In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A X B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells

Journal of Experimental Medicine

Volumn 186, Issue 10, 1997, Pages 1781-1786

  Simon, Markus M ^a   Hausmann, Michael ^a   Tran, Thao ^a   Ebnet, Klaus ^a,d   Tschopp, Jürg ^b   ThaHla, Ron ^c   Müllbacher, Arno ^c  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^d UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMIUM 51; DNA; GRANZYME A; GRANZYME B; IODINE 125; PERFORIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; IMMUNOPATHOGENESIS; INFLUENZA VIRUS A; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; TARGET CELL;

ANIMALS; APOPTOSIS; CYTOPLASMIC GRANULES; CYTOTOXICITY TESTS, IMMUNOLOGIC; CYTOTOXICITY, IMMUNOLOGIC; DNA FRAGMENTATION; FEMALE; GRANZYMES; LEUKEMIA L1210; LYMPHOMA; MALE; MAST-CELL SARCOMA; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PORE FORMING CYTOTOXIC PROTEINS; SERINE ENDOPEPTIDASES; T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED;

EID: 0030723209     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.10.1781     Document Type: Article

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