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Volumn 1792, Issue 5, 2009, Pages 401-408

Leptin signaling in brain: A link between nutrition and cognition?

Author keywords

Cognitive function; Food intake; Hippocampus; Hypothalamus; Neuroprotection

Indexed keywords

LEPTIN;

EID: 64249132485     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2008.12.004     Document Type: Review
Times cited : (181)

References (168)
  • 1
    • 0022897953 scopus 로고
    • Dynamics of recovery of body composition after overfeeding, food restriction or starvation of mature female rats
    • Harris R.B., Kasser T.R., and Martin R.J. Dynamics of recovery of body composition after overfeeding, food restriction or starvation of mature female rats. J. Nutr. 116 (1986) 2536-2546
    • (1986) J. Nutr. , vol.116 , pp. 2536-2546
    • Harris, R.B.1    Kasser, T.R.2    Martin, R.J.3
  • 4
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield L.A., Smith F.J., Guisez Y., Devos R., and Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269 (1995) 546-549
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 7
    • 10344260142 scopus 로고    scopus 로고
    • Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates
    • Ostlund R.E., Yang J.W., Klein S., and Gingerich R. Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J. Clin. Endocrinol. Metab. 81 (1996) 3909-3913
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 3909-3913
    • Ostlund, R.E.1    Yang, J.W.2    Klein, S.3    Gingerich, R.4
  • 9
    • 27344431720 scopus 로고    scopus 로고
    • NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
    • Luquet S., Perez F.A., Hnasko T.S., and Palmiter R.D. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310 (2005) 683-685
    • (2005) Science , vol.310 , pp. 683-685
    • Luquet, S.1    Perez, F.A.2    Hnasko, T.S.3    Palmiter, R.D.4
  • 10
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • Krude H., Biebermann H., Luck W., Horn R., Brabant G., and Gruters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat. Genet. 19 (1998) 155-157
    • (1998) Nat. Genet. , vol.19 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Gruters, A.6
  • 11
    • 0032863468 scopus 로고    scopus 로고
    • Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
    • Yaswen L., Diehl N., Brennan M.B., and Hochgeschwender U. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat. Med. 5 (1999) 1066-1070
    • (1999) Nat. Med. , vol.5 , pp. 1066-1070
    • Yaswen, L.1    Diehl, N.2    Brennan, M.B.3    Hochgeschwender, U.4
  • 14
    • 0030775971 scopus 로고    scopus 로고
    • Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
    • Schwartz M.W., Seeley R.J., Woods S.C., Weigle D.S., Campfield L.A., Burn P., and Baskin D.G. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46 (1997) 2119-2123
    • (1997) Diabetes , vol.46 , pp. 2119-2123
    • Schwartz, M.W.1    Seeley, R.J.2    Woods, S.C.3    Weigle, D.S.4    Campfield, L.A.5    Burn, P.6    Baskin, D.G.7
  • 15
    • 0031440266 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
    • Spanswick D., Smith M.A., Groppi V.E., Logan S.D., and Ashford M.L. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390 (1997) 521-525
    • (1997) Nature , vol.390 , pp. 521-525
    • Spanswick, D.1    Smith, M.A.2    Groppi, V.E.3    Logan, S.D.4    Ashford, M.L.5
  • 16
    • 17844401180 scopus 로고    scopus 로고
    • Molecular and anatomical determinants of central leptin resistance
    • Munzberg H., and Myers Jr. M.G. Molecular and anatomical determinants of central leptin resistance. Nat. Neurosci. 8 (2005) 566-570
    • (2005) Nat. Neurosci. , vol.8 , pp. 566-570
    • Munzberg, H.1    Myers Jr., M.G.2
  • 18
    • 0032424694 scopus 로고    scopus 로고
    • Transcription factor STAT3 in leptin target neurons of the rat hypothalamus
    • Hakansson M.L., and Meister B. Transcription factor STAT3 in leptin target neurons of the rat hypothalamus. Neuroendocrinology 68 (1998) 420-427
    • (1998) Neuroendocrinology , vol.68 , pp. 420-427
    • Hakansson, M.L.1    Meister, B.2
  • 19
    • 0038747134 scopus 로고    scopus 로고
    • Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin
    • Munzberg H., Huo L., Nillni E.A., Hollenberg A.N., and Bjorbaek C. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology 144 (2003) 2121-2131
    • (2003) Endocrinology , vol.144 , pp. 2121-2131
    • Munzberg, H.1    Huo, L.2    Nillni, E.A.3    Hollenberg, A.N.4    Bjorbaek, C.5
  • 21
    • 33845867730 scopus 로고    scopus 로고
    • Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding
    • Xu A.W., Ste-Marie L., Kaelin C.B., and Barsh G.S. Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology 148 (2007) 72-80
    • (2007) Endocrinology , vol.148 , pp. 72-80
    • Xu, A.W.1    Ste-Marie, L.2    Kaelin, C.B.3    Barsh, G.S.4
  • 23
    • 0036321620 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding
    • Zhao A.Z., Huan J.N., Gupta S., Pal R., and Sahu A. A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Nat. Neurosci. 5 (2002) 727-728
    • (2002) Nat. Neurosci. , vol.5 , pp. 727-728
    • Zhao, A.Z.1    Huan, J.N.2    Gupta, S.3    Pal, R.4    Sahu, A.5
  • 24
    • 33644665508 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling
    • Morrison C.D., Morton G.J., Niswender K.D., Gelling R.W., and Schwartz M.W. Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling. Am. J. Physiol. Endocrinol. Metab. 289 (2005) E1051-E1057
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.289
    • Morrison, C.D.1    Morton, G.J.2    Niswender, K.D.3    Gelling, R.W.4    Schwartz, M.W.5
  • 25
    • 0037338694 scopus 로고    scopus 로고
    • Intracellular mechanisms involved in leptin regulation of sympathetic outflow
    • Rahmouni K., Haynes W.G., Morgan D.A., and Mark A.L. Intracellular mechanisms involved in leptin regulation of sympathetic outflow. Hypertension 41 (2003) 763-767
    • (2003) Hypertension , vol.41 , pp. 763-767
    • Rahmouni, K.1    Haynes, W.G.2    Morgan, D.A.3    Mark, A.L.4
  • 26
    • 33745838578 scopus 로고    scopus 로고
    • Central insulin action in energy and glucose homeostasis
    • Plum L., Belgardt B.F., and Bruning J.C. Central insulin action in energy and glucose homeostasis. J. Clin. Invest. 116 (2006) 1761-1766
    • (2006) J. Clin. Invest. , vol.116 , pp. 1761-1766
    • Plum, L.1    Belgardt, B.F.2    Bruning, J.C.3
  • 29
    • 0018621289 scopus 로고
    • Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
    • Woods S.C., Lotter E.C., McKay L.D., and Porte Jr. D. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 282 (1979) 503-505
    • (1979) Nature , vol.282 , pp. 503-505
    • Woods, S.C.1    Lotter, E.C.2    McKay, L.D.3    Porte Jr., D.4
  • 30
    • 0037382853 scopus 로고    scopus 로고
    • Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin
    • Kohno D., Gao H.Z., Muroya S., Kikuyama S., and Yada T. Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 52 (2003) 948-956
    • (2003) Diabetes , vol.52 , pp. 948-956
    • Kohno, D.1    Gao, H.Z.2    Muroya, S.3    Kikuyama, S.4    Yada, T.5
  • 31
    • 4444266408 scopus 로고    scopus 로고
    • Peptide YY directly inhibits ghrelin-activated neurons of the arcuate nucleus and reverses fasting-induced c-Fos expression
    • Riediger T., Bothe C., Becskei C., and Lutz T.A. Peptide YY directly inhibits ghrelin-activated neurons of the arcuate nucleus and reverses fasting-induced c-Fos expression. Neuroendocrinology 79 (2004) 317-326
    • (2004) Neuroendocrinology , vol.79 , pp. 317-326
    • Riediger, T.1    Bothe, C.2    Becskei, C.3    Lutz, T.A.4
  • 33
    • 0035709033 scopus 로고    scopus 로고
    • Glucosensing neurons do more than just sense glucose
    • Levin B.E. Glucosensing neurons do more than just sense glucose. Int. J. Obes. Relat. Metab. Disord. 25 Suppl. 5 (2001) S68-S72
    • (2001) Int. J. Obes. Relat. Metab. Disord. , vol.25 , Issue.SUPPL. 5
    • Levin, B.E.1
  • 35
    • 0036065628 scopus 로고    scopus 로고
    • Central administration of oleic acid inhibits glucose production and food intake
    • Obici S., Feng Z., Morgan K., Stein D., Karkanias G., and Rossetti L. Central administration of oleic acid inhibits glucose production and food intake. Diabetes 51 (2002) 271-275
    • (2002) Diabetes , vol.51 , pp. 271-275
    • Obici, S.1    Feng, Z.2    Morgan, K.3    Stein, D.4    Karkanias, G.5    Rossetti, L.6
  • 36
    • 33746299000 scopus 로고    scopus 로고
    • Integration of metabolic stimuli in the hypothalamic arcuate nucleus
    • van den Top M., and Spanswick D. Integration of metabolic stimuli in the hypothalamic arcuate nucleus. Prog. Brain Res. 153 (2006) 141-154
    • (2006) Prog. Brain Res. , vol.153 , pp. 141-154
    • van den Top, M.1    Spanswick, D.2
  • 38
    • 42449086900 scopus 로고    scopus 로고
    • Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome
    • Bingham N.C., Anderson K.K., Reuter A.L., Stallings N.R., and Parker K.L. Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology 149 (2008) 2138-2148
    • (2008) Endocrinology , vol.149 , pp. 2138-2148
    • Bingham, N.C.1    Anderson, K.K.2    Reuter, A.L.3    Stallings, N.R.4    Parker, K.L.5
  • 41
    • 33845911799 scopus 로고    scopus 로고
    • Distributed neural control of energy balance: contributions from hindbrain and hypothalamus
    • Grill H.J. Distributed neural control of energy balance: contributions from hindbrain and hypothalamus. Obesity (Silver Spring) 14 Suppl. 5 (2006) 216S-221S
    • (2006) Obesity (Silver Spring) , vol.14 , Issue.SUPPL. 5
    • Grill, H.J.1
  • 42
    • 0036142589 scopus 로고    scopus 로고
    • Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake
    • Grill H.J., Schwartz M.W., Kaplan J.M., Foxhall J.S., Breininger J., and Baskin D.G. Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake. Endocrinology 143 (2002) 239-246
    • (2002) Endocrinology , vol.143 , pp. 239-246
    • Grill, H.J.1    Schwartz, M.W.2    Kaplan, J.M.3    Foxhall, J.S.4    Breininger, J.5    Baskin, D.G.6
  • 43
    • 0033835211 scopus 로고    scopus 로고
    • Leptin-much more than a satiety signal
    • Harris R.B. Leptin-much more than a satiety signal. Annu. Rev. Nutr. 20 (2000) 45-75
    • (2000) Annu. Rev. Nutr. , vol.20 , pp. 45-75
    • Harris, R.B.1
  • 44
    • 0037636366 scopus 로고    scopus 로고
    • The physiology of cellular liporegulation
    • Unger R.H. The physiology of cellular liporegulation. Annu. Rev. Physiol. 65 (2003) 333-347
