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Volumn 14, Issue 9, 2009, Pages 3380-3400

Targeting the AMPK pathway for the treatment of type 2 diabetes

Author keywords

AMPK; Energy metabolism; Review; Type 2 diabetes

Indexed keywords

RODENTIA;

EID: 63849085094     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3460     Document Type: Article
Times cited : (240)

References (176)
  • 2
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • DOI 10.1038/414799a
    • A. R. Saltiel and C. R. Kahn: Insulin signalling and the regulation of glucose and lipid metabolism. Nature, 414(6865), 799-806(2001) (Pubitemid 34000783)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 6
    • 40749093652 scopus 로고    scopus 로고
    • Role of Physical Activity in Diabetes Management and Prevention
    • DOI 10.1016/j.jada.2008.01.016, PII S0002822308000175
    • C. Hayes and A. Kriska: Role of physical activity in diabetes management and prevention. J Am Diet Assoc, 108(4 Suppl 1), S19-23(2008) (Pubitemid 351389295)
    • (2008) Journal of the American Dietetic Association , vol.108 , Issue.SUPPL. 4
    • Hayes, C.1    Kriska, A.2
  • 7
    • 4644320002 scopus 로고    scopus 로고
    • Physical activity/exercise and type 2 diabetes
    • DOI 10.2337/diacare.27.10.2518
    • R. J. Sigal, G. P. Kenny, D. H. Wasserman and C. Castaneda-Sceppa: Physical activity/exercise and type 2 diabetes. Diabetes Care, 27(10), 2518-39(2004) (Pubitemid 39281418)
    • (2004) Diabetes Care , vol.27 , Issue.10 , pp. 2518-2539
    • Sigal, R.J.1    Kenny, G.P.2    Wasserman, D.H.3    Castaneda-Sceppa, C.4
  • 11
    • 0026322241 scopus 로고
    • Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men
    • K. R. Segal, A. Edano, A. Abalos, J. Albu, L. Blando, M. B. Tomas and F. X. Pi-Sunyer: Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men. J Appl Physiol, 71(6), 2402-11(1991)
    • (1991) J. Appl. Physiol. , vol.71 , Issue.6 , pp. 2402-2411
    • Segal, K.R.1    Edano, A.2    Abalos, A.3    Albu, J.4    Blando, L.5    Tomas, M.B.6    Pi-Sunyer, F.X.7
  • 12
    • 0035039274 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise
    • N. Musi, N. Fujii, M. F. Hirshman, I. Ekberg, S. Froberg, O. Ljungqvist, A. Thorell and L. J. Goodyear: AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise. Diabetes, 50(5), 921-7(2001) (Pubitemid 32374520)
    • (2001) Diabetes , vol.50 , Issue.5 , pp. 921-927
    • Musi, N.1    Fujii, N.2    Hirshman, M.F.3    Ekberg, I.4    Froberg, S.5    Ljungqvist, O.6    Thorell, A.7    Goodyear, L.J.8
  • 13
    • 37249066135 scopus 로고    scopus 로고
    • Exercise training-induced improvements in insulin action
    • DOI 10.1111/j.1748-1716.2007.01783.x
    • J. A. Hawley and S. J. Lessard: Exercise training-induced improvements in insulin action. Acta Physiol (Oxf), 192(1), 127-35(2008) (Pubitemid 350265363)
    • (2008) Acta Physiologica , vol.192 , Issue.1 , pp. 127-135
    • Hawley, J.A.1    Lessard, S.J.2
  • 14
    • 1842433830 scopus 로고    scopus 로고
    • Long-term glycaemic control with pioglitazone in patients with type 2 diabetes
    • DOI 10.1111/j.1368-5031.2004.0108.x
    • I. W. Campbell: Long-term glycaemic control with pioglitazone in patients with type 2 diabetes. Int J Clin Pract, 58(2), 192-200(2004) (Pubitemid 38425750)
    • (2004) International Journal of Clinical Practice , vol.58 , Issue.2 , pp. 192-200
    • Campbell, I.W.1
  • 15
    • 10344248699 scopus 로고    scopus 로고
    • Rosiglitazone, but not glyburide, reduces circulating proinsulin and the proinsulin:insulin ratio in type 2 diabetes
    • DOI 10.1210/jc.2004-0705
    • S. A. Smith, L. E. Porter, N. Biswas and M. I. Freed: Rosiglitazone, but not glyburide, reduces circulating proinsulin and the proinsulin:insulin ratio in type 2 diabetes. J Clin Endocrinol Metab, 89(12), 6048-53(2004) (Pubitemid 39628413)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.12 , pp. 6048-6053
    • Smith, S.A.1    Porter, L.E.2    Biswas, N.3    Freed, M.I.4
  • 16
    • 0036724346 scopus 로고    scopus 로고
    • Preservation of pancreatic β-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk Hispanic women
    • T. A. Buchanan, A. H. Xiang, R. K. Peters, S. L. Kjos, A. Marroquin, J. Goico, C. Ochoa, S. Tan, K. Berkowitz, H. N. Hodis and S. P. Azen: Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women. Diabetes, 51(9), 2796-803(2002) (Pubitemid 34970933)
    • (2002) Diabetes , vol.51 , Issue.9 , pp. 2796-2803
    • Buchanan, T.A.1    Xiang, A.H.2    Peters, R.K.3    Kjos, S.L.4    Marroquin, A.5    Goico, J.6    Ochoa, C.7    Tan, S.8    Berkowitz, K.9    Hodis, H.N.10    Azen, S.P.11
  • 17
    • 33644762010 scopus 로고    scopus 로고
    • Effect of pioglitazone on pancreatic β-cell function and diabetes risk in Hispanic women with prior gestational diabetes
    • DOI 10.2337/diabetes.55.02.06.db05-1066
    • A. H. Xiang, R. K. Peters, S. L. Kjos, A. Marroquin, J. Goico, C. Ochoa, M. Kawakubo and T. A. Buchanan: Effect of pioglitazone on pancreatic beta-cell function and diabetes risk in Hispanic women with prior gestational diabetes. Diabetes, 55(2), 517-22(2006) (Pubitemid 43343284)
    • (2006) Diabetes , vol.55 , Issue.2 , pp. 517-522
    • Xiang, A.H.1    Peters, R.K.2    Kjos, S.L.3    Marroquin, A.4    Goico, J.5    Ochoa, C.6    Kawakubo, M.7    Buchanan, T.A.8
  • 21
    • 45149118855 scopus 로고    scopus 로고
    • Intensive glycemic control in the ACCORD and ADVANCE trials
    • DOI 10.1056/NEJMe0804182
    • R. G. Dluhy and G. T. McMahon: Intensive glycemic control in the ACCORD and ADVANCE trials. N Engl J Med, 358(24), 2630-3(2008) (Pubitemid 351831365)
    • (2008) New England Journal of Medicine , vol.358 , Issue.24 , pp. 2630-2633
    • Dluhy, R.G.1    McMahon, G.T.2
  • 22
    • 18144451494 scopus 로고    scopus 로고
    • Beneficial effects of metformin on haemostasis and vascular function in man
    • P. J. Grant: Beneficial effects of metformin on haemostasis and vascular function in man. Diabetes Metab, 29(4 Pt 2), 6S44-52(2003) (Pubitemid 37187090)
    • (2003) Diabetes and Metabolism , vol.29 , Issue.II4
    • Grant, P.J.1
  • 23
    • 33644747421 scopus 로고    scopus 로고
    • Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
    • DOI 10.2337/diabetes.55.02.06.db05-1064
    • B. J. Davis, Z. Xie, B. Viollet and M. H. Zou: Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes, 55(2), 496-505(2006) (Pubitemid 43343281)
    • (2006) Diabetes , vol.55 , Issue.2 , pp. 496-505
    • Davis, B.J.1    Xie, Z.2    Viollet, B.3    Zou, M.-H.4
  • 24
