Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin

Diabetes

Volumn 52, Issue 4, 2003, Pages 948-956

  Kohno, Daisuke ^a,b   Gao, Hong Zhi ^a,c   Muroya, Shinji ^a,c   Kikuyama, Sakae ^b   Yada, Toshihiko ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b WASEDA UNIVERSITY   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; FURA 2; GHRELIN; LEPTIN; NEUROPEPTIDE Y; OREXIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

ANIMAL CELL; ARCUATE NUCLEUS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CONTROLLED STUDY; FEEDING; FLUORESCENCE; FOOD INTAKE; IMMUNOCYTOCHEMISTRY; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ARCUATE NUCLEUS; CALCIUM; CALCIUM CHANNELS, N-TYPE; CARRIER PROTEINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; GLUCOSE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; MALE; NEURONS; NEUROPEPTIDE Y; NEUROPEPTIDES; PEPTIDE HORMONES; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR CROSS-TALK; SIGNAL TRANSDUCTION;

EID: 0037382853     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.4.948     Document Type: Article

References (41)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K: Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660, 1999
2. Tschop M, Similey DL, Heiman ML: Ghrelin induces adiposity in rodents. Nature 407:908-913, 2000
3. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo, Kangawa K, Matsukura S: A role for ghrelin in the central regulation of feeding. Nature 409:194-198, 2001
4. Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, Hayashi T, Inoue G, Hosoda K, Kojima M, Kangawa K, Nakao K: Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 50:227-232, 2001
5. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, Kasuga M: Ghrelin is an appetitestimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120:337-345, 2001
6. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DG, Ghatei MA, Bloom SR: The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141:4325-4328, 2000
7. Wren AM, Seal LJ, Cohen MA, Bynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR: Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86:5992-5995, 2001
8. Inui A: Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat Rev Neurosci 2:551-560, 2001
9. Cummings DE, Purnell JQ, Fravo RS, Schmidova K, Wisse BE, Weigle DS: A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50:1714-1719, 2001
10. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF: Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7:1189-1192, 1986
11. Kalra SP, Dube MG, Sahu A, Phelps CP, Kalra PS: Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc Natl Acad Sci U S A 88:10931-10935, 1991
12. Willesen MG, Kristensen P, Romer J: Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 70:306-316, 1999
13. Wang L, Saint-Pierre DH, Tache Y: Peripheral ghrelin selectively increases Fos expression in neuropeptide Y: synthesizing neurons in mouse hypothalamic arcuate nucleus. Neurosci Lett 325:47-51, 2002
14. Hewson AK, Dickson SL: Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats. J Neuroendocrinol 12:1047-1049, 2000
15. Lawrence CB, Snape AC, Baudoin FM, Luckman SM: Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers. Endocrinology 143:155-162, 2002
16. Wu D, Chen C, Zhang J, Bowers CY, Clarke IJ: The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3′,5′-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs. J Endocrinol 148:197-205, 1996
17. Chen C: Growth Hormone secretagogue actions on the pituitary gland: multiple receptors for multiple ligands? Clin Exp Pharmacol Physiol 27:323-329, 2000
18. Cheng K, Chan WW, Butler B, Barreto A Jr., Smith RG: Evidence for a role of protein kinase-C in His-D-Trp-Ala-Trp-D-Phe-Lys-NH2-induced growth hormone release from rat primary pituitary cells. Endocrinology 129:3337-3342, 1991
19. Friedman JM, Halaas JL: Leptin and the regulation of body weight in mammals. Nature 395:763-770, 1998
20. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M: Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573-585, 1998
21. Suzuki R, Shimojima H, Funahashi H, Nakajo S, Yamada S, Guan JL, Tsurugano S, Uehara K, Takeyama Y, Kikuyama S, Shioda S: Orexin-1 receptor immunoreactivity in chemically identified target neurons in the rat hypothalamus. Neurosci Lett 324:5-8, 2002
22. Jain MR, Horvath TL, Kalra PS, Kalra SP: Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats. Regul Pept 87:19-24, 2000
23. Yamanaka A, Kunii K, Nambu T, Tsujino N, Sakai A, Matsuzaki I, Miwa Y, Goto K, Sakurai T: Orexin-induced food intake involves neuropeptide Y pathway. Brain Res 859:404-409, 2000
24. Dube MG, Horvath TL, Kalra PS, Kalra SP: Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats. Peptides 21:1557-1560, 2000
25. Muroya S, Yada T, Shioda S, Takigawa M: Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y. Neurosci Lett 264:113-116, 1999
26. 2+ in orexin neurons of the rat lateral hypothalamus. Neurosci Lett 309:165-168, 2001
27. Yada T, Sakurada M, Ihida K, Nakata M, Murata F, Arimura A, Kikuchi M: Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet β-cells. J Biol Chem 269:1290-1293, 1994
28. 2+ channel activity. Endocrinology 133:1685-1692, 1993
29. Nishino S, Ripley B, Overeem S, Nevsimalova S, Lammers GJ, Vankova J, Okun M, Rogers W, Brooks S, Mignot E: Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy. Ann Neurol 50:381-388, 2001
30. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM: Leptin enters the brain by a saturable system indipendent of insulin. Peptides 17:305-311, 1996
31. King PJ, Widdowson PS, Doods HN, Williams G: Regulation of neuropeptide Y release by neuropeptide Y receptor ligands and calcium channel antagonists in hypothalamic slices. J Neurochem 73:641-646, 1999
32. Chen X, DiMaggio DA, Han SP, Westfall TC: Autoreceptor-induced inhibition of neuropeptide Y release from PC-12 cells is mediated by Y2 receptors. Am J Physiol 273:H1737-H1744, 1997
33. Trautwein W, Hescheler J: Regulation of cardiac L-type calcium current by phosphorylation and G proteins. Annu Rev Physiol 52:257-274, 1990
34. Shimizu-Albergine M, Ippolito DL, Beavo JA: Downregulation of fasting-induced cAMP response element-mediated gene induction by leptin in neuropeptide Y neurons of the arcuate nucleus. J Neurosci 21:1238-1246, 2001
35. Backberg M, Hervieu G, Wilson S, Meister B: Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake. Eur J Neurosci 15:315-328, 2002
36. Moriguchi T, Sakurai T, Nambu T, Yanagisawa M, Goto K: Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia. Neurosci Lett 264:101-104, 1999
37. Traebert M, Riediger T, Whitebread S, Scharrer E, Schmid HA: Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. J Neuroendocrinol 14:580-586, 2002
38. Zhao AZ, Bornfieldt KE, Beavo JA: Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. J Clin Invest 102:869-873, 1998
39. Zhao AZ, Shinohara MM, Huang D, Shimizu M, Eldar-Finkelman H, Krebs EG, Beavo JA, Bornfield KE: Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. J Biol Chem 275:11348-11354, 2000
40. Zhao AZ, Huan JN, Gupta S, Pal R, Sahu A: A phosphatidylinositol 3-kinase phosphodiesterase 3B cyclic AMP pathway in hypothalamic action of leptin on feeding. Nat Neurosci 5:727-728, 2002
41. Shanley LJ, Irving AJ, Rae MG, Ashford ML, Harvey J: Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels. Nat Neurosci 5:299-300, 2002