Region-specific reduction in leptin-induced phosphorylation of signal transducer and activator of transcription-3 (STAT3) in the rat hypothalamus is associated with leptin resistance during pregnancy

Endocrinology

Volumn 145, Issue 8, 2004, Pages 3704-3711

  Ladyman, S R ^a   Grattan, D R ^a,b  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ARCUATE NUCLEUS; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DIET RESTRICTION; ENZYME PHOSPHORYLATION; FEMALE; FOOD INTAKE; HORMONE RESISTANCE; HYPERPHAGIA; HYPOTHALAMUS; HYPOTHALAMUS NUCLEUS; LATERAL HYPOTHALAMUS; MICRODISSECTION; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SATIETY; WESTERN BLOTTING; ZONA INCERTA;

ANIMALS; ARCUATE NUCLEUS; DNA-BINDING PROTEINS; EATING; FEMALE; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; LEPTIN; PHOSPHORYLATION; PREGNANCY; PREGNANCY, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 3843112232     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-0338     Document Type: Article

References (51)

1. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543
2. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546
3. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P 1995 Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549
4. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL 1996 Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292-295
5. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM 1995 Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1:1155-1161
6. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM 1996 Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632-635
7. Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, Skoda RC 1996 Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA 93:6231-6235
8. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP 1996 Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-495
9. Bjorbaek C, Uotani S, da Silva B, Flier JS 1997 Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 272:32686-32695
10. Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, Lai CF, Tartaglia LA 1996 The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 93:8374-8378
11. Tartaglia LA 1997 The leptin receptor. J Biol Chem 272:6093-6096
12. Hubschle T, Thom E, Watson A, Roth J, Klaus S, Meyerhof W 2001 Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation. J Neurosci 21:2413-2424
13. Shirley B 1984 The food intake of rats during pregnancy and lactation. Lab Anim Sci 34:169-172
14. Naismith DJ, Richardson DP, Pritchard AE 1982 The utilization of protein and energy during lactation in the rat, with particular regard to the use of fat accumulated in pregnancy. Br J Nutr 48:433-441
15. Cripps AW, Williams VJ 1975 The effect of pregnancy and lactation on food intake, gastrointestinal anatomy and the absorptive capacity of the small intestine in the albino rat. Br J Nutr 33:17-32
16. Gavrilova O, Barr V, Marcus-Samuels B, Reitman M 1997 Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor. J Biol Chem 272:30546-30551
17. Garcia MD, Casanueva FF, Dieguez C, Senaris RM 2000 Gestational profile of leptin messenger ribonucleic acid (mRNA) content in the placenta and adipose tissue in the rat, and regulation of the mRNA levels of the leptin receptor subtypes in the hypothalamus during pregnancy and lactation. Biol Reprod 62:698-703
18. Amico JA, Thomas A, Crowley RS, Burmeister LA 1998 Concentrations of leptin in the serum of pregnant, lactating, and cycling rats and of leptin messenger ribonucleic acid in rat placental tissue. Life Sci 63:1387-1395
19. Kawai M, Yamaguchi M, Murakami T, Shima K, Murata Y, Kishi K 1997 The placenta is not the main source of leptin production in pregnant rat: gestational profile of leptin in plasma and adipose tissues. Biochem Biophys Res Commun 240:798-802
20. Butte NF, Hopkinson JM, Nicolson MA 1997 Leptin in human reproduction: serum leptin levels in pregnant and lactating women. J Clin Endocrinol Metab 82:585-589
21. Hardie L, Trayhurn P, Abramovich D, Fowler P 1997 Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin Endocrinol (Oxf) 47:101-106
22. Chehab FF, Lim ME, Lu R 1996 Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 12:318-320
23. Mounzih K, Qiu J, Ewart-Toland A, Chehab FF 1998 Leptin is not necessary for gestation and parturition but regulates maternal nutrition via a leptin resistance state. Endocrinology 139:5259-5262
24. Palkovits M, Brownstein MJ 1988 Maps and guide to microdissection of the rat brain. New York: Elsevier Science Publishing Co., Inc.
25. Tarttelin MF, Gorski RA 1971 Variations in food and water intake in the normal and acyclic female rat. Physiol Behav 7:847-852