    • 34547670934 scopus 로고    scopus 로고
    • High Molecular Weight Adiponectin as a Predictor of Long-Term Clinical Outcome in Patients With Coronary Artery Disease
    • DOI 10.1016/j.amjcard.2007.03.062, PII S0002914907008594
    • T. Inoue, N. Kotooka, T. Morooka, H. Komoda, T. Uchida, Y. Aso, T. Inukai, T. Okuno and K. Node: High molecular weight adiponectin as a predictor of long-term clinical outcome in patients with coronary artery disease. Am J Cardiol, 100(4), 569-74(2007) (Pubitemid 47223129)
    • (2007) American Journal of Cardiology , vol.100 , Issue.4 , pp. 569-574
    • Inoue, T.1    Kotooka, N.2    Morooka, T.3    Komoda, H.4    Uchida, T.5    Aso, Y.6    Inukai, T.7    Okuno, T.8    Node, K.9
  • 25
    • 41149094470 scopus 로고    scopus 로고
    • Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide
    • DOI 10.1093/cvr/cvn017
    • A. T. Gonon, U. Widegren, A. Bulhak, F. Salehzadeh, J. Persson, P. O. Sjoquist and J. Pernow: Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide. Cardiovasc Res, 78(1), 116-22(2008) (Pubitemid 351430967)
    • (2008) Cardiovascular Research , vol.78 , Issue.1 , pp. 116-122
    • Gonon, A.T.1    Widegren, U.2    Bulhak, A.3    Salehzadeh, F.4    Persson, J.5    Sjoquist, P.-O.6    Pernow, J.7
  • 26
    • 34848877206 scopus 로고    scopus 로고
    • Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infraction (MI)
    • M. Naruszewicz, I. Laniewska, B. Millo and M. Dluzniewski: Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infraction (MI). Atherosclerosis, 194(2), e-17984(2007)
    • (2007) Atherosclerosis , vol.194 , Issue.2
    • Naruszewicz, M.1    Laniewska, I.2    Millo, B.3    Dluzniewski, M.4
  • 27
    • 33845332346 scopus 로고    scopus 로고
    • Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle
    • DOI 10.1113/jphysiol.2006.120972
    • J. B. Birk and J. F. Wojtaszewski: Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscle. J Physiol, 577(Pt 3), 1021-32(2006) (Pubitemid 44873663)
    • (2006) Journal of Physiology , vol.577 , Issue.3 , pp. 1021-1032
    • Birk, J.B.1    Wojtaszewski, J.F.P.2
  • 28
    • 33947173689 scopus 로고    scopus 로고
    • AS160 phosphorylation is associated with activation of alpha2beta2gamma1-but not alpha2beta2gamma3-AMPK trimeric complex in skeletal muscle during exercise in humans
    • J. T. Treebak, J. B. Birk, A. J. Rose, B. Kiens, E. A. Richter and J. F. Wojtaszewski: AS160 phosphorylation is associated with activation of alpha2beta2gamma1-but not alpha2beta2gamma3-AMPK trimeric complex in skeletal muscle during exercise in humans. Am J Physiol Endocrinol Metab, 292(3), E-71522(2007)
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.292 , Issue.3
    • Treebak, J.T.1    Birk, J.B.2    Rose, A.J.3    Kiens, B.4    Richter, E.A.5    Wojtaszewski, J.F.6
  • 29
    • 0023885305 scopus 로고
    • The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains
    • S. K. Hanks, A. M. Quinn and T. Hunter: The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science, 241(4861), 42-52(1988)
    • (1988) Science , vol.241 , Issue.4861 , pp. 42-52
    • Hanks, S.K.1    Quinn, A.M.2    Hunter, T.3
  • 30
    • 0029910018 scopus 로고    scopus 로고
    • Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase
    • DOI 10.1074/jbc.271.44.27879
    • S. A. Hawley, M. Davison, A. Woods, S. P. Davies, R. K. Beri, D. Carling and D. G. Hardie: Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J Biol Chem, 271(44), 27879-87(1996) (Pubitemid 26367365)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.44 , pp. 27879-27887
    • Hawley, S.A.1    Davison, M.2    Woods, A.3    Davies, S.P.4    Beri, R.K.5    Carling, D.6    Hardie, D.G.7
  • 31
    • 0034141355 scopus 로고    scopus 로고
    • The regulation of AMP-activated protein kinase by phosphorylation
    • DOI 10.1042/0264-6021:3450437
    • S. C. Stein, A. Woods, N. A. Jones, M. D. Davison and D. Carling: The regulation of AMP-activated protein kinase by phosphorylation. Biochem J, 345 Pt 3, 437-43(2000) (Pubitemid 30099070)
    • (2000) Biochemical Journal , vol.345 , Issue.3 , pp. 437-443
    • Stein, S.C.1    Woods, A.2    Jones, N.A.3    Davison, M.D.4    Cabling, D.5
  • 32
    • 0032567252 scopus 로고    scopus 로고
    • Functional domains of the α1 catalytic subunit of the AMP-activated protein kinase
    • DOI 10.1074/jbc.273.52.35347
    • B. E. Crute, K. Seefeld, J. Gamble, B. E. Kemp and L. A. Witters: Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase. J Biol Chem, 273(52), 35347-54(1998) (Pubitemid 29028244)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.52 , pp. 35347-35354
    • Crute, B.E.1    Seefeld, K.2    Gamble, J.3    Kemp, B.E.4    Witters, L.A.5
  • 33
    • 33846945033 scopus 로고    scopus 로고
    • Conserved α-helix acts as autoinhibitory sequence in AMP-activated protein kinase α subunits
    • DOI 10.1074/jbc.M605790200
    • T. Pang, B. Xiong, J. Y. Li, B. Y. Qiu, G. Z. Jin, J. K. Shen and J. Li: Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits. J Biol Chem, 282(1), 495-506(2007) (Pubitemid 47076612)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.1 , pp. 495-506
    • Pang, T.1    Xiong, B.2    Li, J.-Y.3    Qiu, B.-Y.4    Jin, G.-Z.5    Shen, J.-K.6    Li, J.7
  • 34
    • 0032529139 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform
    • I. Salt, J. W. Celler, S. A. Hawley, A. Prescott, A. Woods, D. Carling and D. G. Hardie: AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. Biochem J, 334(Pt 1), 177-87(1998) (Pubitemid 28420987)
    • (1998) Biochemical Journal , vol.334 , Issue.1 , pp. 177-187
    • Salt, I.1    Celler, J.W.2    Hawley, S.A.3    Prescott, A.4    Woods, A.5    Carling, D.6    Hardie, D.G.7
  • 35
    • 0029925785 scopus 로고    scopus 로고
    • Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro
    • A. Woods, P. C. Cheung, F. C. Smith, M. D. Davison, J. Scott, R. K. Beri and D. Carling: Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro. J Biol Chem, 271(17), 10282-90(1996)
    • (1996) J. Biol. Chem. , vol.271 , Issue.17 , pp. 10282-10290
    • Woods, A.1    Cheung, P.C.2    Smith, F.C.3    Davison, M.D.4    Scott, J.5    Beri, R.K.6    Carling, D.7
  • 37
    • 0038814313 scopus 로고    scopus 로고
    • A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias
    • DOI 10.1016/S0960-9822(03)00249-5
    • E. R. Hudson, D. A. Pan, J. James, J. M. Lucocq, S. A. Hawley, K. A. Green, O. Baba, T. Terashima and D. G. Hardie: A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias. Curr Biol, 13(10), 861-6(2003) (Pubitemid 36573255)
