Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: Involvement of extracellular matrix degradation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 24, Issue 12, 2004, Pages 2245-2250

  Choy, Jonathan C ^a   Hung, Vivian H Y ^a   Hunter, Arwen L ^a   Cheung, Paul K ^a   Motyka, Bruce ^b   Ing, Swie Goping ^b   Sawchuk, Tracy ^b   Bleackley, R Chris ^b   Podor, Thomas J ^a   McManus, Bruce M ^a   Granville, David J ^a,c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c ST PAUL S HOSPITAL   (Canada)

Author keywords

Apoptosis; Extracellular; Granzyme B; Perforin; Smooth muscle cell

Indexed keywords

CASPASE; FIBRONECTIN; FOCAL ADHESION KINASE; GRANZYME B; MANNOSE 6 PHOSPHATE; PERFORIN; PHOSPHATIDYLSERINE;

APOPTOSIS; ARTICLE; CELL VIABILITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SMOOTH MUSCLE FIBER; SPLEEN CELL;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; CORONARY VESSELS; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; GRANZYMES; HELA CELLS; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PORE FORMING CYTOTOXIC PROTEINS; RATS; SERINE ENDOPEPTIDASES; SPLEEN;

EID: 20844448537     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000147162.51930.b7     Document Type: Article

References (26)

1. Froelich CJ, Orth K, Turbov J, Seth P, Gottlieb R, Babior B, Shah GM, Bleackley RC, Dixit VM, Hanna W. New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J Biol Chem. 1996;271:29073-29079.
2. Pinkoski MJ, Hobman M, Heibein JA, Tomaselli K, Li F, Seth P, Froelich CJ, Bleackley RC. Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis. Blood. 1998;92:1044-1054.
3. Seko Y, Minota S, Kawasaki A, Shinkai Y, Maeda K, Yagita H, Okumura K, Sato O, Takagi A, Tada Y. Perforin-secreting killer cell infiltration and expression of a 65-kD heat-shock protein in aortic tissue of patients with Takayasu's arteritis. J Clin Invest. 1994;93:750-758.
4. Henderson EL, Geng YJ, Sukhova GK, Whittemore AD, Knox J, Libby P. Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms. Circulation. 1999;99:96-104.
5. Fox WM, Hameed A, Hutchins GM, Reitz BA, Baumgartner WA, Beschomer WE, Hruban RH. Perform expression localizing cytotoxic lymphocytes in the intimas of coronary arteries with transplant-related accelerated arteriosclerosis. Hum Pathol. 1993;24:477-482.
6. Choy JC, McDonald PC, Suarez AC, Hung VH, Wilson JE, McManus BM, Granville DJ. Granzyme B in atherosclerosis and transplant vascular disease: association with cell death and atherosclerotic disease severity. Mod Pathol. 2003;16:460-470.
7. Legare JF, Issekutz T, Lee TD, Hirsch G. CD8+ T lymphocytes mediate destruction of the vascular media in a model of chronic rejection. Am J Pathol. 2000;157:859-865.
8. Moien-Afshari F, Choy JC, McManus BM, Laher I. Cyclosporine treatment preserves coronary resistance artery function in rat cardiac allografts. J Heart Lung Transplant. 2004;23:193-203.
9. von der Thusen JH, van Vlijmen BJ, Hoeben RC, Kockx MM, Havekes LM, van Berkel TJ, Biessen EA. Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53. Circulation. 2002;105:2064-2070.
10. Granville DJ, Levy JG, Hunt DW. Photodynamic therapy induces caspase-3 activation in HL-60 cells. Cell Death Differ. 1997;4:623-628.
11. Shi L, Chen G, MacDonald G, Bergeron L, Li H, Miura M, Rotello RJ, Miller DK, Li P, Seshadri T, Yuan J, Greenberg AH. Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B. Proc Natl Acad Sci U S A. 1996;93:11002-11007.
12. Motyka B, Korbutt G, Pinkoski MJ, Heibein JA, Caputo A, Hobman M, Barry M, Shostak I, Sawchuk T, Holmes CF, Gauldie J, Bleackley RC. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. Cell. 2000;103:491-500.
13. Hungerford JE, Compton MT, Matter ML, Hoffstrom BG, Otey CA. Inhibition of pp125FAK in cultured fibroblasts results in apoptosis. J Cell Biol. 1996;135:1383-1390.
14. Trapani JA, Sutton VR, Thia KY, Li YQ, Froelich CJ, Jans DA, Sandrin MS, Browne KA. A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. J Cell Biol. 2003;160:223-233.
15. Galvin JP, Spaeny-Dekking LH, Wang B, Seth P, Hack CE, Froelich CJ. Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo. J Immunol. 1999;162:5345-5350.
16. Veugelers K, Motyka B, Frantz C, Shostak I, Sawchuk T, Bleackley RC. The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis. Blood. 2004;103:3845-3853.
17. Dressel R, Raja SM, Honing S, Seidler T, Froelich CJ, von Figura K, Gunther E. Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells. J Biol Chem. 2004;279:20200-20210.
18. Gross C, Koelch W, DeMaio A, Arispe N, Multhoff G. Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B. J Biol Chem. 2003;278:41173-41181.
19. Multhoff G, Botzler C, Wiesnet M, Muller E, Meier T, Wilmanns W, Issels RD. A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells. Int J Cancer. 1995;61:272-279.
20. Zhu WM, Roma P, Pirillo A, Pellegatta F, Catapano AL. Oxidized LDL induce hsp70 expression in human smooth muscle cells. FEBS Lett. 1995;372:1-5.
21. Sayers TJ, Wiltrout TA, Sowder R, Munger WL, Smyth MJ, Henderson LE. Purification of a factor from the granules of a rat natural killer cell line (RNK) that reduces tumor cell growth and changes tumor morphology. Molecular identity with a granule serine protease (RNKP-1). J Immunol. 1992;148:292-300.
22. Takashita E, Sugimoto K, Adachi Y, Aihara Y, Inoue H, Jiang H, Katakai T, Mori KJ. Destruction of hematopoietic microenvironment by cytotoxic T cells. Exp Hematol. 1997;25:1034-1041.
23. Lindstedt KA, Leskinen MJ, Kovanen PT. Proteolysis of the pericellular matrix: a novel element determining cell survival and death in the pathogenesis of plaque erosion and rupture. Arterioscler Thromb Vasc Biol. 2004;24:1350-1358.
24. Leskinen MJ, Lindstedt KA, Wang Y, Kovanen PT. Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions. Arterioscler Thromb Vasc Biol. 2003;23:238-243.
25. Wagner C, Iking-Konert C, Denefleh B, Stegmaier S, Hug F, Hansch GM. Granzyme B and perform: constitutive expression in human polymorphonuclear neutrophils. Blood. 2004;103:1099-1104.
26. Michel JB. Anoikis in the cardiovascular system: known and unknown extracellular mediators. Arterioscler Thromb Vasc Biol. 2003;23:2146-2154.