    • (2003) Annu. Rev. Physiol. , vol.65 , pp. 333-347
    • Unger, R.H.1
  • 46
    • 0022357327 scopus 로고
    • Increased metabolic efficiency in obese mutant mice
    • Coleman D.L. Increased metabolic efficiency in obese mutant mice. Int. J. Obes. 9 Suppl. 2 (1985) 69-73
    • (1985) Int. J. Obes. , vol.9 , Issue.SUPPL. 2 , pp. 69-73
    • Coleman, D.L.1
  • 50
    • 0030830662 scopus 로고    scopus 로고
    • Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats
    • Dunbar J.C., Hu Y., and Lu H. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes 46 (1997) 2040-2043
    • (1997) Diabetes , vol.46 , pp. 2040-2043
    • Dunbar, J.C.1    Hu, Y.2    Lu, H.3
  • 52
    • 0031748933 scopus 로고    scopus 로고
    • Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins
    • Cusin I., Zakrzewska K.E., Boss O., Muzzin P., Giacobino J.P., Ricquier D., Jeanrenaud B., and Rohner-Jeanrenaud F. Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins. Diabetes 47 (1998) 1014-1019
    • (1998) Diabetes , vol.47 , pp. 1014-1019
    • Cusin, I.1    Zakrzewska, K.E.2    Boss, O.3    Muzzin, P.4    Giacobino, J.P.5    Ricquier, D.6    Jeanrenaud, B.7    Rohner-Jeanrenaud, F.8
  • 53
    • 0031821693 scopus 로고    scopus 로고
    • Leptin induction of UCP1 gene expression is dependent on sympathetic innervation
    • Scarpace P.J., and Matheny M. Leptin induction of UCP1 gene expression is dependent on sympathetic innervation. Am. J. Physiol. 275 (1998) E259-E264
    • (1998) Am. J. Physiol. , vol.275
    • Scarpace, P.J.1    Matheny, M.2
  • 55
    • 33645841079 scopus 로고    scopus 로고
    • Leptin is required for uncoupling protein-1-independent thermogenesis during cold stress
    • Ukropec J., Anunciado R.V., Ravussin Y., and Kozak L.P. Leptin is required for uncoupling protein-1-independent thermogenesis during cold stress. Endocrinology 147 (2006) 2468-2480
    • (2006) Endocrinology , vol.147 , pp. 2468-2480
    • Ukropec, J.1    Anunciado, R.V.2    Ravussin, Y.3    Kozak, L.P.4
  • 56
  • 58
    • 0033657074 scopus 로고    scopus 로고
    • Leptin and the neuroendocrinology of fasting
    • Ahima R.S. Leptin and the neuroendocrinology of fasting. Front. Horm. Res. 26 (2000) 42-56
    • (2000) Front. Horm. Res. , vol.26 , pp. 42-56
    • Ahima, R.S.1
  • 59
    • 0000659858 scopus 로고    scopus 로고
    • Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus
    • Legradi G., Emerson C.H., Ahima R.S., Flier J.S., and Lechan R.M. Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 138 (1997) 2569-2576
    • (1997) Endocrinology , vol.138 , pp. 2569-2576
    • Legradi, G.1    Emerson, C.H.2    Ahima, R.S.3    Flier, J.S.4    Lechan, R.M.5
  • 61
    • 0342858793 scopus 로고    scopus 로고
    • alpha-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression
    • Fekete C., Legradi G., Mihaly E., Huang Q.H., Tatro J.B., Rand W.M., Emerson C.H., and Lechan R.M. alpha-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. J. Neurosci. 20 (2000) 1550-1558
    • (2000) J. Neurosci. , vol.20 , pp. 1550-1558
    • Fekete, C.1    Legradi, G.2    Mihaly, E.3    Huang, Q.H.4    Tatro, J.B.5    Rand, W.M.6    Emerson, C.H.7    Lechan, R.M.8
  • 62
    • 33746308184 scopus 로고    scopus 로고
    • The TRH neuron: a hypothalamic integrator of energy metabolism
    • Lechan R.M., and Fekete C. The TRH neuron: a hypothalamic integrator of energy metabolism. Prog. Brain Res. 153 (2006) 209-235
    • (2006) Prog. Brain Res. , vol.153 , pp. 209-235
    • Lechan, R.M.1    Fekete, C.2
  • 63
    • 2442701352 scopus 로고    scopus 로고
    • Energy balance and reproduction
    • Schneider J.E. Energy balance and reproduction. Physiol. Behav. 81 (2004) 289-317
    • (2004) Physiol. Behav. , vol.81 , pp. 289-317
    • Schneider, J.E.1
  • 64
    • 0022510792 scopus 로고
    • Food-restricted, prepubertal, female rats: rapid recovery of luteinizing hormone pulsing with excess food, and full recovery of pubertal development with gonadotropin-releasing hormone
    • Bronson F.H. Food-restricted, prepubertal, female rats: rapid recovery of luteinizing hormone pulsing with excess food, and full recovery of pubertal development with gonadotropin-releasing hormone. Endocrinology 118 (1986) 2483-2487
    • (1986) Endocrinology , vol.118 , pp. 2483-2487
    • Bronson, F.H.1
  • 65
    • 0021921216 scopus 로고
    • Effect of restricted nutrition on puberty in the lamb: patterns of tonic luteinizing hormone (LH) secretion and competency of the LH surge system
    • Foster D.L., and Olster D.H. Effect of restricted nutrition on puberty in the lamb: patterns of tonic luteinizing hormone (LH) secretion and competency of the LH surge system. Endocrinology 116 (1985) 375-381
    • (1985) Endocrinology , vol.116 , pp. 375-381
    • Foster, D.L.1    Olster, D.H.2
  • 66
    • 0025774012 scopus 로고
    • Effects of dietary energy on ovarian function, estrogen suppression of luteinizing hormone and follicle-stimulating hormone, and competency of the gonadotropin surge
    • McShane T.M., and Keisler D.H. Effects of dietary energy on ovarian function, estrogen suppression of luteinizing hormone and follicle-stimulating hormone, and competency of the gonadotropin surge. Biol. Reprod. 45 (1991) 486-492
