Leptin protects hippocampal CA1 neurons against ischemic injury

Journal of Neurochemistry

Volumn 107, Issue 2, 2008, Pages 578-587

  Zhang, Feng ^a,b   Chen, Jun ^a,b,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c FUDAN UNIVERSITY   (China)

Author keywords

Akt; Extracellular signal related kinase 1 2; Global ischemia; Leptin antagonist; Neuroprotection

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; LEPTIN RECEPTOR; LEPTIN RECEPTOR ANTAGONIST; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RECEPTOR BLOCKING AGENT; RECOMBINANT LEPTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; HIPPOCAMPUS; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BRAIN ISCHEMIA; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHROMONES; CREB-BINDING PROTEIN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; HIPPOCAMPUS; IN SITU NICK-END LABELING; LEPTIN; MALE; MORPHOLINES; NEURONS; NEUROPROTECTIVE AGENTS; ONCOGENE PROTEIN V-AKT; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

RATTUS;

EID: 53149135447     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05645.x     Document Type: Article

References (40)

1. Ahima R. S. (2005) Central actions of adipocyte hormones. Trends Endocrinol. Metab. 16, 307 313.
2. Allan L. A., Morrice N., Brady S., Magee G., Pathak S. Clarke P. R. (2003) Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat. Cell Biol. 5, 647 654.
3. Almog B., Gold R., Tajima K. et al. (2001) Leptin attenuates follicular apoptosis and accelerates the onset of puberty in immature rats. Mol. Cell. Endocrinol. 183, 179 191.
4. Banks A. S., Davis S. M., Bates S. H. Myers Jr. M. G. (2000) Activation of downstream signals by the long form of the leptin receptor. J. Biol. Chem. 275, 14563 14572.
5. Bates S. H. Myers Jr. M. G. (2003) The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol. Metab. 14, 447 452.
6. Bates S. H., Stearns W. H., Dundon T. A. et al. (2003) STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421, 856 859.
7. Bluher S. Mantzoros C. S. (2007) Leptin in reproduction. Curr. Opin. Endocrinol. Diabetes Obes. 14, 458 464.
8. Bonni A., Brunet A., West A. E., Datta S. R., Takasu M. A. Greenberg M. E. (1999) Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286, 1358 1362.
9. Chen J., Nagayama T., Jin K., Stetler R. A., Zhu R. L., Graham S. H. Simon R. P. (1998) Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J. Neurosci. 18, 4914 4928.
10. Choi J. S., Kim S. Y., Cha J. H. et al. (2003) Upregulation of gp130 and STAT3 activation in the rat hippocampus following transient forebrain ischemia. Glia 41, 237 246.
11. Diano S. Horvath T. L. (2008) Anticonvulsant effects of leptin in epilepsy. J. Clin. Invest. 118, 26 28.
12. Ferrer I., Ballabriga J., Marti E., Perez E., Alberch J. Arenas E. (1998) BDNF up-regulates TrkB protein and prevents the death of CA1 neurons following transient forebrain ischemia. Brain Pathol. 8, 253 261.
13. Fortuno A., Rodriguez A., Gomez-Ambrosi J., Muniz P., Salvador J., Diez J. Fruhbeck G. (2002) Leptin inhibits angiotensin II-induced intracellular calcium increase and vasoconstriction in the rat aorta. Endocrinology 143, 3555 3560.
14. Franke T. F., Hornik C. P., Segev L., Shostak G. A. Sugimoto C. (2003) PI3K/Akt and apoptosis: size matters. Oncogene 22, 8983 8998.
15. Friedman J. M. Halaas J. L. (1998) Leptin and the regulation of body weight in mammals. Nature 395, 763 770.
16. Fujimura M., Morita-Fujimura Y., Kawase M., Copin J. C., Calagui B., Epstein C. J. Chan P. H. (1999) Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. J. Neurosci. 19, 3414 3422.
17. Gertler A. (2006) Development of leptin antagonists and their potential use in experimental biology and medicine. Trends Endocrinol. Metab. 17, 372 378.