    • (2003) Current Biology , vol.13 , Issue.10 , pp. 861-866
    • Hudson, E.R.1    Pan, D.A.2    James, J.3    Lucocq, J.M.4    Hawley, S.A.5    Green, K.A.6    Baba, O.7    Terashima, T.8    Hardie, D.G.9
  • 39
    • 1342332128 scopus 로고    scopus 로고
    • Bateman domains and adenosine derivatives form a binding contract
    • DOI 10.1172/JCI200420846
    • B. E. Kemp: Bateman domains and adenosine derivatives form a binding contract. J Clin Invest, 113(2), 182-4(2004) (Pubitemid 38544202)
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.2 , pp. 182-184
    • Kemp, B.E.1
  • 40
    • 0034654362 scopus 로고    scopus 로고
    • Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
    • DOI 10.1042/0264-6021:3460659
    • P. C. Cheung, I. P. Salt, S. P. Davies, D. G. Hardie and D. Carling: Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem J, 346 Pt 3, 659-69(2000) (Pubitemid 30171026)
    • (2000) Biochemical Journal , vol.346 , Issue.3 , pp. 659-669
    • Cheung, P.C.F.1    Salt, I.P.2    Davies, S.P.3    Hardie, D.G.4    Carling, D.5
  • 42
    • 27144548462 scopus 로고    scopus 로고
    • Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1
    • DOI 10.1016/j.bbrc.2005.09.181, PII S0006291X05022059
    • M. J. Rudolph, G. A. Amodeo, Y. Bai and L. Tong: Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1. Biochem Biophys Res Commun, 337(4), 1224-8(2005) (Pubitemid 41509194)
    • (2005) Biochemical and Biophysical Research Communications , vol.337 , Issue.4 , pp. 1224-1228
    • Rudolph, M.J.1    Amodeo, G.A.2    Bai, Y.3    Tong, L.4
  • 43
    • 26444608572 scopus 로고    scopus 로고
    • Structural basis for glycogen recognition by AMP-activated protein kinase
    • DOI 10.1016/j.str.2005.07.008, PII S0969212605002674
    • G. Polekhina, A. Gupta, B. J. van Denderen, S. C. Feil, B. E. Kemp, D. Stapleton and M. W. Parker: Structural basis for glycogen recognition by AMP-activated protein kinase. Structure, 13(10), 1453-62(2005) (Pubitemid 41427585)
    • (2005) Structure , vol.13 , Issue.10 , pp. 1453-1462
    • Polekhina, G.1    Gupta, A.2    Van Denderen, B.J.W.3    Feil, S.C.4    Kemp, B.E.5    Stapleton, D.6    Parker, M.W.7
  • 45
    • 33845949733 scopus 로고    scopus 로고
    • Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
    • DOI 10.1074/jbc.M606357200
    • M. Suter, U. Riek, R. Tuerk, U. Schlattner, T. Wallimann and D. Neumann: Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J Biol Chem, 281(43), 32207-16(2006) (Pubitemid 46036775)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.43 , pp. 32207-32216
    • Suter, M.1    Riek, U.2    Tuerk, R.3    Schlattner, U.4    Wallimann, T.5    Neumann, D.6
  • 46
    • 10944247187 scopus 로고    scopus 로고
    • The AMP-activated protein kinase pathway - New players upstream and downstream
    • DOI 10.1242/jcs.01540
    • D. G. Hardie: The AMP-activated protein kinase pathway-new players upstream and downstream. J Cell Sci, 117(Pt 23), 5479-87(2004) (Pubitemid 40012195)
    • (2004) Journal of Cell Science , vol.117 , Issue.23 , pp. 5479-5487
    • Hardie, D.G.1
  • 47
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • S. A. Hawley, J. Boudeau, J. L. Reid, K. J. Mustard, L. Udd, T. P. Makela, D. R. Alessi and D. G. Hardie: Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol, 2(4), 28(2003)
    • (2003) J. Biol. , vol.2 , Issue.4 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Makela, T.P.6    Alessi, D.R.7    Hardie, D.G.8
  • 50
    • 23044432463 scopus 로고    scopus 로고
    • Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
    • DOI 10.1016/j.cmet.2005.05.009, PII S155041310500166X
    • S. A. Hawley, D. A. Pan, K. J. Mustard, L. Ross, J. Bain, A. M. Edelman, B. G. Frenguelli and D. G. Hardie: Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab, 2(1), 9-19(2005) (Pubitemid 43239821)
    • (2005) Cell Metabolism , vol.2 , Issue.1 , pp. 9-19
    • Hawley, S.A.1    Pan, D.A.2    Mustard, K.J.3    Ross, L.4    Bain, J.5    Edelman, A.M.6    Frenguelli, B.G.7    Hardie, D.G.8
  • 51
    • 23044437445 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells
    • DOI 10.1016/j.cmet.2005.06.005, PII S1550413105001701
    • A. Woods, K. Dickerson, R. Heath, S. P. Hong, M. Momcilovic, S. R. Johnstone, M. Carlson and D. Carling: Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab, 2(1), 21-33(2005) (Pubitemid 43239822)
    • (2005) Cell Metabolism , vol.2 , Issue.1 , pp. 21-33
    • Woods, A.1    Dickerson, K.2    Heath, R.3    Hong, S.-P.4    Momcilovic, M.5    Johnstone, S.R.6    Carlson, M.7    Carling, D.8
  • 52
  • 53
    • 55549096745 scopus 로고    scopus 로고
    • SIRT1 modulation of the acetylation status, cytosolic localization and activity of LKB1; possible role in AMP-activated protein kinase activation
    • F. Lan, J. M. Cacicedo, N. Ruderman and Y. Ido: SIRT1 modulation of the acetylation status, cytosolic localization and activity of LKB1; possible role in AMP-activated protein kinase activation. J Biol Chem 283(41), 27628-35(2008)
    • (2008) J. Biol. Chem. , vol.283 , Issue.41 , pp. 27628-27635
    • Lan, F.1    Cacicedo, J.M.2    Ruderman, N.3    Ido, Y.4
  • 55
    • 34147152841 scopus 로고    scopus 로고
    • Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
    • DOI 10.1042/BJ20061520
    • M. J. Sanders, P. O. Grondin, B. D. Hegarty, M. A. Snowden and D. Carling: Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. The Biochemical journal, 403(1), 139-48(2007) (Pubitemid 46569875)
    • (2007) Biochemical Journal , vol.403 , Issue.1 , pp. 139-148
    • Sanders, M.J.1    Grondin, P.O.2    Hegarty, B.D.3    Snowden, M.A.4    Carling, D.5
  • 56
    • 0031849916 scopus 로고    scopus 로고
    • Evidence for 5'AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
    • DOI 10.2337/diabetes.47.8.1369
    • T. Hayashi, M. F. Hirshman, E. J. Kurth, W. W. Winder and L. J. Goodyear: Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes, 47(8), 1369-73(1998) (Pubitemid 28357021)
    • (1998) Diabetes , vol.47 , Issue.8 , pp. 1369-1373
    • Hayashi, T.1    Hirshman, M.F.2    Kurth, E.J.3    Winder, W.W.4    Goodyear, L.J.5
  • 59
    • 28244466267 scopus 로고    scopus 로고
    • AMP-activated protein kinase α2 activity is not essential for contraction-and hyperosmolarity-induced glucose transport in skeletal muscle
    • DOI 10.1074/jbc.M504208200
    • N. Fujii, M. F. Hirshman, E. M. Kane, R. C. Ho, L. E. Peter, M. M. Seifert and L. J. Goodyear: AMP-activated protein kinase alpha2 activity is not essential for contraction-and hyperosmolarity-induced glucose transport in skeletal muscle. J Biol Chem, 280(47), 39033-41(2005) (Pubitemid 41713853)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.47 , pp. 39033-39041