    • (1991) Biol. Reprod. , vol.45 , pp. 486-492
    • McShane, T.M.1    Keisler, D.H.2
  • 67
    • 0031014413 scopus 로고    scopus 로고
    • Early onset of reproductive function in normal female mice treated with leptin
    • Chehab F.F., Mounzih K., Lu R., and Lim M.E. Early onset of reproductive function in normal female mice treated with leptin. Science 275 (1997) 88-90
    • (1997) Science , vol.275 , pp. 88-90
    • Chehab, F.F.1    Mounzih, K.2    Lu, R.3    Lim, M.E.4
  • 69
    • 0034026809 scopus 로고    scopus 로고
    • Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin
    • Yura S., Ogawa Y., Sagawa N., Masuzaki H., Itoh H., Ebihara K., Aizawa-Abe M., Fujii S., and Nakao K. Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin. J. Clin. Invest. 105 (2000) 749-755
    • (2000) J. Clin. Invest. , vol.105 , pp. 749-755
    • Yura, S.1    Ogawa, Y.2    Sagawa, N.3    Masuzaki, H.4    Itoh, H.5    Ebihara, K.6    Aizawa-Abe, M.7    Fujii, S.8    Nakao, K.9
  • 71
    • 0031854256 scopus 로고    scopus 로고
    • Chronic administration of leptin into the lateral ventricle induces sexual maturation in severely food-restricted female rats
    • Gruaz N.M., Lalaoui M., Pierroz D.D., Englaro P., Sizonenko P.C., Blum W.F., and Aubert M.L. Chronic administration of leptin into the lateral ventricle induces sexual maturation in severely food-restricted female rats. J. Neuroendocrinol. 10 (1998) 627-633
    • (1998) J. Neuroendocrinol. , vol.10 , pp. 627-633
    • Gruaz, N.M.1    Lalaoui, M.2    Pierroz, D.D.3    Englaro, P.4    Sizonenko, P.C.5    Blum, W.F.6    Aubert, M.L.7
  • 73
    • 0031768209 scopus 로고    scopus 로고
    • The stimulatory effect of leptin on the neuroendocrine reproductive axis of the monkey
    • Finn P.D., Cunningham M.J., Pau K.Y., Spies H.G., Clifton D.K., and Steiner R.A. The stimulatory effect of leptin on the neuroendocrine reproductive axis of the monkey. Endocrinology 139 (1998) 4652-4662
    • (1998) Endocrinology , vol.139 , pp. 4652-4662
    • Finn, P.D.1    Cunningham, M.J.2    Pau, K.Y.3    Spies, H.G.4    Clifton, D.K.5    Steiner, R.A.6
  • 74
    • 0035143571 scopus 로고    scopus 로고
    • Intracerebroventricular infusion of leptin elevates the secretion of luteinising hormone without affecting food intake in long-term food-restricted sheep, but increases growth hormone irrespective of bodyweight
    • Henry B.A., Goding J.W., Tilbrook A.J., Dunshea F.R., and Clarke I.J. Intracerebroventricular infusion of leptin elevates the secretion of luteinising hormone without affecting food intake in long-term food-restricted sheep, but increases growth hormone irrespective of bodyweight. J. Endocrinol. 168 (2001) 67-77
    • (2001) J. Endocrinol. , vol.168 , pp. 67-77
    • Henry, B.A.1    Goding, J.W.2    Tilbrook, A.J.3    Dunshea, F.R.4    Clarke, I.J.5
  • 75
    • 0031813699 scopus 로고    scopus 로고
    • Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting
    • Nagatani S., Guthikonda P., Thompson R.C., Tsukamura H., Maeda K.I., and Foster D.L. Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting. Neuroendocrinology 67 (1998) 370-376
    • (1998) Neuroendocrinology , vol.67 , pp. 370-376
    • Nagatani, S.1    Guthikonda, P.2    Thompson, R.C.3    Tsukamura, H.4    Maeda, K.I.5    Foster, D.L.6
  • 76
    • 0028834598 scopus 로고
    • The role of neuropeptide Y (NPY) in the control of LH secretion in the ewe with respect to season, NPY receptor subtype and the site of action in the hypothalamus
    • Barker-Gibb M.L., Scott C.J., Boublik J.H., and Clarke I.J. The role of neuropeptide Y (NPY) in the control of LH secretion in the ewe with respect to season, NPY receptor subtype and the site of action in the hypothalamus. J. Endocrinol. 147 (1995) 565-579
    • (1995) J. Endocrinol. , vol.147 , pp. 565-579
    • Barker-Gibb, M.L.1    Scott, C.J.2    Boublik, J.H.3    Clarke, I.J.4
  • 77
    • 0024413592 scopus 로고
    • Neuropeptide-Y suppresses pulsatile secretion of luteinizing hormone in ovariectomized rats: possible site of action
    • McDonald J.K., Lumpkin M.D., and DePaolo L.V. Neuropeptide-Y suppresses pulsatile secretion of luteinizing hormone in ovariectomized rats: possible site of action. Endocrinology 125 (1989) 186-191
    • (1989) Endocrinology , vol.125 , pp. 186-191
    • McDonald, J.K.1    Lumpkin, M.D.2    DePaolo, L.V.3
  • 80
    • 0030904819 scopus 로고    scopus 로고
    • Food-deprivation increases cocaine-induced conditioned place preference and locomotor activity in rats
    • Bell S.M., Stewart R.B., Thompson S.C., and Meisch R.A. Food-deprivation increases cocaine-induced conditioned place preference and locomotor activity in rats. Psychopharmacology (Berl.) 131 (1997) 1-8
    • (1997) Psychopharmacology (Berl.) , vol.131 , pp. 1-8
    • Bell, S.M.1    Stewart, R.B.2    Thompson, S.C.3    Meisch, R.A.4
  • 81
    • 0029909851 scopus 로고    scopus 로고
    • Feeding, drug abuse, and the sensitization of reward by metabolic need
    • Carr K.D. Feeding, drug abuse, and the sensitization of reward by metabolic need. Neurochem. Res. 21 (1996) 1455-1467
    • (1996) Neurochem. Res. , vol.21 , pp. 1455-1467
    • Carr, K.D.1
  • 83
    • 0034993663 scopus 로고    scopus 로고
