Metabolic flexibility

Proceedings of the Nutrition Society

Volumn 63, Issue 2, 2004, Pages 363-368

  Storlien, Len ^a   Oakes, Nick D ^a   Kelley, David E ^b  

^a ASTRAZENECA R AND D   (Sweden)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Lipid and carbohydrate utilization; Metabolic flexibility; Metabolic syndrome

Indexed keywords

CARBOHYDRATE; FATTY ACID; GLUCOSE; INSULIN; LIPID;

ADIPOSE TISSUE; CARBOHYDRATE DIET; CONFERENCE PAPER; DIABETES MELLITUS; ENERGY; GLUCONEOGENESIS; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; LIPID DIET; LIVER; METABOLIC REGULATION; METABOLIC SYNDROME X; METABOLISM; MUSCLE; OBESITY;

ADIPOSE TISSUE; ENERGY METABOLISM; GLUCOSE; HUMANS; METABOLIC SYNDROME X; MUSCLE, SKELETAL;

EID: 2942722769     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1079/PNS2004349     Document Type: Conference Paper

References (25)

1. Bruce DG, Chisholm DJ, Storlien LH & Kraegen EW (1988) Physiological importance of deficiency in early prandial insulin secretion in non-insulin-dependent diabetes. Diabetes 37, 736-744.
2. Coppack SW, Evans RD, Fisher RM, Frayn KN, Gibbons GF, Humphreys SM, Kirk ML, Potts JL & Hockaday TDR (1992) Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal. Metabolism 41, 264-272.
3. Dodt C, Lönnroth P, Wellhöner JP, Fehm HL & Elam M (2003) Sympathetic control of white adipose tissue in lean and obese humans. Acta Physiologica Scandinavica 177, 351-357.
4. English PJ, Coughlin SR, Hayden K, Malik IA & Wilding JPH (2003) Plasma adiponectin increases postprandially in obese, but not in lean, subjects. Obesity Research 11, 839-844.
5. Frayn KN (2002) Adipose tissue as a buffer for daily lipid flux. Diabetologia 45, 1201-1210.
6. Goto M, Terada S, Kato M, Katoh M, Yokozeki T, Tabata I & Shimokawa T (2000) cDNA cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats. Biochemical and Biophysical Research Communications 274, 350-354.
7. Holmes L, Storlien LH & Smythe GA (1989) Hypothalamic monoamines associated with the cephalic phase insulin response. American Journal of Physiology 256, E236-E241.
8. Kelley DE, Goodpaster B, Wing RR & Simoneau J-A (1999) Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity and weight loss. American Journal of Physiology 277, E1130-E1141.
9. Kelley DE, Goodpaster BH & Storlien LH (2002a) Muscle triglycerides and insulin resistance. Annual Review of Nutrition 22, 325-346.
10. Kelley DE, He J, Menshikova EV & Ritov VB (2002b) Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51, 2944-2950.
11. Kelley DE & Mandarino LJ (2000) Fuel selection in human skeletal muscle in insulin resistance. Diabetes 49, 677-683.
12. Kern PA, Di Gregorio GB, Lu T, Rassouli N & Ranganathan G (2003) Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-α expression. Diabetes 52, 1779-1785.
13. Lin J, Wu H, Tarr PT, et al. (2002) Transcriptional co-activator PGC-1alpha drives the formation of slow-twitch muscle fibres. Nature 418, 797-801.
14. Meirhaeghe A, Crowley V, Lenaghan C, et al. (2003) Characterization of the human, mouse and rat PGC1β (peroxisome-proliferator-activated receptor-γ co-activator 1β) gene in vitro and in vivo. Biochemical Journal 373, 155-165.
15. Mootha VK, Lindgren CM, Eriksson K-F, et al. (2003) PGC-1α- responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature Genetics 34, 267-273.
16. Oakes N, Kjellstedt A, Thalén P, Wettesten M, Löfgren L & Ljung B (2002) Tissue-specific effects of AZ 242, a novel PPARa/g agonist, on glucose and fatty acid metabolism in obese Zucker rats: an in vivo simultaneous multi-tracer assessment. Diabetes 51, Suppl. 2, A110.
17. Patti ME, Atul JB, Crunkhorn S, et al. (2003) Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proceedings of the National Academy of Sciences USA 100, 8466-8471.
18. Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW & Shulman GI (2003) Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 300, 1140-1142.
19. Picard F, Naïmi N, Richard D & Deshaies Y (1999) Response of adipose tissue lipoprotein lipase to the cephalic phase of insulin secretion. Diabetes 48, 452-459.
20. Polyzogopoulou EV, Kalfarentzos F, Vagenakis AG & Alexandrides TK (2003) Restoration of euglycemia and normal acute insulin response to glucose in obese subjects with type 2 diabetes following bariatric surgery. Diabetes 52, 1098-1103.
21. Summers LK, Samra JS, Humphreys SM, Morris RJ & Frayn KN (1996) Subcutaneous abdominal adipose tissue blood flow: variation within and between subjects and relationship to obesity. Clinical Science 91, 679-683.
22. Tiraby C, Tavernier G, Lefort C, Larrouy D, Bouillaud F, Ricquier D & Langin D (2003) Acquirement of brown fat cell features by human white adipocytes. Journal of Biological Chemistry 278, 33370-33376.
23. Wu H, Naya FJ, McKinsey TA, Meercer B, Shelton JM, Chin ER, Simard AR, Michel RN, Bassel-Duby R, Olson EN & Williams RS (2000) MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. EMBO Journal 19, 1963-1973.
24. Wu Z, Puigserver P, Andersson U, Zhang C-Y, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC & Spiegelman B (1999) Mechanisms controlling mitochondrial biogenesis and respiration through thermogenic coactivator PGC-1. Cell 98, 115-124.
25. Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB & Speigelman BM (2001) Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1a. Nature 413, 131-138.