The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Nav1.6 voltage-dependent sodium channel

American Journal of Physiology - Cell Physiology

Volumn 293, Issue 2, 2007, Pages

  Rosker, Christian ^a   Lohberger, Birgit ^a   Hofer, Doris ^a   Steinecker, Bibiane ^a   Quasthoff, Stefan ^a   Schreibmayer, Wolfgang ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Sodium channel; Tetrodotoxin

Indexed keywords

4,9 ANHYDRO TETRODOTOXIN; SAXITOXIN; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ALPHA CHAIN; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DEMYELINATION; DRUG MECHANISM; DRUG PROTEIN BINDING; HEART MUSCLE; METABOLISM; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RNA SYNTHESIS; STEADY STATE; XENOPUS LAEVIS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KINETICS; MEMBRANE POTENTIALS; MICE; MICROINJECTIONS; MUSCLE PROTEINS; NERVE TISSUE PROTEINS; OOCYTES; RATS; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 34547798947     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00070.2007     Document Type: Article

References (34)

1. Akopian AN, Sivilotti L, Wood JN. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 379: 257-262, 1996.
2. Auld VJ, Goldin AL, Krafte DS, Catterall WA, Lester HA, Davidson N, Dunn RJ. A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel. Proc Natl Acad Sci USA 87: 323-327, 1990.
3. Baer M, Best PM, Reuter H. Voltage-dependent action of tetrodotoxin in mammalian cardiac muscle. Nature 263: 344-345, 1976.
4. Bartoo AC, Sprunger LK, Schneider DA. Expression and distribution of TTX-sensitive sodium channel alpha subunits in the enteric nervous system. J Comp Neurol 486: 117-131, 2005.
5. Carmeliet E. Voltage-dependent block by tetrodotoxin of the sodium channel in rabbit cardiac Purkinje fibers. Biophys J 51: 109-114, 1987.
6. Choudhary G, Yotsu-Yamashita M, Shang L, Yasumoto T, Dudley SC. Interactions of the C-11 hydroxyl of tetrodotoxin with the sodium channel outer vestibule. Biophys J 84: 287-294, 2003.
7. Cote PD, De RY, Coupland SG, Schwab Y, Roux MJ, Levinson SR, Kothary R. Physiological maturation of photoreceptors depends on the voltage-gated sodium channel NaV1.6 (Scn8a). J Neurosci 25: 5046-5050, 2005.
8. Craner MJ, Newcombe J, Black JA, Hartle C, Cuzner ML, Waxman SG. Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav16 sodium channels and Na+/Ca2+ exchanger. Proc Natl Acad Sci USA 101: 8168-8173, 2004.
9. Dascal N, Lotan I. Expression of exogenous ion channels and neurotransmitter receptors in RNA-injected Xenopus oocytes. In: Methods in Neurobiology, edited by Longstaff A and Revest P. Totowa, NJ: Humana, 1992, vol. 13, p. 205-225.
10. Fulgenzi G, Graciotti L, Faronato M, Soldovieri MV, Miceli F, Amoroso S, Annunziato L, Procopio A, Taglialatela M. Human neoplastic mesothelial cells express voltage-gated sodium channels involved in cell motility. Int J Biochem Cell Biol 38: 1146-1159, 2006.
11. Gellens ME, George AL Jr, Chen LQ, Chahine M, Horn R, Barchi RL, Kallen RG. Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. Proc Natl Acad Sci USA 89: 554-558, 1992.
12. Hofer D, Lohberger B, Steinecker B, Schmidt K, Quasthoff S, Schreibmayer W. A comparative study of the action of tolperisone on seven different voltage dependent sodium channel isoforms. Eur J Pharmacol 538: 5-14, 2006.
13. Hong SS, Morrow TJ, Paulson PE, Isom LL, Wiley JW. Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat. J Biol Chem 279: 29341-29350, 2004.
14. Hossain WA, Antic SD, Yang Y, Rasband MN, Morest DK. Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea. J Neurosci 25: 6857-6868, 2005.