18. Guo Z., Jiang H., Xu X., Duan W. Mattson M. P. (2008) Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. J. Biol. Chem. 283, 1754 1763.
19. Harada H., Quearry B., Ruiz-Vela A. Korsmeyer S. J. (2004) Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proc. Natl Acad. Sci. USA 101, 15313 15317.
20. Hegyi K., Fulop K., Kovacs K., Toth S. Falus A. (2004) Leptin-induced signal transduction pathways. Cell Biol. Int. 28, 159 169.
21. Imada K. Leonard W. J. (2000) The Jak-STAT pathway. Mol. Immunol. 37, 1 11.
22. Jin K., Mao X. O., Zhu Y. Greenberg D. A. (2002) MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad. J. Neurochem. 80, 119 125.
23. Kiprianova I., Freiman T. M., Desiderato S., Schwab S., Galmbacher R., Gillardon F. Spranger M. (1999) Brain-derived neurotrophic factor prevents neuronal death and glial activation after global ischemia in the rat. J. Neurosci. Res. 56, 21 27.
24. Kloek C., Haq A. K., Dunn S. L., Lavery H. J., Banks A. S. Myers Jr. M. G. (2002) Regulation of Jak kinases by intracellular leptin receptor sequences. J. Biol. Chem. 277, 41547 41555.
25. Lembo G., Vecchione C., Fratta L., Marino G., Trimarco V., d'Amati G. Trimarco B. (2000) Leptin induces direct vasodilation through distinct endothelial mechanisms. Diabetes 49, 293 297.
26. Mercer J. G., Hoggard N., Williams L. M., Lawrence C. B., Hannah L. T. Trayhurn P. (1996) Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 387, 113 116.
27. Nagayama T., Lan J., Henshall D. C., Chen D., O'Horo C., Simon R. P. Chen J. (2000) Induction of oxidative DNA damage in the peri-infarct region after permanent focal cerebral ischemia. J. Neurochem. 75, 1716 1728.
28. Pulsinelli W. A., Brierley J. B. Plum F. (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11, 491 498.
29. Russo V. C., Metaxas S., Kobayashi K., Harris M. Werther G. A. (2004) Antiapoptotic effects of leptin in human neuroblastoma cells. Endocrinology 145, 4103 4112.
30. Shibata M., Hattori H., Sasaki T., Gotoh J., Hamada J. Fukuuchi Y. (2003) Activation of caspase-12 by endoplasmic reticulum stress induced by transient middle cerebral artery occlusion in mice. Neuroscience 118, 491 499.
31. Siren A. L., Fratelli M., Brines M. et al. (2001) Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc. Natl Acad. Sci. USA 98, 4044 4049.
32. Weng Z., Signore A. P., Gao Y., Wang S., Zhang F., Hastings T., Yin X. M. Chen J. (2007) Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling. J. Biol. Chem. 282, 34479 34491.
33. Weston C. R., Balmanno K., Chalmers C., Hadfield K., Molton S. A., Ley R., Wagner E. F. Cook S. J. (2003) Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways. Oncogene 22, 1281 1293.
34. Xing J., Ginty D. D. Greenberg M. E. (1996) Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 273, 959 963.
35. Yano S., Morioka M., Fukunaga K., Kawano T., Hara T., Kai Y., Hamada J., Miyamoto E. Ushio Y. (2001) Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus. J. Cereb. Blood Flow Metab. 21, 351 360.
36. Zhang F., Yin W. Chen J. (2004) Apoptosis in cerebral ischemia: executional and regulatory signaling mechanisms. Neurol. Res. 26, 835 845.
37. Zhang F., Signore A. P., Zhou Z., Wang S., Cao G. Chen J. (2006) Erythropoietin protects CA1 neurons against global cerebral ischemia in rat: potential signaling mechanisms. J. Neurosci. Res. 83, 1241 1251.
38. Zhang F., Wang S., Cao G., Gao Y. Chen J. (2007a) Signal transducers and activators of transcription 5 contributes to erythropoietin-mediated neuroprotection against hippocampal neuronal death after transient global cerebral ischemia. Neurobiol. Dis. 25, 45 53.
39. Zhang F., Wang S., Signore A. P. Chen J. (2007b) Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia. Stroke 38, 2329 2336.
40. Zhang J., Matheny M. K., Tumer N., Mitchell M. K. Scarpace P. J. (2007c) Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292, R868 R874.