    • Fujii, N.1    Hirshman, M.F.2    Kane, E.M.3    Ho, R.C.4    Peter, L.E.5    Seifert, M.M.6    Goodyear, L.J.7
  • 60
    • 0345832116 scopus 로고    scopus 로고
    • 1, 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4- carboxamide-1-β-4-ribofuranoside- but Not Contraction-induced Glucose Uptake in Skeletal Muscle
    • DOI 10.1074/jbc.M306205200
    • S. B. Jorgensen, B. Viollet, F. Andreelli, C. Frosig, J. B. Birk, P. Schjerling, S. Vaulont, E. A. Richter and J. F. Wojtaszewski: Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle. J Biol Chem, 279(2), 1070-9(2004) (Pubitemid 38082628)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.2 , pp. 1070-1079
    • Jorgensen, S.B.1    Viollet, B.2    Andreelli, F.3    Frosig, C.4    Birk, J.B.5    Schjerling, P.6    Vaulont, S.7    Richter, E.A.8    Wojtaszewski, J.F.P.9
  • 61
    • 0037326943 scopus 로고    scopus 로고
    • Selective suppression of AMP-activated protein kinase in skeletal muscle: Update on 'lazy mice'
    • J. Mu, E. R. Barton and M. J. Birnbaum: Selective suppression of AMP-activated protein kinase in skeletal muscle: update on 'lazy mice'. Biochem Soc Trans, 31(Pt 1), 236-41(2003) (Pubitemid 36241436)
    • (2003) Biochemical Society Transactions , vol.31 , Issue.1 , pp. 236-241
    • Mu, J.1    Barton, E.R.2    Birnbaum, M.J.3
  • 62
    • 85184643393 scopus 로고    scopus 로고
    • The {alpha} subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitro {alpha}
    • N. Simard-Lefort, E. St-Amand, S. Morasse, C. H. Cote and A. Marette: The {alpha} subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitro {alpha}. Am J Physiol Endocrinol Metab (2008)
    • (2008) Am. J. Physiol. Endocrinol. Metab.
    • Simard-Lefort, N.1    St-Amand, E.2    Morasse, S.3    Cote, C.H.4    Marette, A.5
  • 63
    • 0035029874 scopus 로고    scopus 로고
    • Effect of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese zucker rats
    • R. Bergeron, S. F. Previs, G. W. Cline, P. Perret, R. R. Russell, 3rd, L. H. Young and G. I. Shulman: Effect of 5-aminoimidazole-4-carboxamide-1-beta-D- ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats. Diabetes, 50(5), 1076-82(2001) (Pubitemid 32374538)
    • (2001) Diabetes , vol.50 , Issue.5 , pp. 1076-1082
    • Bergeron, R.1    Previs, S.F.2    Cline, G.W.3    Perret, P.4    Russell III, R.R.5    Young, L.H.6    Shulman, G.I.7
  • 64
    • 0036307179 scopus 로고    scopus 로고
    • Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome
    • E. S. Buhl, N. Jessen, R. Pold, T. Ledet, A. Flyvbjerg, S. B. Pedersen, O. Pedersen, O. Schmitz and S. Lund: Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome. Diabetes, 51(7), 2199-206(2002) (Pubitemid 34729025)
    • (2002) Diabetes , vol.51 , Issue.7 , pp. 2199-2206
    • Buhl, E.S.1    Jessen, N.2    Pold, R.3    Ledet, T.4    Flyvbjerg, A.5    Pedersen, S.B.6    Pedersen, O.7    Schmitz, O.8    Lund, S.9
  • 65
    • 0036788292 scopus 로고    scopus 로고
    • AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulinresistant high-fat-fed rats
    • M. A. Iglesias, J. M. Ye, G. Frangioudakis, A. K. Saha, E. Tomas, N. B. Ruderman, G. J. Cooney and E. W. Kraegen: AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulinresistant high-fat-fed rats. Diabetes, 51(10), 2886-94(2002)
    • (2002) Diabetes , vol.51 , Issue.10 , pp. 2886-2894
    • Iglesias, M.A.1    Ye, J.M.2    Frangioudakis, G.3    Saha, A.K.4    Tomas, E.5    Ruderman, N.B.6    Cooney, G.J.7    Kraegen, E.W.8
  • 67
    • 0036165489 scopus 로고    scopus 로고
    • 5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice
    • DOI 10.1007/s125-002-8245-8
    • X. M. Song, M. Fiedler, D. Galuska, J. W. Ryder, M. Fernstrom, A. V. Chibalin, H. Wallberg-Henriksson and J. R. Zierath: 5-Aminoimidazole-4- carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice. Diabetologia, 45(1), 56-65(2002) (Pubitemid 34118543)
    • (2002) Diabetologia , vol.45 , Issue.1 , pp. 56-65
    • Song, X.M.1    Fiedler, M.2    Galuska, D.3    Ryder, J.W.4    Fernstrom, M.5    Chibalin, A.V.6    Wallberg-Henriksson, H.7    Zierath, J.R.8
  • 69
    • 24044526514 scopus 로고    scopus 로고
    • AICAR and hyperosmotic stress increase insulin-stimulated glucose transport
    • DOI 10.1152/japplphysiol.01297.2004
    • J. L. Smith, P. B. Patil and J. S. Fisher: AICAR and hyperosmotic stress increase insulin-stimulated glucose transport. J Appl Physiol, 99(3), 877-83(2005) (Pubitemid 41214497)
    • (2005) Journal of Applied Physiology , vol.99 , Issue.3 , pp. 877-883
    • Smith, J.L.1    Patil, P.B.2    Fisher, J.S.3
  • 70
    • 0032704115 scopus 로고    scopus 로고
    • Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle
    • B. F. Holmes, E. J. Kurth-Kraczek and W. W. Winder: Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle. J Appl Physiol, 87(5), 1990-5(1999)
    • (1999) J. Appl. Physiol. , vol.87 , Issue.5 , pp. 1990-1995
    • Holmes, B.F.1    Kurth-Kraczek, E.J.2    Winder, W.W.3
  • 75
    • 4544386858 scopus 로고    scopus 로고
    • AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle
    • B. F. Holmes, D. B. Lang, M. J. Birnbaum, J. Mu and G. L. Dohm: AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle. Am J Physiol Endocrinol Metab, 287(4), E-73943(2004)
    • (2004) Am. J. Physiol. Endocrinol. Metab. , vol.287 , Issue.4
    • Holmes, B.F.1    Lang, D.B.2    Birnbaum, M.J.3    Mu, J.4    Dohm, G.L.5
  • 77
    • 34547610976 scopus 로고    scopus 로고
    • Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift
    • DOI 10.2337/db07-0255
    • K. S. Rockl, M. F. Hirshman, J. Brandauer, N. Fujii, L. A. Witters and L. J. Goodyear: skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift. Diabetes, 56(8), 2062-9(2007) (Pubitemid 47195818)
    • (2007) Diabetes , vol.56 , Issue.8 , pp. 2062-2069
    • Rockl, K.S.C.1    Hirshman, M.F.2    Brandauer, J.3    Fujii, N.4    Witters, L.A.5    Goodyear, L.J.6
  • 81
    • 33745684376 scopus 로고    scopus 로고
    • AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B
    • L. Bertrand, A. Ginion, C. Beauloye, A. D. Hebert, B. Guigas, L. Hue and J. L. Vanoverschelde: AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B. Am J Physiol Heart Circ Physiol, 291(1), H-23950(2006)
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291 , Issue.1
    • Bertrand, L.1    Ginion, A.2    Beauloye, C.3    Hebert, A.D.4    Guigas, B.5    Hue, L.6    Vanoverschelde, J.L.7