    • Leptin reverses sucrose-conditioned place preference in food-restricted rats
    • Figlewicz D.P., Higgins M.S., Ng-Evans S.B., and Havel P.J. Leptin reverses sucrose-conditioned place preference in food-restricted rats. Physiol. Behav. 73 (2001) 229-234
    • (2001) Physiol. Behav. , vol.73 , pp. 229-234
    • Figlewicz, D.P.1    Higgins, M.S.2    Ng-Evans, S.B.3    Havel, P.J.4
  • 84
    • 0034614698 scopus 로고    scopus 로고
    • Modulation of brain reward circuitry by leptin
    • Fulton S., Woodside B., and Shizgal P. Modulation of brain reward circuitry by leptin. Science 287 (2000) 125-128
    • (2000) Science , vol.287 , pp. 125-128
    • Fulton, S.1    Woodside, B.2    Shizgal, P.3
  • 85
    • 0035866247 scopus 로고    scopus 로고
    • Leptin attenuates acute food deprivation-induced relapse to heroin seeking
    • Shalev U., Yap J., and Shaham Y. Leptin attenuates acute food deprivation-induced relapse to heroin seeking. J. Neurosci. 21 (2001) RC129
    • (2001) J. Neurosci. , vol.21
    • Shalev, U.1    Yap, J.2    Shaham, Y.3
  • 87
    • 0029656135 scopus 로고    scopus 로고
    • Food reward: brain substrates of wanting and liking
    • Berridge K.C. Food reward: brain substrates of wanting and liking. Neurosci. Biobehav. Rev. 20 (1996) 1-25
    • (1996) Neurosci. Biobehav. Rev. , vol.20 , pp. 1-25
    • Berridge, K.C.1
  • 88
    • 0344629716 scopus 로고    scopus 로고
    • Reward without dopamine
    • Cannon C.M., and Palmiter R.D. Reward without dopamine. J. Neurosci. 23 (2003) 10827-10831
    • (2003) J. Neurosci. , vol.23 , pp. 10827-10831
    • Cannon, C.M.1    Palmiter, R.D.2
  • 89
    • 0142250829 scopus 로고    scopus 로고
    • Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards
    • Pecina S., Cagniard B., Berridge K.C., Aldridge J.W., and Zhuang X. Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards. J. Neurosci. 23 (2003) 9395-9402
    • (2003) J. Neurosci. , vol.23 , pp. 9395-9402
    • Pecina, S.1    Cagniard, B.2    Berridge, K.C.3    Aldridge, J.W.4    Zhuang, X.5
  • 90
    • 0034331220 scopus 로고    scopus 로고
    • Intra-accumbens amphetamine increases the conditioned incentive salience of sucrose reward: enhancement of reward "wanting" without enhanced "liking" or response reinforcement
    • Wyvell C.L., and Berridge K.C. Intra-accumbens amphetamine increases the conditioned incentive salience of sucrose reward: enhancement of reward "wanting" without enhanced "liking" or response reinforcement. J. Neurosci. 20 (2000) 8122-8130
    • (2000) J. Neurosci. , vol.20 , pp. 8122-8130
    • Wyvell, C.L.1    Berridge, K.C.2
  • 91
    • 0037458468 scopus 로고    scopus 로고
    • Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat
    • Figlewicz D.P., Evans S.B., Murphy J., Hoen M., and Baskin D.G. Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat. Brain Res. 964 (2003) 107-115
    • (2003) Brain Res. , vol.964 , pp. 107-115
    • Figlewicz, D.P.1    Evans, S.B.2    Murphy, J.3    Hoen, M.4    Baskin, D.G.5
  • 96
    • 46749099010 scopus 로고    scopus 로고
    • Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli
    • Rosenbaum M., Sy M., Pavlovich K., Leibel R.L., and Hirsch J. Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J. Clin. Invest. 118 (2008) 2583-2591
    • (2008) J. Clin. Invest. , vol.118 , pp. 2583-2591
    • Rosenbaum, M.1    Sy, M.2    Pavlovich, K.3    Leibel, R.L.4    Hirsch, J.5
  • 100
    • 0029845169 scopus 로고    scopus 로고
    • Localization of leptin receptor mRNA expression in mouse brain
    • Huang X.F., Koutcherov I., Lin S., Wang H.Q., and Storlien L. Localization of leptin receptor mRNA expression in mouse brain. NeuroReport 7 (1996) 2635-2638
    • (1996) NeuroReport , vol.7 , pp. 2635-2638
    • Huang, X.F.1    Koutcherov, I.2    Lin, S.3    Wang, H.Q.4    Storlien, L.5
  • 102
  • 105
    • 36549076414 scopus 로고    scopus 로고
    • Leptin regulation of neuronal excitability and cognitive function
    • Harvey J. Leptin regulation of neuronal excitability and cognitive function. Curr. Opin. Pharmacol. 7 (2007) 643-647
    • (2007) Curr. Opin. Pharmacol. , vol.7 , pp. 643-647
    • Harvey, J.1
  • 106
    • 0037008873 scopus 로고    scopus 로고
    • Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents
    • Li X.L., Aou S., Oomura Y., Hori N., Fukunaga K., and Hori T. Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neuroscience 113 (2002) 607-615
    • (2002) Neuroscience , vol.113 , pp. 607-615
    • Li, X.L.1    Aou, S.2    Oomura, Y.3    Hori, N.4    Fukunaga, K.5    Hori, T.6
  • 108
    • 0035893251 scopus 로고    scopus 로고
    • Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity
    • Shanley L.J., Irving A.J., and Harvey J. Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. J. Neurosci. 21 (2001) RC186
    • (2001) J. Neurosci. , vol.21
    • Shanley, L.J.1    Irving, A.J.2    Harvey, J.3
  • 109
    • 26844500788 scopus 로고    scopus 로고
    • Leptin induces a novel form of NMDA receptor-dependent long-term depression
    • Durakoglugil M., Irving A.J., and Harvey J. Leptin induces a novel form of NMDA receptor-dependent long-term depression. J. Neurochem. 95 (2005) 396-405
    • (2005) J. Neurochem. , vol.95 , pp. 396-405
