell death pathway. Nat Rev Immunol 2002;2:735-747.
33. Waterhouse NJ, Sutton VR, Sedelies KA, et al.: Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis. J Cell Biol 2006;173:133-144.
34. Webby RJ, Andreansky S, Stambas J, Rehg JE, Webster RG, Doherty PC, and Turner SJ: Protection and compensation in the influenza virus-specific CD8+ T cell response. Proc Natl Acad Sci USA 2003;100:7235-7240.
35. Zhao T, Zhang H, Guo Y, and Fan Z: Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death. J Biol Chem 2007;282:12104-12111.