  • 83
    • 33746419647 scopus 로고    scopus 로고
    • Effect of calorie restriction with or without exercise on insulin sensitivity, β-cell function, fat cell size, and ectopic lipid in overweight subjects
    • DOI 10.2337/dc05-2565
    • D. E. Larson-Meyer, L. K. Heilbronn, L. M. Redman, B. R. Newcomer, M. I. Frisard, S. Anton, S. R. Smith, A. Alfonso and E. Ravussin: Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects. Diabetes Care, 29(6), 1337-44(2006) (Pubitemid 44125932)
    • (2006) Diabetes Care , vol.29 , Issue.6 , pp. 1337-1344
    • Larson-Meyer, D.E.1    Heilbronn, L.K.2    Redman, L.M.3    Newcomer, B.R.4    Frisard, M.I.5    Anton, S.6    Smith, S.R.7    Alfonso, A.8    Ravussin, E.9
  • 84
    • 37549054706 scopus 로고    scopus 로고
    • Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients
    • I. M. Jazet, G. Schaart, A. Gastaldelli, E. Ferrannini, M. K. Hesselink, P. Schrauwen, J. A. Romijn, J. A. Maassen, H. Pijl, D. M. Ouwens and A. E. Meinders: Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients. Diabetologia, 51(2), 309-19(2008)
    • (2008) Diabetologia , vol.51 , Issue.2 , pp. 309-319
    • Jazet, I.M.1    Schaart, G.2    Gastaldelli, A.3    Ferrannini, E.4    Hesselink, M.K.5    Schrauwen, P.6    Romijn, J.A.7    Maassen, J.A.8    Pijl, H.9    Ouwens, D.M.10    Meinders, A.E.11
  • 85
    • 50949116173 scopus 로고    scopus 로고
    • Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function
    • S. Hammer, M. Snel, H. J. Lamb, I. M. Jazet, R. W. van der Meer, H. Pijl, E. A. Meinders, J. A. Romijn, A. de Roos and J. W. Smit: Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function. J Am Coll Cardiol, 52(12), 1006-12(2008)
    • (2008) J. Am. Coll. Cardiol. , vol.52 , Issue.12 , pp. 1006-1012
    • Hammer, S.1    Snel, M.2    Lamb, H.J.3    Jazet, I.M.4    Van Der Meer, R.W.5    Pijl, H.6    Meinders, E.A.7    Romijn, J.A.8    De Roos, A.9    Smit, J.W.10
  • 88
    • 33749349202 scopus 로고    scopus 로고
    • Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice
    • DOI 10.2337/db05-1188
    • M. Zang, S. Xu, K. A. Maitland-Toolan, A. Zuccollo, X. Hou, B. Jiang, M. Wierzbicki, T. J. Verbeuren and R. A. Cohen: Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes, 55(8), 2180-91(2006) (Pubitemid 44743614)
    • (2006) Diabetes , vol.55 , Issue.8 , pp. 2180-2191
    • Zang, M.1    Xu, S.2    Maitland-Toolan, K.A.3    Zuccollo, A.4    Hou, X.5    Jiang, B.6    Wierzbicki, M.7    Verbeuren, T.J.8    Cohen, R.A.9
  • 91
    • 34548857700 scopus 로고    scopus 로고
    • SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B
    • DOI 10.1016/j.cmet.2007.08.014, PII S1550413107002598
    • C. Sun, F. Zhang, X. Ge, T. Yan, X. Chen, X. Shi and Q. Zhai: SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab, 6(4), 307-19(2007) (Pubitemid 47468091)
    • (2007) Cell Metabolism , vol.6 , Issue.4 , pp. 307-319
    • Sun, C.1    Zhang, F.2    Ge, X.3    Yan, T.4    Chen, X.5    Shi, X.6    Zhai, Q.7
  • 97
    • 35648944317 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5′-AMP-activated protein kinase
    • DOI 10.1074/jbc.M702390200
    • Q. F. Collins, H. Y. Liu, J. Pi, Z. Liu, M. J. Quon and W. Cao: Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5'-AMP-activated protein kinase. J Biol Chem, 282(41), 30143-9(2007) (Pubitemid 350035266)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.41 , pp. 30143-30149
    • Collins, Q.F.1    Liu, H.-Y.2    Pi, J.3    Liu, Z.4    Quon, M.J.5    Cao, W.6
  • 101
    • 28844433635 scopus 로고    scopus 로고
    • Medicine: The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • DOI 10.1126/science.1120781
    • R. J. Shaw, K. A. Lamia, D. Vasquez, S. H. Koo, N. Bardeesy, R. A. Depinho, M. Montminy and L. C. Cantley: The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science, 310(5754), 1642-6(2005) (Pubitemid 41780780)
    • (2005) Science , vol.310 , Issue.5754 , pp. 1642-1646
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3    Koo, S.-H.4    Bardeesy, N.5    DePinho, R.A.6    Montminy, M.7    Cantley, L.C.8
  • 102
    • 17844368938 scopus 로고    scopus 로고
    • Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver
    • DOI 10.2337/diabetes.54.5.1331
    • M. Foretz, N. Ancellin, F. Andreelli, Y. Saintillan, P. Grondin, A. Kahn, B. Thorens, S. Vaulont and B. Viollet: Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes, 54(5), 1331-9(2005) (Pubitemid 40586661)
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1331-1339
    • Foretz, M.1    Ancellin, N.2    Andreelli, F.3    Saintillan, Y.4    Grondin, P.5    Kahn, A.6    Thorens, B.7    Vaulont, S.8    Viollet, B.9
  • 104
    • 0034074153 scopus 로고    scopus 로고
    • 5-Aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6- phosphatase
    • P. A. Lochhead, I. P. Salt, K. S. Walker, D. G. Hardie and C. Sutherland: 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase. Diabetes, 49(6), 896-903(2000) (Pubitemid 30349410)
    • (2000) Diabetes , vol.49 , Issue.6 , pp. 896-903
    • Lochhead, P.A.1    Salt, I.P.2    Walker, K.S.3    Hardie, D.G.4    Sutherland, C.5
  • 109
    • 0242600806 scopus 로고    scopus 로고
    • 5-Amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes
    • DOI 10.2337/diabetes.52.5.1066
    • H. A. Koistinen, D. Galuska, A. V. Chibalin, J. Yang, J. R. Zierath, G. D. Holman and H. Wallberg-Henriksson: 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes, 52(5), 1066-72(2003) (Pubitemid 36523338)
    • (2003) Diabetes , vol.52 , Issue.5 , pp. 1066-1072
    • Koistinen, H.A.1    Galuska, D.2    Chibalin, A.V.3    Yang, J.4    Zierath, J.R.5    Holman, G.D.6    Wallberg-Henriksson, H.7
  • 110
    • 50349099779 scopus 로고    scopus 로고
    • Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic
    • K. Sakamoto and G. D. Holman: Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic. Am J Physiol Endocrinol Metab, 295(1), E-2937(2008)
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295 , Issue.1
    • Sakamoto, K.1    Holman, G.D.2
  • 112
    • 57349197971 scopus 로고    scopus 로고
    • Resistance exercise increases human skeletal muscle AS160/TBC1D4 phosphorylation in association with enhanced leg glucose uptake during post-exercise recovery
    • H. C. Dreyer, M. J. Drummond, E. L. Glynn, S. Fujita, D. L. Chinkes, E. Volpi and B. B. Rasmussen: Resistance exercise increases human skeletal muscle AS160/TBC1D4 phosphorylation in association with enhanced leg glucose uptake during post-exercise recovery. J Appl Physiol (2008)
    • (2008) J. Appl. Physiol.
