Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats

Diabetes

Volumn 46, Issue 12, 1997, Pages 2040-2043

  Dunbar, Joseph C ^a   Hu, Yuange ^a   Lu, Huiqing ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; NEUROPEPTIDE Y;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY BLOOD FLOW; ARTICLE; BLOOD FLOW VELOCITY; BLOOD PRESSURE REGULATION; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; HEART RATE; HYPERINSULINISM; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; LUMBAR ARTERY; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; RENAL ARTERY; SYMPATHETIC NERVE; SYMPATHETIC TONE; VASCULAR RESISTANCE;

EID: 0030830662     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.12.2040     Document Type: Article

References (39)

1. Defronzo RA, Ferrannini E: Insulin resistance: a multifactoral syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and artherosclerotic cardiovascular disease. Diabetes Care 14:173-194, 1991
2. Haffner SM, Karhapaa P, Mykkanen L, Laakso M: Insulin resistance, body fat distribution, and sex hormones in men. Diabetes 43:212-219, 1994
3. Knowler WC, Pettitt DJ, Saad MF, Bonnett PH: Diabetes mellitus in Pima Indians: incidence, risk factors, and pathogenesis. Diabetes Metab Rev 6:1-27, 1990
4. Dustan HP: Obesity and hypertension. Diabetes Care 14:488-504, 1991
5. Modan M, Halkin H: Hyperinsulinemia or increased sympathetic drive as links for obesity and hypertension. Diabetes Care 14:470-487, 1991
6. Gordon T, Kannel WB: Obesity and cardiovascular disease: the Framingham study. J Clin Endacrinol Metab 5:367-375, 1976
7. Scherrer U, Owlya R, Lepori M: Body fat and sympathetic nerve activity. Cardiovasc Drugs Ther 10:215-222, 1996
8. Scherrer U, Randin D, Tappy L, Vollenweider P, Jequier E, Nicod P: Body fat and sympathetic nerve activity in healthy subjects. Circulation 89:2634-2640, 1994
9. Landsberg L: Pathophysiology of obesity related hypertension: role of insulin and the sympathetic nervous system. J Cardiovasc Pharmacol 23:1-8, 1994
10. Spraul M, Anderson EA, Boyardus C, Rauussin E: Muscle sympathetic nerve activity in response to glucose ingestion: impact of plasma insulin and body fat. Diabetes 43:191-196, 1994
11. Holt SJ, York DA: Studies on the sympathetic efferent nerves of brown adipose tissue of lean and obese Zucker rats. Brain Res 481:106-112, 1989
12. Muzzin P, Eisensmith RC, Copeland KC, Woo SL: Correction of obesity and diabetes in genetically obese mice by leptin gene therapy. Proc Soc Acad Sci U S A 93:14804-14808, 1996
13. Cusin I, Rohner-Jeanrenaod F, Stricker-Krongard A, Jeanrenaud B: The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats: reduced sensitivity compared with lean animals. Diabetes 45:1446-1450, 1996
14. Segal KR, Landt M, Klein S: Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes 45:988-991, 1996
15. Utriainen T, Malmstrom R, Makimattila S, Yki-Jaroinen H: Supraphysiological hyperinsulinemia increases plasma leptin concentration after 4 h in normal subjects. Diabetes 45:1364-1366, 1996
16. Ryan AS, Elahi D: The effects of acute hyperglycemia and hyperinsulinemia on plasma leptin levels: its relationship with body fat, visceral adiposity, and age in women. J Clin Endocrinol Metab 81:4433-4438, 1996
17. White BD, Martin RJ: Evidence for a central mechanism of obesity in the Zucker rat: role of neuropeptide-Y and leptin. Proc Soc Exp Biol Med 214:222-232, 1997
18. Glaum SR, Hara M, Bindokas VP, Lee CC, Polonsky KS, Bell GI, Miller RJ: Leptin, the obese gene product rapidly modulates synaptic transmission in the hypothalamus. Mol Pharmacol 50:230-235, 1996