    • Durakoglugil, M.1    Irving, A.J.2    Harvey, J.3
  • 110
    • 33947191565 scopus 로고    scopus 로고
    • Long-lasting effects of elevated neonatal leptin on rat hippocampal function, synaptic proteins and NMDA receptor subunits
    • Walker C.D., Long H., Williams S., and Richard D. Long-lasting effects of elevated neonatal leptin on rat hippocampal function, synaptic proteins and NMDA receptor subunits. J. Neurosci. Res. 85 (2007) 816-828
    • (2007) J. Neurosci. Res. , vol.85 , pp. 816-828
    • Walker, C.D.1    Long, H.2    Williams, S.3    Richard, D.4
  • 111
    • 0036212158 scopus 로고    scopus 로고
    • Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels
    • Shanley L.J., Irving A.J., Rae M.G., Ashford M.L., and Harvey J. Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels. Nat. Neurosci. 5 (2002) 299-300
    • (2002) Nat. Neurosci. , vol.5 , pp. 299-300
    • Shanley, L.J.1    Irving, A.J.2    Rae, M.G.3    Ashford, M.L.4    Harvey, J.5
  • 112
    • 27744553687 scopus 로고    scopus 로고
    • Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels
    • O'Malley D., Irving A.J., and Harvey J. Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels. FASEB J. 19 (2005) 1917-1919
    • (2005) FASEB J. , vol.19 , pp. 1917-1919
    • O'Malley, D.1    Irving, A.J.2    Harvey, J.3
  • 113
    • 33644835340 scopus 로고    scopus 로고
    • Leptin enhances NR2B-mediated N-methyl-d-aspartate responses via a mitogen-activated protein kinase-dependent process in cerebellar granule cells
    • Irving A.J., Wallace L., Durakoglugil D., and Harvey J. Leptin enhances NR2B-mediated N-methyl-d-aspartate responses via a mitogen-activated protein kinase-dependent process in cerebellar granule cells. Neuroscience 138 (2006) 1137-1148
    • (2006) Neuroscience , vol.138 , pp. 1137-1148
    • Irving, A.J.1    Wallace, L.2    Durakoglugil, D.3    Harvey, J.4
  • 114
    • 17744375347 scopus 로고    scopus 로고
    • Regulation of neuronal and glial proteins by leptin: implications for brain development
    • Ahima R.S., Bjorbaek C., Osei S., and Flier J.S. Regulation of neuronal and glial proteins by leptin: implications for brain development. Endocrinology 140 (1999) 2755-2762
    • (1999) Endocrinology , vol.140 , pp. 2755-2762
    • Ahima, R.S.1    Bjorbaek, C.2    Osei, S.3    Flier, J.S.4
  • 117
    • 33646835379 scopus 로고    scopus 로고
    • Leptin deficiency causes pycnotic change in fetal cingulate cortical cells
    • Udagawa J., Nimura M., Kagohashi Y., and Otani H. Leptin deficiency causes pycnotic change in fetal cingulate cortical cells. Congenit. Anom. (Kyoto) 46 (2006) 16-20
    • (2006) Congenit. Anom. (Kyoto) , vol.46 , pp. 16-20
    • Udagawa, J.1    Nimura, M.2    Kagohashi, Y.3    Otani, H.4
  • 119
    • 33846191186 scopus 로고    scopus 로고
    • Relationships between plasma leptin concentrations and human brain structure: a voxel-based morphometric study
    • Pannacciulli N., Le D.S., Chen K., Reiman E.M., and Krakoff J. Relationships between plasma leptin concentrations and human brain structure: a voxel-based morphometric study. Neurosci. Lett. 412 (2007) 248-253
    • (2007) Neurosci. Lett. , vol.412 , pp. 248-253
    • Pannacciulli, N.1    Le, D.S.2    Chen, K.3    Reiman, E.M.4    Krakoff, J.5
  • 121
    • 1842536210 scopus 로고    scopus 로고
    • Trophic action of leptin on hypothalamic neurons that regulate feeding
    • Bouret S.G., Draper S.J., and Simerly R.B. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304 (2004) 108-110
    • (2004) Science , vol.304 , pp. 108-110
    • Bouret, S.G.1    Draper, S.J.2    Simerly, R.B.3
  • 122
    • 43749095411 scopus 로고    scopus 로고
    • Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro
    • Oldreive C.E., Harvey J., and Doherty G.H. Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro. Neurosci. Lett. 438 (2008) 17-21
    • (2008) Neurosci. Lett. , vol.438 , pp. 17-21
    • Oldreive, C.E.1    Harvey, J.2    Doherty, G.H.3
  • 126
    • 49549118708 scopus 로고    scopus 로고
    • Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials
    • Signore A.P., Zhang F., Weng Z., Gao Y., and Chen J. Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials. J. Neurochem. 106 (2008) 1977-1990
    • (2008) J. Neurochem. , vol.106 , pp. 1977-1990
    • Signore, A.P.1    Zhang, F.2    Weng, Z.3    Gao, Y.4    Chen, J.5
  • 127
    • 39549097113 scopus 로고    scopus 로고
    • Leptin as a neuroprotective agent
    • Tang B.L. Leptin as a neuroprotective agent. Biochem. Biophys. Res. Commun. 368 (2008) 181-185
    • (2008) Biochem. Biophys. Res. Commun. , vol.368 , pp. 181-185
    • Tang, B.L.1
  • 131
    • 0032482988 scopus 로고    scopus 로고
    • Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression
    • Shimabukuro M., Wang M.Y., Zhou Y.T., Newgard C.B., and Unger R.H. Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 9558-9561
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 9558-9561
    • Shimabukuro, M.1    Wang, M.Y.2    Zhou, Y.T.3    Newgard, C.B.4    Unger, R.H.5
  • 133
    • 38349143059 scopus 로고    scopus 로고
    • Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization
    • Guo Z., Jiang H., Xu X., Duan W., and Mattson M.P. Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. J. Biol. Chem. 283 (2008) 1754-1763