    • Dreyer, H.C.1    Drummond, M.J.2    Glynn, E.L.3    Fujita, S.4    Chinkes, D.L.5    Volpi, E.6    Rasmussen, B.B.7
  • 116
    • 0030847432 scopus 로고    scopus 로고
    • Acute stimulation of glucose metabolism in mice by leptin treatment
    • DOI 10.1038/38717
    • S. Kamohara, R. Burcelin, J. L. Halaas, J. M. Friedman and M. J. Charron: Acute stimulation of glucose metabolism in mice by leptin treatment. Nature, 389(6649), 374-7(1997) (Pubitemid 27415217)
    • (1997) Nature , vol.389 , Issue.6649 , pp. 374-377
    • Kamohara, S.1    Burcelin, R.2    Halaas, J.L.3    Friedman, J.M.4    Charron, M.J.5
  • 117
    • 0032971214 scopus 로고    scopus 로고
    • Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats
    • DOI 10.2337/diabetes.48.2.287
    • Y. Minokoshi, M. S. Haque and T. Shimazu: Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats. Diabetes, 48(2), 287-91(1999) (Pubitemid 29061100)
    • (1999) Diabetes , vol.48 , Issue.2 , pp. 287-291
    • Minokoshi, Y.1    Haque, M.S.2    Shimazu, T.3
  • 118
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • DOI 10.1038/415339a
    • Y. Minokoshi, Y. B. Kim, O. D. Peroni, L. G. Fryer, C. Muller, D. Carling and B. B. Kahn: Leptin stimulates fattyacid oxidation by activating AMP-activated protein kinase. Nature, 415(6869), 339-43(2002) (Pubitemid 34087557)
    • (2002) Nature , vol.415 , Issue.6869 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.-B.2    Peroni, O.D.3    Fryer, L.G.D.4    Muller, C.5    Carling, D.6    Kahn, B.B.7
  • 119
    • 33644699965 scopus 로고    scopus 로고
    • The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects
    • DOI 10.2337/diabetes.54.11.3154
    • C. R. Bruce, V. A. Mertz, G. J. Heigenhauser and D. J. Dyck: The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects. Diabetes, 54(11), 3154-60(2005) (Pubitemid 43334369)
    • (2005) Diabetes , vol.54 , Issue.11 , pp. 3154-3160
    • Bruce, C.R.1    Mertz, V.A.2    Heigenhauser, G.J.F.3    Dyck, D.J.4
  • 120
    • 22244477735 scopus 로고    scopus 로고
    • Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ?
    • DOI 10.1097/00003677-200507000-00003
    • M. A. Febbraio and B. K. Pedersen: Contraction-induced myokine production and release: is skeletal muscle an endocrine organ? Exerc Sport Sci Rev, 33(3), 114-9(2005) (Pubitemid 40994563)
    • (2005) Exercise and Sport Sciences Reviews , vol.33 , Issue.3 , pp. 114-119
    • Febbraio, M.A.1    Pedersen, B.K.2
  • 121
    • 34249682779 scopus 로고    scopus 로고
    • Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle
    • DOI 10.2337/db06-1733
    • S. Glund, A. Deshmukh, Y. C. Long, T. Moller, H. A. Koistinen, K. Caidahl, J. R. Zierath and A. Krook: Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle. Diabetes, 56(6), 1630-7(2007) (Pubitemid 46842596)
    • (2007) Diabetes , vol.56 , Issue.6 , pp. 1630-1637
    • Glund, S.1    Deshmukh, A.2    Yun, C.L.3    Moller, T.4    Koistinen, H.A.5    Caidahl, K.6    Zierath, J.R.7    Krook, A.8
  • 122
    • 58149345626 scopus 로고    scopus 로고
    • Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine skeletal Muscle
    • I. Nieto-Vazquez, S. Fernandez-Veledo, C. de Alvaro and M. Lorenzo: Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine skeletal Muscle. Diabetes (2008)
    • (2008) Diabetes
    • Nieto-Vazquez, I.1    Fernandez-Veledo, S.2    De Alvaro, C.3    Lorenzo, M.4
  • 124
    • 0035406121 scopus 로고    scopus 로고
    • Hepatocyte Nuclear Factor-4α Involved in Type 1 Maturity-Onset Diabetes of the Young Is a Novel Target of AMP-Activated Protein Kinase
    • I. Leclerc, C. Lenzner, L. Gourdon, S. Vaulont, A. Kahn and B. Viollet: Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase. Diabetes, 50(7), 1515-21(2001) (Pubitemid 33639590)
    • (2001) Diabetes , vol.50 , Issue.7 , pp. 1515-1521
    • Leclerc, I.1    Lenzner, C.2    Gourdon, L.3    Vaulont, S.4    Kahn, A.5    Viollet, B.6
  • 125
    • 0033815967 scopus 로고    scopus 로고
    • Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase
    • A. Woods, D. Azzout-Marniche, M. Foretz, S. C. Stein, P. Lemarchand, P. Ferre, F. Foufelle and D. Carling: Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Mol Cell Biol, 20(18), 6704-11(2000)
    • (2000) Mol. Cell. Biol. , vol.20 , Issue.18 , pp. 6704-6711
    • Woods, A.1    Azzout-Marniche, D.2    Foretz, M.3    Stein, S.C.4    Lemarchand, P.5    Ferre, P.6    Foufelle, F.7    Carling, D.8
  • 126
    • 0032511053 scopus 로고    scopus 로고
    • Amp-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes
    • DOI 10.1074/jbc.273.24.14767
    • M. Foretz, D. Carling, C. Guichard, P. Ferre and F. Foufelle: AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes. J Biol Chem, 273(24), 14767-71(1998) (Pubitemid 28272762)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.24 , pp. 14767-14771
    • Foretz, M.1    Carling, D.2    Guichard, C.3    Ferre, P.4    Foufelle, F.5
  • 127
    • 0032541083 scopus 로고    scopus 로고
    • The 5'-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex
    • DOI 10.1016/S0014-5793(98)00745-5, PII S0014579398007455
    • I. Leclerc, A. Kahn and B. Doiron: The 5'-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex. FEBS Lett, 431(2), 180-4(1998) (Pubitemid 28334212)
    • (1998) FEBS Letters , vol.431 , Issue.2 , pp. 180-184
    • Leclerc, I.1    Kahn, A.2    Doiron, B.3
  • 129
    • 0031425839 scopus 로고    scopus 로고
    • AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
    • G. F. Merrill, E. J. Kurth, D. G. Hardie and W. W. Winder: AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol, 273(6 Pt 1), E1107-12(1997)
    • (1997) Am. J. Physiol. , vol.273 , Issue.1-6 PART
    • Merrill, G.F.1    Kurth, E.J.2    Hardie, D.G.3    Winder, W.W.4
  • 133
    • 21044443195 scopus 로고    scopus 로고
    • AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscle
    • DOI 10.1113/jphysiol.2004.081687
    • A. C. Smith, C. R. Bruce and D. J. Dyck: AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscle. J Physiol, 565(Pt 2), 547-53(2005) (Pubitemid 40872481)
    • (2005) Journal of Physiology , vol.565 , Issue.2 , pp. 547-553
    • Smith, A.C.1    Bruce, C.R.2    Dyck, D.J.3
  • 136
    • 0012785395 scopus 로고    scopus 로고
    • Metformin reverses fatty liver disease in obese, leptin-deficient mice
    • H. Z. Lin, S. Q. Yang, C. Chuckaree, F. Kuhajda, G. Ronnet and A. M. Diehl: Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat Med, 6(9), 998-1003(2000)