19. Cheung CC, Thornton JE, Kuijper JC, Weigle DS, Clifton DK, Steiner RA: Leptin is a metabolic gate to the onset of puberty in the female rat. Endocrinology 138:855-858, 1997
20. Chehab FF, Mounzih K, Lu R, Lim ME: Early onset of reproductive function in normal female mice treated with leptin. Science 275:88-90, 1997
21. Golden PL, MacCagnan TJ, Pardridge WM: Human blood-brain barrier leptin receptor binding and endocytosis in isolated human brain microvessels. J Clin Invest 99:14-18, 1997
22. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM: Leptin enters the brain by a saturable system independent of insulin. Peptide 17:305-311, 1996
23. Dunbar JC, Ergene E, Anderson GF, Barraco RA; Decreased cardiorespiratory effect of neuropeptide Y in the nucleus tractus solitarius in diabetes. Am J Physiol 262:R865-R871, 1992
24. Ergene E, Dunbar JC, Barraco RA: Visceroendocrine response elicited by neuropeptide-Y in the nucleus tractus solitarius. Brain Res Bull 32:461-465, 1993
25. Wright-Richey J, Schultz-Klarr S, Dunbar JC: The effect of a ventral medial hypothalamic lesion on the insulin-induced hypotensive response in normal rats. Acta Diabetol 31:91-97, 1994
26. Schultz-Klarr S, Wright-Richey J, Dunbar JC: Plasma glucose, insulin and cardiovascular responses after intravenous and intracerebroventricular injection of insulin. Diabetes Res Clin Pract 26:81-89, 1994
27. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Pronkard DE, Porte D Jr, Woods SC, Seeley RJ, Weigle DS: Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide-Y gene expression in ob/ob mice. Diabetes 45:531-535, 1996
28. Wabitsch M, Jensen PB, Blum WF, Christoffensen CT, Englaro P, Heinze E, Rascher W, Teller W, Tornqvist H, Hauner H: Insulin and cortisol promote leptin production in cultured human fat cells. Diabetes 45:1435-1438, 1996
29. Anderson EA, Hoffman RP, Bolon TW, Sinkey CA, Mark AL: Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest 87:2246-2252, 1991
30. Barash IA, Cheung CC, Weigle DS, Ren H, Kabigting EB, Kuijper JL, Clifton DK, Steiner RA: Leptin is a metabolic signal to the reproductive system. Endocrinology 137:3144-3147, 1996
31. Collins S, Kuhn CM, Petro AE, Swick AG, Chruny BA, Sorwit RS: Role of leptin in rat regulation. Nature 380:677, 1996
32. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Morgan PJ, Trayhurn P: Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J Neuroendocrinol 8:733-735, 1996
33. Morgan DA, Bolon TW, Ginsberg BH, Mark AL: Nonuniform regional sympathetic responses to hyperinsulinemia in rats. Am J Physiol 264:R423-R427, 1993
34. Stoos BA, Metting PJ, Britton SL: Autoregulatory capacity in renal and mesenteric vasculatures of minealocorticoid hypertensive dogs. Am J Physiol 261:H1205-H1213, 1991
35. Kosaki A, Yamada K, Kozuya H: Reduced expression of the leptin gene (ob) by catecholamine through a G (s) protein-coupled pathway in 3T3-L1 adipocytes. Diabetes 45:1744-1749, 1996
36. Gettys TW, Harkness PJ, Watson PM: The beta 3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes. Endocrinology 137:4054-4057, 1996
37. Collins S, Surwit RS: Pharmacologic manipulation of ob expression in a dietary model of obesity. J Biol Chem 271:9437-9440, 1996
38. Brzechffa PR, Jakimiuk AJ, Agarwal SK, Weitsman SR, Buyalos RP, Magoffin DA: Serum immunoreactive leptin concentration in women with polycystic ovary syndrome. J Clin Endocrinol Metab 81:4166-4169, 1996
39. Ronnemaa T, Karonen SL, Rissanen A, Koskenvuo M, Koivisto VA: Relation between plasma leptin levels and measures of body fat in identical twins discordant for obesity. Ann Intern Med 126:26-31, 1997