26. Seeber RM, Smith JT, Waddell BJ 2002 Plasma leptin-binding activity and hypothalamic leptin receptor expression during pregnancy and lactation in the rat. Biol Reprod 66:1762-1767
27. Johnstone LE, Higuchi T 2001 Food intake and leptin during pregnancy and lactation. Prog Brain Res 133:215-227
28. Moore BJ, Brasel JA 1984 One cycle of reproduction consisting of pregnancy, lactation or no lactation, and recovery: effects on carcass composition in ad libitum-fed and food-restricted rats. J Nutr 114:1548-1559
29. Rocha M, Bing C, Williams G, Puerta M 2003 Pregnancy-induced hyperphagia is associated with increased gene expression of hypothalamic agouti-related peptide in rats. Regul Pept 114:159-165
30. Mistry AM, Romsos DR 2002 Intracerebroventricular leptin administration reduces food intake in pregnant and lactating mice. Exp Biol Med 227: 616-619
31. Scarpace PJ, Matheny M, Tumer N 2001 Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats. Neuroscience 104:1111-1117
32. Shek EW, Scarpace PJ 2000 Resistance to the anorexic and thermogenic effects of centrally administrated leptin in obese aged rats. Regul Pept 92:65-71
33. El-Haschimi K, Pierroz DD, Hileman SM, Bjorbaek C, Flier JS 2000 Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 105:1827-1832
34. Cusin I, Rohner-Jeanrenaud F, Stricker-Krongrad A, Jeanrenaud B 1996 The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals. Diabetes 45:1446-1450
35. Vickers MH, Breier BH, Cutfield WS, Hofman PL, Gluckman PD 2000 Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition. Am J Physiol Endocrinol Metab 279:E83-E87
36. Anguita RM, Sigulem DM, Sawaya AL 1993 Intrauterine food restriction is associated with obesity in young rats. J Nutr 123:1421-1428
37. Tomimatsu T, Yamaguchi M, Murakami T, Ogura K, Sakata M, Mitsuda N, Kanzaki T, Kurachi H, Irahara M, Miyake A, Shima K, Aono T, Murata Y 1997 Increase of mouse leptin production by adipose tissue after midpregnancy: gestational profile of serum leptin concentration. Biochem Biophys Res Commun 240:213-215
38. Kronfeld-Schor N, Zhao J, Silvia BA, Bicer E, Mathews PT, Urban R, Zimmerman S, Kunz TH, Widmaier EP 2000 Steroid-dependent up-regulation of adipose leptin secretion in vitro during pregnancy in mice. Biol Reprod 63: 274-280
39. Frederich RC, Lollmann B, Hamann A, Napolitano-Rosen A, Kahn BB, Lowell BB, Flier JS 1995 Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest 96:1658-1663
40. Seeley RJ, van Dijk G, Campfield LA, Smith FJ, Burn P, Nelligan JA, Bell SM, Baskin DG, Woods SC, Schwartz MW 1996 Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats. Horm Metab Res 28:664-668
41. McCowen KC, Chow JC, Smith RJ 1998 Leptin signaling in the hypothalamus of normal rats in vivo. Endocrinology 139:4442-4447
42. Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AW, Wang Y, Banks AS, Lavery HJ, Haq AK, Maratos-Flier E, Neel BG, Schwartz MW, Myers Jr MG 2003 STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421:856-859
43. Wilson BD, Bagnol D, Kaelin CB, Ollmann MM, Gantz I, Watson SJ, Barsh GS 1999 Physiological and anatomical circuitry between agouti-related protein and leptin signaling. Endocrinology 140:2387-2397
44. Khorram O, DePalatis LR, McCann SM 1984 Changes in hypothalamic and pituitary content of immunoreactive α-melanocyte-stimulating hormone during the gestational and postpartum periods in the rat. Proc Soc Exp Biol Med 177:318-326
45. Jacob RJ, Dziura J, Medwick MB, Leone P, Caprio S, During M, Shulman GI, Sherwin RS 1997 The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus. Diabetes 46:150-152
46. Martin RL, Perez E, He YJ, Dawson Jr R, Millard WJ 2000 Leptin resistance is associated with hypothalamic leptin receptor mRNA and protein down-regulation. Metabolism 49:1479-1484
47. McCormack JT, Greenwald GS 1974 Progesterone and oestradiol-17β concentrations in the peripheral plasma during pregnancy in the mouse. J Endocrinol 62:101-107
48. Hervey E, Hervey GR 1967 The effects of progesterone on body weight and composition in the rat. J Endocrinol 37:361-381
49. Grueso E, Rocha M, Puerta M 2001 Plasma and cerebrospinal fluid leptin levels are maintained despite enhanced food intake in progesterone-treated rats. Eur J Endocrinol 144:659-665
50. Fox SR, Harlan RE, Shivers BD, Pfaff DW 1990 Chemical characterization of neuroendocrine targets for progesterone in the female rat brain and pituitary. Neuroendocrinology 51:276-283
51. Francis K, Meddle SL, Bishop VR, Russell JA 2002 Progesterone receptor expression in the pregnant and parturient rat hypothalamus and brainstem. Brain Res 927:18-26