Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin

Journal of Clinical Investigation

Volumn 105, Issue 6, 2000, Pages 749-755

  Yura, Shigeo ^a   Ogawa, Yoshihiro ^a   Sagawa, Norimasa ^a   Masuzaki, Hiroaki ^a   Itoh, Hiroaki ^a   Ebihara, Ken ^a   Aizawa Abe, Megumi ^a   Fujii, Shingo ^a   Nakao, Kazuwa ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; GONADOTROPIN; LEPTIN; LUTEINIZING HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; CONTROLLED STUDY; FEMALE; FEMALE INFERTILITY; HYPERLEPTINEMIA; HYPOGONADOTROPIC HYPOGONADISM; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUBERTY; REPRODUCTION;

EID: 0034026809     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI8353     Document Type: Article

References (50)

1. Cameron, J.L. 1996. Nutritional determinants of puberty. Nutr. Rev. 54:s17-s22.
2. Bronson, F.H., and Manning, J.M. 1991. The energetic regulation of ovulation: a realistic role for body fat. Biol. Reprod. 44:945-950.
3. Frisch, R.E. 1984. Body fat, puberty and fertility. Biol. Rev. 59:161-188.
4. Azziz, R. 1989. Reproductive endocrinologic alterations in female asymptomatic obesity. Fertil. Steril. 52:703-725.
5. Bouvattier, C., Lahlou, N., Roger, M., and Bougneres, P. 1998. Hyperleptinaemia is associated with impaired gonadotrophin response to GnRH during late puberty in obese girls, not buys. Eur. J. Endocrinol. 138:653-658.
6. Spiegelman, B.M., and Flier, J.S. 1996. Adipogenesis and obesity: founding out the big picture. Cell. 87:377-389.
7. Ailhaud, G., Grimaldi, P., and Negrel, R. 1992. Cellular and molecular aspects of adipose tissue development. Annu. Rev. Nutr. 12:207-233.
8. Zhang, Y., et al. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:425-432.
9. Ogawa, Y., et al. 1995. Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. J. Clin. Invest. 96:1647-1652.
10. Pelleymounter, M.A., et al. 1995. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:540-543.
11. Halaas, J.L., et al. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 269:543-546.
12. Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R., and Burn, P. 1995. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:546-549.
13. Swerdloff, R.S., et al. 1978. The hypothalamic-pituitary axis in genetically obese (ob/ob) mice: response to luteinizing hormone-releasing hormone. Endocrinology. 103:542-547.
14. Chehab, F.F., Lim, M.E., and Lu, R. 1996. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat. Genet. 12:318-320.
15. Mounzih, K., Lu, R., and Chehab, F.F. 1997. Leprin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology. 138:1190-1193.
16. Chehab, F.F., Mounzih, K., Lu, R., and Lim, M.E. 1997. Early onset of reproductive function in normal female mice treated with leptin. Science. 275:88-90.
17. Ahima, R.S., Dushay, J., Flier, S.N., Prabakaran, D., and Flier, J.S. 1997. Leptin accelerates the onset of puberty in normal female mice. J. Clin. Invest. 99:391-395.
18. Ahima, R.S., et al. 1996. Role of leptin in the neuroendocrine response to fasting. Nature. 382:250-252.
19. Nagatani, S., et al. 1998. Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting. Neuroendocrinology. 67:370-376.
20. Cheung, C.C., et al. 1997. Leptin is a metabolic gate for the onset of puberty in the female rat. Endocrinology. 138:855-858.
21. Ahima, R.S., Prabakaran, D., and Flier, J.S. 1998. Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function. J. Clin. Invest. 101:1020-1027.
22. Mantzoros, C.S., Flier, J.S., and Rogol, A.D. 1997. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J. Clin. Endocrinol. Metab. 82:1066-1070.
23. Frederich, R.C., et al. 1995. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Med. 1:1311-1314.
24. Maffei, M., et al. 1995. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med. 1:1155-1161.
