Immunohistochemical localization of leptin receptor in the rat brain

Neuroscience Letters

Volumn 243, Issue 1-3, 1998, Pages 41-44

  Shioda, Seiji ^a   Funahashi, Hisayuki ^a   Nakajo, Shigeo ^b   Yada, Toshihiko ^c,d   Maruta, Osamu ^a   Nakai, Yasumitsu ^a  

^a SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHOWA UNIVERSITY   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

^d Lab of Intracellular Metabolism   (Japan)

Author keywords

Brain; Immunohistochemistry; Leptin receptor; Obesity; Rat; Western blotting

Indexed keywords

LEPTIN RECEPTOR;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; BRAIN; CEREBELLUM CORTEX; DORSAL RAPHE NUCLEUS; HYPOTHALAMUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INFERIOR OLIVE; MALE; NEOCORTEX; NONHUMAN; OBESITY; OLFACTORY BULB; PRIORITY JOURNAL; RAT; SOLITARY TRACT NUCLEUS; TISSUE DISTRIBUTION; VAGUS NERVE NUCLEUS;

ANIMALS; ARCUATE NUCLEUS; BLOTTING, WESTERN; BRAIN CHEMISTRY; CARRIER PROTEINS; HYPOTHALAMIC AREA, LATERAL; IMMUNOHISTOCHEMISTRY; MALE; NEOCORTEX; OBESITY; PURKINJE CELLS; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; VAGUS NERVE;

EID: 0031887488     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00082-2     Document Type: Article

References (18)

1. Banks W.A., Kastin A.J., Huang W., Jaspan J.B., Maness L.M. Leptin enters the brain by a saturable system independent of insulin. Peptides. 17:1996;305-311.
2. Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:1995;546-549.
3. Couce M.E., Burguera B., Parisi J.E., Jensen M.D., Lloyd R.V. Localization of leptin receptor in the human brain. Neuroendocrinology. 66:1997;145-150.
4. Elmquist J.K., Ahima R.S., Maratos-Flier E., Flier J.S., Saper C.B. Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology. 138:1996;839-842.
5. Erickson J.C., Hollopeter G., Palmiter R.D. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science. 274:1996;1704-1707.
6. Ghilardi N., Skoda R.C. The leptin receptor activates Janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol. Endocrinol. 11:1997;393-399.
7. Huang X.F., Koutcherov I., Lin S., Wang H.Q., Storlien L. Localization of leptin receptor mRNA expression in mouse brain. NeuroReport. 7:1996;2635-2638.
8. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 387:1996;113-116.
9. Satoh N., Ogawa Y., Katuura G., Hayase M., Tsuji T., Imagawa K., Yoshimasa Y., Nishi S., Hosoda K., Nakao K. The arcuate nucleus as a primary site of satiety effect of leptin in rats. Neurosci. Lett. 224:1997;149-152.
10. Schwartz M.W., Baskin D.G., Bukowski T.R., Kuijper J.L., Foster D., Lasser G., Prunkard D.E., Porte D. Jr., Woods S.C., Seeley R.J., Weigle D.S. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes. 45:1996;531-535.
11. Schwartz M.W., Seeley R.J., Campfield L.A., Burn P., Baskin D.G. Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98:1996;1101-1106.
12. Spanswick D., Smith M.A., Groppi V.E., Logan S.D., Ashford M.L.J. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature. 390:1997;521-525.
13. Stephens T.W., Basinski M., Bristow P.K., Bue-Valleskey J.M., Burgett S.G., Craft L., Hale J., Hoffman J., Hsing H.M., Kriauciunas A., MacKellar W., Rosteck P.R. Jr., Schoner B., Smith D., Tinsley F.C., Zhang X.-Y., Heiman M. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 377:1995;530-532.
14. Swanson, L.W., The hypothalamus. In Handbook of Chemical Neuroanatomy, Vol. 5, Elsevier, Amsterdam, 1987, pp. 1-124.
15. Tartaglia L.A., Devos R., Richards G.J., Campfield L.A., Clark F.T., Deeds J., Muir C., Sanker S., Moriarty A., Moore K.J., Smutko J.S., Mays G.G., Woof E.A., Monroe C.A., Tepper R.I. Identification and expression cloning of a leptin receptor. OB-R, Cell. 83:1995;1263-1271.
16. Woods A.J., Stock M.J. Leptin activation in hypothalamus. Nature. 381:1996;745.
17. Zarjevski N., Cusin I., Vetter R., Rohner-Jeanrenaud F., Jeanrenaud B. Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology. 133:1993;1753-1758.
18. Zhang Y., Proenca R., Maflei M., Barone M., Leopld L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-432.