    • (2008) J. Biol. Chem. , vol.283 , pp. 1754-1763
    • Guo, Z.1    Jiang, H.2    Xu, X.3    Duan, W.4    Mattson, M.P.5
  • 135
    • 34548256784 scopus 로고    scopus 로고
    • Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia
    • Zhang F., Wang S., Signore A.P., and Chen J. Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia. Stroke 38 (2007) 2329-2336
    • (2007) Stroke , vol.38 , pp. 2329-2336
    • Zhang, F.1    Wang, S.2    Signore, A.P.3    Chen, J.4
  • 136
    • 53149135447 scopus 로고    scopus 로고
    • Leptin protects hippocampal CA1 neurons against ischemic injury
    • Zhang F., and Chen J. Leptin protects hippocampal CA1 neurons against ischemic injury. J. Neurochem. 107 (2008) 578-587
    • (2008) J. Neurochem. , vol.107 , pp. 578-587
    • Zhang, F.1    Chen, J.2
  • 137
    • 0035930457 scopus 로고    scopus 로고
    • Neuroprotective effects of leptin in vivo and in vitro
    • Dicou E., Attoub S., and Gressens P. Neuroprotective effects of leptin in vivo and in vitro. NeuroReport 12 (2001) 3947-3951
    • (2001) NeuroReport , vol.12 , pp. 3947-3951
    • Dicou, E.1    Attoub, S.2    Gressens, P.3
  • 138
    • 49649118850 scopus 로고    scopus 로고
    • Leptin increases adult hippocampal neurogenesis in vivo and in vitro
    • Garza J.C., Guo M., Zhang W., and Lu X.Y. Leptin increases adult hippocampal neurogenesis in vivo and in vitro. J. Biol. Chem. 283 (2008) 18238-18247
    • (2008) J. Biol. Chem. , vol.283 , pp. 18238-18247
    • Garza, J.C.1    Guo, M.2    Zhang, W.3    Lu, X.Y.4
  • 139
    • 36348980042 scopus 로고    scopus 로고
    • Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling
    • Weng Z., Signore A.P., Gao Y., Wang S., Zhang F., Hastings T., Yin X.M., and Chen J. Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling. J. Biol. Chem. 282 (2007) 34479-34491
    • (2007) J. Biol. Chem. , vol.282 , pp. 34479-34491
    • Weng, Z.1    Signore, A.P.2    Gao, Y.3    Wang, S.4    Zhang, F.5    Hastings, T.6    Yin, X.M.7    Chen, J.8
  • 141
  • 147
    • 27744486073 scopus 로고    scopus 로고
    • Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity
    • Winocur G., Greenwood C.E., Piroli G.G., Grillo C.A., Reznikov L.R., Reagan L.P., and McEwen B.S. Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity. Behav. Neurosci. 119 (2005) 1389-1395
    • (2005) Behav. Neurosci. , vol.119 , pp. 1389-1395
    • Winocur, G.1    Greenwood, C.E.2    Piroli, G.G.3    Grillo, C.A.4    Reznikov, L.R.5    Reagan, L.P.6    McEwen, B.S.7
  • 148
    • 33646789779 scopus 로고    scopus 로고
    • Effects of leptin on memory processing
    • Farr S.A., Banks W.A., and Morley J.E. Effects of leptin on memory processing. Peptides 27 (2006) 1420-1425
    • (2006) Peptides , vol.27 , pp. 1420-1425
    • Farr, S.A.1    Banks, W.A.2    Morley, J.E.3
  • 149
    • 17144428096 scopus 로고    scopus 로고
    • Central nervous effects of leptin and insulin on hippocampal leptin and insulin receptor expression following a learning task in Wistar rats
    • Paulus K., Schulz C., and Lehnert H. Central nervous effects of leptin and insulin on hippocampal leptin and insulin receptor expression following a learning task in Wistar rats. Neuropsychobiology 51 (2005) 100-106
    • (2005) Neuropsychobiology , vol.51 , pp. 100-106
    • Paulus, K.1    Schulz, C.2    Lehnert, H.3
  • 150
    • 0033931981 scopus 로고    scopus 로고
    • Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
    • El-Haschimi K., Pierroz D.D., Hileman S.M., Bjorbaek C., and Flier J.S. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J. Clin. Invest. 105 (2000) 1827-1832
    • (2000) J. Clin. Invest. , vol.105 , pp. 1827-1832
    • El-Haschimi, K.1    Pierroz, D.D.2    Hileman, S.M.3    Bjorbaek, C.4    Flier, J.S.5
  • 151
    • 0037663897 scopus 로고    scopus 로고
    • Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible
    • Banks W.A., and Farrell C.L. Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible. Am. J. Physiol. Endocrinol. Metab. 285 (2003) E10-E15
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.285
    • Banks, W.A.1    Farrell, C.L.2
  • 152
    • 43549114292 scopus 로고    scopus 로고
    • Mechanisms of leptin action and leptin resistance
    • Myers M.G., Cowley M.A., and Munzberg H. Mechanisms of leptin action and leptin resistance. Annu. Rev. Physiol. 70 (2008) 537-556
    • (2008) Annu. Rev. Physiol. , vol.70 , pp. 537-556
    • Myers, M.G.1    Cowley, M.A.2    Munzberg, H.3
  • 153
    • 38549095604 scopus 로고    scopus 로고
    • Leptin resistance during pregnancy in the rat
    • Ladyman S.R. Leptin resistance during pregnancy in the rat. J. Neuroendocrinol. 20 (2008) 269-277
    • (2008) J. Neuroendocrinol. , vol.20 , pp. 269-277
    • Ladyman, S.R.1
  • 154
    • 45349103885 scopus 로고    scopus 로고
    • Leptin resistance and the response to positive energy balance
    • Morrison C.D. Leptin resistance and the response to positive energy balance. Physiol. Behav. 94 (2008) 660-663
    • (2008) Physiol. Behav. , vol.94 , pp. 660-663
    • Morrison, C.D.1
  • 155
    • 34347235476 scopus 로고    scopus 로고
    • Elevated leptin: consequence or cause of obesity?