25. Considine, R.V., et al. 1996. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334:292-295.
26. Saad, M.F., et al. 1998. Diurnal and ultradian rhythmicity of plasma leptin: effects of gender and adiposity. J. Clin. Endocrinol. Metab. 83:453-459.
27. Ogawa, Y., et al. 1999. Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin. Diabetes. 48:1822-1829.
28. Masuzaki, H., et al. 1999. Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation. Diabetes. 48:1615-1622.
29. Suda, M., et al. 1998. Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide. Proc. Natl. Acad. Sci. USA. 95:2337-2342.
30. Glass, J.D., and Dolan, P.L. 1988. Melatonin acts in the brain to mediate seasonal steroid inhibition of luteinizing hormone secretion in the white-footed mouse (Peromyscus leucopus). Proc. Soc. Exp. Biol. Med. 188:375-380.
31. Chandrashekar, V., Bartke, A., and Wagner, T.E. 1992. Neuroendocrine function in adult female transgenic mice expressing the human growth hormone gene. Endocrinology. 130:1802-1808.
32. Plant, T.M., and Durrant, A.R. 1997. Circulating leptin does not appear to provide a signal for triggering the initiation of puberty in the male rhesus monkey (Macaca mulatta). Endocrinology. 138:4505-4508.
33. Henry, B.A., et al. 1999. Central administration of leptin to ovariectomized ewes inhibits food intake without affecting the secretion of hormones from the pituitary gland: evidence for a dissociation of effects on appetite and neuroendocrine function. Endocrinology. 140:1175-1182.
34. Yu, W.H., Kimura, M., Walczewska, A., Karanth, S., and McCann, S.M. 1997. Role of leptin in hypothalamic-pituitary function. Proc. Natl. Acad. Sci. USA. 94:1023-1028.
35. Gruaz, N.M., et al. 1998. Chronic administration of leptin into the lateral ventricle induces sexual maturation in severely food-restricted female rats. J. Neuroendocrinol. 10:627-633.
36. Zachow, R.J., and Magoffin, D.A. 1997. Direct intraovarian effects of leptin: impaitment of the synergisitc action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells. Endocrinology. 138:847-850.
37. Seeley, R.J., et al. 1997. Melanocortin receptors in leptin effects. Nature. 390:349.
38. Satoh, N., et al. 1998. Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system. Neurosci. Lett. 249:107-110.
39. Schwartz, M.W., et al. 1997. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes. 46:2119-2123.
40. Thornton, J.F., Cheung, C.C., Clifton, D.K., and Steiner, R.A. 1997. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology. 138:5063-5066.
41. Bultman, S.J., Michaud, E.J., and Woychik, R.P. 1992. Molecular characterization of the mouse agouti locus. Cell. 71:1195-1204.
42. Miller, M.W., et al. 1993. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev. 7:454-467.
43. Lu, D., et al. 1994. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor Nature. 371:799-802.
44. 1) on mating preference in C57BL/6J mice. Proc. SD Acad. Sci. 59:156-159.
45. Ioffe, E., Moon, B., Connolly, E., and Friedmann, J.M. 1998. Abnormal regulation of the leptin gene in the pathogenesis of obesity. Proc. Natl. Acad. Sci. USA. 95:11852-11857.
46. Ewart, T.A., Mounzih, K., Qiu, J., and Chehab, F.F. 1999. Effect of the genetic background on the reproduction of leptin-deficient obese mice. Endocrinology. 140:734-738.
47. 1a) and non-agouti (aa) mice in relation to the problem of hereditary obesity. Science. 115:647-649.
48. Granholm, N.H., Jeppesen, K.W., and Japs, R.A. 1986. Progressive infertility in female lethal yellow mice (Ay/a; strain C57BL/6J). J. Reprod. Fertil. 76:279-287.
49. Caro, J.E., et al. 1996. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet. 348:159-161.
50. Schwartz, M.W., Peskind, E., Raskind, M., Boyko, E.J., and Porte, D.J. 1996. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat. Med. 2:589-593.