    • (2000) Nat. Med. , vol.6 , Issue.9 , pp. 998-1003
    • Lin, H.Z.1    Yang, S.Q.2    Chuckaree, C.3    Kuhajda, F.4    Ronnet, G.5    Diehl, A.M.6
  • 137
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • DOI 10.1172/JCI200317797
    • A. Xu, Y. Wang, H. Keshaw, L. Y. Xu, K. S. Lam and G. J. Cooper: The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest, 112(1), 91-100(2003) (Pubitemid 38056380)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.1 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.L.5    Cooper, G.J.S.6
  • 141
    • 34250751754 scopus 로고    scopus 로고
    • AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside
    • DOI 10.1042/BJ20070105
    • B. Guigas, N. Taleux, M. Foretz, D. Detaille, F. Andreelli, B. Viollet and L. Hue: AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside. Biochem J, 404(3), 499-507(2007) (Pubitemid 46953924)
    • (2007) Biochemical Journal , vol.404 , Issue.3 , pp. 499-507
    • Guigas, B.1    Taleux, N.2    Foretz, M.3    Detaille, D.4    Andreelli, F.5    Viollet, B.6    Hue, L.7
  • 143
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    • S. E. Kahn: The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia, 46(1), 3-19(2003) (Pubitemid 36237741)
    • (2003) Diabetologia , vol.46 , Issue.1 , pp. 3-19
    • Kahn, S.E.1
  • 144
    • 0028817815 scopus 로고
    • Overview of 6 years' therapy of type II diabetes: A progressive disease. U. K. Prospective Diabetes Study Group
    • U. K. prospective diabetes study 16
    • U. K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U. K. Prospective Diabetes Study Group. Diabetes, 44(11), 1249-58(1995)
    • (1995) Diabetes , vol.44 , Issue.11 , pp. 1249-1258
  • 145
    • 0036896505 scopus 로고    scopus 로고
    • Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: Role in β-cell adaptation and failure in the etiology of diabetes
    • M. Prentki, E. Joly, W. El-Assaad and R. Roduit: Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. Diabetes, 51 Suppl 3, S405-13 (2002) (Pubitemid 35403424)
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 3
    • Prentki, M.1    Joly, E.2    El-Assaad, W.3    Roduit, R.4
  • 149
    • 0036894375 scopus 로고    scopus 로고
    • Genetic manipulations of fatty acid metabolism in β-cells are associated with dysregulated insulin secretion
    • K. Eto, T. Yamashita, J. Matsui, Y. Terauchi, M. Noda and T. Kadowaki: Genetic manipulations of fatty acid metabolism in beta-cells are associated with dysregulated insulin secretion. Diabetes, 51 Suppl 3, S414-20 (2002) (Pubitemid 35403425)
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 3
    • Eto, K.1    Yamashita, T.2    Matsui, J.3    Terauchi, Y.4    Noda, M.5    Kadowaki, T.6
  • 150
    • 0037301056 scopus 로고    scopus 로고
    • AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase
    • B. A. Kefas, H. Heimberg, S. Vaulont, D. Meisse, L. Hue, D. Pipeleers and M. Van de Casteele: AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase. Diabetologia, 46(2), 250-4(2003) (Pubitemid 36343889)
    • (2003) Diabetologia , vol.46 , Issue.2 , pp. 250-254
    • Kefas, B.A.1    Heimberg, H.2    Vaulont, S.3    Meisse, D.4    Hue, L.5    Pipeleers, D.6    Casteele, M.7
  • 151
    • 0038363852 scopus 로고    scopus 로고
    • AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase
    • DOI 10.1677/jme.0.0300151
    • B. A. Kefas, Y. Cai, Z. Ling, H. Heimberg, L. Hue, D. Pipeleers and M. Van de Casteele: AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase. J Mol Endocrinol, 30(2), 151-61(2003) (Pubitemid 36592509)
    • (2003) Journal of Molecular Endocrinology , vol.30 , Issue.2 , pp. 151-161
    • Kefas, B.A.1    Cai, Y.2    Ling, Z.3    Heimberg, H.4    Hue, L.5    Pipeleers, D.6    Van De Casteele, M.7
  • 152
    • 40749090482 scopus 로고    scopus 로고
    • Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokinemediated apoptosis and CD8+ T-cell-induced cytotoxicity
    • A. Riboulet-Chavey, F. Diraison, L. K. Siew, F. S. Wong and G. A. Rutter: Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokinemediated apoptosis and CD8+ T-cell-induced cytotoxicity. Diabetes, 57(2), 415-23(2008)
    • (2008) Diabetes , vol.57 , Issue.2 , pp. 415-423
    • Riboulet-Chavey, A.1    Diraison, F.2    Siew, L.K.3    Wong, F.S.4    Rutter, G.A.5
  • 153
    • 33847009048 scopus 로고    scopus 로고
    • AICAR potentiates ROS production induced by chronic high glucose: Roles of AMPK in pancreatic β-cell apoptosis
    • DOI 10.1016/j.cellsig.2006.10.004, PII S0898656806002737
    • W. H. Kim, J. W. Lee, Y. H. Suh, H. J. Lee, S. H. Lee, Y. K. Oh, B. Gao and M. H. Jung: AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis. Cell Signal, 19(4), 791-805(2007) (Pubitemid 46275369)
    • (2007) Cellular Signalling , vol.19 , Issue.4 , pp. 791-805
    • Kim, W.-H.1    Lee, J.W.2    Suh, Y.H.3    Lee, H.J.4    Lee, S.H.5    Oh, Y.K.6    Gao, B.7    Jung, M.H.8
  • 155
    • 28044464932 scopus 로고    scopus 로고
    • Over-expression of AMP-activated protein kinase impairs pancreatic β-cell function in vivo
    • DOI 10.1677/joe.1.06413
    • S. K. Richards, L. E. Parton, I. Leclerc, G. A. Rutter and R. M. Smith: Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo. J Endocrinol, 187(2), 225-35(2005) (Pubitemid 41685182)
    • (2005) Journal of Endocrinology , vol.187 , Issue.2 , pp. 225-235
    • Richards, S.K.1    Parton, L.E.2    Leclerc, I.3    Rutter, G.A.4    Smith, R.M.5
  • 157
    • 0038584871 scopus 로고    scopus 로고
    • Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression
    • DOI 10.1042/BJ20021812
    • G. da Silva Xavier, I. Leclerc, A. Varadi, T. Tsuboi, S. K. Moule and G. A. Rutter: Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J, 371(Pt 3), 761-74(2003) (Pubitemid 36578875)
    • (2003) Biochemical Journal , vol.371 , Issue.3 , pp. 761-774
    • Da Silva Xavier, G.1    Leclerc, I.2    Varadi, A.3    Tsuboi, T.4    Moule, S.K.5    Rutter, G.A.6
  • 158
    • 0032213768 scopus 로고    scopus 로고
    • AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic β cells, and may regulate insulin release
    • I. P. Salt, G. Johnson, S. J. Ashcroft and D. G. Hardie: AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. Biochem J, 335(Pt 3), 533-9(1998) (Pubitemid 28515405)
    • (1998) Biochemical Journal , vol.335 , Issue.3 , pp. 533-539