    • Scarpace P.J., and Zhang Y. Elevated leptin: consequence or cause of obesity?. Front. Biosci. 12 (2007) 3531-3544
    • (2007) Front. Biosci. , vol.12 , pp. 3531-3544
    • Scarpace, P.J.1    Zhang, Y.2
  • 156
    • 0035800015 scopus 로고    scopus 로고
    • Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats
    • Scarpace P.J., Matheny M., and Tumer N. Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats. Neuroscience 104 (2001) 1111-1117
    • (2001) Neuroscience , vol.104 , pp. 1111-1117
    • Scarpace, P.J.1    Matheny, M.2    Tumer, N.3
  • 157
    • 0042922605 scopus 로고    scopus 로고
    • Leptin signaling in the hypothalamus during chronic central leptin infusion
    • Pal R., and Sahu A. Leptin signaling in the hypothalamus during chronic central leptin infusion. Endocrinology 144 (2003) 3789-3798
    • (2003) Endocrinology , vol.144 , pp. 3789-3798
    • Pal, R.1    Sahu, A.2
  • 160
    • 60849120123 scopus 로고    scopus 로고
    • HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and independent mechanisms
    • PMID:19017730, in press
    • C.L. White, A. Whittington, M.J. Barnes, Z.Q.Wang, G. Bray, C.D. Morrison, HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and independent mechanisms, Am. J. Physiol. Endocrinol. Metab. (in press) [PMID:19017730].
    • Am. J. Physiol. Endocrinol. Metab
    • White, C.L.1    Whittington, A.2    Barnes, M.J.3    Wang, Z.Q.4    Bray, G.5    Morrison, C.D.6
  • 162
    • 9244219587 scopus 로고    scopus 로고
    • Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    • Munzberg H., Flier J.S., and Bjorbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145 (2004) 4880-4889
    • (2004) Endocrinology , vol.145 , pp. 4880-4889
    • Munzberg, H.1    Flier, J.S.2    Bjorbaek, C.3
  • 163
    • 3843112232 scopus 로고    scopus 로고
    • Region-specific reduction in leptin-induced phosphorylation of signal transducer and activator of transcription-3 (STAT3) in the rat hypothalamus is associated with leptin resistance during pregnancy
    • Ladyman S.R., and Grattan D.R. Region-specific reduction in leptin-induced phosphorylation of signal transducer and activator of transcription-3 (STAT3) in the rat hypothalamus is associated with leptin resistance during pregnancy. Endocrinology 145 (2004) 3704-3711
    • (2004) Endocrinology , vol.145 , pp. 3704-3711
    • Ladyman, S.R.1    Grattan, D.R.2
  • 164
    • 21344432100 scopus 로고    scopus 로고
    • Role of selective leptin resistance in diet-induced obesity hypertension
    • Rahmouni K., Morgan D.A., Morgan G.M., Mark A.L., and Haynes W.G. Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes 54 (2005) 2012-2018
    • (2005) Diabetes , vol.54 , pp. 2012-2018
    • Rahmouni, K.1    Morgan, D.A.2    Morgan, G.M.3    Mark, A.L.4    Haynes, W.G.5
  • 165
    • 0037388560 scopus 로고    scopus 로고
    • Differential mechanisms and development of leptin resistance in A/J versus C57BL/6J mice during diet-induced obesity
    • Prpic V., Watson P.M., Frampton I.C., Sabol M.A., Jezek G.E., and Gettys T.W. Differential mechanisms and development of leptin resistance in A/J versus C57BL/6J mice during diet-induced obesity. Endocrinology 144 (2003) 1155-1163
    • (2003) Endocrinology , vol.144 , pp. 1155-1163
    • Prpic, V.1    Watson, P.M.2    Frampton, I.C.3    Sabol, M.A.4    Jezek, G.E.5    Gettys, T.W.6
  • 166
    • 33745630063 scopus 로고    scopus 로고
    • Leptin is a link between adipose tissue and inflammation
    • Harle P., and Straub R.H. Leptin is a link between adipose tissue and inflammation. Ann. N.Y. Acad. Sci. 1069 (2006) 454-462
    • (2006) Ann. N.Y. Acad. Sci. , vol.1069 , pp. 454-462
    • Harle, P.1    Straub, R.H.2
  • 168
    • 33750453786 scopus 로고    scopus 로고
    • Convergence between bone and energy homeostases: leptin regulation of bone mass
    • Karsenty G. Convergence between bone and energy homeostases: leptin regulation of bone mass. Cell Metab. 4 (2006) 341-348
    • (2006) Cell Metab. , vol.4 , pp. 341-348
    • Karsenty, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.