15. Klein JP, Khera DS, Nersesyan H, Kimchi EY, Waxman SG, Blumenfeld H. Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy. Brain Res 1000: 102-109, 2004.
16. Klugbauer N, Lacinova L, Flockerzi V, Hofmann F. Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells. EMBO J 14: 1084-1090, 1995.
17. Levin SI, Khaliq ZM, Aman TK, Grieco TM, Kearney JA, Raman IM, Meisler MH. Impaired motor function in mice with cell-specific knockout of sodium channel Scn8a [Na(V)1.6] in cerebellar Purkinje neurons and granule cells. J Neurophysiol 96: 785-793, 2006.
18. Lipkind GM, Fozzard HA. KcsA crystal structure as framework for a molecular model of the Na(+) channel pore. Biochemistry 39: 8161-8170, 2000.
19. Maier SKG, Westenbroek RE, Schenkman KA, Feigl EO, Scheuer T, Catterall WA. An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart. Proc Natl Acad Sci USA 99: 4073-4078, 2002.
20. Miyazawa K, Noguchi T. Distribution and origin of tetrodotoxin. J Toxicol Toxin Rev 20: 11-33, 2001.
21. Musarella M, Alcaraz G, Caillol G, Boudier JL, Couraud F, Utillo-Touati A. Expression of Nav16 sodium channels by Schwann cells at neuromuscular junctions: role in the motor endplate disease phenotype. Glia 53: 13-23, 2006.
22. Narahashi T. Pharmacology of tetrodotoxin. J Toxicol Toxin Rev 20: 67-84, 2001.
23. Narahashi T, Moore JW, Scott WR. Tetrodotoxin blockage of sodium conductance increase in lobster giant axons. J Gen Physiol 47: 965-974, 1964.
24. Oliveira JS, Redaelli E, Zaharenko AJ, Cassulini RR, Konno K, Pimenta DC, Freitas JC, Clare JJ, Wanke E. Binding specificity of sea anemone toxins to Nav 1.1-16 sodium channels: unexpected contributions from differences in the IV/S3-S4 outer loop. J Biol Chem 279: 33323-33335, 2004.
25. Patton DE, Isom LL, Catterall WA, Goldin AL. The adult rat brain beta 1 subunit modifies activation and inactivation gating of multiple sodium channel alpha subunits. J Biol Chem 269: 17649-17655, 1994.
26. Pires OR, Sebben A, Schwartz EF, Bloch C, Morales RAV, Schwartz CA. The occurrence of 11-oxotetrodotoxin, a rare tetrodotoxin analogue, in the brachycephalidae frog Brachycephalus ephippium. Toxicon 42: 563-566, 2003.
27. Sandtner W, Szendroedi J, Zarrabi T, Zebedin E, Hilber K, Glaaser I, Fozzard HA, Dudley SC, Todt H. Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel. Mol Pharmacol 66: 648-657, 2004.
28. Schiavon E, Sacco T, Cassulini RR, Gurrola G, Tempia F, Possani LD, Wanke E. Resurgent current and voltage sensor trapping enhanced activation by a beta-scorpion toxin solely in Na(v)1.6 channel - Significance in mice Purkinje neurons. J Biol Chem 281: 20326-20337, 2006.
29. Sivilotti L, Okuse K, Akopian AN, Moss S, Wood JN. A single serine residue confers tetrodotoxin insensitivity on the rat sensory-neuron-specific sodium channel SNS. FENS Lett 409: 49-52, 1997.
30. Smith MR, Smith RD, Plummer NW, Meisler MH, Goldin AL. Functional analysis of the mouse Scn8a sodium channel. J Neurosci 18: 6093-6102, 1998.
31. Terlau H, Olivera BM. Conus venoms: a rich source of novel ion channel-targeted peptides. Physiol Rev 84: 41-68, 2004.
32. Trimmer JS, Cooperman SS, Tomiko SA, Zhou JY, Crean SM, Boyle MB, Kallen RG, Sheng ZH, Barchi RL, Sigworth FJ, Goodman RH, Agnew WS, Mandel G. Primary structure and functional expression of a mammalian skeletal muscle sodium channel. Neuron 3: 33-49, 1989.
33. Waxman SG, Craner MJ, Black JA. Na+ channel expression along axons in multiple sclerosis and its models. Trends Pharmacol Sci 25: 584-591, 2004.
34. Yotsu-Yamashita M, Sugimoto A, Takai A, Yasumoto T. Effects of specific modifications of several hydroxyls of tetrodotoxin on its affinity to rat brain membrane. J Pharmacol Exp Ther 289: 1688-1696, 1999.