    • Salt, I.P.1    Johnson, G.2    Ashcroft, S.J.H.3    Hardie, D.G.4
  • 159
    • 34250665869 scopus 로고    scopus 로고
    • Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells
    • DOI 10.1016/j.lfs.2007.04.034, PII S0024320507003517
    • X. Wang, L. Zhou, L. Shao, L. Qian, X. Fu, G. Li, T. Luo, Y. Gu, F. Li, J. Li, S. Zheng and M. Luo: Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells. Life Sci, 81(2), 160-5(2007) (Pubitemid 46929110)
    • (2007) Life Sciences , vol.81 , Issue.2 , pp. 160-165
    • Wang, X.1    Zhou, L.2    Shao, L.3    Qian, L.4    Fu, X.5    Li, G.6    Luo, T.7    Gu, Y.8    Li, F.9    Li, J.10    Zheng, S.11    Luo, M.12
  • 160
    • 50449090523 scopus 로고    scopus 로고
    • Berberine acutely inhibits insulin secretion from beta-cells through 3', 5'-cyclic adenosine 5'-monophosphate signaling pathway
    • L. Zhou, X. Wang, L. Shao, Y. Yang, W. Shang, G. Yuan, B. Jiang, F. Li, J. Tang, H. Jing and M. Chen: Berberine acutely inhibits insulin secretion from beta-cells through 3', 5'-cyclic adenosine 5'-monophosphate signaling pathway. Endocrinology, 149(9), 4510-8(2008)
    • (2008) Endocrinology , vol.149 , Issue.9 , pp. 4510-4518
    • Zhou, L.1    Wang, X.2    Shao, L.3    Yang, Y.4    Shang, W.5    Yuan, G.6    Jiang, B.7    Li, F.8    Tang, J.9    Jing, H.10    Chen, M.11
  • 161
    • 0346732321 scopus 로고    scopus 로고
    • 5′-AMP-activated Protein Kinase Controls Insulin-containing Secretory Vesicle Dynamics
    • DOI 10.1074/jbc.M307800200
    • T. Tsuboi, G. da Silva Xavier, I. Leclerc and G. A. Rutter: 5'-AMP-activated protein kinase controls insulincontaining secretory vesicle dynamics. J Biol Chem, 278(52), 52042-51(2003) (Pubitemid 38035789)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.52 , pp. 52042-52051
    • Tsuboi, T.1    Da Silva Xavier, G.2    Leclerc, I.3    Rutter, G.A.4
  • 162
    • 0141866857 scopus 로고    scopus 로고
    • NN414, a SUR1/Kir6.2-selective potassium channel opener, reduces blood glucose and improves glucose tolerance in the VDF Zucker rat
    • DOI 10.2337/diabetes.52.10.2513
    • R. D. Carr, C. L. Brand, T. B. Bodvarsdottir, J. B. Hansen and J. Sturis: NN414, a SUR1/Kir6.2-selective potassium channel opener, reduces blood glucose and improves glucose tolerance in the VDF Zucker rat. Diabetes, 52(10), 2513-8(2003) (Pubitemid 37210539)
    • (2003) Diabetes , vol.52 , Issue.10 , pp. 2513-2518
    • Carr, R.D.1    Brand, C.L.2    Bodvarsdottir, T.B.3    Hansen, J.B.4    Sturis, J.5
  • 163
    • 0037219411 scopus 로고    scopus 로고
    • β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
    • DOI 10.2337/diabetes.52.1.102
    • A. E. Butler, J. Janson, S. Bonner-Weir, R. Ritzel, R. A. Rizza and P. C. Butler: Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes, 52(1), 102-10(2003) (Pubitemid 36042113)
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 164
    • 0031913829 scopus 로고    scopus 로고
    • Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat
    • DOI 10.2337/diabetes.47.3.358
    • A. Pick, J. Clark, C. Kubstrup, M. Levisetti, W. Pugh, S. Bonner-Weir and K. S. Polonsky: Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes, 47(3), 358-64(1998) (Pubitemid 28104196)
    • (1998) Diabetes , vol.47 , Issue.3 , pp. 358-364
    • Pick, A.1    Clark, J.2    Kubstrup, C.3    Levisetti, M.4    Pugh, W.5    Bonner-Weir, S.6    Polonsky, K.S.7
  • 165
    • 0022970945 scopus 로고
    • Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
    • C. E. Murry, R. B. Jennings and K. A. Reimer: Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation, 74(5), 1124-36(1986) (Pubitemid 17174962)
    • (1986) Circulation , vol.74 , Issue.5 , pp. 1124-1136
    • Murry, C.E.1    Jennings, R.B.2    Reimer, K.A.3
  • 166
    • 1142297593 scopus 로고    scopus 로고
    • Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection
    • DOI 10.1016/j.cardiores.2003.10.022
    • Y. Nishino, T. Miura, T. Miki, J. Sakamoto, Y. Nakamura, Y. Ikeda, H. Kobayashi and K. Shimamoto: Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection. Cardiovascular research, 61(3), 610-9(2004) (Pubitemid 38210166)
    • (2004) Cardiovascular Research , vol.61 , Issue.3 , pp. 610-619
    • Nishino, Y.1    Miura, T.2    Miki, T.3    Sakamoto, J.4    Nakamura, Y.5    Ikeda, Y.6    Kobayashi, H.7    Shimamoto, K.8
  • 167
    • 27144457438 scopus 로고    scopus 로고
    • Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
    • DOI 10.1038/nm1295, PII N1295
    • R. Shibata, K. Sato, D. R. Pimentel, Y. Takemura, S. Kihara, K. Ohashi, T. Funahashi, N. Ouchi and K. Walsh: Adiponectin protects against myocardial ischemiareperfusion injury through AMPK-and COX-2-dependent mechanisms. Nat Med, 11(10), 1096-103(2005) (Pubitemid 41486832)
    • (2005) Nature Medicine , vol.11 , Issue.10 , pp. 1096-1103
    • Shibata, R.1    Sato, K.2    Pimentel, D.R.3    Takemura, Y.4    Kihara, S.5    Ohashi, K.6    Funahashi, T.7    Ouchi, N.8    Walsh, K.9
  • 170
    • 33646070557 scopus 로고    scopus 로고
    • Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats
    • J. B. Majithiya and R. Balaraman: Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats. Life Sci, 78(22), 2615-24(2006)
    • (2006) Life Sci. , vol.78 , Issue.22 , pp. 2615-2624
    • Majithiya, J.B.1    Balaraman, R.2
  • 171
    • 11144283703 scopus 로고    scopus 로고
    • Metabolic activation of AMP kinase in vascular smooth muscle
    • DOI 10.1152/japplphysiol.00075.2004
    • L. J. Rubin, L. Magliola, X. Feng, A. W. Jones and C. C. Hale: Metabolic activation of AMP kinase in vascular smooth muscle. J Appl Physiol, 98(1), 296-306(2005) (Pubitemid 40041260)
    • (2005) Journal of Applied Physiology , vol.98 , Issue.1 , pp. 296-306
    • Rubin, L.J.1    Magliola, L.2    Feng, X.3    Jones, A.W.4    Hale, C.C.5
  • 173
    • 3142616447 scopus 로고    scopus 로고
    • Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of AMP-activated protein kinase signaling
    • DOI 10.1074/jbc.M402558200
    • R. Shibata, N. Ouchi, S. Kihara, K. Sato, T. Funahashi and K. Walsh: Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of ampactivated protein kinase signaling. J Biol Chem, 279(27), 28670-4(2004) (Pubitemid 38900150)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.27 , pp. 28670-28674
    • Shibata, R.1    Ouchi, N.2    Kihara, S.3    Sato, K.4    Funahashi, T.5    Walsh, K.6


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